Doxiciclina Genfar

Quick links

Choose a section

Quick links to important sections

Advertisements
Advertisements

Overview of Doxiciclina Genfar

What is Doxiciclina Genfar?

Doxiciclina Genfar is a pharmaceutical formulation containing doxycycline, a broad-spectrum antibiotic belonging to the tetracycline class. It is designed to inhibit the growth of various types of bacteria by interfering with their ability to produce essential proteins necessary for reproduction and survival.

Classification and Mechanism

As a member of the tetracycline group, the active ingredient in Doxiciclina Genfar is characterized by its ability to address a wide range of microorganisms. It is primarily bacteriostatic, meaning it prevents the multiplication of bacteria rather than killing them outright, allowing the body's immune system to eliminate the remaining pathogens.

Common Applications

This medication is typically utilized in the management of various bacterial conditions, including:

  • Respiratory Infections: Such as certain types of pneumonia and chronic bronchitis.
  • Skin and Soft Tissue Infections: Including severe acne and certain inflammatory skin conditions.
  • Genitourinary Infections: Specifically those caused by susceptible organisms.
  • Vector-borne Diseases: It is often used to treat illnesses transmitted by ticks, fleas, or lice, such as Rocky Mountain spotted fever or Lyme disease.
  • Prophylaxis: In specific scenarios, it may be used as a preventive measure against malaria for individuals traveling to certain regions.

Composition

Doxiciclina Genfar is produced as a generic alternative, providing the same active therapeutic agent as brand-name versions. The "Genfar" designation refers to the manufacturer, indicating that the product meets specific quality standards for generic medications while maintaining the same chemical properties and intended pharmacological effects as the reference product.

Regulatory References

  1. World Health Organization (WHO) Model List of Essential Medicines
Advertisements

What side effects are possible with Doxiciclina Genfar?

Possible side effects and safety information

The safety profile for Doxiciclina is formally categorized by the body systems affected and the frequency with which adverse reactions occur.


Critical Safety Restrictions and Warnings

  • Permanent Tooth Discoloration: Use during the last half of pregnancy, in infancy, and in childhood up to 8 years of age is restricted. This is due to the potential for permanent discoloration (yellow-gray-brown) of the teeth and enamel hypoplasia during the period of tooth development. Exceptions are made only for severe or life-threatening conditions where other treatments are unavailable or inadequate.
  • Intracranial Hypertension (Pseudotumor Cerebri): This serious adverse reaction, characterized by symptoms like headache and blurred vision, is documented. While rare, it carries a risk of permanent vision loss. The product labeling also cautions against co-administration with other medications that increase this risk.
  • Severe Skin Reactions (SCARs): Officially documented severe cutaneous adverse reactions, including Stevens-Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), require immediate discontinuation of the medication.

Adverse Reactions by Body System

System-Organ Class Common/Important Adverse Reactions
Gastrointestinal Nausea, vomiting, diarrhea, esophagitis, esophageal ulcerations. The risk of Clostridium difficile-associated diarrhea (CDAD) is noted.
Dermatologic Photosensitivity (exaggerated sunburn reaction) is a common adverse effect, requiring avoidance of sun/UV light exposure. Urticaria and other skin rashes are also documented.
Hematologic Changes in blood cell counts, such as hemolytic anemia, neutropenia, and thrombocytopenia, are part of the known safety profile.

Drug Interactions and Other Safety Notes

The medication's safety information highlights potential interactions with anticoagulants and oral contraceptives, which may necessitate adjustments to the concomitant medicine or the use of alternative safety measures. Supervision is noted in the event of pre-existing liver impairment.

Advertisements

Overdose and Emergency Response

Overdose and when to seek help

Official regulatory information states that exceeding the recommended dosage of Doxiciclina Genfar may result in an increased incidence of known side effects and can lead to the aggravation of severe, dose-related reactions.

Overdose Scope

Element Regulatory Statement
Documented Overdose Presentations Primarily an increased incidence of side effects, including the potential for aggravated Intracranial Hypertension (IH) symptoms.
Physiological Systems Affected Central Nervous System (CNS) (severe headache, blurred vision), Hepatic system (potential for increased toxicity), and Renal system (dose-related rise in Blood Urea Nitrogen).
Dose-Related Factors Adverse events are noted as related to exceeding the recommended dosage.
Population-Specific Notes Hepatic Impairment: Caution is required due to the potential for increased hepatic toxicity.

