Evipress

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Evipress

Method of action: Antihypertensive, Hypotensive

Treatment option: Hypertension

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Evipress

Property Description
Active Ingredient Lercanidipine hydrochloride
Form Film-coated tablet
Pharmacological Class Calcium Channel Blocker (CCB) / Dihydropyridine
General Purpose Management of high blood pressure (Antihypertensive agent)
Origin Synthetic compound

Evipress is a synthetic, single-ingredient medication classified as an antihypertensive agent used for the management of high blood pressure. Its active substance, Lercanidipine hydrochloride, places it in the major pharmacological category of Calcium Channel Blockers (CCBs), specifically as a dihydropyridine derivative. This prescription-only medicine functions primarily to help normalize elevated blood pressure in adults, providing systemic circulatory control.

What Type of Medicine is Evipress?

Evipress belongs to the pharmacological class of Calcium Channel Blockers (CCBs), a type of agent that affects the cardiovascular system. It is recognized as a third-generation dihydropyridine derivative. This sub-class is clinically recognized for its high vascular selectivity, which means its primary action is targeted at the smooth muscle of peripheral blood vessels with minimal direct impact on the heart muscle itself.

The drug's unique positioning is focused on providing effective vasodilation for patients requiring long-term, stable control of their blood pressure, a typical use scenario. This makes it a differentiated option among the broader class of vasoselective calcium antagonists.

Composition and Form: The Lercanidipine Tablet

Evipress contains Lercanidipine hydrochloride as its sole active component and is supplied as a film-coated tablet intended for oral administration. The chemical structure of Lercanidipine is characterized by high lipophilicity, a property that facilitates its sustained therapeutic action following absorption. This sustained action means the drug provides a reliable, long-lasting effect on reducing vascular resistance throughout the day.

The standardized tablet form ensures a predictable delivery of the precisely defined quantity of the active ingredient. This is essential for achieving consistent and reliable control of blood pressure over time, which is the primary general purpose supported by extensive research.

What side effects are possible with Evipress?

Possible Side Effects and Safety Information

Evipress (emtricitabine/rilpivirine/tenofovir disoproxil) has a safety profile documented by regulatory authorities, classifying adverse events by system-organ class and frequency.

Frequency Common Adverse Reactions (Observed in ge 1% of patients) System-Organ Classes
Very Common Headache, Diarrhea, Nausea Nervous System, Gastrointestinal
Common Depression, Insomnia, Dizziness, Vomiting, Abdominal pain, Fatigue, Abnormal dreams, Rash Psychiatric, Nervous System, Gastrointestinal, Skin

Serious and Clinically Significant Adverse Reactions

Regulatory documents highlight several serious and potentially life-threatening risks:

  • New Onset or Worsening Renal Impairment: This can include acute renal failure, Fanconi syndrome, and proximal renal tubulopathy, primarily linked to the tenofovir component. Renal function monitoring is mandatory for all patients, especially those with pre-existing risk factors.
  • Lactic Acidosis/Severe Hepatomegaly with Steatosis: A rare but serious, potentially fatal condition associated with nucleoside reverse transcriptase inhibitors (NRTIs).
  • Severe Skin and Hypersensitivity Reactions: Cases of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) have been reported, requiring immediate cessation of treatment if suspected.
  • Psychiatric Effects: Severe depression, depressed mood, and suicidal ideation have been documented with the rilpivirine component.
  • Bone Effects: Decreases in bone mineral density have been observed, leading to a risk of osteomalacia or fractures.
  • Immune Reconstitution Inflammatory Syndrome (IRIS): Inflammatory symptoms due to an improving immune system responding to previously dormant infections may occur shortly after starting therapy.

Restrictions and Safety Notes

  • HBV Co-Infection: For patients with HIV and Hepatitis B co-infection, abrupt discontinuation of Evipress can lead to a severe acute exacerbation of hepatitis B. Close monitoring of liver function is necessary if treatment is stopped.
  • Contraindications: Evipress is strictly contraindicated with certain drug classes (e.g., proton pump inhibitors, certain anticonvulsants, certain anti-mycobacterials, St. John's Wort) due to potential for significant drug interactions that could reduce the level of rilpivirine, resulting in loss of therapeutic effect and development of viral resistance.
  • Renal Impairment: The product is not recommended for patients with moderate or severe renal impairment (estimated creatinine clearance less than 50 mL/min).

