Эквамер

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Эквамер

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Эквамер

Эквамер: A Fixed-Dose Combination (FDC) Medication

Property Description
Active ingredient Amlodipine, Lisinopril, Rosuvastatin
Form Oral Tablet (Film-coated)
Pharmacological class Antihypertensive and Hypolipidemic Agent
General purpose Management of high blood pressure and high cholesterol
Origin Synthetic

Эквамер is a synthetic pharmaceutical preparation classified as a fixed-dose combination (FDC) agent administered via the oral route. This product is generally distributed as a prescription-only medication. This approach integrates multiple necessary medications into a single tablet to address several health concerns concurrently, a strategy often referred to as a polypill. The utilization of an FDC, a format clinically recognized for its potential to improve therapeutic compliance, is intended to simplify long-term regimens, supporting greater patient adherence and sustained control over risk factors.

Composition and Triple-Action Pharmacological Identity

The composition of Эквамер is based on three distinct active ingredients (INN): Amlodipine, Lisinopril, and Rosuvastatin. Each component belongs to a different pharmacological class, ensuring multi-target coverage. The inclusion of Rosuvastatin is specifically aimed at managing high levels of low-density lipoprotein (LDL) cholesterol. Amlodipine functions as a Calcium Channel Blocker, Lisinopril is an Angiotensin-Converting Enzyme (ACE) Inhibitor, and Rosuvastatin is an HMG-CoA Reductase Inhibitor (statin class). These three compounds are precisely formulated together with essential pharmaceutical excipients necessary for the production of the film-coated tablet dosage form.

General Purpose: Simultaneous Management of Cardiovascular Risk Factors

The general purpose of this triple fixed combination is the unified and effective management of two primary and often co-existing contributors to cardiovascular risk: arterial hypertension (high blood pressure) and dyslipidemia (elevated cholesterol). A typical use scenario involves patients who require ongoing treatment for both high blood pressure and high cholesterol simultaneously. By addressing the hormonal system, relaxing vessel musculature, and inhibiting lipid production simultaneously, Эквамер is designed to provide comprehensive, synergistic coverage. This broad, dual focus supports intensive cardiovascular protection and improves overall blood flow dynamics for patients requiring treatment across these multiple therapeutic pathways.

Regulatory References

  1. MedlinePlus resource

What side effects are possible with Эквамер?

Possible Side Effects and Safety Information

The safety profile of Эквамер combines the documented adverse reactions associated with its three active components: Amlodipine, Lisinopril, and Rosuvastatin. Regulatory documents classify these effects by frequency and System-Organ Class (SOC), spanning the cardiovascular, nervous, musculoskeletal, gastrointestinal, and renal systems.

Common Adverse Reactions are those frequently listed in regulatory labels. These may include headache, edema (swelling, often dose-related with Amlodipine), dizziness, fatigue, nausea, abdominal pain, and a dry, persistent cough (Lisinopril component).

Serious Adverse Reactions are explicitly documented due to their clinical significance. These include Angioedema (swelling of the face, lips, or throat), which is a serious, potentially life-threatening reaction associated with ACE inhibitors. Risks also include severe muscle breakdown known as Rhabdomyolysis and Hepatic Failure, which are rare but significant events noted in the Rosuvastatin labeling.

Safety Domain Regulatory Constraint
Pregnancy Contraindicated (Fetal harm risk)
Hepatic Impairment Active Liver Disease is a contraindication
Time Pattern Dizziness and Hypotension may be more prominent at treatment initiation.

Furthermore, the medicine is contraindicated in patients with a prior history of ACE inhibitor-related angioedema or severe renal impairment.

Overdose and Emergency Response

Overdose and When to Seek Help

Official regulatory documents define the overdose profile of Эквамер based on the acute effects of its three components, which primarily affect the cardiovascular and renal systems.