Emergency Response and Management

Element Regulatory Statement
When Immediate Medical Help Is Required Seek immediate medical attention upon the onset of severe symptoms like severe headache or blurred vision. Immediate ophthalmologic evaluation is required if IH symptoms develop.
Antidote / Management Management is symptomatic and supportive. Haemodialysis and peritoneal dialysis are not effective as they do not alter serum half-life.

Official Overdose Statements

  • Overdosing may result in an increased incidence of known side effects.
  • Severe symptoms, such as those related to Intracranial Hypertension, require urgent clinical intervention.
  • Management is limited by the lack of efficacy of dialysis in removing the drug.

Connection to the Overall Overdose Profile

The regulatory profile defines overdose as an exacerbation of documented systemic effects, particularly affecting the CNS and liver. It mandates seeking immediate attention for severe signs like headache or blurred vision. Official guidance explicitly states that treatment must be symptomatic and supportive, while confirming that dialysis is ineffective for drug removal.

Advertisements

Therapeutic Uses of Doxiciclina Genfar

What Doxiciclina Genfar Treats: Main Uses and Therapeutic Benefits

Doxiciclina Genfar is commonly used to help with a variety of conditions presenting with acute or disruptive symptom patterns, and is applied across domains where additional symptomatic support is needed. This medication is relevant for easing symptoms related to infections of the respiratory and urinary tracts, specific sexually transmitted diseases (like Chlamydia), and vector-borne illnesses such as Rocky Mountain Spotted Fever and early Lyme disease. It is also used in managing the persistent inflammatory manifestations of chronic skin disorders like Acne Vulgaris and Rosacea.

Its utility extends to preventative use, where it may assist in reducing the likelihood of acute symptomatic episodes, particularly for Malaria prophylaxis in travelers. The medication is helpful in situations where symptoms cluster into patterns requiring supportive management, offering symptomatic relief that supports patients during difficult episodes and contributes to easing the overall symptom load.


Quick Fact: Relief for Persistent Cutaneous Lesions Doxiciclina Genfar is commonly used to help address groups of symptoms that may become intense or disruptive, such as the papules, pustules, and facial redness associated with inflammatory Acne and Rosacea, and may assist with short-term symptomatic assistance.


Regulatory References

  1. NIH MedlinePlus Drug Information
Advertisements

Eligibility and Restrictions for Use

Doxiciclina Genfar is an antibiotic for which regulatory documents define strict population eligibility based on age, reproductive status, and specific health conditions.

Absolute Contraindications (Must Not Use)

The medicine is contraindicated in persons with a documented hypersensitivity to doxycycline, any other tetracycline-class drug, or any excipients. Use is also strictly prohibited for pregnant women and nursing mothers due to risks to the fetus or infant. Specific non-eligibility rules apply to patients with Myasthenia Gravis or those taking the drug isotretinoin.

Age and Conditional Use

Age Group Eligibility Status (Regulatory Basis)
Children Under 8 Years Contraindicated for general use due to the risk of permanent tooth discoloration [1.1].
Children 8 to 12 Years Conditional Use (must be carefully justified if alternatives are unavailable) [1.1].
Adults & Adolescents (12+) Eligible under standard labeled conditions [1.7].

Condition-Based Eligibility

Patients with severe hepatic impairment must not use this medicine. However, Doxiciclina Genfar is generally eligible for use in patients with impaired renal function, as no dose reduction is required by regulatory agencies, unlike with many other antibiotics [2.1].

Advertisements

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory information for Doxiciclina Genfar (Doxycycline) identifies specific interactions categorized by their effect on drug exposure and safety. This information is derived from authoritative government prescribing documents.

Prohibited Combinations and Restrictions

The concurrent use of Oral Retinoids (e.g., Isotretinoin) must be avoided due to the documented risk of increased intracranial pressure (pseudotumor cerebri). The co-administration of tetracyclines with the anesthetic Methoxyflurane has been reported to cause fatal renal toxicity and is therefore restricted.

