Diprovate Plus

Each gram of Betamethasone Topical (Diprovate Plus) (Betamethasone Topical (Diprovate Plus)*) Cream* contains: 640 mcg Betamethasone Topical (Diprovate Plus) dipropionate (equivalent to 500 mcg Betamethasone Topical (Diprovate Plus)).

Each gram of Betamethasone Topical (Diprovate Plus) (Betamethasone Topical (Diprovate Plus)*) Ointment* contains: 640 mcg Betamethasone Topical (Diprovate Plus) dipropionate (equivalent to 500 mcg Betamethasone Topical (Diprovate Plus)).

Betamethasone Topical (Diprovate Plus) (Betamethasone Topical (Diprovate Plus)*) Cream and Ointment contain Betamethasone Topical (Diprovate Plus) dipropionate, a synthetic corticosteroid with anti-inflammatory activity to be administered topically.

Betamethasone Topical (Diprovate Plus) dipropionate is a white to creamy white odorless crystalline powder insoluble in water; freely soluble in acetone and in chloroform; sparingly soluble in alcohol. It has a molecular weight of 504.16 and the empirical formula C₂₈H₃₇FO₇; a chemical name of 9-fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione,17,21-dipropionate.

Each mL contains anthraquinone glycosides 50 mg, Salicylic Acid (Diprovate Plus) 10 mg and alcohol 60%.

Zinc Oxide (Diprovate Plus) is an inorganic compound with the formula ZnO. ZnO is a white powder that is insoluble in water, and it is widely used as an additive in numerous materials and products including rubbers, plastics, ceramics, glass, cement, lubricants, paints, ointments, adhesives, sealants, pigments, foods, batteries, ferrites, fire retardants, and first-aid tapes. It occurs naturally as the mineral zincite, but most Zinc Oxide (Diprovate Plus) is produced synthetically. Zinc Oxide (Diprovate Plus) can be used in ointments, creams, and lotions to protect against sunburn and other damage to the skin caused by ultraviolet light. It is also widely used to treat a variety of other skin conditions, in products such as baby powder and barrier creams to treat diaper rashes, calamine cream, anti-dandruff shampoos, and antiseptic ointments.

Betamethasone Topical (Diprovate Plus) is a potent topical corticosteroid indicated for adults, elderly and children >1 year for the relief of inflammatory and pruritic manifestations of steriod responsive dermatoses. These include atopic dermatitis (including infantile atopic dermatitis), nummular dermatitis (discoid eczema), prurigo nodularis, psoriasis (excluding widespread plague psoriasis), lichen simplex chronicus (neurodermatitis) and lichen planus, seborrhoeic dermatitis, irritant or allergic contact dermatitis, discoid lupus erythomatosus, adjunct to systemic steroid therapy in generalized erythroderma, insect bite reactions and miliaria (prickly heat).

For Dermatologic Use: Salicylic Acid (Diprovate Plus) 6% is a topical aid in the removal of excessive keratin in hyperkeratotic skin disorders including verrucae, and the various ichthyoses (vulgaris, sex-linked and lamellar), keratosis palmaris and plantaris keratosis pilaris, pityriasis rubra pilaris, and psoriasis (including body, scalp, palms and soles).

For Podiatric Use: Salicylic Acid (Diprovate Plus) 6% is a topical aid in the removal of excessive keratin on dorsal and plantar hyperkeratotic lesions.

Topical preparations of 6% Salicylic Acid (Diprovate Plus) have been reported to be useful adjunctive therapy for verrucae plantares.

Zinc Oxide (Diprovate Plus) 60: Regular use may help protect against premature skin aging, appearance of wrinkles and pigmentation and sunburn. Improve quality of skin and leave the skin supple and healthy.

Zinc Oxide (Diprovate Plus) sensitive 30: Skin friendly with broad UV protection, protects against premature skin aging, helps protect against hyperpigmentation.

Betamethasone Topical (Diprovate Plus) is a topical steroid. It reduces the actions of chemicals in the body that cause inflammation, redness, and swelling.

Betamethasone Topical (Diprovate Plus) is used to treat the inflammation caused by a number of conditions such as allergic reactions, eczema, and psoriasis. The dental paste form of Betamethasone Topical (Diprovate Plus) is used to treat mouth ulcers.

