Duxaril

Treatment of the symptoms of cognitive decline of ischemic origin in elderly patients.

Treatment of the symptoms of neurosensory decline of ischemic origin in elderly patients, including visual and auditory deficit.

Treatment of tinnitus, vertigo and balance disorders of ischemic origin in elderly patients. this Drug belong to the (diphenylmethyl) group

Contraindications include alcohol abuse (adds to the central nervous system (CNS) depressant effects), blood disease, enlarged prostate, glaucoma, heart or blood vessel disease, lung disease, Parkinsons disease, stomach ulcers, urination problems (thioxanthenes may worsen the condition), liver disease (higher blood levels of thioxanthenes may occur, increasing the likelihood of side effects), Reyes syndrome (the risk of liver problems may be increased), and seizure disorders (the risk of seizures may be increased).

Duxaril may increase the plasma-level of concomitantly given lithium. In order to avoid lithium intoxication, lithium plasma levels should be monitored closely. If chlorprothixene is given concomitantly with opioids, the opioid dose should be reduced (by approx. 50%), because chlorprothixene amplifies the therapeutic actions and side-effects of opioids massively. Avoid the concomitant use of chlorprothixene and tramadol (Ultram). Massive seizures may be encountered with this combination. Consider additive sedative effects and confusional states to emerge, if chlorprothixene is given with benzodiazepines or barbituates. Choose particular low doses of these drugs. Exert particular caution in combining chlorprothixene with other anticholinergic drugs (tricyclic antidepressants and antiparkinsonian agents): Particularly the elderly may develop delirium, high fever, severe obstipation, even ileus and glaucoma.

Rare side effects have been reported: Weight loss, peripheral neuropathy with abnormal sensations in the lower limbs or paresthesiae (prickling, pins-and-needles, numbness). These effects have usually been observed during the long-term treatment of ≥1 year. These signs disappear following cessation of the treatment. Nausea, heartburns and epigastric heaviness, dyspepsia, disorders of the intestinal transit, sleep disorders eg, insomnia or drowsiness, agitation, anxiety, palpitations, vertiginous sensations.

Duxaril is a typical antipsychotic drug of the thioxanthene (tricyclic) class. Duxaril exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.