Diovol Plus

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Diovol Plus

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Diovol Plus

Quick Facts

Property Description
Active Ingredients Aluminum Hydroxide, Magnesium Hydroxide, Simethicone
Form Oral Suspension, Chewable Tablets
Pharmacological Class Antacid and Antiflatulent
General Purpose Symptomatic relief of acid indigestion, heartburn, and gas
Origin Synthetic Compounds

Defining Diovol Plus: A Fixed-Dose Combination Medicine

Diovol Plus is an Over-the-Counter (OTC), synthetic medication classified as a fixed-dose combination product intended for oral administration. This formulation is distinct because it combines two high-level pharmacological classes: an Antacid (Aluminum Hydroxide and Magnesium Hydroxide) and an Antiflatulent (Simethicone). The combination is designed to address the full spectrum of digestive discomfort simultaneously, distinguishing it from single-agent antacids. The product's historical formulations have often been positioned as low sodium and sucrose-free options, particularly in mint-flavored variations.


What are the Active Ingredients and Dosage Forms?

The medicine's function is defined by its three active ingredients: the antacid inorganic salts Aluminum Hydroxide and Magnesium Hydroxide, and the silicone-based anti-foaming agent Simethicone. The pairing of the two metal hydroxides is clinically recognized for providing effective acid neutralization while intentionally balancing their respective effects on bowel motility. Diovol Plus is available for oral administration in a liquid oral suspension and chewable tablets, offering patients flexibility and rapid delivery of the active agents.


General Purpose and Mechanism of Symptom Relief

The general purpose of Diovol Plus is to provide effective, rapid, and dual-action relief from common digestive symptoms. The antacid components work by quickly raising the pH level in the stomach, which helps to alleviate the burning sensation associated with heartburn and acid indigestion. Concurrently, Simethicone acts locally as a non-systemic surfactant to break down large, trapped gas bubbles in the gastrointestinal tract. This means the product effectively reduces feelings of bloating, pressure, and discomfort caused by flatulence directly within the digestive system, rather than relying on systemic absorption.

Regulatory References

  1. MedlinePlus Antacid Information

What side effects are possible with Diovol Plus?

Possible Side Effects and Safety Information

This section outlines the officially documented adverse reactions and safety restrictions associated with Diovol Plus, strictly based on regulatory health authority documents.

Documented Adverse Reactions

The most common side effects observed primarily involve the Gastrointestinal System. These may include changes in bowel habits, such as diarrhea or constipation, as well as reports of nausea or vomiting. Other documented effects include headache and the occasional appearance of white-colored stool.

Clinically Significant and Systemic Risks

Regulatory information highlights the risk of systemic imbalances, particularly with prolonged use or high dosages. Serious considerations include the potential for hypophosphatemia (low phosphate levels), which may present as unusual tiredness, loss of appetite, or muscle weakness. Symptoms of magnesium toxicity (e.g., slow/shallow breathing, mental confusion, or deep sleep) are a risk, especially in restricted patient groups.

Safety Restrictions and Limitations

The use of this medicine is contraindicated in individuals with severe kidney impairment due to the presence of aluminum and magnesium salts. Caution is also advised for patients with existing kidney conditions or fluid restrictions.

Regulatory safety information notes the high potential for Drug-Drug Interactions. Diovol Plus can reduce the absorption and effectiveness of other essential medications, such as certain antibiotics, iron supplements, and digoxin, necessitating separation of administration times. The safety profile also includes the risk of hypersensitivity reactions (severe allergy) to any component of the product. Prolonged use (typically more than two weeks) requires consultation.

Overdose and Emergency Response

The official overdose profile for this antacid product is primarily defined by the systemic risk of hypermagnesemia, or excessive magnesium levels in the blood, resulting from the magnesium hydroxide component. This toxicity risk is significantly heightened in individuals with impaired kidney function, as their ability to clear the absorbed minerals is reduced.

Documented Clinical Manifestations and Outcomes

Severe overdose may lead to neuromuscular depression, presenting as profound muscle weakness, loss of deep tendon reflexes, and the risk of respiratory paralysis. Cardiovascular depression is also a documented outcome, potentially causing low blood pressure (hypotension) and serious disturbances in heart rhythm that may progress to cardiac arrest. Other acute symptoms listed in regulatory documents include lethargy, confusion, and abdominal cramping.

Emergency Action Required

In the event of suspected overdose, official regulatory documentation requires individuals to seek immediate medical attention or contact a Poison Control Center right away for prompt assessment and management. Supportive measures described in regulatory literature for severe hypermagnesemia include the administration of Intravenous Calcium Gluconate to counter certain effects, and in high-risk cases, Hemodialysis may be necessary.