Overdose and Emergency Response

Overdose and when to seek help

Official regulatory documents state that an overdose of Evipress (Lercanidipine hydrochloride) may present with exaggerated effects of its primary action. Clinical manifestations are centered on the cardiovascular system, potentially leading to significant hypotension (dangerously low blood pressure) due to excessive peripheral vasodilation. This severe drop in blood pressure may trigger a compensatory reflex tachycardia (fast heart rate). However, at very high exposures, the label also documents the risk of bradycardia (slow heart rate) and, critically, negative inotropic effects (impaired heart muscle function), which can escalate to life-threatening systemic toxicity. Associated symptoms reported in regulatory summaries include dizziness, headache, and somnolence (sleepiness).


In the event of a suspected overdose, it is essential to seek immediate medical attention. Regulatory authorities mandate that individuals must contact emergency services or go straight to an emergency department. Management is defined as symptomatic and supportive, as no specific antidote is known for Lercanidipine. Officially described supportive measures may include gastric lavage and the administration of activated charcoal to minimize absorption. Continuous observation and the maintenance of vital functions, potentially involving specific interventions like administering calcium gluconate solution, are required due to the risk of severe circulatory effects.

Therapeutic Uses of Evipress

What Evipress Treats: Main Uses and Benefits

Evipress (containing the active ingredient lercanidipine hydrochloride) is applied across domains where additional symptomatic support is needed. It is used in situations involving certain distressing symptoms. The medication is commonly used across conditions presenting with acute episodes where symptoms become more noticeable.

Evipress is considered relevant for easing symptoms related to systemic imbalance that interfere with daily comfort. The medication may assist with maintaining functional stability, providing supportive relief when symptoms interfere with routine activities. It is relevant for easing symptoms related to inflammatory or irritative states and is applied across therapeutic domains where additional symptomatic support is needed. This supports the patient during difficult episodes by easing distress and contributing to improved day-to-day comfort.

Quick Fact: Relief for Symptoms related to physiological strain

Eligibility and Restrictions for Use

Evipress is officially indicated for the treatment of mild to moderate essential hypertension in adults aged 18 years and older. Use in the pediatric population (under 18) is not recommended due to insufficient safety and efficacy data, as defined by regulatory documents.

Evipress is formally contraindicated and must not be used in the following populations:

  • Patients with severe hepatic or renal impairment (GFR < 30 ml/min).
  • Individuals with untreated congestive cardiac failure, unstable angina pectoris, or a myocardial infarction within one month.
  • Patients with left ventricular outflow tract obstruction or hypersensitivity to the drug class (dihydropyridines).
  • Women who are pregnant or breastfeeding.

Conditional use requiring special care is mandated for elderly patients and those with mild to moderate renal or hepatic dysfunction, as well as individuals with specific conditions like ischaemic heart disease or sick sinus syndrome (without a pacemaker). All eligibility rules are defined strictly by regulatory labeling.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The official regulatory documents for Evipress (Lercanidipine) define clear constraints on co-administration, primarily based on the drug’s metabolism via the CYP3A4 enzyme. These interaction patterns establish mandatory restrictions and monitoring requirements.

Contraindicated Combinations and Restrictions

Co-administration is strictly prohibited with the immunosuppressant Ciclosporin and with potent CYP3A4 inhibitors, which include medications such as ketoconazole and ritonavir. These combinations significantly increase the plasma concentration of Lercanidipine. Furthermore, the consumption of Grapefruit/grapefruit juice is strictly restricted, as it also raises systemic exposure and enhances the blood pressure-lowering effect. Alcohol must be avoided as it may potentiate the vasodilating effect.

Exposure-Modifying Agents

Substances that act as CYP3A4 inducers, such as phenytoin or rifampicin, are documented to potentially reduce Lercanidipine plasma levels, risking a decrease in antihypertensive efficacy. Conversely, Lercanidipine co-administration has been officially documented to increase the exposure (Cmax or AUC) of other critical medicines, including Digoxin and Simvastatin.

Timing and Population Notes

A mandatory administration rule requires Lercanidipine to be taken on an empty stomach (at least 15 minutes before a meal). This requirement prevents high-fat food from substantially increasing drug absorption. In patient populations with hepatic impairment, the drug’s antihypertensive effect may be enhanced due to altered clearance, and its use is not recommended in severe cases.

Mechanism of Action

How Evipress Works

The action of Evipress (Lercanidipine) is a purely mechanistic process centered on the modulation of calcium ion flow into the cells that determine vascular tension.

Evipress acts as an antagonist that specifically blocks the L-type Voltage-Gated Calcium Channels (Ca v1.2) found on the vascular smooth muscle cells of peripheral arterioles. This primary interaction inhibits the influx of extracellular calcium ions, which is required for muscle contraction.

The inhibition of calcium influx immediately modulates the cell's excitation-contraction pathway, leading to a sharp reduction in the activation of the contraction enzyme, Myosin Light Chain Kinase ( MLCK). This molecular event results in the relaxation and widening (vasodilation) of the arterioles, a physiological change in peripheral vascular resistance.

Lercanidipine exhibits vasoselectivity, meaning its mechanism primarily targets the peripheral blood vessels over myocardial tissue. This arteriolar dilation reduces the Total Peripheral Resistance (TPR) and Systemic Vascular Resistance (SVR), which represents the primary physiological consequence of the drug's molecular action.

Dosage and Administration Information

How to Use Evipress

Evipress (lercanidipine hydrochloride) is administered according to specific procedural guidelines detailed in official prescribing information, focusing on consistent, once-daily usage.


Administration Scope

The medication is supplied as a film-coated tablet intended exclusively for oral administration. The usage protocol is highly dependent on timing relative to food intake to ensure reliable drug absorption. The standard adult starting dose is 10 mg once daily, which also often serves as the maintenance dose. The maximum daily dose recommended is 20 mg.


Official Usage Protocol

Feature Official Instruction
Frequency and Schedule Taken once daily, preferably in the morning.
Timing in Relation to Meals Must be taken at least 15 minutes before breakfast or any other meal.
Dose Titration Maximal effect may require approximately 2 weeks; dose adjustment from 10 mg to 20 mg is done gradually.
Special Restriction Grapefruit or grapefruit juice must not be consumed during treatment.
Missed Dose Rule If a dose is forgotten, it should be skipped if the next dose is almost due; a double dose must never be taken.
Tablet Handling Tablets that are scored may be divided to facilitate swallowing.

Population-Specific Considerations

Official instructions specify that older adults generally do not require a dose adjustment, but treatment must be initiated with special care. Similarly, patients with mild to moderate renal or hepatic impairment require cautious initiation, with increases to the 20 mg dose done carefully. The use of Evipress is not recommended for pediatric patients (under 18 years) as safety and efficacy data have not been established.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Evipress


Evidence for Use in Essential Hypertension

The clinical evaluation for Evipress (lercanidipine) was studied for its role in the evaluation of high blood pressure in adults, which is the main condition research examined. Randomized Controlled Trials (RCTs) were the primary research design used. These short-term, controlled studies typically focused on monitoring changes in systolic and diastolic blood pressure and evaluating the proportion of participants who reached a predefined target blood pressure level.

Research explored how blood pressure measurements evolved in the observed populations over defined time intervals. The evidence gathered provides context regarding short-term changes in blood pressure levels.

Comparator and Placebo Trials

Research examined how Evipress compared to an inactive substance (placebo) and how it was compared against other established treatments for high blood pressure. Findings described patterns that were recorded in the trials alongside other commonly used antihypertensive medicines. Trials assessed and documented patterns of tolerability, tracking adverse events like leg swelling (peripheral edema) or headache, which were documented in this class of medication’s trials.

Studies in Special Populations

Evipress was evaluated in specific patient groups, including the elderly population (typically those aged 60 and above). The medicine was also observed in studies that included patients with co-occurring conditions, such as Type 2 Diabetes Mellitus and certain groups experiencing Chronic Renal Failure (CRF). Research provides insight into short-term changes in these groups, but results apply only to the populations studied.

Key Gaps and Areas of Uncertainty in Research

Studies help show what has been observed so far, and the research includes recognized limitations and uncertainties. Long-term effects are not fully established. Dedicated, multi-year research focusing on major cardiovascular outcomes, such as heart attack or stroke, has not been the primary focus of the available evidence. Additionally, data for certain high-risk groups remain insufficient because many key RCTs incorporated specific exclusion criteria.

Frequently Asked Questions (FAQ)

Common questions about Evipress (FAQ)

Q: What is the main reason Evipress is prescribed?

According to official product information, Evipress (Lercanidipine) is indicated for treating mild to moderate essential hypertension, which is the medical term for high blood pressure with no known specific cause. It is approved for the management and lowering of high blood pressure in adults.

Q: Is Evipress considered a new or old type of medication?

Evipress is a member of a class of medicines known as Calcium Channel Blockers, specifically the dihydropyridine type. This class of medication has been recognized and used in medical practice for several decades for blood pressure management.

Q: Is Evipress the same as other medicines that treat similar conditions?

Evipress is not the same as other medicines, but it belongs to a group of drugs known as Calcium Channel Blockers, which are used to manage blood pressure. While it shares a similar function with others in its class, its specific active substance (Lercanidipine) gives it a distinct profile.

Q: Does Evipress have any severe side effects I should be aware of?

Official documents outline rare but serious side effects that require immediate medical attention. These may include signs of an allergic reaction, such as swelling of the face, lip, tongue, or throat. Another serious reported effect is an increased frequency or severity of pre-existing chest pain (angina pectoris).

Q: What are the most common side effects people experience with Evipress?

The most frequently reported side effects (affecting up to 1 in 10 people) include headache, a fast heartbeat (tachycardia), palpitations, flushing (sudden reddening of the face, neck, or chest), and ankle swelling.

Q: Can Evipress affect my ability to drive or operate machinery?

Yes, caution is advised in official warnings. The medicine may cause effects such as dizziness, weakness, or drowsiness. If a person experiences any of these symptoms, official information suggests they should avoid driving or operating heavy machinery.

Q: How is Evipress classified by regulatory bodies like the FDA or EMA?

Evipress is classified by regulatory bodies as a Calcium Channel Blocker, which belongs to the dihydropyridine class of medicines. This classification describes its known method of action, which is focused on modulating calcium flow to help relax blood vessels.

Q: What kind of studies were done to support the use of Evipress?

The use of Evipress is supported by clinical trials that examined its ability to lower blood pressure. Regulatory documents provide guidance based on clinical studies, including those examining its use in certain groups, such as older adults.

Q: Is there any research evidence showing Evipress is effective for long-term use?

Official information indicates that Evipress is approved for treating essential hypertension, which is a chronic, long-term medical condition. This indication is for a chronic condition, and the drug is therefore suitable for long-term use as outlined by official prescribing information.

Q: Is Evipress known to cause any skin reactions or rashes?

Yes, the product information lists certain skin-related reactions. Skin rash and itching are listed as uncommon side effects (affecting up to 1 in 100 people), and hives (urticaria) are listed as a rare side effect (up to 1 in 1,000 people).

Q: Does Evipress interact with common herbal supplements?

Official instructions specifically warn that the medicine must not be taken with grapefruit or grapefruit juice. Regulatory guidance suggests caution with other supplements and herbal remedies, as limited specific data may be available on their combined effects.

Q: Are there any known drug-disease interactions for Evipress?

The drug is contraindicated in patients with several serious underlying health issues. These include severe kidney impairment, severe liver impairment, untreated congestive cardiac failure, and certain heart conditions such as left ventricular outflow tract obstruction.

Q: What is the significance of the specific warnings and precautions section for Evipress?

The warnings and precautions section highlights situations where special care is needed. For example, the drug requires careful monitoring in patients with conditions like sick sinus syndrome or ischaemic heart disease (heart disease caused by reduced blood flow), as noted in regulatory documents.

Q: Is it possible to be allergic to Evipress?

The medicine is contraindicated (should not be taken) in patients with known hypersensitivity to the active substance, Lercanidipine, or to any other dihydropyridine medicine, or any of the inactive ingredients used in the tablet.

Q: Does Evipress have any known impact on mood or sleep?

Official safety data indicates the potential for impact on the central nervous system. Sleepiness (somnolence) is listed as a rare side effect. Reports from post-marketing experience also include insomnia (difficulty sleeping) and anxiety with an unknown frequency.

Q: What are the most common reasons why a patient might be told to stop Evipress?

Reasons for discontinuation typically relate to the development of a contraindication (a condition that makes the drug unsafe to use, like new severe organ failure) or the occurrence of severe adverse reactions, such as a serious allergic response or new, worsening chest pain.

Q: What is the recommended approach if Evipress doesn't seem to be working?

According to official prescribing information, if the initial dose does not provide adequate control of blood pressure, the treatment strategy may involve increasing the dose or using the drug as part of a combination therapy with other blood pressure medicines.

Q: Does the efficacy of Evipress change over time?

The drug is intended for the long-term management of high blood pressure. While the full maximal therapeutic effect may take approximately two weeks to fully develop after starting treatment, the drug is designed to sustain its effectiveness over time.

Q: Are there specific patient populations where Evipress has been studied more extensively?