Betamethasone Topical (Diprovate Plus) may also be used for other purposes not listed in this medication guide.

Salicylic Acid (Diprovate Plus) is a keratolytic (peeling agent). Salicylic Acid (Diprovate Plus) causes shedding of the outer layer of skin.

Salicylic Acid (Diprovate Plus) topical (for the skin) is used in the treatment of acne, dandruff, seborrhea, or psoriasis, and to remove corns, calluses, and warts.

Salicylic Acid (Diprovate Plus) topical may also be used for purposes not listed in this medication guide.

Zinc Oxide (Diprovate Plus) contains Zinc Oxide (Diprovate Plus). When applied to the skin Zinc Oxide (Diprovate Plus) forms a temporary barrier protecting the skin from external irritants. It also decreases inflammation and reduces bacterial growth in injured skin.

Zinc Oxide (Diprovate Plus) is used to treat diaper rash and other minor skin irritations.

Zinc Oxide (Diprovate Plus) may also be used for purposes not listed in this medication guide.

Shake well before use.

Apply Betamethasone Topical (Diprovate Plus) Spray to the affected skin areas twice daily and rub in gently.

Use Betamethasone Topical (Diprovate Plus) Spray for up to 4 weeks of treatment. Treatment beyond 4 weeks is not recommended.

Discontinue Betamethasone Topical (Diprovate Plus) Spray when control is achieved.

Do not use if atrophy is present at the treatment site.

Do not bandage, cover, or wrap the treated skin area unless directed by a physician.

Avoid use on the face, scalp, axilla, groin, or other intertriginous areas.

Betamethasone Topical (Diprovate Plus) Spray is for topical use only. It is not for oral, ophthalmic, or intravaginal use.

How supplied

Dosage Forms And Strengths

Spray, 0.05% for topical use. Each gram of Betamethasone Topical (Diprovate Plus) Spray contains 0.643 mg Betamethasone Topical (Diprovate Plus) dipropionate USP (equivalent to 0.5 mg Betamethasone Topical (Diprovate Plus)) in a slightly thickened, white to off-white oil-in-water emulsion.

Storage And Handling

Betamethasone Topical (Diprovate Plus) Spray is a slightly thickened, white to off-white, non-sterile emulsion supplied in high density polyethylene bottles with a heat induction seal lined polypropylene cap. The drug is supplied in the following volumes:

60 mL (NDC 67857-808-17)

120 mL (NDC 67857-808-04)

Store at controlled room temperature of 20°C to 25°C (68°F to 77°F), excursions permitted to 15°C to 30°C (59°F to 86°F).

Each unit is co-packaged with a manual spray pump for installation by the pharmacist prior to dispensing.

Handling/Instructions For The Pharmacist

1. Remove the spray pump from the wrapper.
2. Remove and discard the cap from the bottle.
3. Keeping the bottle upright, insert the spray pump into the bottle and turn clockwise until it is closed tightly.
4. Dispense the bottle with the spray pump inserted.
5. Include the date dispensed in the space provided on the carton.

Manufactured by: DPT Laboratories, Ltd., San Antonio, TX 78215 Distributed by: Promius Pharma, LLC., Princeton, NJ 08540. Revised: Jan 2016.

Rx only

FOR TOPICAL USE ONLY.

NOT FOR OPHTHALMIC, ORAL OR INTRAVAGINAL USE.

DESCRIPTION

Virasal is a topical preparation containing 27.5% Salicylic Acid (Diprovate Plus) in a proprietary film-forming vehicle that comprises isopropyl alcohol, butyl acetate, polyvinyl butyral, isopropyl metacresol, trimethyl pentanyl diisobutyrate, phenic acid and acrylates copolymer. The pharmacologic activity of Virasal is generally attributed to the keratolytic activity of Salicylic Acid (Diprovate Plus) which is incorporated into a polyacrylic, film-forming virucidal vehicle designed to cover the wart without the need for a bandage. The structural formula of Salicylic Acid (Diprovate Plus) is:

CLINICAL PHARMACOLOGY

Although the exact mode of action for Salicylic Acid (Diprovate Plus) in the treatment of warts is unknown, its activity appears to be associated with its keratolytic action, which results in mechanical removal of epidermal cells infected with wart viruses.

