Efavet 2

Copper (Efavet 2) has been designed for the demands of modern life. With a wide range of nutrients and trace minerals, Copper (Efavet 2) gives nutritional support to the area of health which are most relevance to women.

Each cap contains starflower oil 100 mg, evening primrose oil 100 mg, citrus bioflavonoids 10 mg, natural mixed carotenoids 2 mg, vitamin D (as D3 200 IU) 5 mcg, vitamin E 30 mg, vitamin C 60 mg, vitamin K 90 mcg, thiamin (vitamin B1) 10 mg, riboflavin (vitamin B2) 5 mg, niacin (vitamin B3) 36 mg, vitamin B6 10 mg, folic acid 400 mcg, vitamin B12 20 mcg, biotin 50 mcg, pantothenic acid 6 mg, magnesium 100 mg, iron 12 mg, zinc 12 mg, Copper (Efavet 2) 1500 mcg, manganese 2.5 mg, selenium 100 mcg, chromium 50 mcg, para-aminobenzoic acid (PABA) 30 mg.

No artificial colours, gluten, presevatives, starch or sugar, salt or yeast.

Copper (Efavet 2) has not been tested on animals.

A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic Acid (Efavet 2) is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. [PubChem]

Vitamin A (Efavet 2) (Glucoenergan, Reactivan) is a stimulant which was developed in the 1960s as an appetite suppressant, but was later withdrawn for this application due to problems with dependence and abuse. It is around half the potency of dexamphetamine, and is prescribed at a dose of 10-60mg, although abusers of the drug tend to rapidly develop tolerance and escalate their dose. Reactivan is still rarely used for treating depressive day-time fatigue, lack of concentration and lethargy, particularly in individuals who have chronic medical conditions, as its favourable safety profile makes it the most suitable drug in some cases.

3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.

Vitamin B12 (Efavet 2) (commonly known as Vitamin B12 (Efavet 2)) is the most chemically complex of all the vitamins. Vitamin B12 (Efavet 2)'s structure is based on a corrin ring, which, although similar to the porphyrin ring found in heme, chlorophyll, and cytochrome, has two of the pyrrole rings directly bonded. The central metal ion is Co (cobalt). Vitamin B12 (Efavet 2) cannot be made by plants or by animals, as the only type of organisms that have the enzymes required for the synthesis of cyanocobalamin are bacteria and archaea. Higher plants do not concentrate cyanocobalamin from the soil and so are a poor source of the substance as compared with animal tissues. Vitamin B12 (Efavet 2) is naturally found in foods including meat (especially liver and shellfish), eggs, and milk products.

Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide.

Vitamin B3 (Efavet 2) Lotion: Helps to reduce the appearance of blemishes on larger areas (back and upper chest). It absorbs easily to the skin and does not bleach clothes. Non-photosensitizing, fragrance-free and paraben-free.

Vitamin B3 (Efavet 2) Isocorrexion Hydrating Cream: Specially formulated for acne prone skin. Nicotinamide and Anti-Bacterial Adhesive substance (ABA's) helps to clear blemishes. Biophytosebum provides a moisturizing effect, reducing dryness and skin tightness caused by conventional acne treatment.

Vitamin B3 (Efavet 2) Oil-Free Cream: An oil-free formula enriched with mattifying agents. It helps to clear blemishes by promoting oil-free skin.

Vitamin B3 (Efavet 2) UV High Protection Cream SPF 45: Protects acne-prone skin from daily sun-induced irritation and damage, keeping the skin hydrated and blemish-free at the same time. Non-sensitizing, non-comodogenic, fragrance-free and paraben-free.

Vitamin B3 (Efavet 2) Gel: Provides intensive anti-blemish skin care for localized spots and promotes disappearance on the face or other small areas. It is non-sensitizing, fragrance-free and paraben-free.

Vitamin B3 (Efavet 2) Moussant Soap Free Cleansing Gel: Helps clear blemishes by purifying and cleansing the skin gently.

The 4-methanol form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).

A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Vitamin E (Efavet 2)&

Zinc (Efavet 2) Capsule: Each capsule contains Zinc (Efavet 2) sulphate monohydrate 54.93 mg, thiamine nitrate 10 mg, riboflavin 10 mg, pyridoxine hydrochloride 3 mg, Zinc (Efavet 2) (coated) equivalent to cyanocobalamin 15 mcg, ascorbic acid 150 mg, Zinc (Efavet 2) 1 mg, nicotinamide 50 mg and calcium pantothenate 12.5 mg.

Zinc (Efavet 2) Syrup: Each 5 mL contains Zinc (Efavet 2) gluconate 34.9 mg, thiamine mononitrate 2.5 mg, riboflavin 2.5 mg, pyridoxine hydrochloride 1 mg, cyanocobalamin 3 mcg, ascorbic acid 50 mg, d-panthenol 12.5 mg and niacinamide 25 mg in a flavoured liquid glucose sorbitol syrup base.

Copper (Efavet 2) 0.4 mg/mL (Cupric Chloride Injection, USP) is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN). Administration helps to maintain Copper (Efavet 2) serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.

Folic Acid (Efavet 2) is used in the treatment and prevention of the folate deficiency state. It does not correct folate deficiency due to dihydrofolate reductase inhibitors. Folic Acid (Efavet 2) is also used in women of child-bearing potential and pregnant women to protect against neural tube defects in their offspring. It is also used for the treatment of folate-deficient megaloblastic anaemia, chronic haemolytic states such as thalassaemia major or sickle-cell anaemia.

potential relief of pain, morning stiffness, and joint tenderness in rheumatoid arthritis sufferers, lowering total cholesterol and LDL, and raising HDL cholesterol,cardiovascular protection, slowing the development of cataracts, retinopathy, and cardiovascular damage of Diabetes mellitus, reduction itching, redness, and toughness of atopic skin and symptoms of atopic bronchial asthma, increasing lymphocytes.

Hypoallergenic infant formula for routine feeding especially for babies w/ family history of atopy.

Magnesium (Efavet 2) Sulfate Injection, USP is suitable for replacement therapy in Magnesium (Efavet 2) deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those observed in hypocalcemia. In such cases, the serum Magnesium (Efavet 2) (Mg++) level is usually below the lower limit of normal (1.5 to 2.5 mEq/liter) and the serum calcium (Ca++) level is normal (4.3 to 5.3 mEq/liter) or elevated.

In total parenteral nutrition (TPN), Magnesium (Efavet 2) sulfate may be added to the nutrient admixture to correct or prevent hypomagnesemia which can arise during the course of therapy.

Magnesium (Efavet 2) Sulfate Injection, USP is also indicated for the prevention and control of seizures (convulsions) in pre-eclampsia and eclampsia, respectively.

Oral

Selenium (Efavet 2) deficiency

Adult: 100-500 mcg of Selenium (Efavet 2) daily.

Intramuscular

Selenium (Efavet 2) deficiency

Adult: 100-500 mcg of Selenium (Efavet 2) daily.

Intravenous

Selenium (Efavet 2) deficiency

Adult: 100-500 mcg of Selenium (Efavet 2) daily.

Vitamin A (Efavet 2) injection is effective for the treatment of Vitamin A (Efavet 2) deficiency.

The parenteral administration is indicated when the oral administration is not feasible as in anorexia, nausea, vomiting, pre- and postoperative conditions, or it is not available as in the "Malabsorption Syndrome" with accompanying steatorrhea.

Pediatric Use: Vitamin A (Efavet 2) treatment for deficiency states has been recognized as an especially effective and important therapy in the pediatric population.

Vitamin A (Efavet 2) supplementation for deficiency states in this population has been addressed by the Committee on Clinical Practice Issues of the American Society for Clinical Nutrition, by the American Society for

Parenteral and Enteral Nutrition, and by the World Health Organization.

Vitamin B1 (Efavet 2) deficiency

Pernicious anemia, both uncomplicated and accompanied by nervous system involvement.

Dietary deficiency of Vitamin B12 (Efavet 2), occurring in strict vegetarians and in their breast-fed infants. (Isolated Vitamin B12 (Efavet 2) deficiency is very rare).

Malabsorption of Vitamin B12 (Efavet 2), resulting from structural or functional damage to the stomach, where intrinsic factor is secreted or to the ileum, where intrinsic factor facilitates Vitamin B12 (Efavet 2) absorption. These conditions include tropical sprue, and nontropical sprue (idiopathic steatorrhea, gluten-induced enteropathy). Folate deficiency in these patients is usually more severe than Vitamin B12 (Efavet 2) deficiency.

Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy). Total gastrectomy always produces Vitamin B12 (Efavet 2) deficiency.

Structural lesions leading to Vitamin B12 (Efavet 2) deficiency include regional ileitis, ileal resections, malignancies, etc.

Competition for Vitamin B12 (Efavet 2) by intestinal parasites or bacteria.

The fish tapeworm (Diphyilobothrium latum) absorbs huge quantities of Vitamin B12 (Efavet 2) and infested patients often have associated gastric atrophy. The blind-loop syndrome may produce deficiency of Vitamin B12 (Efavet 2) or folate.

Inadequate utilization of Vitamin B12 (Efavet 2). This may occur if antimetabolites for the vitamin are employed in the treatment of neoplasia.

For the Schilling Test.

Vitamin B2 (Efavet 2) deficiency

Helps clear blemishes. Vitamin B3 (Efavet 2) Moussant Soap-Free Cleansing Gel Purifies & cleanses the skin. Vitamin B3 (Efavet 2) Oil-Free Cream Promotes oil-free skin. Vitamin B3 (Efavet 2) Isocorrexion Use for acne prone skin. Reduces skin dryness & tightness caused by conventional acne treatment. Vitamin B3 (Efavet 2) Lotion For body acne in chest & back. Vitamin B3 (Efavet 2) UV High Protection Cream SPF 45 For sun protection for acne prone skin. Vitamin B3 (Efavet 2) Gel For localized spots.

Coenzyme A (metabolite of dexpanthenol) is important for deep penetrating moisturizer; stimulates epithelization; has wound healing effect; has an anti-inflammatory effect.

Only the D-Panthenol is the provitamin of D-Pantothenic acid (Vitamin B5 (Efavet 2)), not the L-Panthenol.

A cream with dexpanthenol regularly applied to the skin improves the moisture content of dry skin significantly.

A cream with 5% dexpanthenol accelerates the healing of superficial wounds by approximately 30%.

An ointment with dexpanthenol prevents erythema due to UV light.

Dexpanthenol ointment also protects the lips against solar herpes, Sun burns, mild burns, skin irritations, dry or cracked skin, cosmetic or shaving rashes, post chemical peeling treatment, post laser resurfacing treatment ( 11th -15th day).

Dexpanthenol is effective for preventing / treating nappy dermatitis in infants.

* Sideroblastic anaemia

* Treatment and prophylaxis of Vitamin B6 (Efavet 2) deficiency states

This medicine is indicated in all conditions where there is a disturbance of calcium metabolism due to impaired 1-α hydroxylation such as when there is reduced renal function. The main indications are:

a) Renal osteodystrophy

b) Hyperparathyroidism (with bone disease)

c) Hypoparathyroidism

d) Neonatal hypocalcaemia

e) Nutritional and malabsorptive rickets and osteomalacia

f) Pseudo-deficiency (D-dependent) rickets and osteomalacia

g) Hypophosphataemic Vitamin D (Efavet 2) resistant rickets and osteomalacia

Oral

Vitamin E (Efavet 2) deficiency

Adult: 40-50 mg of d-α tocopherol daily.

Child: Neonate: 10 mg/kg once daily; 1 mth-18 yr: 2-10 mg/kg/day, up to 20 mg/kg.

Oral

Supplementation in cystic fibrosis

Adult: 100-200 mg daily of dl-α-tocoferil acetate or 67-135 mg daily of d-α-tocopherol.

Child: As α- tocopheryl acetate: 1 mth-1 yr 50 mg once daily; 1-12 yr 100 mg once daily; 12-18 yr 200 mg once daily. Dose to be adjusted as needed.

Oral

Abetalipoproteinaemia

Adult: 50-100 mg/kg daily of dl-α-tocoferil acetate or about 33-67 mg/kg daily of d-α-tocopherol.

Child: Neonate: 100 mg/kg once daily; 1 mth-18 yr: 50-100 mg/kg once daily.

is recommended for first-line treatment of weak, brittle, splitting, or soft nails.

therapy should be taken regularly as directed to maintain strong, healthy nails. Clinical improvement is generally realized within 3 to 6 months. 1-3 Cessation of therapy may result in deterioration of nail health within 6 to 9 months.

