Femikadin

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Femikadin

Property Description
Active Ingredients Ethinyl Estradiol, Levonorgestrel
Form Oral Tablet
Pharmacological Class Hormonal Contraceptive (Estrogens/Progestins)
Common Use Pregnancy Prevention
Origin Synthetic

Defining Femikadin: A Combined Hormonal Contraceptive

Femikadin is classified as a Combined Oral Contraceptive (COC), which is a prescription-only medicine primarily used for pregnancy prevention in women of reproductive potential. This drug belongs to the established pharmacological class of Hormonal Contraceptives, specifically a combination of synthetic estrogen and progestin compounds. Combined oral contraceptives are recognized as an effective method for preventing pregnancy.

Composition and Origin: Synthetic Estrogen and Progestin

Femikadin's core composition includes two active ingredients: Ethinyl Estradiol and Levonorgestrel. This specific combination of hormones is utilized in various birth control formulations; other brands containing the same dual components include Altavera, Aviane, and Levlen. Both are synthetic derivatives of naturally occurring steroid hormones, which facilitates stable action when administered orally. The formulation is clinically recognized for achieving the hormonal changes required for effective conception control.

General Purpose of Femikadin

The general purpose of Femikadin is to provide multi-faceted protection against unintended pregnancy, offering an effective method for control over reproductive life. The combined action of the synthetic hormones interrupts the biological prerequisites for conception. These systemic effects primarily involve ovulation inhibition, preventing the monthly release of an egg, and secondary mechanisms that alter the uterine environment. This approach is utilized by individuals seeking a daily, non-surgical method of family planning.

Regulatory References

  1. IARC Monograph on Combined Estrogen-Progestogen Contraceptives
  2. DailyMed Levonorgestrel and Ethinyl Estradiol

What side effects are possible with Femikadin?

Adverse Reactions and Safety Profile

The official safety information for this medicine details documented side effects ranging from very common to rare, as required by government regulatory agencies (e.g., EMA, FDA). All reported reactions are classified by frequency and grouped by the body system affected (System-Organ Class).

Common and Frequency-Classified Effects

Adverse reactions that are frequently observed in clinical documentation, typically falling into the Very Common (ge 1/10) or Common (ge 1/100 to < 1/10) categories, may include headaches/migraines, nausea/vomiting, breast tenderness/pain, and irregular uterine bleeding (spotting or breakthrough bleeding). Effects are commonly reported across System-Organ Classes such as Vascular Disorders, Nervous System Disorders, and Reproductive System and Breast Disorders.

Serious Adverse Reactions (Regulatory Warnings)

Government regulatory documents highlight serious risks that require explicit warning. These typically include the risk of Venous Thromboembolism (VTE), such as Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE), as well as Arterial Thromboembolism (ATE), including stroke and myocardial infarction. Other serious documented risks are the development of Liver Tumours (benign or malignant).

Safety Restrictions and Considerations

Contraindications define situations where the medicine must not be used, such as a history of VTE, ATE, severe liver disease, or known sex-steroid sensitive malignancies. Population-specific considerations mandate caution or restrict use in specific patient groups; for instance, the risk of serious cardiovascular events is noted as elevated in females who smoke and are over 35 years old. Exposure-related patterns documented in the label indicate that the risk of thromboembolism is generally highest during the first year of use.

Connection to the Overall Safety Profile

The official safety profile provides a regulatory-defined framework that structures the understanding of risks by first establishing absolute restrictions on use via contraindications. It then systematically documents all known adverse events using strict frequency classification, clearly distinguishing between common and rare but serious, life-threatening events. This formal structure ensures that safety information is communicated in a standardized, verifiable manner.

Overdose and Emergency Response

Overdose and When to Seek Help

Official regulatory information for combined oral contraceptives, such as Femikadin (Ethinyl Estradiol and Levonorgestrel), outlines the officially documented clinical signs and mandatory actions required in the event of an overdose.

Overdose is generally not associated with severe or life-threatening toxicities in healthy individuals, and severe outcomes are classified as unlikely to occur. The most commonly documented overdose presentations are confined to specific, non-life-threatening manifestations.