The virucidal complex incorporated into Virasal’s proprietary vehicle is designed to help reduce risk of reinfection at the wart site, as well as prevent viral contamination of the product under normal usage.

INDICATIONS AND USAGE

Virasal is indicated for the topical treatment and removal of common warts and plantar warts.

CONTRAINDICATIONS

Patients with diabetes or impaired blood circulation should not use Virasal. Virasal also should not be used on moles, birthmarks, and unusual warts with hair growing from them, or warts on the face.

PRECAUTIONS

Virasal is for external use only. Do not permit Virasal to contact eyes or mucous membranes. If contact with eyes or mucous membranes occurs, immediately flush with water for 15 minutes. Virasal should not be allowed to contact normal skin surrounding wart, since localized irritation may occur. Treatment should be discontinued if excessive irritation occurs. Virasal is flammable. Keep away from fire or flame. Keep bottle tightly capped when not in use.

ADVERSE REACTIONS

A localized irritant reaction may occur if Virasal is applied to the normal skin surrounding the wart. Any irritation may normally be controlled by temporarily discontinuing use and by applying the medication only to the wart site when treatment is resumed.

DOSAGE AND ADMINISTRATION

Prior to applying Virasal, soak wart in warm water for five minutes. Remove any loosened tissue by gently rubbing with a brush, wash cloth, or emery board. Dry wart site thoroughly. Using the brush applicator supplied, apply Virasal twice to entire wart surface, allowing the first application to dry before applying the second. Continue treatment once or twice a day as directed by physician. Be careful not to apply to surrounding skin.

Clinically visible improvement will normally occur during the first or second week of therapy. Maximum resolution may be expected after four to six weeks of Virasal use.

HOW SUPPLIED

Virasal is supplied in 10ml amber bottles with a brush applicator (NDC 42783-312-10).

Store at controlled room temperature, 15° to 30°C (59° to 86°F).

Manufactured for:

Elorac, Inc.

Vernon Hills, IL 60061

U.S. Patent Pending

Revised 06/2011

221619

Usual Adult Dose for Dermatologic Lesion

Zinc Oxide (Diprovate Plus) topical 30% ointment:

Apply topically to affected area as needed.

Usual Adult Dose for Diaper Rash

Zinc Oxide (Diprovate Plus) topical 10% cream:

Zinc Oxide (Diprovate Plus) topical 10% ointment:

Zinc Oxide (Diprovate Plus) topical 13% cream:

Zinc Oxide (Diprovate Plus) topical 13% ointment:

Zinc Oxide (Diprovate Plus) topical 11.3% stick:

Zinc Oxide (Diprovate Plus) topical 30% ointment:

Clean the diaper area and allow to dry. Apply liberal amount topically with each diaper change.

Usual Pediatric Dose for Dermatologic Lesion

Zinc Oxide (Diprovate Plus) topical 30% ointment:

Apply topically to affected area as needed.

Usual Pediatric Dose for Diaper Rash

Zinc Oxide (Diprovate Plus) topical 10% cream:

Zinc Oxide (Diprovate Plus) topical 10% ointment:

Zinc Oxide (Diprovate Plus) topical 13% cream:

Zinc Oxide (Diprovate Plus) topical 13% ointment:

Zinc Oxide (Diprovate Plus) topical 11.3% stick:

Zinc Oxide (Diprovate Plus) topical 30% ointment:

Clean the diaper area and allow to dry. Apply liberal amount topically with each diaper change.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

For external use only.

Do not use in or near the eyes.

When treating diaper rash, instruct caregiver to discontinue use of Zinc Oxide (Diprovate Plus) and consult a physician if the rash becomes very red, raw, has blisters, pustules, pus, peeling areas or crusty patches, is located primarily in skin creases, lasts longer than a few days, or the baby also has a fever, diarrhea, or strong smelling urine.

Dialysis

Data not available

See also:
What is the most important information I should know about Betamethasone Topical (Diprovate Plus)?

Use this medication exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger amounts or for longer than recommended.