Interactions Affecting Drug Exposure

The systemic absorption of Doxycycline is impaired by substances containing multivalent cations (calcium, aluminum, magnesium, iron). These include antacids, iron-containing preparations, and Bismuth Subsalicylate. To mitigate this, a timing separation of at least two to three hours is required between taking Doxycycline and these products. Separately, anti-epileptics such as Barbiturates, Carbamazepine, and Phenytoin are documented to increase the metabolic clearance of Doxycycline, which decreases its plasma half-life.

Pharmacodynamic Effects

Doxycycline can depress plasma prothrombin activity, necessitating a potential downward adjustment of co-administered anticoagulant drugs (e.g., Warfarin). Concurrent use with Penicillin should be avoided as bacteriostatic drugs may interfere with the bactericidal action of penicillin. Use alongside oral contraceptives may also render the latter less effective.

Advertisements

Mechanism of Action

How Doxiciclina Genfar Works

Targeted Blockade of Bacterial Protein Manufacturing

The medicine's primary action is a bacteriostatic effect achieved by selectively binding to the 30S ribosomal subunit of the target bacteria. This molecular interaction physically prevents transfer RNA (tRNA) from attaching, which immediately halts the process of polypeptide chain elongation. The physiological consequence is the cessation of bacterial growth and replication, which establishes the conditions necessary for host immune clearance.

️ Modulation of Host Tissue-Degrading Enzymes

Doxycycline has a secondary, non-antibiotic mechanism involving the inhibition of host Matrix Metalloproteinases (MMPs). It acts as a chelator of metal ions (Ca^2+, Zn^2+) necessary for MMP activity, reducing the functional strength of these enzymes. This mechanistic domain constrains the degradation of host connective tissues and the extracellular matrix associated with inflammatory responses.

Functional Constraint by Resistance Mechanisms

The functionality of the mechanism is constrained by bacterial resistance, primarily through efflux pumps that actively expel the drug, or ribosomal protection proteins that block the drug's binding site on the 30S subunit. When these counter-mechanisms are engaged, the drug fails to maintain the necessary intracellular concentration or target binding, resulting in the lack of bacteriostatic effect.

Advertisements

Dosage and Administration Information

How to Use Doxiciclina Genfar: Official Administration Guidelines

This section outlines the standardized usage instructions for Doxycycline (the active ingredient in Doxiciclina Genfar) as outlined in standardized pharmaceutical documentation. These instructions detail the required dose, frequency, and administration technique.

Official Administration Scope

Category Standardized Instructions
Route of Administration Oral (Capsules or Tablets).
Dosing Schedule Adults (General): 200 mg on the first day (administered as 100 mg every 12 hours), followed by a maintenance dose of 100 mg once daily. Severe Infection: 100 mg every 12 hours throughout therapy.
Timing in Relation to Meals May be taken with food or milk if the patient experiences gastric irritation. Certain low-dose or delayed-release formulations may require administration on an empty stomach.
Preparation Requirements Must be swallowed with an adequate amount of fluid (a full glass of water). Capsules and tablets must not be crushed or chewed.
Age-Group Rules Children > 8 years and ≤ 45 kg: Weight-based dosing applies, beginning with 4.4 mg/kg on day one. Renal Impairment: No dosage adjustment is typically required.
Special Procedural Conditions The medicine must be taken while the patient is in an upright position (sitting or standing). The patient must remain upright for at least 30 minutes after ingestion.

Resulting Procedural Structure

The official protocol defines a clear procedural structure to ensure proper use, requiring a 200 mg loading period followed by a consistent maintenance dose, whether once or twice daily. This structure also mandates specific administration techniques, such as remaining upright for 30 minutes and using sufficient fluid, to ensure the medicine passes through the esophagus correctly. Course duration varies, typically from 7 days for some short-term uses up to 60 days for prophylaxis.

Advertisements

Recent Clinical Evidence

Research Evidence / Overview of Studies for Doxiciclina Genfar

This summary reports on the types of research and outcomes studied for Doxycycline, focusing strictly on published scientific literature and regulatory data.


Evidence for Bacterial Infections and Rosacea

Bacterial Infections: Research examining Doxycycline for various bacterial infections primarily involves short-term, randomized controlled trials (RCTs). These studies centered on measuring microbiological clearance (change in the presence of the target pathogen) and assessing the clinical evolution of symptoms in observed populations.