The official label provides specific guidelines regarding the use of the medicine in older adults and in individuals who have mild to moderate kidney or liver impairment, suggesting these groups were specifically examined in clinical research to inform prescribing guidance.

Q: What does the official documentation say about overdose with Evipress?

Official documentation indicates that taking more than the prescribed amount may cause an excessive drop in blood pressure (hypotension). This can be accompanied by an irregular or faster heartbeat (tachycardia), which may result in dizziness, headache, or potentially unconsciousness.

Q: Are there different brand names for the medicine Evipress?

Yes. Evipress is one brand name for the active substance Lercanidipine hydrochloride. This same substance is sold under various other brand names in different parts of the world, such as Zanidip or Carmen.

Q: Why do some people need to take Evipress for a short time and others for a long time?

Evipress is primarily indicated for essential hypertension, which is typically a chronic (long-term) condition. The duration of therapy is not set by the drug label but is decided based on the individual's specific diagnosis and ongoing need for blood pressure control.

Q: What is the difference between Evipress and its generic version?

Evipress is a brand name. Generic versions of the medicine contain the exact same active substance (Lercanidipine hydrochloride) at the same strength, and they must meet regulatory standards for quality, safety, and effectiveness to be considered interchangeable.

Q: Are there any known issues with alcohol consumption while on Evipress?

Yes. Regulatory warnings indicate that alcohol consumption may increase certain effects of the medicine, particularly feelings of dizziness or light-headedness. Official documentation advises caution regarding alcohol use during treatment.

Q: What precautions should be taken when handling Evipress?

The primary safety precautions relate to the risk of side effects like dizziness or drowsiness. Because of these potential effects, specific caution is advised regarding activities that require attention, such as driving or operating machinery.

Q: Are there specific symptoms that require immediate medical attention while taking Evipress?

Yes, symptoms that are noted to require immediate medical attention include signs of severe allergic reaction (such as swelling of the face, lip, tongue, or throat) or the onset or worsening of chest pain (angina pectoris).

Q: How does Evipress differ from placebo in clinical trials?

Evipress is a vasoselective calcium antagonist. Clinical trials demonstrated that Evipress possesses antihypertensive efficacy, meaning it successfully lowers high blood pressure compared to an inactive substance.

Q: Is it common to feel tired or dizzy when starting Evipress?

Feeling tired (asthenia) or dizzy are known side effects. Official data lists dizziness and feeling weak or tired as uncommon (affecting up to 1 in 100 people), while headache is listed as a common side effect.

Q: Can Evipress be used during pregnancy, according to official guidelines?

The official product information states that the drug is not recommended during pregnancy. This is due to a lack of sufficient data available to assess the drug’s safety for the unborn child.

Q: What does the drug label say about using Evipress while breastfeeding?

The drug label states that Evipress should not be used while breastfeeding. There is insufficient data to determine whether the active substance passes into breast milk and if it could affect the infant.

Q: Does Evipress require any specific monitoring or blood tests?

Special care and monitoring are noted in regulatory documents for specific patient situations. For instance, changes in liver function have been reported, and blood pressure monitoring is necessary when the medicine is used alongside certain other drugs.

Q: How quickly does Evipress usually start working after the first dose?

While the drug begins to act on blood vessels soon after it is taken, the full, maximal blood pressure-lowering effect may take approximately two weeks to fully appear. This gradual onset is a factor in the typical dose adjustment process.

Q: How long does the effect of one dose of Evipress typically last?

Evipress is designed to be taken once daily. This dosing schedule, specified in regulatory information, indicates that the intended therapeutic effect of lowering blood pressure is sustained for a full 24-hour period.

Q: How do I know if Evipress is working for me?

Evipress is used to control high blood pressure. Official information states that its effectiveness is determined through monitoring changes in blood pressure measurements. The full therapeutic effect may take about two weeks to be achieved.

How should Evipress be stored and disposed of?

How to Store and Dispose of Evipress (Lercanidipine)

The official labeling for Evipress (lercanidipine hydrochloride) specifies mandatory storage and disposal rules to maintain product quality and safety.


Required Storage Conditions

Detail Requirement
Temperature Do not store above 25 C.
Protection Protect from light and moisture.
Packaging Keep in the original package until use.
Child Safety Keep out of the sight and reach of children.

Disposal Instructions

Do not use Evipress after the expiry date (EXP) stated on the carton. Expired or unused tablets must not be thrown away via wastewater or household waste. All waste material should be disposed of in accordance with local requirements to ensure environmental protection.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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