Do not cover treated skin areas with a bandage or other covering unless your doctor has told you to. If you are treating the diaper area of a baby, do not use plastic pants or tight-fitting diapers. Covering the skin that is treated with Betamethasone Topical (Diprovate Plus) can increase the amount of the drug your skin absorbs, which may lead to unwanted side effects. Follow your doctor's instructions.

Avoid using this medication on your face, near your eyes, or on body areas where you have skin folds or thin skin.

Do not use this medication on a child without a doctor's advice. Children are more sensitive to the effects of Betamethasone Topical (Diprovate Plus).

Betamethasone Topical (Diprovate Plus) will not treat a bacterial, fungal, or viral skin infection.

Contact your doctor if your condition does not improve or if it gets worse after using this medication for several days.

See also:
What is the most important information I should know about Salicylic Acid (Diprovate Plus)?

Less common or rare

Skin irritation not present before use of Salicylic Acid (Diprovate Plus) (moderate or severe)

Frequency not known

Dryness and peeling of skin

flushing

redness of skin

unusually warm skin

Symptoms of Salicylic Acid (Diprovate Plus) poisoning

Confusion

diarrhea

dizziness

fast or deep breathing

headache (severe or continuing)

hearing loss

lightheadedness

nausea

rapid breathing

ringing or buzzing in ears (continuing)

severe drowsiness

stomach pain

vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

-Skin irritation not present before use of Salicylic Acid (Diprovate Plus) (mild) -stinging

See also:
What is the most important information I should know about Zinc Oxide (Diprovate Plus)?

Hypersensitivity to any component, including salicylates wool fat (or lanolin), or other constituents of the ointment.

- Skin oozing.

- Skin superinfected.

- Do not apply to the breasts during breastfeeding because of the risk of ingestion of the product by the newborn.

This medicine is usually applied 1 or 2 times daily. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Do not take by mouth. Betamethasone Topical (Diprovate Plus) is for use only on the skin.

Wash your hands before and after using this medicine, unless you are using the medicine to treat the skin on your hands.

Apply a small amount to the affected area and rub it gently into the skin. Do not apply Betamethasone Topical (Diprovate Plus) over a large area of skin.

To use Betamethasone Topical (Diprovate Plus) foam, spray some of the foam onto a plate or other cool surface. Pick up a small amount of the foam with your fingers and gently massage it into your scalp. Repeat until all affected areas are treated.

Do not cover the treated skin area unless your doctor tells you to. Covering the skin that is treated with Betamethasone Topical (Diprovate Plus) can increase the amount of medicine your skin absorbs, which may lead to unwanted side effects. Follow your doctor's instructions.

When treating the diaper area of a baby, do not use plastic pants or tight-fitting diapers.

Use Betamethasone Topical (Diprovate Plus) regularly to get the most benefit. Stop using the medicine once your symptoms clear up.

You should not use Betamethasone Topical (Diprovate Plus) for longer than 4 weeks.

Call your doctor if your skin condition does not improve after several days of treatment, or if it gets worse while using Betamethasone Topical (Diprovate Plus).

Store at room temperature away from moisture and heat.

The foam is flammable. Do not use near high heat or open flame. Do not smoke until the foam has completely dried on your skin.

Use Salicylic Acid (Diprovate Plus) shampoo as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• To use shampoo as a scalp treatment: Use before bathing. Do not wet hair. Apply Salicylic Acid (Diprovate Plus) shampoo with the applicator directly to affected areas of the scalp. Leave on for 5 minutes, gradually increasing the treatment time up to 1 hour, or as directed by your doctor. After treatment, rinse thoroughly with water. Wash your hands after each use. You may use a non-medicated shampoo after using Salicylic Acid (Diprovate Plus) shampoo, if desired.
• To use shampoo as a medicated shampoo: Wet hair, apply Salicylic Acid (Diprovate Plus) shampoo with the applicator directly to scalp, and massage vigorously for several minutes. Rinse thoroughly. Be sure to wash your hands after each use. Use Salicylic Acid (Diprovate Plus) shampoo daily until the condition clears, or as directed by your doctor.
• To use the gel on the skin: Moisten the affected area and keep damp for at least 5 minutes before you apply Salicylic Acid (Diprovate Plus) shampoo. Apply Salicylic Acid (Diprovate Plus) shampoo to the affected area as directed. Cover the treated area at night unless your doctor tells you otherwise. If applying to an area that cannot be covered, check with your doctor for instructions. Wash Salicylic Acid (Diprovate Plus) shampoo off in the morning.
• To use gel as a scalp treatment: Apply Salicylic Acid (Diprovate Plus) shampoo with the applicator directly to affected areas of the scalp. Avoid contact with unaffected hair or skin. Leave the medicine on for 10 to 20 minutes initially, gradually increasing the treatment time to one hour, or as directed by your doctor. The gel may be washed off using the medicated shampoo or warm water in a bath or shower.
• Wash hands immediately after you use Salicylic Acid (Diprovate Plus) shampoo, unless your hands are part of the treated area.
• If you miss a dose of Salicylic Acid (Diprovate Plus) shampoo, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Salicylic Acid (Diprovate Plus) shampoo.