Chronic Skin Conditions (Rosacea): The evidence base for Rosacea inflammatory lesions is built upon medium-term RCTs, often comparing the study agent to placebo. Researchers monitored outcomes such as the change in the count of inflammatory lesions over follow-up durations typically up to 16 weeks. Data for other Rosacea manifestations, such as facial redness (erythema), may remain less consistent.


Long-Term Data and Specific Populations

Durability and Long-Term Use: For most indications studied, evidence is derived from short-term intervals. Consequently, there is limited information to characterize the persistence of observed patterns after treatment has stopped or the patterns observed with extended use.

Special Populations:

  • Pediatric Patients (Children): Early research concerns limited the study of Doxycycline in children under the age of eight. However, more recent studies have examined outcomes in children over two years old for short durations. Findings from these studies apply only to the populations studied in those trials.
  • Other Groups: Research has also explored Doxycycline in specific high-risk populations for certain prophylaxis uses, but findings across different subgroups, such as cisgender women, have been reported as mixed.

Uncertainty in the Research Record: A key ongoing uncertainty across multiple indications studied is the long-term impact on the selection of antimicrobial resistance in the general population, which research continues to monitor. The research record suggests the need for additional data to address these limitations and provide sufficient information for long-term outcomes.

Key Studies & References

  1. Doxycycline for Malaria Chemoprophylaxis and Treatment: Report from the CDC Expert Meeting on Malaria Chemoprophylaxis
  2. Doxycycline: MedlinePlus Drug Information
  3. Efficacy of Doxycycline Treatment for Knee Osteoarthritis (Brandt et al. 2005 RCT)
  4. Malaria Prevention in Travelers: Drugs - JBI Systematic Review (Comparing Doxycycline, Mefloquine, Atovaquone–proguanil)
  5. Doxycycline - Electronic Essential Medicines List (eEML) - WHO
  6. Doxycycline Hyclate - StatPearls - NCBI Bookshelf
Advertisements

Frequently Asked Questions (FAQ)

Common questions about Doxiciclina Genfar (FAQ)

Q: Do I need to take Doxiciclina Genfar with food to prevent stomach upset?

A: Official recommendations state that taking the medicine with food or milk may help reduce the possibility of experiencing gastric irritation. The official product information notes that taking the medicine with food or milk is an option if gastric irritation occurs. However, some specific formulations may require administration on an empty stomach, and any specific administration instructions should be followed as provided by the healthcare professional.

Q: Does Doxiciclina Genfar affect the effectiveness of oral birth control pills?

A: Official information indicates that Doxiciclina (Doxycycline) has the potential to reduce the effectiveness of oral contraceptives, often those containing estrogen. Due to this potential interaction, it is documented that alternative or additional contraceptive measures may be required during treatment.

Q: How long after taking Doxiciclina Genfar should I wait to take antacids or calcium supplements?

A: A time separation is documented because antacids or supplements containing multivalent cations (such as calcium, aluminum, magnesium, and iron) can impair the absorption of Doxiciclina. To mitigate this effect, official guidance suggests separating the dosing time by at least two to four hours.

Q: What kind of stomach issues are most common when taking this medication?

A: Gastrointestinal issues are among the most frequently documented adverse reactions in the safety profile. Common side effects can include nausea, vomiting, and diarrhea. The official product information also notes the risk of esophagitis or esophageal ulcerations if not taken with enough fluid.

Q: Can taking Doxiciclina Genfar cause issues with my throat or esophagus?

A: Official safety information documents a risk of throat or esophageal irritation and ulceration. This risk is associated with administration without adequate fluid or failing to remain in an upright position after ingestion, which is why strict administration techniques are mandated in the product label.

Q: Is it normal to experience increased sensitivity to the sun while taking this medicine?

A: Photosensitivity is documented as a common adverse effect associated with Doxiciclina (Doxycycline). This can lead to an exaggerated sunburn reaction when the skin is exposed to sun or UV light. Specific recommendations for sun protection are noted in the safety information.

Q: Can Doxiciclina Genfar cause a yeast infection, and why does this happen?

A: Official warnings note the risk of a condition called 'superinfection,' which can include fungal infections such as oral or vaginal thrush (yeast infection). This occurs because the antibiotic can affect the balance of microorganisms in the body, potentially allowing non-susceptible organisms, like fungi, to overgrow.