Patients with deficiency of B-complex vitamins, vitamin C and Zinc (Efavet 2) or where supplementation of these vitamins and Zinc (Efavet 2) can be beneficial. Such patients and conditions include: Patients who are on prolonged antibiotic therapy; those who are suffering from infection, injuries, burns, fever, illness; patients with diarrhoea and GI disorders; patients who have undergone surgical operations; patients on diet restrictions eg, in diabetes, anorexia and alcoholism and in elderly persons; pregnant and lactating women due to increased nutritional needs.

Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Folic Acid (Efavet 2) (vitamin B 9) is necessary for strong blood.

Lack of Folic Acid (Efavet 2) may lead to anemia (weak blood). Your health care professional may treat this by prescribing Folic Acid (Efavet 2) for you.

Some conditions may increase your need for Folic Acid (Efavet 2). These include:

• Alcoholism
• Anemia, hemolytic
• Diarrhea (continuing)
• Fever (prolonged)
• Hemodialysis
• Illness (prolonged)
• Intestinal diseases
• Liver disease
• Stress (continuing)
• Surgical removal of stomach

In addition, infants smaller than normal, breast-fed infants, or those receiving unfortified formulas (such as evaporated milk or goat's milk) may need additional Folic Acid (Efavet 2).

Increased need for Folic Acid (Efavet 2) should be determined by your health care professional.

Some studies have found that Folic Acid (Efavet 2) taken by women before they become pregnant and during early pregnancy may reduce the chances of certain birth defects (neural tube defects).

Claims that Folic Acid (Efavet 2) and other B vitamins are effective for preventing mental problems have not been proven. Many of these treatments involve large and expensive amounts of vitamins.

Injectable Folic Acid (Efavet 2) is given by or under the direction of your health care professional. Another form of Folic Acid (Efavet 2) is available without a prescription.

Magnesium (Efavet 2) is used as a dietary supplement for individuals who are deficient in Magnesium (Efavet 2). Although a balanced diet usually supplies all the Magnesium (Efavet 2) a person needs, Magnesium (Efavet 2) supplements may be needed by patients who have lost Magnesium (Efavet 2) because of illness or treatment with certain medicines.

Lack of Magnesium (Efavet 2) may lead to irritability, muscle weakness, and irregular heartbeat.

Injectable Magnesium (Efavet 2) is given only by or under the supervision of a health care professional. Some oral Magnesium (Efavet 2) preparations are available only with a prescription. Others are available without a prescription.

Selenium (Efavet 2) is mineral that is found in soil and occurs naturally in certain foods (such as whole grains, Brazil nuts, sunflower seeds, and seafood). Selenium (Efavet 2) is not produced in the body, but it is needed for proper thyroid and immune system function.

Selenium (Efavet 2) is used to treat or prevent Selenium (Efavet 2) deficiency.

Selenium (Efavet 2) has been used in alternative medicine as an aid to treat Hashimoto's thyroiditis (an autoimmune disorder of the thyroid), and to treat high cholesterol.

Not all uses for Selenium (Efavet 2) have been approved by the FDA. Selenium (Efavet 2) should not be used in place of medication prescribed for you by your doctor.

Selenium (Efavet 2) may also be used for purposes not listed in this product guide.

Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Vitamin A (Efavet 2) is needed for night vision and for growth of skin, bones, and male and female reproductive organs. In pregnant women Vitamin A (Efavet 2) is necessary for the growth of a healthy fetus.

Lack of Vitamin A (Efavet 2) may lead to a rare condition called night blindness (problems seeing in the dark), as well as dry eyes, eye infections, skin problems, and slowed growth. Your health care professional may treat these problems by prescribing Vitamin A (Efavet 2) for you.

Some conditions may increase your need for Vitamin A (Efavet 2). These include:

• Diarrhea
• Eye diseases
• Intestine diseases
• Infections (continuing or chronic)
• Measles
• Pancreas disease
• Stomach removal
• Stress (continuing)

In addition, infants receiving unfortified formula may need Vitamin A (Efavet 2) supplements.

Vitamin A (Efavet 2) absorption will be decreased in any condition in which fat is poorly absorbed.

Increased need for Vitamin A (Efavet 2) should be determined by your health care professional.

Claims that Vitamin A (Efavet 2) is effective for treatment of conditions such as acne or lung diseases, or for treatment of eye problems, wounds, or dry or wrinkled skin not caused by lack of Vitamin A (Efavet 2) have not been proven. Although Vitamin A (Efavet 2) is being used to prevent certain types of cancer, some experts feel there is not enough information to show that this is effective, particularly in well-nourished individuals.

Injectable Vitamin A (Efavet 2) is given by or under the supervision of a health care professional. Other forms of Vitamin A (Efavet 2) are available without a prescription.

Thiamine is Vitamin B1 (Efavet 2). Thiamine is found in foods such as cereals, whole grains, meat, nuts, beans, and peas. Thiamine is important in the breakdown of carbohydrates from foods into products needed by the body.

Thiamine is used to treat or prevent Vitamin B1 (Efavet 2) deficiency. Thiamine injection is used to treat beriberi, a serious condition caused by prolonged lack of Vitamin B1 (Efavet 2).

Thiamine taken by mouth (oral) is available without a prescription. Injectable thiamine must be given by a healthcare professional.

Thiamine may also be used for purposes not listed in this medication guide.

Cyanocobalamin is a man-made form of Vitamin B12 (Efavet 2). Vitamin B12 (Efavet 2) is important for growth, cell reproduction, blood formation, and protein and tissue synthesis.

Cyanocobalamin is used to treat Vitamin B12 (Efavet 2) deficiency in people with pernicious anemia and other conditions.

Cyanocobalamin may also be used for purposes not listed in this medication guide.

Riboflavin is Vitamin B2 (Efavet 2). Vitamins are naturally occurring substances necessary for many processes in the body. Riboflavin is important in the maintenance of many tissues of the body.

Riboflavin is used to prevent and to treat deficiencies of riboflavin.

Riboflavin may also be used for other purposes not listed in this medication guide.

Pyridoxine is Vitamin B6 (Efavet 2). Vitamins occur naturally in foods such as meat, poultry, nuts, whole grains, bananas, and avocados. Vitamin B6 (Efavet 2) is important for many processes in the body.

Pyridoxine is used to treat or prevent Vitamin B6 (Efavet 2) deficiency. It is also used to treat a certain type of anemia (lack of red blood cells). Pyridoxine injection is also used to treat some types of seizure in babies.

Pyridoxine taken by mouth (oral) is available without a prescription. Injectable pyridoxine must be given by a healthcare professional.

Pyridoxine may also be used for purposes not listed in this medication guide.

Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are available in the foods that you eat. Vitamin D (Efavet 2) is necessary for strong bones and teeth.

Lack of Vitamin D (Efavet 2) may lead to a condition called rickets, especially in children, in which bones and teeth are weak. In adults it may cause a condition called osteomalacia, in which calcium is lost from bones so that they become weak. Your doctor may treat these problems by prescribing Vitamin D (Efavet 2) for you. Vitamin D (Efavet 2) is also sometimes used to treat other diseases in which calcium is not used properly by the body.

Ergocalciferol is the form of Vitamin D (Efavet 2) used in vitamin supplements.

Some conditions may increase your need for Vitamin D (Efavet 2). These include:

• Alcoholism
• Intestine diseases
• Kidney disease
• Liver disease
• Overactivity of the parathyroid glands with kidney failure
• Pancreas disease
• Surgical removal of stomach

In addition, individuals and breast-fed infants who lack exposure to sunlight, as well as dark-skinned individuals, may be more likely to have a Vitamin D (Efavet 2) deficiency. Increased need for Vitamin D (Efavet 2) should be determined by your health care professional.

Alfacalcidol, calcifediol, calcitriol, and dihydrotachysterol are forms of Vitamin D (Efavet 2) used to treat hypocalcemia (not enough calcium in the blood). Alfacalcidol, calcifediol, and calcitriol are also used to treat certain types of bone disease that may occur with kidney disease in patients who are undergoing kidney dialysis.

Claims that Vitamin D (Efavet 2) is effective for treatment of arthritis and prevention of nearsightedness or nerve problems have not been proven. Some psoriasis patients may benefit from Vitamin D (Efavet 2) supplements; however, controlled studies have not been performed.

Injectable Vitamin D (Efavet 2) is given by or under the supervision of a health care professional. Some strengths of ergocalciferol and all strengths of alfacalcidol, calcifediol, calcitriol, and dihydrotachysterol are available only with your doctor's prescription. Other strengths of ergocalciferol are available without a prescription. However, it may be a good idea to check with your health care professional before taking Vitamin D (Efavet 2) on your own. Taking large amounts over long periods may cause serious unwanted effects.

Vitamin E (Efavet 2) is an antioxidant that occurs naturally in foods such as nuts, seeds, and leafy green vegetables. Vitamin E (Efavet 2) is a fat-soluble vitamin important for many processes in the body.

Vitamin E (Efavet 2) is used to treat or prevent Vitamin E (Efavet 2) deficiency. People with certain diseases may need extra Vitamin E (Efavet 2).

Vitamin E (Efavet 2) may also be used for purposes not listed in this medication guide.

Zinc (Efavet 2) is a naturally occurring mineral. Zinc (Efavet 2) is important for growth and for the development and health of body tissues.

Zinc (Efavet 2) sulfate is used to treat and to prevent Zinc (Efavet 2) deficiency.

Zinc (Efavet 2) sulfate may also be used for purposes not listed in this medication guide.

Copper (Efavet 2) 0.4 mg/mL (Cupric Chloride Injection, USP) contains 0.4 mg Copper (Efavet 2)/mL and is administered intravenously only after dilution. The additive should be diluted in a volume of fluid not less than 100 mL. For the adult receiving TPN, the suggested additive dosage is 0.5 to 1.5 mg Copper (Efavet 2)/day (1.25 to 3.75 mL/day). For pediatric patients, the suggested additive dosage is 20 mcg Copper (Efavet 2)/kg/day (0.05 mL/kg/day). Infants weighing less than 1500 gm may have increased requirements because of their low body reserves and increased requirements for growth.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

Usual Adult Dose for Megaloblastic Anemia

1 mg orally, intramuscularly, subcutaneously or IV once a day. May continue until clinical symptoms of folate deficiency and the hematological profile have normalized.

Usual Adult Dose for Folic Acid (Efavet 2) Deficiency

400 to 800 mcg orally, intramuscularly, subcutaneously or IV once a day.

Women of childbearing age, pregnant, and lactating women: 800 mcg orally, intramuscularly, subcutaneously or IV once a day.

Usual Pediatric Dose for Folic Acid (Efavet 2) Deficiency

Infant:

0.1 mg orally, intramuscularly, subcutaneously or IV once a day.

Child:

Less than 4 years: up to 0.3 mg orally, intramuscularly, subcutaneously or IV once a day.

4 years or older: 0.4 mg orally, intramuscularly, subcutaneously or IV once a day.

Usual Pediatric Dose for Vitamin/Mineral Supplementation

Recommended daily allowance (RDA):

Premature neonates: 50 mcg/day (15 mcg/kg/day).

Full-term neonates and infants 1 to 6 months: 25 to 35 mcg/day.

Children:

1 to 3 years: 150 mcg/day.

4 to 8 years: 200 mcg/day.

9 to 13 years: 300 mcg/day.

14 years and older: 400 mcg/day.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Rarely, a dosage of 2 mg/day may be required, particularly in patients with malabsorption, alcoholism, chronic hemolysis, chronic exfoliative skin disease or who are on concomitant anticonvulsant therapy.

Dialysis

Folic Acid (Efavet 2) is removed by both hemodialysis and peritoneal dialysis. The amount removed varies with type equipment used.

Because folate may accumulate in patients with end-stage renal disease, side effects may be more likely in this patient who is undergoing dialysis. Once this patient's body stores of folate are replete, three times a week dosing may be just as beneficial as once daily dosing but should portend a lower risk of side effects.

Other Comments

The recommended daily allowance of Folic Acid (Efavet 2) for adult males and females ranges from 150 to 200 and 150 to 180 mcg/day, respectively.

There is a potential danger in administering Folic Acid (Efavet 2) to patients with undiagnosed anemia, since Folic Acid (Efavet 2) may obscure the diagnosis of pernicious anemia by alleviating the hematologic manifestations of the disease while allowing the neurologic complications to progress.

Severe megaloblastic anemia may require therapy for 4 to 5 weeks. Once stabilized, if dietary intake is inadequate, maintenance therapy can be started.

Reconstitution: 131 g to 900 mL water.

Usual Adult Dose for Hypomagnesemia

500 to 1000 mg Magnesium (Efavet 2) gluconate (27 to 54 mg elemental Magnesium (Efavet 2)) orally 3 times a day.