Use Zinc Oxide (Diprovate Plus) cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• First, wash your hands. Then wash and dry the affected area, unless otherwise directed by your doctor. Apply a generous amount of medicine to completely cover the affected area. Wash your hands immediately after using Zinc Oxide (Diprovate Plus) cream.
• Zinc Oxide (Diprovate Plus) cream is for external use only. Avoid getting Zinc Oxide (Diprovate Plus) cream in your eyes, nose, or mouth.
• Use Zinc Oxide (Diprovate Plus) cream when diaper rash, redness, chafing, or skin irritation appears.
• Change wet and dirty diapers at once, clean the diaper area, and allow the area to dry.
• To help prevent diaper rash, apply Zinc Oxide (Diprovate Plus) cream to the diaper area before you have to, especially at bedtime.
• Apply Zinc Oxide (Diprovate Plus) cream freely as often as needed with each diaper change, especially at bedtime.
• For minor, noninfected scrapes and burns, apply a thin layer of Zinc Oxide (Diprovate Plus) cream, using a bandage if necessary.
• If diaper rash worsens or does not improve within 7 days, contact your child's doctor.
• If you miss a dose of Zinc Oxide (Diprovate Plus) cream, use it as soon as you remember. Continue to use it as directed by your doctor or on the package label.

Ask your health care provider any questions you may have about how to use Zinc Oxide (Diprovate Plus) cream.

This medication is used to treat a variety of skin conditions (e.g., eczema, dermatitis, allergies, rash). Betamethasone Topical (Diprovate Plus) reduces the swelling, itching, and redness that can occur in these types of conditions. This medication is a strong corticosteroid.

How to use Betamethasone Topical (Diprovate Plus) topical

Use this medication on the skin only. However, do not use it on the face, groin, or underarms or for diaper rash unless directed to do so by your doctor.

Wash and dry your hands. Before applying the medication, clean and dry the affected area. Apply a thin film of the medication to the affected area and gently rub in, usually 1-2 times daily or as directed by your doctor.

Do not cover, bandage, or wrap the area unless directed to do so by your doctor. If your doctor directs you to use this medication in the diaper area on an infant, do not use tight-fitting diapers or plastic pants.

If you are using the lotion form of this medication, shake the bottle well before each dose.

After applying the medication, wash your hands unless you are using this medication to treat the hands. When applying this medication near the eyes, avoid getting it in the eyes as this may worsen or cause glaucoma. Also, avoid getting this medication in the nose or mouth. If you get the medication in these areas, rinse with plenty of water.

Use this medication only for the condition for which it was prescribed. Do not use it for longer than prescribed.

Inform your doctor if your condition persists or worsens after 2 weeks.

This medication is used on the skin to treat common skin and foot (plantar) warts. Salicylic Acid (Diprovate Plus) helps cause the wart to gradually peel off. This medication is also used to help remove corns and calluses. This product should not be used on the face or on moles, birthmarks, warts with hair growing from them, or genital/anal warts.

Salicylic Acid (Diprovate Plus) is a keratolytic. It belongs to the same class of drugs as aspirin (salicylates). It works by increasing the amount of moisture in the skin and dissolving the substance that causes the skin cells to stick together. This makes it easier to shed the skin cells. Warts are caused by a virus. Salicylic Acid (Diprovate Plus) does not affect the virus.