Documented Manifestations and Emergency Actions

The following clinical signs are reported in official prescribing information following the ingestion of large, supra-therapeutic doses:

Documented Manifestations Regulatory Guidance on Action
Nausea and Vomiting Seek immediate medical attention for assessment
Withdrawal Bleeding (Vaginal Bleeding) Management is symptomatic and supportive treatment

Individuals must seek immediate medical attention for any known or suspected overdose. The official management protocol is defined as symptomatic and supportive treatment, as no specific antidote is known for this combination. A specific regulatory note addresses the pediatric population: vaginal bleeding is a recognized manifestation in premenarchal females who ingest an overdose. Hospital monitoring may be required to provide supportive care.

Therapeutic Uses of Femikadin

Femikadin is commonly applied in clinical settings that involve acute or unstable symptom patterns, marked by the need for support for family planning and supportive management of distressing gynecological and hormonal symptoms. The combination of Ethinyl Estradiol and Levonorgestrel is used in areas where short-term symptom management is appropriate and contributes to easing the overall symptom load.

This medication is generally indicated to prevent unintended pregnancy, and may be part of symptomatic management for heavy or irregular menstruation, and conditions like endometriosis. The medication is applied in addressing conditions such as unintended pregnancy, difficult and irregular menstruation, and hormone-related symptoms such as acne.

The medication helps address symptom clusters that may become intense or disruptive, supporting patients in maintaining control over their family planning and functional stability. It is often used during phases when symptoms become more noticeable, and offers symptomatic relief that helps patients cope more steadily.


Quick Fact: Relief for Cycle Discomfort

Femikadin is commonly used to help with conditions characterized by periods of heightened symptoms, such as pronounced menstrual pain (dysmenorrhea) and heavy bleeding (menorrhagia), assisting with maintaining functional stability through cycle regulation.

Regulatory References

  1. NIH MedlinePlus overview on Ethinyl Estradiol and Levonorgestrel

Eligibility and Restrictions for Use

Regulatory documents define precise patient populations for whom the use of Femikadin is restricted or prohibited.

Populations Who Must Not Use Femikadin (Contraindications)

Official labeling mandates that Femikadin is contraindicated and must not be used by individuals who meet the following criteria:

  • Known Hypersensitivity: Patients who have a documented history of severe allergic or hypersensitivity reactions, such as anaphylaxis or serious skin reactions, to the active drug substance (Femikadin) or any other component in its formulation.
  • NSAID-Sensitive Allergy History: Individuals with a history of developing asthma, hives (urticaria), or other allergy-like reactions following the use of aspirin or other Nonsteroidal Anti-inflammatory Drugs (NSAIDs).
  • Cardiovascular Surgery: Patients in the immediate peri-operative setting for coronary artery bypass graft (CABG) surgery.

Other Eligibility Restrictions

Population Group Regulatory Status
Late Pregnancy Use is generally prohibited/contraindicated, particularly in the later stages (e.g., third trimester).
Lactation/Breastfeeding Use is not recommended in women who are breastfeeding due to potential physiological effects.
Pediatric Patients Use in children and adolescents is often not established or specified in the label's eligibility sections.

These official rules serve to protect patients by strictly excluding those whose clinical state or allergy history presents a defined, high-risk non-eligibility profile as documented in government regulatory sources.

What should I know about interactions with other medicines?

The official interaction profile for Femikadin is classified by government regulators into several categories based on pharmacokinetic (PK) and pharmacodynamic (PD) effects.

A formal contraindication exists for co-administration with Hepatitis C drug regimens that contain ombitasvir/paritaprevir/ritonavir, with or without dasabuvir, due to the documented risk of significant alanine aminotransferase (ALT) enzyme elevations. Co-administration with oral tranexamic acid is also prohibited due to the synergy that increases thromboembolic risk.

The largest interaction domain involves enzyme induction. Medicines such as Carbamazepine, Phenytoin, Rifampin, and the herbal product St. John's Wort accelerate the metabolism and reduce the plasma concentrations of both Ethinyl Estradiol and Levonorgestrel, officially leading to a decreased contraceptive effectiveness. Conversely, Femikadin can act as a mild enzyme inhibitor, leading to increased exposure of co-administered drugs like Lamotrigine, Theophylline, or Midazolam.

In terms of procedural constraints, regulatory labeling requires that the medicine be discontinued at least four weeks prior to and for two weeks following any major surgery or period of prolonged immobilization, due to the recognized increased risk of thromboembolism associated with combined hormonal contraceptives. Grapefruit juice is documented to potentially increase the exposure of the estrogen component.