Usual Adult Dose for Dietary Supplement

500 to 1000 mg Magnesium (Efavet 2) gluconate (27 to 54 mg elemental Magnesium (Efavet 2)) orally once a day.

Usual Pediatric Dose for Hypomagnesemia

10 to 20 mg/kg of elemental Magnesium (Efavet 2) per dose orally 4 times a day. Use Magnesium (Efavet 2) gluconate oral liquid preparations for more accurate measurement of dose.

Renal Dose Adjustments

Do not use without physician supervision in patients with renal impairment due to increased risk of hypermagnesemia. The use of Magnesium (Efavet 2) salts are generally contraindicated in patients with severe renal dysfunction.

Liver Dose Adjustments

Data not available

Dose Adjustments

May increase by 500 to 1,000 mg/day (27 to 54 mg elemental Magnesium (Efavet 2)) in order to achieve a normal serum Magnesium (Efavet 2) level. Daily doses > 1,000 mg (54 mg elemental Magnesium (Efavet 2)) should be given in 2 to 3 divided doses.

Precautions

Because Magnesium (Efavet 2) is primarily eliminated by the kidney, there is significant risk of hypermagnesemia in patients with renal dysfunction.

Dialysis

Data not available; however, use of Magnesium (Efavet 2) salts is generally contraindicated in renal failure.

Other Comments

Magnesium (Efavet 2) supplements are often used with "low normal" serum Magnesium (Efavet 2) levels in patients predisposed to hypomagnesemia (e.g., patients on diuretics).

Selenium (Efavet 2) Injection provides 40 mcg Selenium (Efavet 2)/mL. For metabolically stable adults receiving TPN, the suggested additive dosage level is 20 to 40 mcg Selenium (Efavet 2)/day. For pediatric patients, the suggested additive dosage level is 3 mcg/kg/day.

In adults, Selenium (Efavet 2) deficiency states resulting from long-term TPN support, Selenium (Efavet 2) as selenomethionine or selenious acid, administered intravenously at 100 mcg/day for a period of 24 and 31 days, respectively, has been reported to reverse deficiency symptoms without toxicity.

Aseptic addition of Selenium (Efavet 2) Injection to the TPN solution under laminar flow hood is recommended. Selenium (Efavet 2) is physically compatible with the electrolytes and other trace elements usually present in amino-acid/dextrose solution used for TPN. Frequent monitoring of plasma Selenium (Efavet 2) levels is suggested as a guideline for subsequent administration. The normal whole blood range for Selenium (Efavet 2) is approximately 10 to 37 mcg/100 mL.

Parenteral drug products should be inspected visually for particulate matter and discoloration, whenever solution and container permit.

Usual Adult Dose for Vitamin A (Efavet 2) Deficiency

Initial dose: 100,000 Units intramuscularly once a day for 3 days

Maintenance dose: 50,000 Units intramuscularly once a day for 2 weeks

Use: Treatment of Vitamin A (Efavet 2) deficiency when oral administration is not feasible or not available (e.g. anorexia, nausea, vomiting, pre- or post-operative conditions, "Malabsorption Syndrome" with accompanying steatorrhea)

Usual Adult Dose for Vitamin/Mineral Supplementation

US Recommended Dietary Allowance (RDA):

Adult male: 900 mcg retinol activity equivalents (RAE) (3000 international units [IU])

Tolerable Upper Intake Level (UL): 3000 mcg RAE (10,000 IU)

Adult female: 700 mcg RAE (2330 IU)

UL: 3000 mcg RAE (10,000 IU)

Comments:

-The Vitamin A (Efavet 2) RDA is given as mcg of retinol activity equivalents (RAE) to account for the different bioactivities of retinol and provitamin A carotenoids.

-The body converts all dietary Vitamin A (Efavet 2) into retinol; 2 mcg of beta-carotene from dietary supplements is converted to 1 mcg of retinol.

-The tolerable upper intake level is the maximum daily intake that is unlikely to have adverse health effects.

Usual Pediatric Dose for Vitamin A (Efavet 2) Deficiency

Infants (under 1 year): 7500 to 15,000 Units intramuscularly once a day

Duration of therapy: 10 days

1 to 8 years: 17,500 to 35,000 Units intramuscularly once a day

Duration of therapy: 10 days

Adult dose:

Initial dose: 100,000 Units intramuscularly once a day for 3 days

Maintenance dose: 50,000 Units intramuscularly once a day for 2 weeks

Use: Treatment of Vitamin A (Efavet 2) deficiency when oral administration is not feasible or not available (e.g. anorexia, nausea, vomiting, pre- or post-operative conditions, "Malabsorption Syndrome" with accompanying steatorrhea)

Usual Pediatric Dose for Vitamin/Mineral Supplementation

US Recommended Dietary Allowance (RDA):

0 to 6 months: 400 mcg retinol activity equivalents (RAE) (1332 international units [IU])

Tolerable Upper Intake Level (UL): 600 mcg RAE (2000 IU)

7 to 12 months: 500 mcg RAE (1665 IU)

UL: 600 mcg RAE (2000 IU)

1 to 3 years: 300 mcg RAE (1000 IU)

UL: 900 mcg RAE (3000 IU)

4 to 8 years: 400 mcg RAE (1332 IU)

UL: 900 mcg RAE (3000 IU)

9 to 13 years: 600 mcg RAE (2000 IU)

UL: 1700 mcg RAE (5667 IU)

14 to 18 years, male: 900 mcg RAE (3000 IU)

UL: 2800 mcg RAE (9333 IU)

14 to 18 years, female: 700 mcg RAE (2330 IU)

UL: 2800 mcg RAE (9333 IU)

Comments:

-The Vitamin A (Efavet 2) RDA is given as mcg of retinol activity equivalents (RAE) to account for the different bioactivities of retinol and provitamin A carotenoids.

-The body converts all dietary Vitamin A (Efavet 2) into retinol; 2 mcg of beta-carotene from dietary supplements is converted to 1 mcg of retinol.

-The tolerable upper intake level is the maximum daily intake that is unlikely to have adverse health effects.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

US Recommended Dietary Allowance (RDA):

Pregnancy:

14 to 18 years: 750 mcg retinol activity equivalents (RAE) (2500 international units [IU])

UL: 2800 mcg RAE (9333 IU)

18 to 50 years: 770 mcg RAE (2564 IU)

UL: 3000 mcg RAE (10,000 IU)

Lactation:

14 to 18 years: 1200 mcg RAE (2564 IU)

UL: 2800 mcg RAE (9333 IU)

18 to 50 years: 1300 mcg RAE (4329 IU)

UL: 3000 mcg RAE (10,000 IU)

Comments:

-The Vitamin A (Efavet 2) RDA is given as mcg of retinol activity equivalents (RAE) to account for the different bioactivities of retinol and provitamin A carotenoids.

-The body converts all dietary Vitamin A (Efavet 2) into retinol; 2 mcg of beta-carotene from dietary supplements is converted to 1 mcg of retinol.

-The tolerable upper intake level is the maximum daily intake that is unlikely to have adverse health effects.

Precautions

CONTRAINDICATIONS:

-Administration of the intramuscular formulation intravenously

-Hypervitaminosis A

-Hypersensitivity to any of the ingredients

-The safety of doses exceeding 6000 units Vitamin A (Efavet 2) in pregnancy has not been established. Use of high doses in pregnancy or patients who may become pregnant is contraindicated. Doses above the recommended dietary allowance (RDA) may cause fetal harm; fetal abnormalities (central nervous system, eye, and palate malformations) were seen in animal overdose models. If patients become pregnant, apprise them of potential fetal harms.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Vitamin B12 (Efavet 2) Atlantic Laboratories is used as injections SC, IV, IM, intralumbar, and also oral. With anemia associated with Vitamin B12 (Efavet 2) deficiency is introduced on 100-200 mcg in 2 days. In anemia with symptoms of funicular myelosis and megalocytic anemia with diseases of the nervous system - 400-500 micrograms in the first 7 days daily, then 1 time every 5-7 days. In the period of remission in the absence of events funicular myelosis maintenance dose - 100 mcg 2 times a month, in the presence of neurological symptoms - at 200-400 mcg 2-4 times a month. In acute post-hemorrhagic anemia and iron anemia by 30-100 mcg 2-3 times a week. When aplastic anemia (especially in children) - 100 micrograms before clinical improvement. When nutritional anemia in infants and preterm - 30 mcg / day during 15 days.

In diseases of the central and peripheral nervous system and neurological diseases with a pain syndrome is administered in increasing doses - 200-500 mcg, with the improvement in the state - 100 mcg / day. The course of treatment with Vitamin B12 (Efavet 2) Atlantic Laboratories is 2 weeks. In traumatic lesions of peripheral nervous system - at 200-400 mcg every other day for 40-45 days.

When hepatitis and cirrhosis - 30-60 mcg / day or 100 mg every other day for 25-40 days.

Dystrophy in young children, Down syndrome and cerebral palsy - by 15-30 mcg every other day.

When funicular myelosis, amyotrophic lateral sclerosis can be introduced into the spinal canal at 15-30 mcg, gradually increasing the dose of 200-250 micrograms.

In radiation sickness, diabetic neuropathy, sprue - by 60-100 mcg daily for 20-30 days.

When deficiency of Vitamin B12 (Efavet 2) to prevent - IV or IM for 1 mg 1 time a month; for treatment - IV or IM for 1 mg daily for 1-2 weeks, the maintenance dose is 1-2 mg IV or IM from 1 per week, up to 1 per month. Duration of treatment is determined individually.

Vitamin B3 (Efavet 2) Lotion: Apply to the areas being treated after cleansing twice a day, AM & PM.

Vitamin B3 (Efavet 2) Isocorrexion & Vitamin B3 (Efavet 2) Oil-Free Cream: Apply to the face and affected areas (neck, chest and back) after cleansing twice a day, AM & PM. Massage delicately to facilitate absorption.

Vitamin B3 (Efavet 2) UV High Protection Cream SPF 45: Reapply every 2-3 hrs.

Vitamin B3 (Efavet 2) Gel: Apply small amount of gel on affected areas by massaging gently in AM & PM.

Vitamin B3 (Efavet 2) Moussant Soap Free Cleansing Gel: Apply in AM & PM to damp skin, face and affected areas (neck, chest and back) by massaging delicately. Rinse thoroughly and dry gently. May be used in shower.

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Capsule,

Oral:

D3-50: 1.25 MG (50000 UT) [dairy free, egg free, fish derivative free, gluten free, kosher certified, no artificial color(s), nut free, soy free, sugar free, wheat free, yeast free]

Vitamin D (Efavet 2): 1.25 MG (50000 UT) [contains fd&c yellow #10 (quinoline yellow), fd&c yellow #6 (sunset yellow), soybean oil]

Vitamin D (Efavet 2): 250 MCG (10000 UT) [contains fd&c yellow #10 aluminum lake, fd&c yellow #6 aluminum lake, gelatin (bovine)]

Vitamin D (Efavet 2): 625 MCG (25000 UT) [contains soybean oil]

Dialyvite Vitamin D (Efavet 2) 5000: 125 MCG (5000 UT)

Pronutrients Vitamin D3: 25 MCG (1000 UT) [contains soybean oil]

Weekly-D: 1.25 MG (50000 UT) [contains fd&c red #40]

Generic: 1.25 MG (50000 UT), 250 MCG (10000 UT)

Capsule,

Oral [preservative free]:

Vitamin D (Efavet 2): 125 MCG (5000 UT) [dairy free, dye free, egg free, gluten free, no artificial color(s), nut free, soy free, sugar free, wheat free, yeast free]

D3-50: 1.25 MG (50000 UT) [dairy free, egg free, fish derivative free, gluten free, kosher certified, no artificial color(s), nut free, soy free, sugar free, wheat free, yeast free]

Generic: 10,000 units, 125 MCG (5000 UT), 25 MCG (1000 UT), 50 MCG (2000 UT)

Liquid,

Oral:

Aqueous Vitamin D (Efavet 2): 10 mcg/mL (50 mL) [gluten free, lactose free, sugar free; contains corn oil, methylparaben, polysorbate 80]

Bio-D-Mulsion: 10 mcg/0.03 mL (30 mL [DSC]) [contains sesame oil]

Bio-D-Mulsion Forte: 50 mcg/0.03 mL (30 mL [DSC]) [contains sesame oil]

BProtected Pedia D-Vite: 10 mcg/mL (50 mL) [alcohol free, sugar free; contains polysorbate 80, propylene glycol, sodium benzoate; cherry flavor]