How to use Salicylic Acid (Diprovate Plus) topical

Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.

This medication is for use on the skin only. To avoid irritation, do not let this medication come into contact with your eyes, nose, mouth, groin, or any broken skin. If you do get the medication in those areas, flush the area with cool water for 15 minutes. Wash hands after use.

First, soak the corn, callus, or wart in warm water for about 5 minutes to soften the treatment area. Dry thoroughly. Your doctor may direct you to use a pumice stone, callus file, or emery board to carefully remove the top dead layers of skin after soaking and before applying the medication. This dead skin removal is only to help the medication work better. Do not try to rub the wart or callus off.

If you are using a liquid/gel, apply a few drops or a thin coat of the medication to cover the entire wart, callus, or corn using the applicator if provided. Be careful to apply it only to the affected area and not the surrounding skin. Let dry for 5 minutes. Depending on the brand used, you may need to apply the medication twice with each treatment. Check your product package and follow the directions carefully. You may cover the area loosely with a bandage. Repeat this procedure 1 to 2 times daily for up to 2 weeks for corns and calluses and 12 weeks for warts or as directed by your doctor.

If you are using a medicated pad or bandage, you may need to cut the pad so that it covers the treatment area completely but does not touch the surrounding skin. Peel off the protective covering and place the patch/bandage over the area. Leave in place according to package directions. Remove and place a new patch/bandage as directed (usually every 8 to 48 hours depending on brand). Repeat this procedure for up to 2 weeks for corns and calluses and 12 weeks for warts.

Dosage is based on your medical condition, product type/brand, and response to treatment. Do not use large amounts, apply this medication more often, or use it for a longer period than directed. Your condition will not clear faster, but the chance for side effects may be increased.

Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time each day.

If your condition persists or worsens, or if you think you may have a serious medical problem, seek immediate medical attention.

This medication is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations (e.g., diaper rash, skin burns from radiation therapy). Emollients are substances that soften and moisturize the skin and decrease itching and flaking. Some products (e.g., Zinc Oxide (Diprovate Plus), white petrolatum) are used mostly to protect the skin against irritation (e.g., from wetness).

Dry skin is caused by a loss of water in the upper layer of the skin. Emollients/moisturizers work by forming an oily layer on the top of the skin that traps water in the skin. Petrolatum, lanolin, mineral oil and dimethicone are common emollients. Humectants, including glycerin, lecithin, and propylene glycol, draw water into the outer layer of skin. Many products also have ingredients that soften the horny substance (keratin) that holds the top layer of skin cells together (e.g., urea, alpha hydroxy acids such as lactic/citric/glycolic acid, and allantoin). This helps the dead skin cells fall off, helps the skin keep in more water, and leaves the skin feeling smoother and softer.

How to use Zinc Oxide (Diprovate Plus) topical

Use this product as directed. Some products require priming before use. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.

Some products need to be shaken before use. Check the label to see if you should shake the bottle well before using. Apply to the affected areas of the skin as needed or as directed on the label or by your doctor. How often you apply the medication will depend on the product and your skin condition. To treat dry hands, you may need to use the product every time you wash your hands, applying it throughout the day.

If you are using this product to help treat diaper rash, clean the diaper area well before use and allow the area to dry before applying the product.

If you are using this product to help treat radiation skin burns, check with radiation personnel to see if your brand can be applied before radiation therapy.

Follow all the directions on the label for proper use. Apply to the skin only. Avoid sensitive areas such as your eyes, inside your mouth/nose, and the vaginal/groin area, unless the label or your doctor directs you otherwise. Check the label for directions about any areas or types of skin where you should not apply the product (e.g., on the face, any areas of broken/chapped/cut/irritated/scraped skin, or on a recently shaved area of the skin). Consult your doctor or pharmacist for more details.

Use this medication regularly to get the most benefit from it. Most moisturizers need water to work well. Apply the product after bathing/showering while the skin is still damp. For very dry skin, your doctor may instruct you to soak the area before using the product. Long, hot, or frequent bathing/washing can worsen dry skin.

If your condition persists or worsens, or if you think you may have a serious medical problem, seek immediate medical attention.

See also:
What other drugs will affect Betamethasone Topical (Diprovate Plus)?