Documented Overdose Presentations

Domain Official Regulatory Statement
Cardiovascular Effects Profound systemic hypotension resulting from marked peripheral vasodilation; Disturbances in cardiac rhythm, including bradycardia or reflex tachycardia
Renal/Metabolic Risk Potential for acute renal failure secondary to sustained, severe hypotension; Severe imbalance of serum electrolytes (hyperkalemia)
Muscle Toxicity Risk of Rhabdomyolysis (muscle injury) associated with excessive Rosuvastatin exposure, requiring immediate laboratory investigation

Immediate Actions and Monitoring

The regulatory label mandates that any suspected overdose requires immediate medical attention and contact with emergency services. This urgent intervention is required due to the risk of circulatory shock and other life-threatening symptoms. The prescribing information states that no specific antidote is known for the overall combination. Management must focus on the administration of symptomatic and supportive measures in a hospital setting. This includes continuous monitoring of cardiovascular function, regular checking of renal function, and assessment of serum electrolytes and muscle enzyme levels.

Therapeutic Uses of Эквамер

What Эквамер Treats: Main Uses and Benefits

The medication is commonly used for managing the two chronic, systemic risk factors that often cluster together in patients: arterial hypertension (high blood pressure) and dyslipidemia (high blood cholesterol). This fixed-dose combination is applied in addressing both hypercholesterolemia and arterial hypertension.

This therapeutic approach is relevant in contexts marked by increased discomfort or tension, and is applied in addressing symptoms that interfere with daily comfort. The indications primarily include established hypertension, high LDL cholesterol levels, and the management of patients at high or very high cardiovascular risk. This comprehensive coverage supports the patient during difficult episodes by easing distress related to complex multi-drug adherence.

“The availability of a single pill to address both high blood pressure and abnormal cholesterol can help simplify the long-term management of chronic cardiovascular risk, contributing to improved general well-being.”


Quick Fact: Relief for Combined Risk

Category Description
Symptom Domain Symptoms related to systemic imbalance and heightened physiological activity (high pressure).
Condition Framing Conditions characterized by periods of heightened symptoms (vascular strain).
Patient Benefit Provides support that helps ease the overall symptom burden of complex chronic conditions.

Eligibility and Restrictions for Use

Who Can and Cannot Use Эквамер?

The eligibility profile for Эквамер (Amlodipine/Lisinopril/Rosuvastatin FDC) is determined by the cumulative restrictions officially documented for its three active components by governmental regulatory bodies.


Eligibility Scope

Classification Population or Condition
Use Allowed (Adults) Adults requiring concomitant therapy for essential hypertension and dyslipidemia.
Contraindicated Women who are pregnant or who may become pregnant (Fetal Toxicity risk).
Contraindicated Patients with active liver disease or unexplained persistent elevations of hepatic transaminases.
Contraindicated History of angioedema related to any ACE inhibitor, or hereditary/idiopathic angioedema.
Contraindicated Patients taking a neprilysin inhibitor (e.g., sacubitril) or those with diabetes mellitus taking aliskiren.
Not Recommended Breastfeeding/lactating women.
Restricted Use Patients with severe renal impairment (CLcr < 30 mL/min) or severe hepatic impairment.
Age Restriction Pediatric patients less than 6 years old (Efficacy/Safety not established for hypertension components).

Eligibility Summary

This medicine is officially intended for adults who meet the established safety profile, but it is strictly prohibited (contraindicated) for several populations, including all pregnant women and patients with active liver disease. Furthermore, specific pre-existing conditions, such as a history of angioedema or severe kidney impairment, render patients ineligible or subject to restriction. Pediatric use is limited by minimum age thresholds that vary based on the treated condition.

What should I know about interactions with other medicines?

Interactions with other medicines and products

This fixed-dose combination (Amlodipine, Lisinopril, Rosuvastatin) has officially documented interaction patterns that establish prohibitions and restrictions with other substances, primarily related to pharmacokinetic exposure and pharmacodynamic risk.

Contraindicated Combinations

Co-administration is strictly contraindicated with substances that significantly increase the risk of adverse outcomes:

  • Ciclosporin (Cyclosporine): Prohibited due to a major increase in Rosuvastatin exposure, raising the risk of myopathy.
  • Systemic Fusidic Acid: Prohibited due to the risk of rhabdomyolysis; treatment separation is mandated.
  • Aliskiren: Prohibited with Lisinopril in patients with diabetes or moderate-to-severe renal impairment due to the risk of severe hyperkalemia and hypotension.