Vitamin D (Efavet 2): 10 mcg/mL (50 mL) [gluten free, lactose free, sugar free; contains polysorbate 80]

D-Vita: 10 mcg/mL (50 mL [DSC]) [alcohol free, gluten free, lactose free, sugar free; contains polysorbate 80, propylene glycol, sodium benzoate; fruit flavor]

D-Vite Pediatric: 10 mcg/mL (50 mL) [alcohol free, gluten free, lactose free, no artificial color(s), sugar free; contains disodium edta, polysorbate 80, propylene glycol, saccharin sodium, sodium benzoate]

D3 Vitamin: 10 mcg/mL (50 mL) [contains polysorbate 80, sodium benzoate]

Generic: 10 mcg/mL (50 mL, 52 mL)

Liquid,

Oral [preservative free]:

Generic: 125 mcg/mL (52 mL)

Liquid, Sublingual:

Generic: 5000 units/mL (60 mL)

Tablet,

Oral:

Delta D3: 10 MCG (400 UNIT) [gelatin free, gluten free, lactose free, no artificial color(s), no artificial flavor(s), starch free, sugar free, yeast free]

Dialyvite Vitamin D3 Max: 1.25 MG (50000 UT) [scored]

Vitamin D3 Super Strength: 50 MCG (2000 UT) [gluten free]

Vitamin D3 Ultra Potency: 1.25 MG (50000 UT)

Generic: 10 MCG (400 UNIT), 125 MCG (5000 UT), 20 MCG (800 UNIT), 25 MCG (1000 UT), 50 MCG (2000 UT), 75 MCG (3000 UT)

Tablet,

Oral [preservative free]:

Generic: 5000 units, 10 MCG (400 UNIT), 25 MCG (1000 UT), 50 MCG (2000 UT)

Tablet Chewable,

Oral:

Generic: 10 MCG (400 UNIT)

Tablet Chewable,

Oral [preservative free]:

Generic: 50 MCG (2000 UT)

Dosing: Adult

Note: 1 mcg = 40 units

Hypoparathyroidism (off-label use): Note: Active Vitamin D (Efavet 2) preparations (ie, alfacalcidol, calcitriol) in conjunction with calcium supplementation are recommended therapy. Addition of cholecalciferol (or ergocalciferol) may be considered for supplemental therapy (Endocrine Society [Brandi 2016]).

Osteoporosis, prevention (off-label use): Adults ≥50 years of age:

Oral: 800 to 1,000 units/day is recommended, through dietary sources and/or supplementation if needed (NOF [Cosman 2014]).

Vitamin D (Efavet 2) insufficiency/deficiency treatment (off-label use): Note: Repletion strategies may vary depending on desired target serum 25(OH)D levels as well as the clinical status of the patient. The optimal serum 25(OH)D level is controversial; the Institute of Medicine recommends a 25(OH)D level >20 ng/mL as sufficient in nearly all persons (IOM 2011), whereas others have suggested targeting a level of ~30 ng/mL to minimize the risk of fractures, particularly in patients with osteoporosis (AACE [Camacho 2016]; NOF [Cosman 2014]). However, some data suggest levels >40 ng/mL (median level in one trial: ~48 ng/mL) are associated with increased risk of falls in postmenopausal women (Sanders 2010; Smith 2017).

Therefore, some experts recommend a range of 20 to 40 ng/mL as a reasonable target in most patients (Dawson-Hughes 2018). In patients with normal absorption, for every 100 units/day of cholecalciferol, the serum 25(OH)D level is expected to increase by ~0.7 to 1 ng/mL after a few weeks (ASPEN [McKeever 2017]; Dawson-Hughes 2018). The dose-response declines as the 25(OH)D concentration increases above 40 ng/mL (100 nmol/L) (Dawson-Hughes 2018). The following recommendations are based primarily on expert opinion and clinical experience:

Initial dosing (according to baseline serum 25(OH)D level):

Serum 25(OH)D 20 to 30 ng/mL: Initial: Supplementation dosing:

Oral: 600 to 800 units once daily; a repeat serum 25(OH)D level is not required (Dawson-Hughes 2018) or 1,000 to 2,000 units once daily; may consider a repeat serum 25(OH)D level in ~3 months to determine if the target level has been achieved (Khan 2010).

Serum 25(OH)D 10 to <20 ng/mL: Initial:

Supplementation dosing:

Oral: 800 to 1,000 units once daily (Dawson-Hughes 2018)

OR

Therapeutic dosing (ie, high-dose cholecalciferol):

Oral: 50,000 units once

Serum 25(OH)D <10 ng/mL or in patients with deficiency symptoms: Initial: Therapeutic dosing (ie, high-dose cholecalciferol):

Oral: 50,000 units once

Maintenance dosing: Maintenance dosing is highly patient specific and dependent on target 25(OH)D level, and may range from: 600 to 800 units/day (Dawson-Hughes 2018) to 1,000 to 2,000 units/day (AACE [Camacho 2016]; NOF [Cosman 2014]).

Special populations (obese patients, patients on medications known to affect Vitamin D (Efavet 2) metabolism, patients with malabsorption syndromes or gastrectomy): Higher doses or longer durations may be necessary for adequate repletion (AACE [Camacho 2016]; Dawson-Hughes 2018).

Vitamin D (Efavet 2) deficiency/insufficiency in patients with chronic kidney disease (off-label use):

Oral:

Note: In patients without severe and progressive hyperparathyroidism, including chronic kidney disease stages G3 to G5 and dialysis or transplant patients, KDIGO guidelines recommend correcting Vitamin D (Efavet 2) deficiency and insufficiency with treatment strategies recommended for the general population using cholecalciferol (or ergocalciferol) while avoiding hypercalcemia and ensuring phosphate levels are in the normal range. An individualized monitoring approach to direct treatment is also recommended (KDIGO 2009; KDIGO 2017). In patients in whom serum parathyroid hormone levels are progressively rising and remain persistently elevated despite correction of modifiable factors (eg, hyperphosphatemia, Vitamin D (Efavet 2) deficiency), calcitriol or Vitamin D (Efavet 2) analogs are suggested instead of cholecalciferol (or ergocalciferol) (KDOQI commentary [Uhlig 2010]).

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Vitamin D (Efavet 2) deficiency, prevention (eg, Rickets prevention): (AAP [Folsom 2017]; AAP [Wagner 2008]; Munns 2016):

Oral:

Breast-fed infants (fully or partially):

Oral: 400 units/day beginning in the first few days of life. Continue supplementation until infant is weaned to ≥1,000 mL/day or 1 qt/day of Vitamin D (Efavet 2)-fortified formula or whole milk (after 12 months of age)

Formula-fed infants ingesting <1,000 mL of Vitamin D (Efavet 2)-fortified formula:

Oral: 400 units/day

Children and Adolescents without adequate intake:

Oral: 400 to 600 units/day.

Vitamin D (Efavet 2) deficiency, treatment:

Oral:

Infants:

Oral: 2,000 units daily for 6 weeks to achieve a serum 25(OH)D level >20 ng/mL; followed by a maintenance dose of 400 to 1,000 units daily. Note: For patients at high risk of fractures a serum 25(OH)D level >30 ng/mL has been suggested (AAP [Golden 2014]).

Children and Adolescents:

Oral: 2,000 units daily for 6 to 8 weeks to achieve serum 25(OH)D level >20 ng/mL; followed by a maintenance dose of 600 to 1,000 units daily. Note: For patients at high risk of fractures a serum 25(OH)D level >30 ng/mL has been suggested (AAP [Golden 2014]).

Vitamin D (Efavet 2) deficiency in cystic fibrosis, prevention and treatment:

Oral:

CF guidelines (Tangricha [CF Foundation] 2012):

Recommended initial daily intake to maintain serum 25(OH)D level ≥30 ng/mL:

Infants:

Oral: 400 to 500 units/day

Children ≤10 years:

Oral: 800 to 1,000 units/day

Children >10 years and Adolescents:

Oral: 800 to 2,000 units/day

Dosing adjustment for serum 25(OH)D level between 20 to 30 ng/mL and patient adherence established (Step 1 increase):

Infants:

Oral: 800 to 1,000 units/day

Children ≤10 years:

Oral: 1,600 to 3,000 units/day

Children >10 years and Adolescents:

Oral: 1,600 to 6,000 units/day

Dosing adjustment for serum 25(OH)D level <20 ng/mL or persistently between 20 to 30 ng/mL and patient adherence established (Step 2 increase):

Infants: Increase up to a maximum 2,000 units/day

Children ≤10 years: Increase to a maximum of 4,000 units/day

Children >10 years and Adolescents: Increase to a maximum of 10,000 units/day

Alternate dosing (Hall 2010):

Initial dose: Serum 25(OH)D level ≤30 ng/mL

Infants:

Oral: 8,000 units/

Children and Adolescents:

Oral: 800 units/day

Medium-dose regimen: Serum 25(OH)D level remains ≤30 ng/mL and patient compliance established

Infants and Children <5 years:

Oral: 12,000 units/week for 12 weeks

Children ≥5 years and Adolescents:

Oral: 50,000 units/week for 12 weeks

High-dose regimen: Repeat 25(OH)D level remains ≤30 ng/mL and patient compliance established

Infants and Children <5 years:

Oral: 12,000 units twice weekly for 12 weeks

Children ≥5 years and Adolescents:

Oral: 50,000 units twice weekly for 12 weeks

Vitamin D (Efavet 2) insufficiency or deficiency associated with CKD (stages 2 to 5, 5D), treatment; serum 25 hydroxyvitamin D [25(OH)D] level ≤30 ng/mL (KDOQI Guidelines 2009):

Oral:

Serum 25(OH)D level 16 to 30 ng/mL: Infants, Children, and Adolescents: 2,000 units/day for 3 months or 50,000 units every month for 3 months

Serum 25(OH)D level 5 to 15 ng/mL: Infants, Children, and Adolescents: 4,000 units/day for 12 weeks or 50,000 units every other week for 12 weeks

Serum 25(OH)D level <5 ng/mL: Infants, Children, and Adolescents: 8,000 units/day for 4 weeks then 4,000 units/day for 2 months for total therapy of 3 months or 50,000 units/week for 4 weeks followed by 50,000 units 2 times/month for a total therapy of 3 months

Maintenance dose [once repletion accomplished; serum 25(OH)D level >30 ng/mL]: Infants, Children, and Adolescents: 200 to 1,000 units/day

Nutritional rickets, treatment: Limited data available (Munns 2016): Administer in combination with calcium supplementation:

Daily therapy (preferred):

Infants:

Oral: 2,000 units daily for ≥3 months, followed by maintenance dose of 400 units daily

Children:

Oral: 3,000 to 6,000 units daily for ≥3 months, followed by maintenance dose of 600 units daily

Adolescents:

Oral: 6,000 units daily for ≥3 months, followed by maintenance dose of 600 units daily

Single-dose therapy:

Infants ≥3 months:

Oral: 50,000 units once, or in divided doses over several days; after 3 months, initiate maintenance dose of 400 units daily

Children:

Oral: 150,000 units once, or in divided doses over several days; after 3 months, initiate maintenance dose of 600 units daily

Adolescents:

Oral: 300,000 units once, or in divided doses over several days; after 3 months, initiate maintenance dose of 600 units daily

Usual Adult Dose for Vitamin E (Efavet 2) Deficiency

Treatment: 60 to 75 units orally once daily.

Prevention: 30 units orally once daily.

Usual Adult Dose for Tardive Dyskinesia

600 to 1600 units orally per day.

Usual Adult Dose for Sickle Cell Anemia

450 units orally per day.

Usual Adult Dose for Alzheimer's Disease

1000 units orally twice daily.

Usual Adult Dose for Dietary Supplement

Oral liquid formulation (Vitamin E (Efavet 2)): 200 units (10 mL) orally once daily.

Usual Pediatric Dose for Vitamin E (Efavet 2) Deficiency

1 unit/kg/day orally of water-miscible Vitamin E (Efavet 2).

Usual Pediatric Dose for Retinopathy Prophylaxis

Prevention of retinopathy of prematurity or Bronchopulmonary dysplasia (BPD) secondary to oxygen therapy: 15 to 30 units/kg/day to maintain plasma levels between 1.5 to 2 mcg/mL (may need as high as 100 units/kg/day). Note: AAP considers this use investigational and routine use is not recommended.

Usual Pediatric Dose for Cystic Fibrosis

100 to 400 units/day orally.

Usual Pediatric Dose for Dietary Supplement

Dosing: 1 unit Vitamin E (Efavet 2) = 1 mg dl-alpha-tocopherol acetate.