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to salicylic acid or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Young children may be at increased risk of unwanted effects because of increased absorption of salicylic acid through the skin. Also, young children may be more likely to get skin irritation from salicylic acid. Salicylic acid should not be applied to large areas of the body, used for long periods of time, or used under occlusive dressing (air-tight covering, such as kitchen plastic wrap) in infants and children. Salicylic acid should not be used in children younger than 2 years of age.

Geriatric

Elderly people are more likely to have age-related blood vessel disease. This may increase the chance of problems during treatment with salicylic acid.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

See also:
What other drugs will affect Salicylic Acid (Diprovate Plus)?

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to Salicylic Acid (Diprovate Plus) or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Young children may be at increased risk of unwanted effects because of increased absorption of Salicylic Acid (Diprovate Plus) through the skin. Also, young children may be more likely to get skin irritation from Salicylic Acid (Diprovate Plus). Salicylic Acid (Diprovate Plus) should not be applied to large areas of the body, used for long periods of time, or used under occlusive dressing (air-tight covering, such as kitchen plastic wrap) in infants and children. Salicylic Acid (Diprovate Plus) should not be used in children younger than 2 years of age.

Geriatric

Elderly people are more likely to have age-related blood vessel disease. This may increase the chance of problems during treatment with Salicylic Acid (Diprovate Plus).

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

See also:
What other drugs will affect Zinc Oxide (Diprovate Plus)?

Avoid applying other skin medications on the same treatment area with Zinc Oxide (Diprovate Plus), unless your doctor has told you to.

It is not likely that other drugs you take orally or inject will have any effect on topically applied Zinc Oxide (Diprovate Plus). But many drugs can interact with each other. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

See also:
What are the possible side effects of Betamethasone Topical (Diprovate Plus)?

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

In two randomized, multicenter, prospective vehicle-controlled clinical trials, subjects with moderate plaque psoriasis of the body applied Betamethasone Topical (Diprovate Plus) Spray or vehicle spray twice daily for 4 weeks. A total of 352 subjects applied Betamethasone Topical (Diprovate Plus) Spray and 180 subjects applied vehicle spray.

Adverse reactions that occurred in at least 1% of subjects treated with Betamethasone Topical (Diprovate Plus) Spray for up to 28 days are presented in Table 1.

Less common adverse reactions (with occurrence lower than 1% but higher than 0.1%) in subjects treated with Betamethasone Topical (Diprovate Plus) spray were application site reactions including telangiectasia, dermatitis, discoloration, folliculitis and skin rash, in addition to dysgeusia and hyperglycemia. These adverse reactions were not observed in subjects treated with vehicle.

Postmarketing Experience

Because adverse reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Postmarketing reports for local adverse reactions to topical corticosteroids have also included striae, irritation, dryness, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, hypertrichosis, and miliaria.

See also:
What are the possible side effects of Salicylic Acid (Diprovate Plus)?

Less common or rare

Skin irritation not present before use of Salicylic Acid (Diprovate Plus) (moderate or severe)

Frequency not known

Dryness and peeling of skin

flushing

redness of skin

unusually warm skin

Symptoms of Salicylic Acid (Diprovate Plus) poisoning

Confusion

diarrhea

dizziness

fast or deep breathing

headache (severe or continuing)

hearing loss

lightheadedness

nausea

rapid breathing

ringing or buzzing in ears (continuing)

severe drowsiness

stomach pain

vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

-Skin irritation not present before use of Salicylic Acid (Diprovate Plus) (mild) -stinging

See also:
What are the possible side effects of Zinc Oxide (Diprovate Plus)?

Applies to Zinc Oxide (Diprovate Plus) topical: topical application cream, topical application dressing, topical application gel/jelly, topical application lotion, topical application ointment, topical application paste, topical application powder, topical application spray

In addition to its needed effects, some unwanted effects may be caused by Zinc Oxide (Diprovate Plus) topical (the active ingredient contained in Zinc Oxide (Diprovate Plus)). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking Zinc Oxide (Diprovate Plus) topical:

Incidence not known:

• hives
• itching
• skin rash

Minor Side Effects

Some of the side effects that can occur with Zinc Oxide (Diprovate Plus) topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known:

• Worsening of diaper rash