Mechanism of Action

How Femikadin Works

Central Mechanism: Disrupting Hormonal Control

Femikadin's mechanism begins with its primary action on the Hypothalamic-Pituitary-Ovarian (HPO) axis, where its progestin component functions as a receptor agonist on progesterone receptors. This interaction introduces negative feedback that alters the neuroendocrine signals originating from the hypothalamus and pituitary gland. The resulting physiological consequence is the suppression of the crucial Luteinizing Hormone (LH) surge.


Peripheral Mechanisms: Modulating Organ Activity

This central suppression leads to anovulation by blocking the final steps of follicular development and rupture within the ovary, thus eliminating the release of an egg. Concurrently, the drug acts peripherally on the lower reproductive tract. It promotes endometrial modification (thinning of the uterine lining) and increases the viscosity of cervical mucus. These peripheral changes contribute to the overall physiological effect by inhibiting sperm migration and altering the uterine environment.

Dosage and Administration Information

Instruction Map: How to use Femikadin — Official Administration Guidelines

This section outlines the established procedural framework for using Femikadin. Adherence to the specific daily and sequential schedule is the core principle of its official use.


Administration Scope

Feature Guideline Statement
Route of administration: Oral.
Dosing schedule: One tablet is taken daily in a cyclic pattern. Official regimens include 21 days of active hormone tablets followed by 7 days of inactive tablets (21/7), or extended use with 84 active tablets followed by 7 inactive days (84/7).
Timing in relation to meals (if applicable): Taken without regard to meals.
Age-group administration rules: Standard dosing applies to women of reproductive potential. Administration may commence immediately after a first-trimester miscarriage or abortion.
Missed-dose rules: Specific procedural steps are mandated for handling missed active tablets to maintain the dosing schedule, which varies based on the number of tablets missed and the time in the cycle.

Resulting Procedural Structure

Official step sequence:

  • Take one tablet orally every day at the same time, swallowing it whole.
  • Follow the pre-set sequential order of tablets on the blister pack, starting with the active hormone tablets.
  • Continue the cycle by switching to inactive/placebo tablets as directed by the pack design, then immediately begin the next pack without a break.
  • When starting the first cycle after switching from certain other contraceptive methods, a non-hormonal back-up method is required for the initial 7 days.

Connection to the overall use protocol (2–4 sentences): The official protocol establishes a continuous, oral, cyclic administration structure defined by the strict sequential use of active and inactive tablets. This structure mandates once-daily adherence at a consistent time and provides explicit procedural rules for correcting deviations, such as a missed tablet, to maintain the prescribed pattern of use. The medication is intended for long-term daily administration without prescribed interruptions between the defined cycles.

Recent Clinical Evidence

Evidence for Use in Pregnancy Prevention (Contraception)

The foundation for Femikadin’s use in preventing pregnancy comes from pivotal Phase 3 randomized controlled trials (RCTs). This research was studied for its ability to affect reproductive function. Trials calculate study outcomes, such as the failure rate and changes in ovarian activity. Research describes patterns observed where these outcomes were reported based on the assumption of perfect use. Uncertainty remains on whether trial results fully translate to real-world experience, and whether study outcomes may vary for individuals with higher Body Mass Index (BMI).


Evidence for Cycle Regulation and Symptom Management

Femikadin was studied for its use in conditions associated with cycle-related symptoms using observational studies and secondary trial findings. Studies monitored outcomes related to physical discomfort by examining changes in menstrual patterns and symptom severity. Findings describe patterns where participant-reported measures evolved over intermediate durations. Evidence quality varies across studies, and limited information for long-term outcomes regarding the durability of altered patterns exists.


Long-Term Evidence from Large-Scale Studies

Research into long-term systemic effects relies on large-scale epidemiological studies that track health patterns over many years. These studies monitored data related to the long-term incidence for specific cancers (e.g., ovarian) and examined metabolic biomarkers. The observational study data requires complex analysis to account for other factors, meaning findings describe group patterns observed in studies, not individual predictions.


Evidence in Specific Populations and Conditions

Research examined the use in various populations, including adolescents who have reached menarche. Studies also explored potential differences in outcomes related to factors like BMI. Data for certain subgroups remain insufficient, and comparative evidence is lacking in some areas.


Areas of Research Uncertainty and Data Gaps

The most significant gap lies in the difference between study outcomes calculated under perfect adherence in trials versus the results observed in typical use settings. Furthermore, long-term effects for all potential systemic outcomes are not fully established, and subgroup findings remain uncertain in areas where research is ongoing.