Oral:

Adequate Intake (AI):

1 to less than 6 months: 4 units daily

6 to less than 12 months: 5 units daily

Recommended Daily Allowance (RDA):

1 to 3 years: 6 units daily

4 to 8 years: 7 units daily

9 to 13 years: 11 units daily

13 years and Older: 15 units daily

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Although no longer available in the U.S., Vitamin E (Efavet 2) injectable administered intravenously to premature infants may result in a potentially fatal syndrome consisting of thrombocytopenia, hepatomegaly, splenomegaly, ascites, and renal, hepatic, and pulmonary dysfunction.

Oral administration of large doses (200 mg per day) of a hyperosmolar Vitamin E (Efavet 2) preparation to low-birthweight infants has been associated with the development of necrotizing enterocolitis.

Dialysis

Data not available

Other Comments

The oral liquid formulation (Vitamin E (Efavet 2) [R]) is intended to enhance absorption in patients with conditions associated with malabsorption (e.g., Crohn's disease, ulcerative colitis ) or for patients who have difficulty swallowing capsules.

The oral liquid formulation (Vitamin E (Efavet 2) [R]) may be taken directly or mixed with water or other beverage. It must be shaken well prior to each use and refrigerated after opening.

Zinc (Efavet 2) 1 mg/mL (Zinc (Efavet 2) Chloride Injection, USP) contains 1 mg Zinc (Efavet 2)/mL and is administered intravenously only after dilution. The additive should be diluted prior to administration in a volume of fluid not less than 100 mL. For the metabolically stable adult receiving TPN, the suggested intravenous dosage is 2.5 to 4 mg Zinc (Efavet 2)/day (2.5 to 4 mL/day). An additional 2 mg Zinc (Efavet 2)/day (2 mL/day) is suggested for acute catabolic states. For the stable adult with fluid loss from the small bowel, an additional 12.2 mg Zinc (Efavet 2)/liter of small bowel fluid lost (12.2 mL/liter of small bowel fluid lost), or an additional 17.1 mg Zinc (Efavet 2)/kg of stool or ileostomy output (17.1 mL/kg of stool or ileostomy output) is recommended. Frequent monitoring of Zinc (Efavet 2) blood levels is suggested for patients receiving more than the usual maintenance dosage level of Zinc (Efavet 2).

For full term infants and children up to 5 years of age, 100 mcg Zinc (Efavet 2)/kg/day

(0.1 mL/kg/day) is recommended. For premature infants (birth weight less than 1500 g) up to 3 kg in body weight, 300 mcg Zinc (Efavet 2)/kg/day (0.3 mL/kg/day) is suggested.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. See PRECAUTIONS.

How supplied

Zinc (Efavet 2) 1 mg/mL (Zinc (Efavet 2) Chloride Injection, USP) is supplied in 10 mL Plastic Vials (List No. 4090).

Store at 20 to 25°C (68 to 77°F).

HOSPIRA, INC., LAKE FOREST, IL 60045 USA. Revised: October, 2004

Pregnancy or suspected malignant genital tumor of its existence, acute inflammation, subacute or chronic genital tract, congenital or acquired anatomic abnormalities of the uterus and cervix, endometriosis, malposition and malsituaciones accused the uterus, uterine hypoplasia, genital bleeding of unknown etiology blood clotting disorders, Wilson’s disease, allergy to Copper (Efavet 2).

See also:
What is the most important information I should know about Folic Acid (Efavet 2)?

Because it may mask the hematologic abnormalities while neurological damage progresses, Folic Acid (Efavet 2) should not be used in the therapy of patients with vitamin B12 deficiency of any cause, unless there is associated folate deficiency. The Folic Acid (Efavet 2) content of one tablet a day however, is unlikely to mask pernicious anemia should this condition be present. Also, pregnancy during pernicious anemia is very rare.

Contraindications have not yet been identified.

See also:
What is the most important information I should know about Magnesium (Efavet 2)?

Do NOT use Calcium Carbonate/Magnesium (Efavet 2) Carbonate if:

you are allergic to any ingredient in Calcium Carbonate/Magnesium (Efavet 2) Carbonate

you have an increased calcium level in your blood

Contact your doctor or health care provider right away if any of these apply to you.

See also:
What is the most important information I should know about Selenium (Efavet 2)?

Selenium (Efavet 2) Injection should not be given undiluted by direct injection into a peripheral vein because of the potential for infusion phlebitis.

See also:
What is the most important information I should know about Vitamin A (Efavet 2)?

The intravenous administration. Hypervitaminosis A. Sensitivity to any of the ingredients in this preparation. Use in Pregnancy: Safety of amounts exceeding 6,000 Units of Vitamin A (Efavet 2) daily during pregnancy has not been established at this time. The use of Vitamin A (Efavet 2) in excess of the recommended dietary allowance may cause fetal harm when administered to a pregnant woman. Animal reproduction studies have shown fetal abnormalities associated with overdosage in several species. Malformations of the central nervous system, the eye, the palate, and the urogenital tract are recorded. Vitamin A (Efavet 2) in excess of the recommended dietary allowance is contraindicated in women who are or may become pregnant. If Vitamin A (Efavet 2) is used during pregnancy, or if the patient becomes pregnant while taking Vitamin A (Efavet 2), the patient should be apprised of the potential hazard to the fetus.

See also:
What is the most important information I should know about Vitamin B1 (Efavet 2)?

Contraindications for Vitamin B1 (Efavet 2) (Vitamin B1 (Efavet 2))

Hypersensitivity to Vitamin B1 (Efavet 2) or any component of a product containing Vitamin B1 (Efavet 2).

See also:
What is the most important information I should know about Vitamin B12 (Efavet 2)?

Hypersensitivity to the components of the formula. History of allergy to the cobalamins (Vitamin B12 (Efavet 2) and similar substances). Malignant tumors. By stimulating the growth of tissues, the Cobamamide could increase the high rate of cell multiplication. Sensitivity to cobalt. History of allergies to cobalamin (Vitamin B12 (Efavet 2) and related substances).

- Malignant tumor: Due to the action of Vitamin B12 (Efavet 2) on the growth of tissue cell multiplication rate high, the risk of exacerbation should be taken into account.

- Children under 6 years because of the dosage form

See also:
What is the most important information I should know about Vitamin B2 (Efavet 2)?

None well documented.

Contraindications for Vitamin B3 (Efavet 2) (Vitamin B3 (Efavet 2))

Nicotinic acid is contraindicated in patients with a known hypersensitivity to any component of this medication; significant or unexplained hepatic dysfunction; active peptic ulcer disease; or arterial bleeding.

Haemophiliacs, patients with ileus (due to mechanical obstruction).

See also:
What is the most important information I should know about Vitamin B6 (Efavet 2)?

Contraindications for Vitamin B6 (Efavet 2) (Vitamin B6 (Efavet 2))

Vitamin B6 (Efavet 2) is contraindicated in those hypersensitive to any component of a Vitamin B6 (Efavet 2)-containing product.

See also:
What is the most important information I should know about Vitamin D (Efavet 2)?

OTC labeling: Replesta products only: When used for self-medication, do not use if you have hypercalcemia, primary hyperparathyroidism, sarcoidosis, hypervitaminosis D, Williams syndrome, or are pregnant.

Documentation of allergenic cross-reactivity for Vitamin D (Efavet 2) is limited. However, because of similarities in chemical structure and/or pharmacologic actions, the possibility of cross-sensitivity cannot be ruled out with certainty.

See also:
What is the most important information I should know about Vitamin E (Efavet 2)?

Hypersensitivity to Vitamin E (Efavet 2) or any component of the formulation

contraindicated in patients allergic or hypersensitive to any of its ingredients.

See also:
What is the most important information I should know about Zinc (Efavet 2)?

Hypersensitivity to any of the ingredients of Zinc (Efavet 2).

Use Folic Acid (Efavet 2) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Folic Acid (Efavet 2) may be administered as an injection by your health care professional.
• If you are using Folic Acid (Efavet 2) at home, carefully follow the injection procedures taught to you by your health care provider. If the medicine contains particles, is discolored, or if the vial is cracked or damaged in any way, do not use it.
• Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when full.
• If you miss a dose of Folic Acid (Efavet 2), use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Folic Acid (Efavet 2).

Use Magnesium (Efavet 2) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Magnesium (Efavet 2) by mouth with food.
• If you miss a dose of Magnesium (Efavet 2) and are using it regularly, take it as soon as possible. If it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Magnesium (Efavet 2).

Use Selenium (Efavet 2) lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Shake well before each use.
• Remove jewelry before using Selenium (Efavet 2) lotion.
• Do not use on broken or inflamed skin or scalp.
• To use Selenium (Efavet 2) lotion on the scalp - Massage 1 or 2 teaspoonfuls of the medicine on the wet scalp. Leave on the scalp for 2 to 3 minutes. Rinse scalp thoroughly. Wash hands well after treatment. If you are using Selenium (Efavet 2) lotion before or after bleaching, tinting, or permanent waving of hair, rinse hair for at least 5 minutes in cool running water.
• To use Selenium (Efavet 2) lotion on the skin - Apply a sufficient amount to cover affected areas of the body. Lather well with a small amount of water. Leave the medicine on the skin for 10 minutes. Rinse thoroughly in the shower. Wash hands well after treatment.
• If you miss a dose of Selenium (Efavet 2) lotion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once

Ask your health care provider any questions you may have about how to use Selenium (Efavet 2) lotion.

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Pyridoxine tablets are taken by mouth. Injectable pyridoxine is injected into a muscle or into a vein through an IV. You may be shown how to use injections at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

The recommended dietary allowance of pyridoxine increases with age. Follow your healthcare provider's instructions. You may also consult the Office of Dietary Supplements of the National Institutes of Health, or the U.S. Department of Agriculture (USDA) Nutrient Database (formerly "Recommended Daily Allowances") listings for more information.

Pyridoxine is only part of a complete program of treatment that may also include a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you should eat or avoid to help control your condition.

Store at room temperature away from moisture and heat.

Use: Labeled Indications

Trace element added to parenteral nutrition (PN) to prevent Copper (Efavet 2) deficiency; orally as a dietary supplement

Folic Acid (Efavet 2) is the man-made form of folate. Folate is a B-vitamin naturally found in some foods. It is needed to form healthy cells, especially red blood cells.

Folic Acid (Efavet 2) supplements may come in different forms (such as L-methylfolate, levomefolate, methyltetrahydrofolate). They are used to treat or prevent low folate levels. Low folate levels can lead to certain types of anemia. Conditions that can cause low folate levels include poor diet, pregnancy, alcoholism, liver disease, certain stomach/intestinal problems, kidney dialysis, among others. Women of childbearing age should receive adequate amounts of Folic Acid (Efavet 2) either through their diet or supplements to prevent infant spinal cord birth defects.

How to use Folic Acid (Efavet 2)

Take this product by mouth with or without food as directed by your doctor, usually once daily. If you are taking the over-the-counter product, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.

Dosage is based on your medical condition and response to treatment. Do not increase your dose or take this product more often than directed.

Take this product regularly to get the most benefit from it. To help you remember, take it at the same time each day. Follow the diet plan recommended by your doctor or dietician. See also Notes section.

If your condition persists or worsens, or if you think you may have a serious medical problem, get medical help right away.

This medication is a mineral supplement used to prevent and treat low amounts of Magnesium (Efavet 2) in the blood. Magnesium (Efavet 2) is very important for the normal functioning of cells, nerves, muscles, bones, and the heart. Usually, a well-balanced diet provides normal blood levels of Magnesium (Efavet 2). However, certain situations cause your body to lose Magnesium (Efavet 2) faster than you can replace it from your diet. These situations include treatment with "water pills" (diuretics such as furosemide, hydrochlorothiazide), a poor diet, alcoholism, or other medical conditions (e.g., severe diarrhea/vomiting, stomach/intestinal absorption problems, poorly controlled diabetes).

How to use Magnesium (Efavet 2) amino acid chelate

Take this product by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.

It is best to take Magnesium (Efavet 2) supplements with a meal to reduce stomach upset and diarrhea unless otherwise directed by the product instructions or your doctor.

Take each dose with a full glass (8 ounces or 240 milliliters) of water unless your doctor directs you otherwise. Swallow extended-release capsules and delayed-release/enteric coated tablets or capsules whole. Do not crush or chew extended-release or delayed-release/enteric coated capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

If you are using a liquid product, use a medication measuring device to carefully measure the dose. Do not use a household spoon because you may not get the correct dose. If you are using a suspension, shake the bottle well before each dose.

Take this medication regularly in order to get the most benefit from it. Remember to take it at the same time(s) each day. Dosage is based on your medical condition and response to treatment. Do not increase your dose or take it more often than directed on the product package or by your doctor. Too much Magnesium (Efavet 2) in the blood can cause serious side effects.