Q: Can Doxiciclina Genfar cause headaches or vision changes?

A: Severe headaches and vision changes, such as blurred vision, are documented symptoms of a serious, though rare, adverse reaction called intracranial hypertension (pseudotumor cerebri). Official safety information indicates this condition carries a risk of permanent vision loss.

Q: Can Doxiciclina Genfar cause an increased heart rate or chest pain?

A: Official safety information lists symptoms such as chest pain and irregular heart rhythm among the serious side effects that have been reported with Doxycycline. These symptoms are listed among the serious side effects that have been reported and may necessitate consulting a healthcare professional.

Q: What is the risk of skin rash when taking Doxiciclina Genfar?

A: Various forms of skin rash and urticaria (hives) are documented as adverse effects. Regulatory documentation also includes critical warnings about rare, severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson Syndrome, which necessitate immediate discontinuation.

Q: Are there any specific recommendations for sun protection while using Doxiciclina Genfar?

A: Due to the common risk of photosensitivity, official recommendations advise specific measures to protect the skin from sun exposure. This includes limiting time in the sun, wearing protective clothing, and applying a high SPF sunscreen (e.g., SPF 15+ or 30+).

Q: What is the difference between Doxiciclina and other tetracycline antibiotics?

A: Doxiciclina (Doxycycline) is characterized as a long-acting tetracycline, meaning it remains in the body longer than short- or intermediate-acting types. Additionally, official information notes that its absorption is generally considered less impaired by food or milk compared to some other medicines in the tetracycline class.

Q: How quickly can I expect to see an improvement in my symptoms after starting Doxiciclina Genfar?

A: While the medicine typically begins to inhibit bacterial growth and reduce inflammation within the first 24 to 48 hours after starting treatment, the time it takes to see a noticeable improvement in symptoms can vary. This often depends on the specific condition being treated, the site of infection, and the individual's response.

Q: Is it safe to drink alcohol in small amounts while on Doxiciclina Genfar?

A: Official information indicates that occasional or light consumption of alcohol is not typically restricted with Doxiciclina (Doxycycline). However, heavy or chronic consumption of alcohol may decrease the overall effectiveness of the medicine.

Q: Are there any common interactions between Doxiciclina Genfar and pain relief medicines?

A: The official regulatory interaction lists for Doxiciclina (Doxycycline) do not typically include a documented interaction with common non-prescription pain relief medicines, such as ibuprofen. However, the official warnings highlight interactions with other classes of drugs.

Q: Is Doxiciclina Genfar used to prevent malaria in travelers?

A: Yes, Doxiciclina (Doxycycline) has received approval for the prevention of malaria. This includes use for people traveling to certain areas where malaria is a risk, and specific guidelines exist for its prophylactic use in this context.

Q: Does Doxiciclina Genfar have any anti-inflammatory effects in addition to being an antibiotic?

A: Yes, studies and official information indicate that Doxycycline has properties that allow it to inhibit certain enzymes (Matrix Metalloproteinases or MMPs) which are involved in inflammation. This demonstrates an anti-inflammatory effect that is separate from its primary action as an antibiotic.

Q: Can Doxiciclina Genfar be used for long-term conditions like acne or rosacea?

A: Doxiciclina (Doxycycline) is approved for the treatment of inflammatory lesions of rosacea and is commonly used for acne. Specific low-dose formulations are available and may be used for the long-term management of rosacea.

Q: Can Doxiciclina Genfar interfere with the results of any lab tests?

A: There are currently no reports in the official drug safety information indicating that Doxiciclina (Doxycycline) interferes with the results of standard lab tests typically ordered by a healthcare provider.

Q: Can Doxiciclina Genfar be used to treat or prevent Lyme disease after a tick bite?

A: Yes, Doxiciclina (Doxycycline) is approved for the treatment of Lyme disease. It is also noted in medical guidelines as a preferred regimen for the antibiotic prevention (prophylaxis) of Lyme disease following a high-risk tick bite.

Q: Can Doxiciclina Genfar cause changes to the appearance of fingernails or toenails?