Key Studies & References

  1. Ethinyl Estradiol and Levonorgestrel: MedlinePlus Drug Information
  2. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans - Combined Estrogen-Progestogen Contraceptives

Frequently Asked Questions (FAQ)

Common questions about Femikadin (FAQ)

Q: Is Femikadin the same type of medicine as [similar common drug name]?

A: Femikadin is classified in official documents as a Combined Oral Contraceptive (COC). This means it contains two types of synthetic hormones: an estrogen and a progestin. Other medicines may belong to different contraceptive classes, such as those containing only a progestin, even if they are used for similar purposes.

Q: How quickly does Femikadin start working?

A: According to official product information, contraceptive effectiveness is generally achieved after the initial seven consecutive days of taking the active tablets correctly. Regulatory documents state that a non-hormonal backup method is typically required for the initial 7 days when starting or switching from certain methods.

Q: Can Femikadin cause weight gain or loss?

A: Official safety information lists changes in weight (both gain and loss) as possible adverse reactions associated with the use of this medicine. However, a clear cause-and-effect relationship between the medication and these weight changes has not been established in all available data.

Q: Does Femikadin interact with common pain relievers like ibuprofen?

A: Regulatory documents do not list a major interaction between Femikadin (Ethinyl Estradiol/Levonorgestrel) and common pain relievers like ibuprofen (a Nonsteroidal Anti-inflammatory Drug). In general, it is standard practice to inform a healthcare provider about all medications being used.

Q: Can men take Femikadin, or is it only for women?

A: Femikadin is indicated (approved) only for use in women of reproductive potential for the prevention of pregnancy. It is not approved or studied for use in men.

Q: Are there any long-term effects of taking Femikadin?

A: Official product labeling highlights several known serious risks associated with long-term use. These include an increased risk of blood clots, such as venous and arterial thromboembolism, and the development of benign or malignant liver tumors. The highest documented risk of blood clots is generally observed during the first year of use.

Q: Is Femikadin known to cause mood swings or depression?

A: Yes, depression or a depressed mood is listed in the official safety profile as a common side effect of combined hormonal contraceptives. If severe changes in mood or symptoms of depression are experienced, consultation with a healthcare provider is noted as important.

Q: Can Femikadin be taken with birth control pills?

A: Femikadin is a combined oral contraceptive pill. According to official guidelines, it should not be used in combination with other hormonal contraceptives (like other pills, patches, or rings). Doing so could lead to an overdose of hormones and increase the risk of serious side effects.

Q: Are there any specific foods or supplements to avoid while on Femikadin?

A: Official regulatory documents explicitly mention that consumption of Grapefruit juice may potentially increase the amount of the estrogen component in the bloodstream. Consultation with a healthcare provider regarding diet and supplement use is part of the standard usage protocol.

Q: Is Femikadin a steroid or a hormone medicine?

A: Femikadin is classified as a hormonal medicine because it contains synthetic estrogen and progestin. Both of these active ingredients are synthetic steroid hormones, meaning they are man-made versions of naturally occurring sex steroids.

Q: What happens if you miss a dose of Femikadin?

A: Missing a dose reduces the medicine's contraceptive effectiveness. Regulatory instructions provide specific procedures for handling missed active tablets based on the number of pills missed and the time in the cycle. Following the specific instructions is essential for minimizing the potential for reduced efficacy.

Q: Is it normal to feel a little dizzy when first starting Femikadin?

A: Official safety data lists dizziness as an adverse reaction that has been reported by some users of this medication. If dizziness or any other concerning effect is experienced, a healthcare provider should be consulted.

Q: What should I do if the side effects of Femikadin are bothering me?

A: Official labeling states that if the first appearance or worsening of any condition or risk factor (including bothersome side effects) is experienced, the patient should contact a physician. This step allows a physician to assess the condition and determine the appropriate course of action.

Q: What happens if I accidentally take two doses of Femikadin?

A: According to official overdose information, symptoms of taking too much are generally mild. They may include nausea, vomiting, or minor bleeding. There are no reports of serious harm following an overdose of this medication.

Q: Can Femikadin be split or crushed to make it easier to swallow?

A: The administration instructions state that the tablet should be taken orally and swallowed whole every day at the same time. To ensure correct dose delivery, the administration instructions generally imply that the tablets should not be split or crushed.

Q: Is it better to take Femikadin in the morning or at night?

A: Regulatory guidance requires that the tablet be taken every day at the same time, consistently. The instructions do not specify whether this time must be morning, afternoon, or night. The consistent daily timing is the mandated factor, allowing flexibility in choosing morning or night.

Q: Does Femikadin affect the results of any common lab tests?

A: Yes, official safety information indicates that combined hormonal contraceptives are known to alter the results of certain laboratory tests. These can include tests related to blood clotting, lipid (cholesterol) profiles, and thyroid function.

Q: Is Femikadin a medication that requires regular monitoring by a doctor?

A: The official label notes that users must contact their physician if certain risk factors or symptoms appear. Furthermore, the list of contraindications (reasons not to use the drug) often requires ongoing medical monitoring of conditions (like severe hypertension or liver disease) to ensure continued eligibility.

Q: Can Femikadin cause problems with my stomach or digestion?

A: Yes, common adverse reactions listed in the official safety profile include nausea and vomiting. The product information also states that severe gastrointestinal issues may interfere with how well the medicine is absorbed.

Q: Are there any specific lifestyle changes recommended while on Femikadin?

A: The product label explicitly advises against use in females who smoke and are over 35 years old due to a significantly elevated risk of serious cardiovascular events. It also mandates that the medicine must be stopped before major surgery or any period of prolonged bed rest.

Q: Does Femikadin expire, and is it still effective after the expiration date?

A: The medicine has a determined expiration date (shelf life) for the sealed package. Once the package is opened, there is a specific in-use stability period (e.g., 30 days) after which it should be discarded. The official label provides no assurance of effectiveness or safety if the medication is used after its expiration date.

Q: Can people with diabetes safely use Femikadin?

A: Femikadin is contraindicated (must not be used) in patients who have Diabetes Mellitus with established vascular involvement (complications that affect blood vessels). For patients with diabetes who do not have vascular complications, the label indicates that use may require caution and specific medical monitoring.

Q: Does Femikadin cause hair loss or changes in hair texture?

A: Yes, official adverse reaction data lists hair loss (alopecia) as an uncommon side effect that has been associated with the use of combined hormonal contraceptives.

Q: Can you take Femikadin if you have a known history of allergies?

A: The medicine is contraindicated (must not be used) if you have a documented hypersensitivity (severe allergic reaction) to the active ingredients or any component in the formulation. This also applies if you have a history of developing an allergy-like reaction to NSAIDs.

Q: Does Femikadin interact with blood thinners like warfarin?

A: Regulatory information indicates that this medicine can reduce the effect of blood thinners such as warfarin. When co-administered, the use of a blood thinner may need to be adjusted, and blood clotting parameters may require closer monitoring.

Q: Is Femikadin considered a 'new' drug or has it been around for a while?

A: The active ingredients in Femikadin, Ethinyl Estradiol and Levonorgestrel, represent a widely utilized and established hormonal combination within the field of birth control. This combination has been clinically recognized and used for decades.

Q: Does Femikadin affect blood pressure or heart rate?

A: The product is contraindicated (not to be used) in patients with severe hypertension (high blood pressure) due to the risk of serious cardiovascular events. While effects on baseline heart rate are not specified, the potential for effects on blood pressure is a documented risk factor.

Q: Does Femikadin have any known interaction with caffeine or energy drinks?

A: Regulatory documents indicate that the estrogen component of Femikadin may increase the blood levels of caffeine. This potential interaction could increase the risk or severity of side effects associated with caffeine consumption.

How should Femikadin be stored and disposed of?

How to Store and Dispose of Femikadin — Official Regulatory Information

Storage Requirements

Storage Scope Official Regulatory Statement
Temperature Store at controlled room temperature, 20 C to 25 C (68 F to 77 F). Do not store above 30 C (86 F). Do not freeze.
Protection Protect from light and moisture. Keep in the original container, which must remain tightly closed.
Stability Once the container is opened, the product must be used within 30 days. Discard any unused portion after the 30-day in-use period.
Child Safety Store out of the sight and reach of children.

Disposal Instructions

Disposal Scope Official Regulatory Statement
General Rule Dispose of unused or expired product through an authorized collection site or drug take-back program.
Prohibited Do not dispose of this medicine by flushing it down a toilet or drain, nor should it be placed in household trash.

These statements define the precise conditions for the drug's quality and safety. Storing Femikadin within the controlled temperature range and protecting it from moisture and light maintains its efficacy up to its expiration date. The 30-day in-use stability period governs how long the medicine can be relied upon after the container is opened. Following the mandatory disposal protocol ensures the product is safely removed from the home and prevents environmental contamination.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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