Tell your doctor if symptoms of low Magnesium (Efavet 2) blood levels (e.g., muscle cramps, tiredness, irritability, depression) persist or worsen. If you think you may have a serious medical problem, seek immediate medical attention.

Selenium (Efavet 2) is used as a dietary supplement mainly in the treatment of Selenium (Efavet 2) deficiency affecting young women and children with Keshan disease. It is also used for treatment of osteoarthiritis associated with poor Selenium (Efavet 2) levels in body called Kashin-Beck Disease. Selenium (Efavet 2) supplements are also used in patients with HIV/ AIDS to maintain the adequate Selenium (Efavet 2) levels.

Vitamin A (Efavet 2) is used to prevent or treat low levels of the vitamin in people who do not get enough of it from their diets. Most people who eat a normal diet do not need extra Vitamin A (Efavet 2). However, some conditions (such as protein deficiency, diabetes, hyperthyroidism, liver/pancreas problems) can cause low levels of Vitamin A (Efavet 2). Vitamin A (Efavet 2) plays an important role in the body. It is needed for growth and bone development and to maintain the health of the skin and eyesight. Low levels of Vitamin A (Efavet 2) may cause vision problems (such as night blindness) and permanent eye damage.

How to use Vitamin A (Efavet 2)

Take this vitamin by mouth with or without food, usually once daily. Follow all directions on the product package, or take as directed by your doctor. If you are uncertain about any of the information, consult your doctor or pharmacist.

If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

Dosage is based on your age, medical condition, and response to treatment.

Use this vitamin regularly to get the most benefit from it. To help you remember, take it at the same time each day. Do not increase your dose or use this vitamin more often than recommended. Your condition will not improve any faster, and your risk of side effects will increase.

Tell your doctor if your condition persists or worsens. If you think you may have a serious medical problem, seek immediate medical attention.

Vitamin B2 (Efavet 2) (riboflavin) supplementation is used to prevent and treat riboflavin deficiency. Vitamin B2 (Efavet 2) may prevent migraine headaches at high doses and be useful for prevention of eye conditions such as cataract, glaucoma and tired eyes (fatigue). Vitamin B2 (Efavet 2) is also used for boosting of immune system, and maintenance of healthy hair, skin, nails and mucous membranes.

Hypercholesterolaemia, hyperlipidemia, hypertriglyceridaemia, pellagra.

It is used for the treatment and prevention of Vitamin B6 (Efavet 2) deficiency. It is important for the breakdown of protein, fats, and carbohydrates from foods.

Vitamin D (Efavet 2) (ergocalciferol-D2, cholecalciferol-D3, alfacalcidol) is a fat-soluble vitamin that helps your body absorb calcium and phosphorus. Having the right amount of Vitamin D (Efavet 2), calcium, and phosphorus is important for building and keeping strong bones. Vitamin D (Efavet 2) is used to treat and prevent bone disorders (such as rickets, osteomalacia). Vitamin D (Efavet 2) is made by the body when skin is exposed to sunlight. Sunscreen, protective clothing, limited exposure to sunlight, dark skin, and age may prevent getting enough Vitamin D (Efavet 2) from the sun.

Vitamin D (Efavet 2) with calcium is used to treat or prevent bone loss (osteoporosis). Vitamin D (Efavet 2) is also used with other medications to treat low levels of calcium or phosphate caused by certain disorders (such as hypoparathyroidism, pseudohypoparathyroidism, familial hypophosphatemia). It may be used in kidney disease to keep calcium levels normal and allow normal bone growth. Vitamin D (Efavet 2) drops (or other supplements) are given to breast-fed infants because breast milk usually has low levels of Vitamin D (Efavet 2).

How to use Vitamin D (Efavet 2)

Take Vitamin D (Efavet 2) by mouth as directed. Vitamin D (Efavet 2) is best absorbed when taken after a meal but may be taken with or without food. Alfacalcidol is usually taken with food. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.

If your doctor has prescribed this medication, take as directed by your doctor. Your dosage is based on your medical condition, amount of sun exposure, diet, age, and response to treatment.

Measure the liquid medication with the dropper provided, or use a medication-measuring spoon/device to make sure you have the correct dose. If you are taking the chewable tablet or wafers, chew the medication thoroughly before swallowing. Do not swallow whole wafers.

Certain medications (bile acid sequestrants such as cholestyramine/colestipol, mineral oil, orlistat) can decrease the absorption of Vitamin D (Efavet 2). Take your doses of these medications as far as possible from your doses of Vitamin D (Efavet 2) (at least 2 hours apart, longer if possible). It may be easiest to take Vitamin D (Efavet 2) at bedtime if you are also taking these other medications. Ask your doctor or pharmacist how long you should wait between doses and for help finding a dosing schedule that will work with all your medications.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day if you are taking it once a day. If you are taking this medication only once a week, remember to take it on the same day each week. It may help to mark your calendar with a reminder.

If your doctor has recommended that you follow a special diet (such as a diet high in calcium), it is very important to follow the diet to get the most benefit from this medication and to prevent serious side effects. Do not take other supplements/vitamins unless ordered by your doctor.

If you think you may have a serious medical problem, get medical help right away.

This supplement is used to prevent or treat a lack of Vitamin E (Efavet 2) in the body. A low body level of Vitamin E (Efavet 2) is rare. Most people who eat a normal diet do not need extra Vitamin E (Efavet 2). However, Vitamin E (Efavet 2) supplements are used in premature newborns and in people who have problems absorbing enough Vitamin E (Efavet 2) from their diets. Vitamin E (Efavet 2) is important in protecting your body's cells from damage. It is known as an antioxidant.

How to use Vitamin E (Efavet 2)

Take this product by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.

If you are using a liquid form of this product, carefully measure your dose using a medication-measuring device or spoon. Do not use a household spoon because you may not get the correct dose. If your liquid form is a suspension, shake the bottle well before each dose.

Dosage is based on your medical condition and response to treatment. Do not increase your dose or take it more often than recommended. Taking too much Vitamin E (Efavet 2) may increase your risk of side effects.

High doses of Vitamin E (Efavet 2) (400 units or more per day) may increase the chance of rare but very serious side effects. There is no proof that high doses of Vitamin E (Efavet 2) help to prevent or treat heart disease. There is very little evidence that it helps prevent or treat Alzheimer's disease. In some people, taking these high doses may even be harmful. Talk to your doctor or pharmacist and discuss the risks and benefits before taking Vitamin E (Efavet 2) supplements.

If your doctor prescribes this product for Vitamin E (Efavet 2) deficiency, use it regularly to get the most benefit from it. To help you remember, take it at the same time each day. You should see improvement of symptoms such as numbness/tingling of the hands/feet and weakness. If your condition persists or worsens, or if you think you may have a serious medical problem, seek immediate medical attention.

Ascorbic Acid: Copper (Efavet 2) may decrease the serum concentration of Ascorbic Acid. Management: To minimize the risk for ascorbic acid degradation, add multivitamin product to TPN solution immediately prior to infusion or administer multivitamin and Copper (Efavet 2) in separate containers. Consider therapy modification

See also:
What other drugs will affect Folic Acid (Efavet 2)?

Medications that interfere with your bodys ability to use folate may also increase the need for this vitamin. Medications can interfere with folate utilization, including: anticonvulsant medications (such as phenytoin, and primidone) metformin (sometimes prescribed to control blood sugar in type 2 diabetes) sulfasalazine (used to control inflammation associated with Crohns disease and ulcerative colitis) triamterene (a diuretic) Methotrexate There has been concern about the interaction between vitamin B12 and Folic Acid (Efavet 2). Folic Acid (Efavet 2) supplements can correct the anemia associated with vitamin B12 deficiency. Unfortunately, Folic Acid (Efavet 2) will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental Folic Acid (Efavet 2) should not exceed 1000 micrograms (g, sometimes mcg) per day to prevent Folic Acid (Efavet 2) from masking symptoms of vitamin B12 deficiency. It is important for older adults to be aware of the relationship between Folic Acid (Efavet 2) and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains Folic Acid (Efavet 2).

None well documented.

See also:
What other drugs will affect Magnesium (Efavet 2)?

Alfacalcidol: May increase the serum concentration of Magnesium (Efavet 2) Salts. Consider therapy modification

Alpha-Lipoic Acid: Magnesium (Efavet 2) Salts may decrease the absorption of Alpha-Lipoic Acid. Alpha-Lipoic Acid may decrease the absorption of Magnesium (Efavet 2) Salts. Consider therapy modification

Baloxavir Marboxil: Polyvalent Cation Containing Products may decrease the serum concentration of Baloxavir Marboxil. Avoid combination

Bictegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Bictegravir. Management: Administer bictegravir under fasting conditions at least 2 hours before or 6 hours after polyvalent cation containing products. Coadministration of bictegravir with or 2 hours after most polyvalent cation products is not recommended. Consider therapy modification

Bisphosphonate Derivatives: Polyvalent Cation Containing Products may decrease the serum concentration of Bisphosphonate Derivatives. Management: Avoid administration of oral medications containing polyvalent cations within: 2 hours before or after tiludronate/clodronate/etidronate; 60 minutes after oral ibandronate; or 30 minutes after alendronate/risedronate. Exceptions: Pamidronate; Zoledronic Acid. Consider therapy modification

Calcitriol (Systemic): May increase the serum concentration of Magnesium (Efavet 2) Salts. Management: Consider using a non-Magnesium (Efavet 2)-containing antacid or phosphate-binding product in patients also receiving calcitriol. If Magnesium (Efavet 2)-containing products must be used with calcitriol, serum Magnesium (Efavet 2) concentrations should be monitored closely. Consider therapy modification

Calcium Channel Blockers: May enhance the adverse/toxic effect of Magnesium (Efavet 2) Salts. Magnesium (Efavet 2) Salts may enhance the hypotensive effect of Calcium Channel Blockers. Monitor therapy

Deferiprone: Polyvalent Cation Containing Products may decrease the serum concentration of Deferiprone. Management: Separate administration of deferiprone and oral medications or supplements that contain polyvalent cations by at least 4 hours. Consider therapy modification

Dolutegravir: Magnesium (Efavet 2) Salts may decrease the serum concentration of Dolutegravir. Management: Administer dolutegravir at least 2 hours before or 6 hours after oral Magnesium (Efavet 2) salts. Administer the dolutegravir/rilpivirine combination product at least 4 hours before or 6 hours after oral Magnesium (Efavet 2) salts. Consider therapy modification

Doxercalciferol: May enhance the hypermagnesemic effect of Magnesium (Efavet 2) Salts. Management: Consider using a non-Magnesium (Efavet 2)-containing antacid or phosphate-binding product in patients also receiving doxercalciferol. If Magnesium (Efavet 2)-containing products must be used with doxercalciferol, serum Magnesium (Efavet 2) concentrations should be monitored closely. Consider therapy modification

Eltrombopag: Polyvalent Cation Containing Products may decrease the serum concentration of Eltrombopag. Management: Administer eltrombopag at least 2 hours before or 4 hours after oral administration of any polyvalent cation containing product. Consider therapy modification

Elvitegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Elvitegravir. Management: Administer elvitegravir 2 hours before or 6 hours after the administration of polyvalent cation containing products. Consider therapy modification

Gabapentin: Magnesium (Efavet 2) Salts may enhance the CNS depressant effect of Gabapentin. Specifically, high dose intravenous/epidural Magnesium (Efavet 2) sulfate may enhance the CNS depressant effects of gabapentin. Magnesium (Efavet 2) Salts may decrease the serum concentration of Gabapentin. Management: Administer gabapentin at least 2 hours after use of a Magnesium (Efavet 2)-containing antacid. Monitor patients closely for evidence of reduced response to gabapentin therapy. Monitor for CNS depression if high dose IV/epidural Magnesium (Efavet 2) sulfate is used. Consider therapy modification

Levothyroxine: Magnesium (Efavet 2) Salts may decrease the serum concentration of Levothyroxine. Management: Separate administration of oral levothyroxine and oral Magnesium (Efavet 2) salts by at least 4 hours. Consider therapy modification

Multivitamins/Fluoride (with ADE): Magnesium (Efavet 2) Salts may decrease the serum concentration of Multivitamins/Fluoride (with ADE). Specifically, Magnesium (Efavet 2) salts may decrease fluoride absorption. Management: To avoid this potential interaction separate the administration of Magnesium (Efavet 2) salts from administration of a fluoride-containing product by at least 1 hour. Consider therapy modification