A: Changes to the appearance of fingernails or toenails (known as nail changes) are documented as a less common side effect associated with Doxiciclina (Doxycycline) use. In rare instances, this can involve the loosening of the nail due to sun exposure.

Q: Does Doxiciclina Genfar have an effect on cholesterol or blood sugar levels?

A: Hypoglycemia (unusually low blood sugar) has been described in scientific reports as a rare, uncommon side effect associated with Doxiciclina (Doxycycline) use. However, no consistent effect on cholesterol levels is widely documented in the official safety information.

Q: How does Doxiciclina Genfar differ from a macrolide antibiotic?

A: Doxiciclina (Doxycycline) belongs to the tetracycline drug class, which has a different mechanism of action than macrolide antibiotics (like Azithromycin). Regulatory comparisons often note differences in dosing; for example, Doxiciclina is typically multi-dose over several days, while some macrolides are single-dose treatments.

Q: What is the official guidance on taking Doxiciclina Genfar for a sinus infection?

A: Doxiciclina (Doxycycline) is an approved regimen for treating bacterial sinusitis. Official guidance recommends its use in cases where a bacterial cause is confirmed or strongly suspected, or when initial first-line treatments are not appropriate.

Q: Can Doxiciclina Genfar cause a metallic or unusual taste sensation?

A: Taste loss (ageusia) is documented as a less common side effect associated with the use of Doxiciclina (Doxycycline). If taste changes are experienced, it is noted that these may be discussed with a healthcare professional.

Q: Do different brands of Doxiciclina, like Genfar, have the same uses and safety profile?

A: Different brands of Doxiciclina (Doxycycline) contain the same active ingredient. Regulatory standards ensure that most generic brands, like Genfar, are considered bioequivalent, meaning they are expected to have equivalent efficacy and a similar safety profile to the original product.

Q: Can taking Doxiciclina Genfar for a long period increase the chance of developing other infections?

A: Official warnings note that the use of an antibiotic may occasionally lead to a condition called superinfection. This happens because the medicine can change the natural balance of microorganisms in the body, potentially causing an overgrowth of non-susceptible organisms, including fungi.

Q: Is there a difference in how Doxiciclina Genfar interacts with different types of birth control?

A: The documented interaction primarily concerns hormonal contraceptives that contain estrogen. Additionally, there are separate warnings advising patients to separate the dose of Doxiciclina from iron-containing placebo pills often found in certain types of birth control packs.

Q: Does Doxiciclina Genfar contain sulfa or sulfites?

A: Doxiciclina (Doxycycline) is classified as a tetracycline and does not contain sulfa drugs. However, official warnings note that individuals with a known sulfite allergy should consult their healthcare provider, as some formulations may contain sulfites as an inactive ingredient.

Q: What are the common uses of Doxiciclina Genfar in treating STIs?

A: Official regulatory guidance confirms Doxiciclina (Doxycycline) is an approved treatment for various sexually transmitted infections (STIs). These indications include, but are not limited to, infections caused by Chlamydia trachomatis and Syphilis.

Q: Is Doxiciclina Genfar generally considered to be bacteriostatic or bactericidal?

A: Doxiciclina (Doxycycline) is officially classified by pharmacological studies and regulatory documents as a bacteriostatic antibiotic. This means its primary function is to inhibit the growth and reproduction of bacteria, rather than directly killing the organisms outright.

Advertisements

How should Doxiciclina Genfar be stored and disposed of?

How to Store and Dispose of Doxiciclina Genfar

Storage and disposal must strictly follow the official conditions outlined in regulatory labeling for doxycycline oral formulations.

Storage Requirements

Doxiciclina Genfar must be stored at Controlled Room Temperature, which is defined as 20^circ to 25 C (68^circ to 77 F). The product requires protection from both light and moisture and must be kept in a tight, light-resistant container. To prevent accidental ingestion, the medication must be stored out of the reach of children, often requiring a child-resistant closure on the dispensed container.

Disposal Instructions

Unused or expired Doxiciclina Genfar should be disposed of according to local regulations. The preferred method is using an authorized drug take-back program. It is officially stated that the medication should not be disposed of in a sink or toilet (wastewater) or household trash, unless local rules explicitly permit it.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

Available in countries:

Equivalent of Doxiciclina Genfar found in:

A-Z Index: