Dolofast (Ketoprofen)

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Dolofast (Ketoprofen)

Property Description
Active ingredient Ketoprofen (propionic acid derivative)
Pharmacological class Nonsteroidal Anti-Inflammatory Drug (NSAID)
Forms Oral capsules, tablets, topical gel, oral solution granules
General purpose Relief of pain, inflammation, and fever
Origin Synthetic organic molecule

What Type of Medicine is Dolofast (Ketoprofen)?

Dolofast is a medicinal preparation whose core active substance is Ketoprofen, which is officially classified as a Nonsteroidal Anti-Inflammatory Drug (NSAID). This compound is a synthetic organic molecule belonging to the propionic acid derivative class of NSAIDs, sharing a structural lineage with substances such as ibuprofen and naproxen. Ketoprofen is clinically recognized for having a simple metabolic profile and a rapid onset of action, factors that contribute to its utility in managing acute symptoms.

Composition and Available Forms of Ketoprofen

The core composition of this medicine is the active ingredient Ketoprofen, which is typically presented as a single-component product. A key feature of Ketoprofen is its availability in multiple pharmaceutical preparations, including systemic forms such as oral capsules and tablets, alongside localized preparations like a topical gel. This variety of forms, encompassing both oral and topical administration, allows the medicine's effects to be targeted either systemically or concentrated at a site of localized discomfort.

The General Purpose of Ketoprofen (Pain, Inflammation, and Fever)

The general purpose of Ketoprofen is to reduce symptoms driven by the inflammatory process, specifically addressing the triad of pain, inflammation, and fever. Ketoprofen is an effective analgesic for moderate pain, comparable to other popular NSAIDs in terms of overall efficacy. This ability to interfere with the body's production of prostaglandins—the chemical mediators responsible for these symptoms—provides a comprehensive therapeutic benefit in managing discomfort driven by an inflammatory response.

Regulatory References

  1. Ketoprofen Drug Product Information - DailyMed (NIH)

What side effects are possible with Dolofast (Ketoprofen)?

Possible Side Effects and Safety Information

Ketoprofen, as an Nonsteroidal Anti-Inflammatory Drug (NSAID), is associated with a safety profile that features specific risks categorized by frequency and physiological system in official regulatory documents. Serious safety concerns are related to the class-wide risks of systemic NSAIDs.

Official Adverse Reaction Frequencies and Systems

Adverse reactions are officially listed based on frequency derived from regulatory data:

  • Common Reactions: Reactions reported in a significant portion of patients (e.g., 1% to 10%) typically involve the digestive system. These include dyspepsia, nausea, abdominal pain, and diarrhea. Effects on the nervous system, such as headache and dizziness, are also frequently listed.
  • Uncommon Reactions: Less frequent effects include skin rash and pruritus.
  • Rare Reactions: The category of rare events includes gastrointestinal ulceration and bleeding, as well as photosensitivity reactions, which are particularly noted with topical use.
  • Not Known Frequency: Serious systemic events like anaphylactic shock and severe bullous skin reactions (e.g., Stevens-Johnson Syndrome) are officially documented but cannot be reliably estimated from available data.

Serious Adverse Reactions

Regulatory documents emphasize that systemic Ketoprofen may pose an increased risk of serious, potentially fatal, Cardiovascular Thrombotic Events, including myocardial infarction and stroke. The risk of serious Gastrointestinal Events, such as bleeding, ulceration, and perforation of the stomach or intestines, is also officially documented as a critical safety concern. These risks may manifest early in the course of treatment and may increase with duration of use.

Population-Specific Safety Notes

The official labeling notes that older adults face a higher risk for serious gastrointestinal complications and renal impairment. Use during the third trimester of pregnancy is contraindicated due to the potential for fetal cardiopulmonary and renal toxicity.

Overdose and Emergency Response

Overdose and when to seek help

Overdosage of Dolofast (Ketoprofen) is documented in regulatory sources as an intensification of its known effects, potentially affecting the gastrointestinal (GI), central nervous (CNS), and renal systems. Documented clinical manifestations may include nausea, vomiting, epigastric pain, headache, drowsiness, confusion, and dizziness.

Regulators list severe or life-threatening outcomes that may occur following a large overdose, including coma, seizures (tonic-clonic convulsions), respiratory depression, acute renal failure, and significant gastrointestinal bleeding.

If an overdose of Ketoprofen is suspected or known to have occurred, regulatory guidance mandates that you seek immediate medical attention or call emergency services immediately. Contacting a local Poison Control Center is also required for further guidance.

The official prescribing information explicitly states that no specific antidote is known for Ketoprofen overdose. Management is therefore restricted to providing symptomatic and supportive care. Decontamination procedures, such as administering activated charcoal or performing gastric lavage, may be utilized under professional medical guidance. Due to the medicine's high protein binding, procedures like hemodialysis are stated as unlikely to be beneficial. Regulators note specific risks in a large overdose, including seizures in children and a potentially heightened risk of acute renal failure in patients with existing renal or hepatic impairment.

Therapeutic Uses of Dolofast (Ketoprofen)

What Dolofast (Ketoprofen) Treats: Main Uses and Benefits

Dolofast (Ketoprofen) is commonly used to help with the symptoms related to inflammatory or irritative states and may be part of symptomatic management for a range of conditions. The medication is used in situations involving certain distressing symptoms. The therapeutic focus is on chronic inflammatory conditions (Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis) and acute episodic pain (gout flares, primary dysmenorrhea). It is also commonly used when short-term symptomatic assistance is needed for pain and inflammation arising from soft tissue injuries (sprains, strains) and post-procedural discomfort.

“The medication is applied when symptoms create noticeable physiological strain and when supportive symptom management is appropriate.”

By addressing these symptom clusters, Dolofast helps maintain a sense of stability when symptoms are more noticeable, supporting the patient during difficult episodes.


Quick Fact: Relief for Pain, Inflammation, and Stiffness

Context Symptom Management
Chronic Use Supports the handling of persistent joint pain and stiffness in arthritis.
Acute Use Applied in scenarios where additional management of discomfort from injuries or dental work is required.
Specific Episodes Used to moderate distressing manifestations of pain in gout and dysmenorrhea.

Regulatory References

  1. NIH MedlinePlus overview

Eligibility and Restrictions for Use

Who Can and Cannot Use Dolofast (Ketoprofen)?

This section outlines the officially documented eligibility and non-eligibility rules for the Nonsteroidal Anti-Inflammatory Drug (NSAID), Ketoprofen, based strictly on government regulatory documents.


Absolute Contraindications (Who Must Not Use)

The medicine is contraindicated and must not be used by the following populations:

  • Patients with a known allergy or hypersensitivity to Ketoprofen or other NSAIDs (including aspirin).
  • Women starting at 30 weeks of gestation (the third trimester of pregnancy).
  • Patients with active peptic ulcers or gastrointestinal bleeding.
  • Patients with severe renal failure, severe hepatic failure, or severe uncontrolled heart failure.
  • Patients undergoing Coronary Artery Bypass Graft (CABG) surgery.

Restricted and Conditional Use

Eligibility for Ketoprofen is also constrained by age and pre-existing health conditions:

  • Pediatric Use: The safety and effectiveness of systemic forms have not been established in patients under 18 years of age.
  • Older Adults (Geriatrics): Use is permitted but requires close medical monitoring and often a reduced initial dose due to increased susceptibility to adverse effects.
  • Organ Impairment: Patients with mild to moderate kidney or liver impairment require caution.
  • Breastfeeding: Use is generally not recommended due to a lack of adequate safety data for the infant.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Ketoprofen, as a nonsteroidal anti-inflammatory drug (NSAID), has established interactions with several categories of medicinal products, often due to its effect on prostaglandin synthesis or its association with serious gastrointestinal (GI) and cardiovascular risks.

Product Category Potential Outcome Cautionary Note/Classification
Anticoagulants (e.g., Warfarin) & Antiplatelet Agents (e.g., Aspirin) Increased risk of serious GI bleeding, ulceration, and hemorrhage. Close monitoring is required; combination with aspirin is generally not recommended.
Diuretics (e.g., Thiazides, Furosemide) & ACE Inhibitors Diminished antihypertensive or natriuretic effect; increased risk of renal impairment or failure. Renal function should be monitored, especially in patients taking diuretics.
Lithium Increased plasma lithium levels and potential for toxicity. Careful observation for signs of lithium toxicity is required.
Methotrexate Increased serum methotrexate levels and toxicity. Use with caution; monitor for signs of accumulation or toxicity.
Other NSAIDs (including COX-2 inhibitors) Increased risk of serious adverse effects, particularly GI issues. Concomitant use should be avoided.
Probenecid Reduced clearance of ketoprofen, increasing its concentration. Concomitant use is not recommended.