Mycophenolate: Magnesium (Efavet 2) Salts may decrease the serum concentration of Mycophenolate. Management: Separate doses of mycophenolate and oral Magnesium (Efavet 2) salts. Monitor for reduced effects of mycophenolate if taken concomitant with oral Magnesium (Efavet 2) salts. Consider therapy modification

Neuromuscular-Blocking Agents: Magnesium (Efavet 2) Salts may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents. Monitor therapy

PenicillAMINE: Polyvalent Cation Containing Products may decrease the serum concentration of PenicillAMINE. Management: Separate the administration of penicillamine and oral polyvalent cation containing products by at least 1 hour. Consider therapy modification

Phosphate Supplements: Magnesium (Efavet 2) Salts may decrease the serum concentration of Phosphate Supplements. Management: Administer oral phosphate supplements as far apart from the administration of an oral Magnesium (Efavet 2) salt as possible to minimize the significance of this interaction. Exceptions: Sodium Glycerophosphate Pentahydrate. Consider therapy modification

Quinolones: Magnesium (Efavet 2) Salts may decrease the serum concentration of Quinolones. Management: Administer oral quinolones several hours before (4 h for moxi/pe/spar-, 2 h for others) or after (8 h for moxi-, 6 h for cipro/dela-, 4 h for lome/pe-, 3 h for gemi-, and 2 h for levo-, nor-, or ofloxacin or nalidixic acid) oral Magnesium (Efavet 2) salts. Exceptions: LevoFLOXacin (Oral Inhalation). Consider therapy modification

Raltegravir: Magnesium (Efavet 2) Salts may decrease the serum concentration of Raltegravir. Management: Avoid the use of oral / enteral Magnesium (Efavet 2) salts with raltegravir. No dose separation schedule has been established that adequately reduces the magnitude of interaction. Avoid combination

Tetracyclines: Magnesium (Efavet 2) Salts may decrease the absorption of Tetracyclines. Only applicable to oral preparations of each agent. Management: Avoid coadministration of oral Magnesium (Efavet 2) salts and oral tetracyclines. If coadministration cannot be avoided, administer oral Magnesium (Efavet 2) at least 2 hours before, or 4 hours after, oral tetracyclines. Monitor for decreased tetracycline therapeutic effects. Exceptions: Eravacycline. Consider therapy modification

Trientine: Polyvalent Cation Containing Products may decrease the serum concentration of Trientine. Management: Avoid concomitant administration of trientine and oral products that contain polyvalent cations. If oral iron supplements are required, separate the administration by 2 hours. If other oral polyvalent cations are needed, separate administration by 1 hour. Consider therapy modification

See also:
What other drugs will affect Selenium (Efavet 2)?

Baloxavir Marboxil: Polyvalent Cation Containing Products may decrease the serum concentration of Baloxavir Marboxil. Avoid combination

Bictegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Bictegravir. Management: Administer bictegravir under fasting conditions at least 2 hours before or 6 hours after polyvalent cation containing products. Coadministration of bictegravir with or 2 hours after most polyvalent cation products is not recommended. Consider therapy modification

Bisphosphonate Derivatives: Polyvalent Cation Containing Products may decrease the serum concentration of Bisphosphonate Derivatives. Management: Avoid administration of oral medications containing polyvalent cations within: 2 hours before or after tiludronate/clodronate/etidronate; 60 minutes after oral ibandronate; or 30 minutes after alendronate/risedronate. Exceptions: Pamidronate; Zoledronic Acid. Consider therapy modification

Deferiprone: Polyvalent Cation Containing Products may decrease the serum concentration of Deferiprone. Management: Separate administration of deferiprone and oral medications or supplements that contain polyvalent cations by at least 4 hours. Consider therapy modification

Dolutegravir: Selenium (Efavet 2) may decrease the serum concentration of Dolutegravir. Management: Administer dolutegravir at least 2 hours before or 6 hours after oral Selenium (Efavet 2). Administer the dolutegravir/rilpivirine combination product at least 4 hours before or 6 hours after oral Selenium (Efavet 2). Consider therapy modification

Eltrombopag: Polyvalent Cation Containing Products may decrease the serum concentration of Eltrombopag. Management: Administer eltrombopag at least 2 hours before or 4 hours after oral administration of any polyvalent cation containing product. Consider therapy modification

Elvitegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Elvitegravir. Management: Administer elvitegravir 2 hours before or 6 hours after the administration of polyvalent cation containing products. Consider therapy modification

PenicillAMINE: Polyvalent Cation Containing Products may decrease the serum concentration of PenicillAMINE. Management: Separate the administration of penicillamine and oral polyvalent cation containing products by at least 1 hour. Consider therapy modification

Raltegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Raltegravir. Management: Administer raltegravir 2 hours before or 6 hours after administration of the polyvalent cations. Dose separation may not adequately minimize the significance of this interaction. Consider therapy modification

Trientine: Polyvalent Cation Containing Products may decrease the serum concentration of Trientine. Management: Avoid concomitant administration of trientine and oral products that contain polyvalent cations. If oral iron supplements are required, separate the administration by 2 hours. If other oral polyvalent cations are needed, separate administration by 1 hour. Consider therapy modification

See also:
What other drugs will affect Vitamin A (Efavet 2)?

The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.

To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.

Some products that may interact with this vitamin include: acitretin, alitretinoin, bexarotene, cholestyramine, isotretinoin, tretinoin, other products that contain Vitamin A (Efavet 2) (such as multivitamins), warfarin.

Avoid taking Vitamin A (Efavet 2) at the same time as you take neomycin, orlistat, and mineral oil. If you take any of these medications, separate your doses from your dose of Vitamin A (Efavet 2) by at least 2 hours.

This document does not contain all possible drug interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems.

See also:
What other drugs will affect Vitamin B1 (Efavet 2)?

Interactions for Vitamin B1 (Efavet 2) (Vitamin B1 (Efavet 2))

Loop Diuretics,

Oral Contraceptives, Stavudine, Tricyclic Antidepressants

See also:
What other drugs will affect Vitamin B12 (Efavet 2)?

In an application of Vitamin B12 (Efavet 2) Atlantic Laboratories with hormonal contraceptives for oral administration may decrease the concentration of cyanocobalamin in plasma.

In an application with anticonvulsant drugs decreased cyanocobalamin absorption from the gut.

In an Vitamin B12 (Efavet 2) Atlantic Laboratories application with neomycin, aminosalicylic acid, colchicine, cimetidine, ranitidine, drugs potassium decreased cyanocobalamin absorption from the gut.

Cyanocobalamin may exacerbate allergic reactions caused by thiamine.

When parenteral application of chloramphenicol may decrease the hematopoietic effects of cyanocobalamin with anemia.

See also:
What other drugs will affect Vitamin B2 (Efavet 2)?

Interactions for Vitamin B2 (Efavet 2) (Vitamin B2 (Efavet 2))

Alcohol - impairs the intestinal absorption of riboflavi

Antidepressants (tricyclics or phenothiazines) - requirements for riboflavin may be increased in patients receiving these medications

Probenecid - concurrent use decreases gastrointestinal absorption of riboflavin; requirements for riboflavin may be increased in patients receiving probenecid.

Interactions for Vitamin B3 (Efavet 2) (Vitamin B3 (Efavet 2))

Antihypertensive Therapy: Nicotinic acid may potentiate the effects of ganglionic blocking agents and vasoactive drugs resulting in postural hypotension

Aspirin: Concomitant aspirin may decrease the metabolic clearance of nicotinic acid. The clinical relevance of this finding is unclear

Other: Concomitant alcohol or hot drinks may increase the side effects of flushing and pruritus and should be avoided at the time of drug ingestion.

Dextropanthenyl alcohol in combination with hydrocortisone may be more effective than topical hydrocortisone alone in some dermatoses.

See also:
What other drugs will affect Vitamin B6 (Efavet 2)?

Interactions for Vitamin B6 (Efavet 2) (Vitamin B6 (Efavet 2))

Amiodarone: Concomitant use of Vitamin B6 (Efavet 2) and amiodarone may enhance amiodarone-induced photosensitivity reactions. Doses of Vitamin B6 (Efavet 2) greater than 5-10 milligrams/day should be avoided by those taking amiodarone Carbamazepine: Chronic use of carbamazepine may result in a significant decrease in plasma pyridoxal 5-phosphate levels Cycloserine: Cycloserine may react with pyridoxal 5-phosphate to form a metabolically inactive oxime, which may result in a functional Vitamin B6 (Efavet 2) deficiency Ethionamide: The use of ethionamide may increase Vitamin B6 (Efavet 2) requirements Fosphenytoin: High doses of Vitamin B6 (Efavet 2) may lower plasma levels of phenytoin. Fosphenytoin is a prodrug of phenytoin Hydralazine: The use of hydralazine may increase Vitamin B6 (Efavet 2) requirements Isoniazid: (isonicotinic acid, INH). Isoniazid reacts with pyridoxal 5-phosphate to form a metabolically inactive hydrazone, which may result in functional Vitamin B6 (Efavet 2) deficiency Levodopa: Concomitant use of levodopa and Vitamin B6 (Efavet 2) in doses of 5 milligrams or more daily may reverse the therapeutic effects of levodopa. Vitamin B6 (Efavet 2) does not reverse the therapeutic effects of levodopa if levodopa is taken concurrently with the levodopa decarboxylase inhibitor carbidopa. Levodopa is typically administered as a combination product with carbidopa

Oral contraceptives: The use of oral contraceptives may increase Vitamin B6 (Efavet 2) requirements. This was more the case with the older oral contraceptive agents with high-dose estrogen/progestin. It appears to be less the case with the newer low-dose estrogen/progestin products Penicillamine: Penicillamine may react with pyridoxal 5-phosphate to form a metabolically inactive thiazolidine, which may result in a functional Vitamin B6 (Efavet 2) deficiency Phenelzine: Phenelzine may react with pyridoxal 5-phosphate to yield a metabolically inactive hydrazone compound Phenobarbital: High doses of Vitamin B6 (Efavet 2) may lower plasma levels of phenobarbital Phenytoin: High doses of Vitamin B6 (Efavet 2) may lower plasma levels of phenytoin Theophylline: Theophylline may react with pyridoxal 5-phosphate leading to low plasma levels of the coenzyme. This may increase the risk of theophylline-induced seizures Valproic acid: Chronic use of valproic acid may result in a significant decrease in plasma pyridoxal 5-phosphate levels.

See also:
What other drugs will affect Vitamin D (Efavet 2)?

Aluminum Hydroxide: Vitamin D (Efavet 2) Analogs may increase the serum concentration of Aluminum Hydroxide. Specifically, the absorption of aluminum may be increased, leading to increased serum aluminum concentrations. Avoid combination

Bile Acid Sequestrants: May decrease the serum concentration of Vitamin D (Efavet 2) Analogs. More specifically, bile acid sequestrants may impair absorption of Vitamin D (Efavet 2) Analogs. Management: Avoid concomitant administration of Vitamin D (Efavet 2) analogs and bile acid sequestrants (eg, cholestyramine). Separate administration of these agents by several hours to minimize the potential risk of interaction. Monitor plasma calcium concentrations. Consider therapy modification

Calcium Salts: May enhance the adverse/toxic effect of Vitamin D (Efavet 2) Analogs. Monitor therapy

Cardiac Glycosides: Vitamin D (Efavet 2) Analogs may enhance the arrhythmogenic effect of Cardiac Glycosides. Monitor therapy

Danazol: May enhance the hypercalcemic effect of Vitamin D (Efavet 2) Analogs. Monitor therapy

Erdafitinib: Serum Phosphate Level-Altering Agents may diminish the therapeutic effect of Erdafitinib. Management: Avoid coadministration of serum phosphate level-altering agents with erdafitinib before initial dose increase period based on serum phosphate levels (Days 14 to 21). Consider therapy modification

Mineral Oil: May decrease the serum concentration of Vitamin D (Efavet 2) Analogs. More specifically, mineral oil may interfere with the absorption of Vitamin D (Efavet 2) Analogs. Management: Avoid concomitant, oral administration of mineral oil and Vitamin D (Efavet 2) analogs. Consider separating the administration of these agents by several hours to minimize the risk of interaction. Monitor plasma calcium concentrations. Consider therapy modification

Multivitamins/Fluoride (with ADE): May enhance the adverse/toxic effect of Vitamin D (Efavet 2) Analogs. Avoid combination

Multivitamins/Minerals (with ADEK, Folate, Iron): May enhance the adverse/toxic effect of Vitamin D (Efavet 2) Analogs. Avoid combination

Orlistat: May decrease the serum concentration of Vitamin D (Efavet 2) Analogs. More specifically, orlistat may impair absorption of Vitamin D (Efavet 2) Analogs. Management: Monitor clinical response (including serum calcium) to oral Vitamin D (Efavet 2) analogs closely if used with orlistat. If this combination must be used, consider giving the Vitamin D (Efavet 2) analog at least 2 hrs before or after orlistat. Consider therapy modification

Sucralfate: Vitamin D (Efavet 2) Analogs may increase the serum concentration of Sucralfate. Specifically, the absorption of aluminum from sucralfate may be increased, leading to an increase in the serum aluminum concentration. Avoid combination

Thiazide and Thiazide-Like Diuretics: May enhance the hypercalcemic effect of Vitamin D (Efavet 2) Analogs. Monitor therapy

Vitamin D (Efavet 2) Analogs: May enhance the adverse/toxic effect of other Vitamin D (Efavet 2) Analogs. Avoid combination

See also:
What other drugs will affect Vitamin E (Efavet 2)?

