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The description Name of the medicinal product Fabamox Duois an automatic translation from the original language.
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Qualitative and quantitative composition
The description Qualitative and quantitative composition Fabamox Duois an automatic translation from the original language.
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Amoxicillin, Clavulanic
Therapeutic indications
The description Therapeutic indications Fabamox Duois an automatic translation from the original language.
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Amoxiclav
prevention of local infections after surgery in dentistry.
®
, resistant to penicillin (strains with MPC ≥2 mg/l).
Dosage (Posology) and method of administration
The description Dosage (Posology) and method of administration Fabamox Duois an automatic translation from the original language.
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Powder
The drug Amoxiclav
dosage pipette-calculation of single doses for the treatment of severe infections in children older than 3 months (at the rate of 40 mg / kg / day (according to amoxicillin) (Table 5).
Table 5
The maximum daily dose of amoxicillin for adults is 6 g, for children-45 mg / kg / day.
5 kg
Contraindications
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Undesirable effects
The description Undesirable effects Fabamox Duois an automatic translation from the original language.
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Amoxiclav
Overdose
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Modified-release film-coated tablets
Pharmacodynamic properties
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Clavulanic acid is a beta-lactam structurally related to penicillins. It inhibits certain beta-lactamases, thereby preventing the inactivation of amoxicillin and expanding its range of activity, including bacteria that are usually resistant to amoxicillin, as well as other penicillins and cephalosporins. By itself, clavulanic acid does not have a clinically significant antibacterial effect.
The description Pharmacokinetic properties Fabamox Duois an automatic translation from the original language.
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in the blood plasma after bolus injection at a dose of 1.2 g (1000 200 mg) of the drug is 105.4 mg/l - for amoxicillin and 28.5 mg / l — for clavulanic acid.
Metabolism
Pharmacotherapeutic group
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Penicillins in combinations
Incompatibilities
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Modified-release film-coated tablets
and methotrexate increases the toxicity of methotrexate.
In patients receiving mycophenolate mofetil, after the start of the combination of amoxicillin with clavulanic acid, there was a decrease in the concentration of the active metabolite — mycophenolic acid, before taking the next dose of the drug by approximately 50%. Changes in this concentration may not accurately reflect the overall changes in mycophenolic acid exposure.