Ketoprofen is contraindicated for the treatment of pain right before or after coronary artery bypass graft (CABG) surgery due to the increased risk of serious cardiovascular thrombotic events. In certain formulations, concomitant use of magnesium or aluminum hydroxide antacids does not appear to interfere with ketoprofen absorption.

Mechanism of Action

How Dolofast (Ketoprofen) Works

Ketoprofen modulates key enzyme-mediated signaling pathways to exert its action, regulating processes driven by specific signaling patterns within biological systems.


Enzyme Inhibition in Prostaglandin Synthesis

Ketoprofen exerts its primary action by inhibiting cyclooxygenase (COX) enzymes, specifically both COX-1 and COX-2 isoforms. This suppression modifies an early molecular step—the conversion of arachidonic acid—thereby reducing the synthesis of various pro-inflammatory mediators, including prostaglandins. This sequence of events results in a reduction in mediator-driven pathway activity.


Regulation of Lipoxygenase Pathways

Beyond its principal effect on COX, Ketoprofen also demonstrates inhibitory activity against the lipoxygenase (LOX) enzyme pathway, which is responsible for the formation of leukotrienes. While a secondary mechanism, this engagement influences feedback regulation within inflammatory cascades. This action influences the level of subsequent mediator activity, and the cascade alters the typical flux within targeted pathways.

Dosage and Administration Information

How to Use Dolofast (Ketoprofen)

Ketoprofen administration follows specific protocols and is dependent on the dosage form and the condition being managed. The medicine is primarily available for oral intake, but options also include topical (gel) and, for acute settings, intravenous or intramuscular routes.


Standard Systemic Dosing Patterns

The standard adult oral dosing regimen is split between immediate-release (IR) and extended-release (ER) forms, guided by the condition being managed.

Form Typical Daily Regimen Maximum Daily Dose
Immediate-Release (IR) 50 mg up to four times daily in divided doses. 300 mg
Extended-Release (ER) 200 mg taken once daily. 200 mg

For acute pain and primary dysmenorrhea, IR forms are typically administered in doses of 25 mg to 50 mg every six to eight hours as needed. The fundamental principle guiding use is to employ the lowest effective dose for the shortest duration necessary.


Administration Conditions and Special Handling

Oral forms of Ketoprofen may be taken with food, milk, or antacids to support gastrointestinal tolerance. Extended-release tablets must be swallowed whole and should not be crushed or chewed, as this alters the intended drug release kinetics. For topical administration, the gel is applied to the affected area and should be gently massaged for absorption, typically two to four times daily. A lower initial dose and a reduced maximum daily dose are required for older adults and individuals with documented renal or hepatic impairment.

Recent Clinical Evidence

Research evidence / Overview of studies

Overview of Studies

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID). Research included laboratory studies examining effects on three specific enzymes involved in inflammation. Clinical studies primarily focused on its use in adults diagnosed with rheumatoid arthritis (RA), specifically in patients who had not responded adequately to other treatments.

Researchers primarily evaluated changes in measures of joint function and joint pain in patients with active RA. The duration of these studies commonly ranged from six months to two years.


Key Efficacy Findings

Initial research focused on measuring how the drug's administration correlated with changes in symptoms. Studies evaluated the time to onset of potential symptom changes. Outcomes were typically measured using established scales, such as the American College of Rheumatology (ACR) response criteria.

  • Joint Pain and Swelling: A number of studies examined whether there was a difference in reported joint tenderness and swelling compared to placebo.
  • Morning Stiffness: Research examined whether the drug may be associated with changes in morning stiffness over time. The study results regarding this measure were noted for further investigation.

Safety and Patient Monitoring

The overall safety profile was evaluated across all phases of clinical development. Studies examined the occurrence and severity of side effects, including nausea, headaches, and liver enzyme elevation. Researchers included blood tests for liver function at regular intervals to monitor for observed enzyme changes, a standard practice due to potential effects associated with NSAID use.

  • Combination Treatment: Research also examined whether the combination treatment was associated with changes in patient outcomes when given alongside methotrexate, a medication often used in RA treatment. This area of research continues to be explored.

Key Studies & References

  1. National Institute for Health and Care Excellence (NICE) Guideline: Rheumatoid arthritis in adults: management

Frequently Asked Questions (FAQ)

Common questions about Dolofast (Ketoprofen) (FAQ)


Q: What kind of pain is Dolofast (Ketoprofen) typically used for?

A: Official documentation indicates that Ketoprofen is generally used to treat mild to moderate pain. It is also approved for managing the signs and symptoms of inflammatory conditions such as rheumatoid arthritis and osteoarthritis, as well as for primary dysmenorrhea (menstrual cramps).


Q: Is Dolofast (Ketoprofen) an NSAID, and what does that mean?

A: Yes, Ketoprofen is classified as a nonsteroidal anti-inflammatory drug, or NSAID. This means the medicine is described in official sources as having properties that help reduce inflammation, relieve pain (analgesic), and lower fever (antipyretic).


Q: Is it normal for Dolofast (Ketoprofen) to cause stomach upset?

A: Yes, regulatory documents list gastrointestinal issues, including upset stomach, nausea, gas, diarrhea, and constipation, among the common side effects that may occur when taking Ketoprofen. Regulatory documents suggest that taking the medicine with food or milk can support gastrointestinal tolerance.


Q: How long does it typically take to feel the pain relief effect of Dolofast (Ketoprofen)?

A: According to official drug monographs, the immediate-release form of Ketoprofen is absorbed rapidly into the bloodstream. Maximum plasma concentrations, which are generally associated with the onset of pain-relieving activity, are reached within one to two hours after taking a dose.


Q: Is Dolofast (Ketoprofen) the same type of medicine as ibuprofen or naproxen?

A: Yes, Ketoprofen belongs to the same pharmacological class of medicines as ibuprofen and naproxen. They are all classified as nonsteroidal anti-inflammatory drugs (NSAIDs) and share similar mechanisms of action in reducing pain and inflammation.


Q: What are the major side effects associated with taking Dolofast (Ketoprofen) long-term?

A: Regulatory warnings indicate that prolonged use may increase the risk of serious cardiovascular events, such as heart attack or stroke, which can be fatal. Additionally, long-term use is associated with a greater risk of serious gastrointestinal problems, including ulceration, bleeding, and perforation of the stomach or intestines.


Q: Are there any specific supplements or foods that interact with Dolofast (Ketoprofen)?

A: Official patient information often suggests caution regarding the use of certain supplements, particularly those that may affect blood clotting or the risk of bleeding. Only drug-to-drug interactions are typically listed in the core interaction tables of regulatory documents.


Q: What is the risk of heart-related side effects with Dolofast (Ketoprofen)?

A: Ketoprofen carries an official Boxed Warning stating that all NSAIDs may increase the risk of serious cardiovascular thrombotic events, including heart attack and stroke. This serious risk may increase the longer the medication is used and in people with pre-existing heart disease.


Q: Why do official documents warn about using Dolofast (Ketoprofen) during late pregnancy?

A: Official warnings advise against using Ketoprofen from 20 weeks of gestation onward. Use during the third trimester carries a risk of premature closure of the fetal ductus arteriosus. Use after 20 weeks is also associated with a rare risk of fetal kidney problems.


Q: Is there a specific population, like older adults, who need to be more cautious about taking Dolofast (Ketoprofen)?

A: Yes, regulatory guidance emphasizes caution for older adults because they are at a higher risk for serious side effects, particularly those affecting the stomach, heart, and kidneys. Regulatory guidelines officially require that a reduced starting dose be considered for this population.


Q: Is it possible for Dolofast (Ketoprofen) to affect kidney function?

A: Regulatory documents indicate that Ketoprofen may cause kidney problems, which can include decreased kidney function or, rarely, kidney failure. This risk is noted to be higher in individuals with certain pre-existing conditions, such as dehydration or existing kidney or heart problems.


Q: Why does the packaging for Dolofast (Ketoprofen) mention a risk of stroke or heart attack?

A: This inclusion is part of the official Boxed Warning for nonsteroidal anti-inflammatory drugs (NSAIDs). It is required to inform patients that NSAIDs may increase the potential risk of serious and potentially fatal cardiovascular events, such as heart attack and stroke.


Q: How quickly does the anti-inflammatory effect of Dolofast (Ketoprofen) begin?

A: The anti-inflammatory action of Ketoprofen is linked to its concentration in the bloodstream. Since the drug is rapidly absorbed and reaches peak concentrations within a couple of hours, the anti-inflammatory effect begins shortly after the onset of pain relief.


Q: What information exists about Dolofast (Ketoprofen) use while breastfeeding?

A: Published data from regulatory-affiliated sources indicates that Ketoprofen is present in breastmilk at low levels. However, official sources have documented rare cases where the drug was suspected in serious adverse reactions in breastfed infants.


Q: Does Dolofast (Ketoprofen) have a sedative effect or cause drowsiness?

A: Yes, dizziness, headache, and drowsiness (somnolence) are listed in official product information as possible side effects of Ketoprofen. Due to the possibility of these effects, caution is described in the product information regarding activities that require full mental alertness.


Q: What are the potential signs of liver problems when taking Dolofast (Ketoprofen)?

A: Official warnings describe signs of potential liver damage for which patients should seek medical advice. These signs may include unexplained nausea, excessive fatigue, itching (pruritus), dark urine, pale stools, and jaundice (yellowing of the skin or eyes).


Q: Is Dolofast (Ketoprofen) known to cause sensitivity to sunlight?

A: Yes, official safety information reports that Ketoprofen can cause increased sensitivity to sunlight (photosensitivity). This reaction may lead to severe sunburn or other skin reactions following sun exposure.


Q: Are there any specific medical conditions that generally prevent someone from taking Dolofast (Ketoprofen)?

A: Regulatory documents state Ketoprofen is contraindicated in people with a history of allergic-type reactions—such as asthma, hives, or severe rash—after taking aspirin or other NSAIDs. It is also contraindicated for pain immediately before or after coronary artery bypass graft (CABG) surgery.


Q: What are the common but less serious side effects of Dolofast (Ketoprofen)?

A: Official sources list common side effects that may be less serious, including headache, dizziness, nervousness, difficulty sleeping (insomnia), heartburn, gas, and minor changes in bowel habits.


Q: Can Dolofast (Ketoprofen) be used for a fever?

A: Yes, as Ketoprofen is classified as an NSAID, regulatory documents describe it as having antipyretic properties, meaning it can help reduce fever.


Q: Is there an increased risk of bleeding from cuts or injuries while taking Dolofast (Ketoprofen)?

A: Ketoprofen can interfere with the function of blood platelets, which are essential for clotting. Official warnings indicate that this may result in an increased risk of bleeding, affecting overall bleeding time and raising the potential for serious gastrointestinal bleeding.


Q: What is the guidance regarding alcohol consumption while taking Dolofast (Ketoprofen)?

A: Official patient information often discourages the consumption of alcoholic beverages while undergoing therapy with Ketoprofen. Alcohol use can significantly increase the risk of gastrointestinal adverse effects, including stomach ulceration and hemorrhage.


Q: Is a headache a reported side effect of Dolofast (Ketoprofen)?

A: Yes, headache is consistently listed as one of the reported common side effects of Ketoprofen in official sources like the FDA and NIH MedlinePlus.


Q: Can Dolofast (Ketoprofen) affect fertility, according to official sources?

A: Some official drug labels for the NSAID class include information regarding a potential, reversible effect on fertility in women. This is described as a general class effect that is associated with stopping the medication.


Q: What is the general classification of Dolofast (Ketoprofen) in terms of safety during pregnancy?

A: The FDA recommends avoiding NSAIDs like Ketoprofen starting at 20 weeks of pregnancy. Its use is associated with potential risks to the fetus after this point, including kidney problems and the premature closing of an important fetal blood vessel.


Q: Is it described in official sources that Dolofast (Ketoprofen) is addictive or habit-forming?

A: No. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) and is not classified as a controlled substance with known addictive or habit-forming potential in official regulatory documents.


Q: Does Dolofast (Ketoprofen) interact with common medications for high blood pressure?

A: Yes, regulatory information indicates that Ketoprofen may interact with certain blood pressure medications. For example, it may reduce the blood pressure-lowering effect of ACE inhibitors and diuretics, and it may also increase the risk of kidney problems when used alongside these medicines.


Q: What does regulatory information say about Dolofast (Ketoprofen) and skin reactions?

A: Official warnings state that severe skin reactions, such as Stevens-Johnson syndrome and toxic epidermal necrolysis, can occur. Regulatory documents state that patients should discontinue use and seek immediate medical help if signs of a serious skin reaction, such as rash, fever, or blistering, are observed.


Q: Is it described that Dolofast (Ketoprofen) could make asthma symptoms worse?

A: Yes. Official contraindications state that Ketoprofen should not be used by individuals who have a history of asthma or other allergic reactions that are triggered by aspirin or other NSAIDs.


Q: What is the risk of an overdose with Dolofast (Ketoprofen)?

A: Official patient information describes that signs of a potential overdose may include severe stomach pain, extreme drowsiness, slowed or shallow breathing, and seizures. Official information emphasizes that immediate medical evaluation should be sought if an overdose is suspected.


Q: What are the common uses of the extended-release form of Dolofast (Ketoprofen)?

A: The extended-release formulation is typically reserved for the long-term management of chronic conditions. Regulatory indications specify its use for treating the sustained signs and symptoms of both rheumatoid arthritis and osteoarthritis.


Q: Is the elimination half-life of Dolofast (Ketoprofen) considered short or long?

A: For the immediate-release form of Ketoprofen, the elimination half-life (the time it takes for half the drug to leave the body) is approximately two hours. This is generally considered to be a short half-life.


Q: Can I take Dolofast (Ketoprofen) if I have a history of ulcers or stomach bleeding?

A: Regulatory information advises caution or lists a relative contraindication for individuals with a history of peptic ulcers, stomach bleeding, or other serious upper gastrointestinal disorders. This is due to the increased risk of potentially fatal gastrointestinal adverse events associated with NSAID use.


Q: Is Dolofast (Ketoprofen) considered a treatment for chronic arthritis?

A: Yes, official drug indications confirm that Ketoprofen is used to manage the signs and symptoms of chronic inflammatory conditions, including both osteoarthritis and rheumatoid arthritis.


Q: Can Dolofast (Ketoprofen) be used for a persistent headache?

A: Ketoprofen is indicated for the treatment of mild to moderate pain. Its use for a persistent headache would fall under this broad indication, but the decision must align with the healthcare provider's assessment.


Q: What is the typical duration of pain relief for a single dose of Dolofast (Ketoprofen)?

A: The dosing frequency for the immediate-release form is typically every six to eight hours as needed for pain. This frequency generally reflects the expected duration of significant pain relief from a single dose.


Q: Does Dolofast (Ketoprofen) come in different formulations, such as capsules or extended-release?

A: Official drug information confirms that Ketoprofen is available in various forms, including immediate-release capsules or tablets and extended-release capsules. Topical gels and injectable forms are also approved in certain regions.


Q: Are there different warnings for topical (gel) versus oral Dolofast (Ketoprofen)?

A: Yes. The oral form carries a Boxed Warning for systemic risks, such as cardiovascular and gastrointestinal events. Because the topical gel has less systemic absorption, its warnings typically focus more on localized skin reactions like rash or sun sensitivity.

How should Dolofast (Ketoprofen) be stored and disposed of?

Storage and Disposal Requirements

Ketoprofen oral formulations must be stored at Controlled Room Temperature, which is defined by regulatory standards as 20 C to 25 C (68 F to 77 F). The product must be protected from freezing, excessive heat, moisture, and light.

The medicine should be kept in a tight, light-resistant container that is tightly closed and includes a child-resistant closure. It is required to be stored out of the reach of children.

Disposal of any unused or expired product must be done in accordance with local regulations. Government guidance recommends utilizing drug take-back programs or, if unavailable, following specific instructions for household trash disposal.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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