Agents with Antiplatelet Properties (e.g., P2Y12 inhibitors, NSAIDs, SSRIs, etc.): Vitamin E (Efavet 2) (Systemic) may enhance the antiplatelet effect of Agents with Antiplatelet Properties. Monitor therapy

Anticoagulants: Vitamin E (Efavet 2) (Systemic) may enhance the anticoagulant effect of Anticoagulants. Monitor therapy

CycloSPORINE (Systemic): Vitamin E (Efavet 2) (Systemic) may decrease the serum concentration of CycloSPORINE (Systemic). Monitor therapy

Ibrutinib: Vitamin E (Efavet 2) (Systemic) may enhance the antiplatelet effect of Ibrutinib. Monitor therapy

Orlistat: May decrease the serum concentration of Vitamins (Fat Soluble). Management: Administer oral fat soluble vitamins at least 2 hours before or after the administration of orlistat. Similar precautions do not apply to parenterally administered fat soluble vitamins. Consider therapy modification

Tipranavir: May enhance the adverse/toxic effect of Vitamin E (Efavet 2) (Systemic). Management: Patients taking tipranavir oral solution are advised to avoid taking additional Vitamin E (Efavet 2), beyond the amounts contained in a multivitamin product. This interaction does not apply to tipranavir capsules. Consider therapy modification

The anticonvulsants carbamazepine, phenytoin, Phenobarbital, and primidone may accelerate biotin metabolism, leading to a reduction in available biotin. Chronic use of these drugs has been associated with decreased plasma concentrations of biotin.

The use of antibiotics may reduce the contribution of biotin made by bacteria within the large intestine.

See also:
What other drugs will affect Zinc (Efavet 2)?

Pyridoxine reduces the effects of levodopa (but this does not occur if a dopa decarboxylase is also given); decreases serum concentrations of phenobarbitone. Concurrent administration of drugs eg, isoniazid, penicillamine and oral contraceptives increase the requirement for pyridoxine.

Absorption of cyanocobalamin from the GIT may be reduced by neomycin, aminosalicylic acid, histamine H₂-receptor antagonists and colchicine. Serum concentrations may be decreased by concurrent administration of oral contraceptives. Many of these interactions are unlikely to be of clinical significance but should be taken into account when performing assays for blood concentrations.

Parenteral chloramphenicol may attenuate the effect of Zinc (Efavet 2) in anaemia.

Folate deficiency states may be produced by a number of drugs including antiepileptics, oral contraceptives, antituberculous drugs, alcohol and Zinc (Efavet 2) antagonists eg, aminopterin, methotrexate, pyrimethamine, trimethoprim and sulphonamides; Zinc (Efavet 2) may decrease serum-phenytoin concentrations.

There may be an increased risk of myopathy or rhabdomyolysis when nicotinic acid is used concurrently with statins. Nicotinamide may increase the requirements for insulin or oral hypoglycaemics.

Ascorbic acid may increase the absorption of iron-deficiency states.

Ascorbic acid is often given in addition to desferrioxamine to patients with iron overload (thalassemia) to achieve better iron excretion. However, early on in treatment when there is excess tissue iron, there is some evidence that ascorbic acid may worsen the iron toxicity, particularly to the heart. Thus, ascorbic acid should not be given for the first month after starting desferrioxamine treatment.

The absorption of Zinc (Efavet 2) may be reduced by iron supplements, penicillamine, phosphorus-containing preparations and tetracyclines. Zinc (Efavet 2) supplements reduce the absorption of Zinc (Efavet 2), ciprofloxacin, iron, norfloxacin, penicillamine and tetracyclines.

Adverse Reactions

Generally well tolerated; excessive Copper (Efavet 2) levels may result in the following adverse effect.

Hepatic: Hepatic insufficiency (including hepatic necrosis)

See also:
What are the possible side effects of Folic Acid (Efavet 2)?

Allergic sensitization has been reported following both oral and parenteral administration of Folic Acid (Efavet 2).

Folic Acid (Efavet 2) is relatively nontoxic in man. Rare instances of allergic responses to Folic Acid (Efavet 2) preparations have been reported and have included erythema, skin rash, itching, general malaise, and respiratory difficulty due to bronchospasm. One patient experienced symptoms suggesting anaphylaxis following injection of the drug. Gastrointestinal side effects, including anorexia, nausea, abdominal distention, flatulence, and a bitter or bad taste, have been reported in patients receiving 15 mg Folic Acid (Efavet 2) daily for 1 month. Other side effects reported in patients receiving 15 mg daily include altered sleep patterns, difficulty in concentrating, irritability, overactivity, excitement, mental depression, confusion, and impaired judgment. Decreased vitamin B12 serum levels may occur in patients receiving prolonged Folic Acid (Efavet 2) therapy.

In an uncontrolled study, orally administered Folic Acid (Efavet 2) was reported to increase the incidence of seizures in some epileptic patients receiving phenobarbital, primidone, or diphenylhydantoin. Another investigator reported decreased diphenylhydantoin serum levels in folate-deficient patients receiving diphenylhydantoin who were treated with 5 mg or 15 mg of Folic Acid (Efavet 2) daily.

CALL YOUR DOCTOR FOR MEDICAL ADVICE ABOUT SIDE EFFECTS. YOU MAY REPORT SIDE EFFECTS TO THE FDA AT 1-800-FDA-1088 OR LEADING PHARMA, LLC AT 844-740-7500.

No serious adverse effects have been noted.

See also:
What are the possible side effects of Magnesium (Efavet 2)?

The adverse effects of parenterally administered Magnesium (Efavet 2) usually are the result of Magnesium (Efavet 2) intoxication. These include flushing, sweating, hypotension, depressed reflexes, flaccid paralysis, hypothermia, circulatory collapse, cardiac and central nervous system depression proceeding to respiratory paralysis. Hypocalcemia with signs of tetany secondary to Magnesium (Efavet 2) sulfate therapy for eclampsia has been reported.

See also:
What are the possible side effects of Selenium (Efavet 2)?

Applies to Selenium (Efavet 2) sulfide topical: topical cream, topical foam, topical lotion, topical shampoo, topical suspension

As well as its needed effects, Selenium (Efavet 2) sulfide topical may cause unwanted side effects that require medical attention.

Severity: Moderate

If any of the following side effects occur while taking Selenium (Efavet 2) sulfide topical, check with your doctor or nurse as soon as possible:

Less common or rare:

• Skin irritation

Minor Side Effects

Some Selenium (Efavet 2) sulfide topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:

• Unusual dryness or oiliness of hair or scalp

• Increase in normal hair loss

See also:
What are the possible side effects of Vitamin A (Efavet 2)?

This vitamin usually has no side effects when used in recommended doses. If you have any unusual effects, contact your doctor or pharmacist promptly.

A very serious allergic reaction to this vitamin is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

See also:
What are the possible side effects of Vitamin B1 (Efavet 2)?

Applies to thiamine: capsule, solution, tablet, tablet enteric coated

As well as its needed effects, thiamine (the active ingredient contained in Vitamin B1 (Efavet 2)) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking thiamine, check with your doctor immediately:

Rare - Soon after receiving injection only

• Coughing
• difficulty in swallowing
• hives
• itching of skin
• swelling of face, lips, or eyelids
• wheezing or difficulty in breathing

See also:
What are the possible side effects of Vitamin B12 (Efavet 2)?

Applies to cyanocobalamin: intramuscular solution

Other dosage forms:

• nasal gel/jelly, nasal spray

As well as its needed effects, cyanocobalamin (the active ingredient contained in Vitamin B12 (Efavet 2)) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking cyanocobalamin, check with your doctor or nurse immediately:

Incidence not known:

• Abdominal or stomach pain
• bleeding from the gums or nose
• blue lips and fingernails
• chest pain
• cough
• coughing that sometimes produces a pink frothy sputum
• decreased urine output
• difficult, fast, noisy breathing, sometimes with wheezing
• difficulty with swallowing
• dilated neck veins
• dizziness
• extreme fatigue
• eye pain
• fast heartbeat
• headache
• hives, itching, or skin rash
• increased sweating
• irregular breathing
• irregular heartbeat
• pale skin
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• ringing in the ears
• swelling of the face, fingers, feet, or lower legs
• tightness in the chest
• unusual tiredness or weakness
• weight gain

Minor Side Effects

Some cyanocobalamin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known:

• Diarrhea
• skin rash with a general disease

See also:
What are the possible side effects of Vitamin B2 (Efavet 2)?

Genitourinary

Yellow-orange discoloration of urine.

Allergic sensitization has been reported rarely following oral and parenteral administration of Vitamin B3 (Efavet 2).

At recommended doses, nicotinamide is expected to be well tolerated. Gastrointestinal distress such as nausea or vomiting have been associated with the administration of nicotinamide or zinc at doses greater than the recommended dose of nicotinamide

Nicotinamide: Dizziness, headache, hyperglycemia, nausea, vomiting, diarrhea, elevations in liver function tests, hepatotoxicity, blurred vision, flushing, rash.

No serious side effects have been reported, even at intakes of up to 10,000 mg (10 grams) per day. Very large amounts of pantothenic acid (several grams per day) can cause diarrhea.

Pantothenic acid works together with Vitamin B5 (Efavet 2), Vitamin B5 (Efavet 2), and Vitamin B5 (Efavet 2) to help make the fuel our bodies run on—ATP.

There is one report of a 76-year-old woman who developed a life-threatening condition (eosinophilic pleuropericardial effusion) while taking 300 mg of pantothenic acid per day and 10 mg of biotin per day.2 However, it is not clear whether the vitamins caused the problem.

See also:
What are the possible side effects of Vitamin B6 (Efavet 2)?

Applies to pyridoxine: capsule, injectable, solution, tablet, tablet enteric coated, tablet extended release

As well as its needed effects, pyridoxine (the active ingredient contained in Vitamin B6 (Efavet 2)) may cause unwanted side effects that require medical attention.

Severity: Moderate

If any of the following side effects occur while taking pyridoxine, check with your doctor or nurse as soon as possible:

With large doses

• Clumsiness
• numbness of hands or feet

See also:
What are the possible side effects of Vitamin D (Efavet 2)?

Vitamin D (Efavet 2) at normal doses usually has no side effects. If you have any unusual effects, contact your doctor or pharmacist promptly.

If your doctor has directed you to take this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Too much Vitamin D (Efavet 2) can cause harmful high calcium levels. Tell your doctor right away if any of these signs of high Vitamin D (Efavet 2)/calcium levels occur: nausea/vomiting, constipation, loss of appetite, increased thirst, increased urination, mental/mood changes, unusual tiredness.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

See also:
What are the possible side effects of Vitamin E (Efavet 2)?

Applies to Vitamin E (Efavet 2): oral capsule, oral capsule liquid filled, oral liquid, oral powder for solution, oral solution, oral tablet, oral tablet chewable

In addition to its needed effects, some unwanted effects may be caused by Vitamin E (Efavet 2) (the active ingredient contained in Centrum Singles-Vitamin E (Efavet 2)). In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking Vitamin E (Efavet 2), check with your doctor or nurse as soon as possible:

With doses greater than 400 Units a day and long-term use

• Blurred vision
• diarrhea
• dizziness
• headache
• nausea or stomach cramps
• unusual tiredness or weakness

Adverse reactions associated with biotin supplementation are rare in the medical literature; however, urticaria and gastrointestinal upset have been reported. As with any oral treatment, if patients experience any adverse reactions or side effects, they should inform their physicians immediately and discontinue use.

See also:
What are the possible side effects of Zinc (Efavet 2)?

Applies to Zinc (Efavet 2) sulfate: capsules, tablets

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur while taking Zinc (Efavet 2) sulfate (the active ingredient contained in Zinc (Efavet 2))

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe vomiting; unusual restlessness; very dry mouth, eyes, or skin.