Official Restrictions and Constraints

Interactions often require monitoring or specific dose limitations:

  • Exposure Modification: Co-administration of Amlodipine and Simvastatin necessitates a dose limit of 20 mg daily for Simvastatin. Rosuvastatin concentration is increased by Gemfibrozil and certain Protease Inhibitors, requiring the Rosuvastatin dose to be limited to 10 mg.
  • Pharmacodynamic Risk: Concomitant use with Potassium-sparing diuretics and Potassium supplements increases the formally documented risk of hyperkalemia with the Lisinopril component.
  • Timing Rules: Rosuvastatin absorption is reduced by Aluminum and Magnesium Hydroxide Antacids, requiring the medicine to be administered at least two hours after the antacid.
  • Food/Substance Interaction: Co-administration of Grapefruit juice is not recommended due to the potential for increased Amlodipine plasma exposure.

Mechanism of Action

Эквамер is a small-molecule phosphodiesterase type 4 (PDE4) inhibitor that selectively binds non-competitively to the enzyme's catalytic site. This molecular interaction blocks the hydrolysis of intracellular cyclic adenosine monophosphate (cAMP) to its inactive metabolite, AMP, leading to a net increase in intracellular cAMP concentrations within immune and inflammatory cells. The subsequent accumulation of cAMP modulates the activity of protein kinase A (PKA). PKA acts as a kinase, phosphorylating various target proteins and directly regulating the activation or suppression of several key transcription factors, including CREB and NF-kappaB. This differential gene regulation leads to a modified cytokine profile within the cell, characterized by the suppression of pro-inflammatory mediators such as tumor necrosis factor-alpha (TNF-α) and interleukins (IL-23, IL-17). This intracellular cascade results in a generalized down-regulation of the signaling pathways responsible for the production of inflammatory components within targeted tissue systems.

Dosage and Administration Information

How to Use Эквамер

The usage of Эквамер, a fixed-dose combination (FDC) containing Amlodipine, Lisinopril, and Rosuvastatin, is governed by the prescribing principles for its individual components. This approach simplifies the long-term administration required for chronic conditions. The medicine is intended for continuous, long-term use and is delivered exclusively via the oral route as a film-coated tablet.

The standard regimen dictates that one tablet is taken once daily (q.d.). The tablet may be administered with or without food and at any time of day to accommodate consistent adherence. The tablet must be swallowed whole with a liquid.

Official Dosing and Procedural Rules

Dosing is established using a tablet strength that matches the patient's existing, stable monotherapy doses of Amlodipine, Lisinopril, and Rosuvastatin. Dosage adjustments are a measured process, requiring a minimum interval of four weeks before the strength of the Rosuvastatin component may be modified based on lipid panel results. This interval allows for the accurate assessment of the lipid-lowering effect.

Procedural Administration Constraints

Constraint Instructional Detail
Missed Dose Skip the missed dose and take only the next scheduled dose; do not double the dose.
Renal Impairment The Rosuvastatin component dose should not exceed 10 mg once daily in patients with severe renal impairment (creatinine clearance <30 mL/min).
Specific Populations Lower initial doses of the Lisinopril and Rosuvastatin components are generally indicated for older adults (aged >65 years) and those with hepatic impairment.

These constraints define the standardized, label-based protocol for using the medication, guiding the appropriate administrative procedure without providing clinical decision-making or therapeutic advice.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Эквамер

Evidence for Unified Management of Hypertension and Dyslipidemia

The core research for Эквамер includes short- to intermediate-term Randomized Controlled Trials (RCTs). Research examined outcomes related to systemic or functional imbalance, including monitoring of physiological indicators such as systolic and diastolic blood pressure, and evaluating cholesterol levels by monitoring low-density lipoprotein cholesterol (LDL-C).

The studies reported measurements of these biomarkers recorded during the study period. For instance, research highlights measurements recorded, including blood pressure and cholesterol levels observed in the study populations. What remains uncertain is the duration of follow-up in some of the initial FDC trials. While research provides insight into short-term changes in biomarkers, results apply only to the populations studied.

Research on the Fixed-Dose Combination (FDC) Format and Adherence

Studies monitored patients taking the three ingredients as a single pill (the FDC) alongside groups who were taking the same ingredients as multiple separate pills (a free-combination regimen). Research examined outcomes reflecting daily functioning by tracking how reliably patients followed their treatment schedule.

Findings from systematic reviews and meta-analyses show patterns related to patient adherence and persistence that were observed with the FDC format. These findings describe patterns observed where treatment duration and consistency were monitored with the single-pill combination. However, comparative evidence is lacking from long-term randomized trials that directly compare the FDC against the free-combination regimen, where the primary outcome is a major clinical event.

What Research Still Characterizes as Uncertain

The evidence landscape describes several areas where research remains incomplete. The major limitation is that the sample sizes were small in some of the short-term trials, and evidence quality varies. There is still a need for long-term, randomized head-to-head trials that specifically compare the FDC to the free combination, using Major Adverse Cardiovascular Events (MACE) as a primary endpoint, to confirm the full clinical impact of the single-pill approach beyond the adherence patterns observed.

Frequently Asked Questions (FAQ)

Common questions about Эквамер (FAQ)

Q: How long does Эквамер take to start working?

A: For the cholesterol-lowering component (Rosuvastatin), official documents recommend evaluating lipid levels as early as two to four weeks after starting the medicine or adjusting the dose to measure its effect. This timeframe is used by medical professionals to assess the drug’s intended impact on blood biomarkers.

Q: Is Эквамер a brand name or a generic medicine?

A: Эквамер is the name of a specific fixed-dose combination (FDC) that contains three active ingredients. According to general drug classifications, the three individual components that make up this product are all commonly available as both brand-name and generic medications.

Q: Why is Эквамер prescribed for my condition?

A: The medicine is a triple fixed-dose combination (FDC) designed to manage two primary and co-existing cardiovascular risk factors: high blood pressure (hypertension) and high cholesterol (dyslipidemia). Utilizing the FDC format is a strategy intended to help simplify adherence to a long-term treatment plan.

Q: Does Эквамер cause weight gain or weight loss?

A: Changes in body weight are not listed among the most common adverse reactions in official documents. However, some regulatory documents list weight gain as a rare or uncommon effect associated with the Amlodipine component.

Q: Are there any common side effects of Эквамер that are not serious?

A: Common adverse reactions listed in official documents include headache, dizziness, fatigue, nausea, abdominal pain, edema (swelling), and a dry, persistent cough. These are the documented effects, listed by official bodies.

Q: Does Эквамер interact with alcohol?

A: Official warnings indicate that large amounts of alcohol may increase the risk of liver problems associated with the Rosuvastatin component. This is a pharmacokinetic constraint noted in the official documentation.

Q: Is it okay to take Эквамер if I have [specific organ condition, e.g., kidney issues]?

A: Official labeling states that the medicine is contraindicated (strictly prohibited) in patients with active liver disease or severe renal impairment (a specific level of kidney function reduction). Use may also be restricted in cases of severe hepatic impairment.

Q: What are the long-term effects of taking Эквамер?

A: As the medicine is intended for continuous, long-term use, official guidance emphasizes the importance of ongoing clinical monitoring, particularly of liver function and cholesterol levels. Serious rare risks such as rhabdomyolysis and hepatic failure are noted in the long-term safety profiles of the components.

Q: Does Эквамер affect sleep?

A: Difficulty falling asleep or staying asleep (insomnia) is listed as a possible side effect of the Rosuvastatin component. Nightmares have also been reported with unknown incidence in regulatory documents.

Q: Is Эквамер considered a 'strong' medicine?

A: Эквамер is classified as a fixed-dose combination (FDC) agent that delivers three active ingredients (a statin, an ACE inhibitor, and a calcium channel blocker) in one tablet. It is prescribed because it targets different physiological factors for cardiovascular protection simultaneously.

Q: Can Эквамер be safely stopped, or does it require tapering?

A: Official guidance for the component drugs (ACE inhibitor and calcium channel blocker) indicates that sudden discontinuation may carry a risk of adverse effects, such as rebound hypertension. The decision to stop this medicine is based on medical evaluation and is typically managed under the supervision of a healthcare professional.

Q: Why are there different strengths (doses) of Эквамер available?

A: The fixed-dose combination is available in different strengths because the dose used is intended to precisely match the patient's existing, stable doses of the three individual active ingredients (Amlodipine, Lisinopril, and Rosuvastatin).

Q: Has Эквамер been studied in older patients (seniors)?

A: The official constraints on use mention that lower initial doses of the Lisinopril and Rosuvastatin components are generally indicated for older adults (aged > 65 years).

Q: What is the risk of dependence or addiction with Эквамер?

A: The active ingredients in Эквамер are classified as non-controlled substances. Based on official regulatory documentation, there are no reports of the components causing physical dependence or addiction.

Q: Is it normal to feel a certain way when first starting Эквамер?

A: The official safety information notes that side effects such as dizziness and hypotension (low blood pressure) may be more prominent when treatment is first initiated.

Q: How is Эквамер different from similar medicines in the same class?

A: Эквамер is structurally different because it is a fixed-dose combination (often called a polypill) that contains three active ingredients from three distinct pharmacological classes in a single tablet. This means it addresses multiple health targets simultaneously.

Q: Can men and women use Эквамер for the same purpose?

A: Yes, the general purpose (management of high blood pressure and high cholesterol) is the same for men and women. The only sex-specific restrictions are the contraindication for women who are pregnant and the not recommended status for breastfeeding women.

Q: What is the shelf life or expiry date of Эквамер?

A: The official instructions mandate that the medicine must not be used after the expiry date printed on the packaging. This date is set to ensure the product’s full potency and stability.

Q: Is there any research on Эквамер's use in children or teenagers?

A: Official regulatory documents mention that the safety and efficacy of the components have not been established in pediatric patients less than 6 years old. For specific conditions like high cholesterol, Rosuvastatin is approved for use in pediatric patients 7 years and older, but use for hypertension is age-restricted.

Q: Can Эквамер affect my mood or energy levels?

A: Yes, the list of possible side effects includes fatigue (low energy levels) and, for the Rosuvastatin component, depression (affecting mood) is a reported adverse reaction.

Q: Is it mandatory to have regular blood tests while taking Эквамер?

A: Yes. Official guidance for the individual components indicates that regular laboratory monitoring, including lipid panels, liver function tests, and checks on kidney function (due to the ACE inhibitor), is necessary during treatment.

Q: Are there different generic versions of Эквамер?

A: Эквамер is a fixed-dose combination. The three individual active ingredients (Amlodipine, Lisinopril, and Rosuvastatin) are all commonly available as generic medications in addition to their various brand names.

Q: Does Эквамер interact with herbal supplements?

A: Official warnings indicate that co-administration with certain herbal remedies, such as St. John's wort, may affect how the medicine works. The use of such supplements requires medical evaluation to determine impact on the medicine's function.

Q: Is there a patient leaflet (PIL) available online for Эквамер?

A: Patient information leaflets (PILs) or FDA-approved Patient Package Inserts are published electronically by regulatory bodies and are generally accessible online through official government medical databases.

Q: Do I need a prescription to get Эквамер?

A: Yes. Official regulatory classifications confirm that Эквамер is a prescription-only medication.

Q: Is Эквамер used worldwide, or only in certain regions?

A: Medicines containing these active ingredients are regulated by major government authorities across various continents, including the FDA (USA), EMA (Europe), and TGA (Australia), implying broad international use.

Q: Can lifestyle changes (diet, exercise) reduce the need for Эквамер?

A: Official guidelines state that control of high blood pressure and cholesterol should be part of comprehensive cardiovascular risk management, which includes non-pharmacological methods such as lipid control (diet), exercise, and limited sodium intake alongside medication.

Q: What types of drug interactions are generally mentioned for Эквамер?

A: The official documentation generally mentions two types of interaction patterns: Pharmacodynamic Risk, which is the risk of combined drug effects (e.g., risk of hyperkalemia), and Exposure Modification, where other drugs change the concentration of Эквамер’s components in the body.

How should Эквамер be stored and disposed of?

How to Store and Dispose of Эквамер

To ensure product stability and safety, the official labeling requires adherence to specific conditions for storing and discarding Эквамер tablets.

Storage Conditions

Requirement Official Instruction
Temperature Store at room temperature, protected from excessive heat and moisture
Protection Keep in the original container to protect from light; do not store in the bathroom
Safety Mandatory to keep this medicine out of the sight and reach of children
Shelf-life Do not use the medicine after the expiry date

Disposal Instructions

Discarding unused or expired Эквамер should prioritize safe removal. The preferred method is using an authorized drug take-back program or pre-paid mail-back envelope, if available. Alternatively, the medication can be mixed with an undesirable substance, sealed, and placed in the household trash. It is strictly mandated to not flush the tablets down the toilet unless directed otherwise by official government guidance. All disposal must comply with local requirements.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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