Therapeutic Uses of Diovol Plus

Main Uses and Benefits of Diovol Plus

Diovol Plus is a combination medication formulated to address symptoms associated with excessive gastric acidity and intestinal gas. It belongs to the therapeutic classes of antacids and antiflatulents.

Primary Indications

The medication is used to provide relief from several gastrointestinal conditions:

  • Hyperacidity: It helps neutralize excess stomach acid associated with heartburn, acid indigestion, and sour stomach.
  • Gastric and Duodenal Ulcers: It can be used as an adjunct therapy to manage symptoms of discomfort caused by peptic ulcers.
  • Gastritis: It assists in relieving the burning sensation and irritation associated with inflammation of the stomach lining.
  • Hiatal Hernia: It manages the acid reflux symptoms often resulting from this condition.
  • Flatulence: The inclusion of an antiflatulent component helps disperse gas bubbles in the digestive tract, relieving pressure, bloating, and fullness.

Mechanism of Action

Diovol Plus works through a dual-action approach to stabilize the gastric environment:

  1. Acid Neutralization: The antacid components react chemically to neutralize existing gastric acid. This raises the pH level of the stomach contents, which reduces the irritation of the esophageal and gastric mucosa and inhibits the activity of pepsin, a digestive enzyme that can aggravate ulcers.
  2. Gas Reduction: The antiflatulent agent reduces the surface tension of gas bubbles within the stomach and intestines. This allows smaller bubbles to coalesce into larger ones that are more easily eliminated through belching or passing gas, thereby reducing physical discomfort and abdominal distension.

Benefits

  • Symptom Management: Provides rapid, temporary relief from the physical discomfort caused by acid-related disorders.
  • Dual-Symptom Relief: Addresses both the chemical (acidity) and physical (gas) aspects of digestive upset simultaneously.
  • Mucosal Protection: By reducing the acidity of gastric juice, the medication helps protect the lining of the esophagus and stomach from acid-induced damage during the healing process.

Eligibility and Restrictions for Use

Who Can and Cannot Use Diovol Plus?

The official eligibility criteria for this medicine are defined by age, current physiological state, and underlying health conditions, as mandated by regulatory authorities. The guidelines below are based on official product labeling.


Eligible Populations

Classification Eligible Group
OTC Use Adults and adolescents 12 years of age and older

Populations with Restrictions or Contraindications

Eligibility Status Non-Eligible Population/Condition
Absolute Contraindication Individuals with severe kidney impairment or disease (risk of mineral accumulation).
Absolute Contraindication Patients with known hypersensitivity or allergy to any active ingredient.
Conditional Use Pregnant or breastfeeding individuals (must consult a healthcare professional before use).
Conditional Use Patients with moderate kidney disease or those on a magnesium-restricted diet.
Non-Self-Medication Children under 12 years of age (requires explicit advice from a physician before use).

The regulatory profile clearly establishes that individuals with severely compromised renal function are prohibited from using the product. All other restricted populations, such as pregnant individuals or those with moderate kidney issues, must obtain professional medical clearance before starting treatment.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The interaction profile of Diovol Plus, which contains Aluminum Hydroxide, Magnesium Hydroxide, and Simethicone, is primarily structured around pharmacokinetic interference caused by the antacid components. The polyvalent metal cations in the antacids bind to certain oral medications in the gastrointestinal tract, leading to a process known as chelation or physicochemical binding. This action results in a reduced systemic exposure of the co-administered drug.


Documented Interaction Patterns

Interaction Type Interacting Substances/Conditions
Exposure-Modifying Tetracycline and Quinolone Antibiotics (e.g., Doxycycline, Ciprofloxacin), Digoxin, Iron Supplements, Atazanavir, Dasatinib, and other medications with pH or cation-dependent absorption.
Contraindicated Combinations Pazopanib, Raltegravir, Eltrombopag.
Substance Constraint Citrate-containing substances (foods, beverages, drug formulations).

Timing and Population Restrictions

To prevent the reduction in absorption, regulatory documents require a mandatory separation of administration timing. Most oral medications should be administered at least 2 hours before or 2 hours after the antacid. Furthermore, combining the aluminum component with citrate is officially documented to increase serum aluminum concentrations, which carries a risk of toxicity. The regulatory label includes a specific caution for patients with Kidney Disease (Renal Dysfunction), who are at increased risk of hyperaluminemia and hypermagnesemia due to reduced systemic clearance of these metal salts.

Mechanism of Action

Rapid Chemical Neutralization of Gastric Acid

This mechanism involves the rapid, non-systemic chemical buffering of Gastric Hydrochloric Acid ( HCl) by the active metal hydroxides ( Al( OH)3 and Mg( OH)2) solely within the stomach lumen. The resulting rapid increase in pH dampens the pH-dependent chemical stimulus that irritates the mucosal lining, leading to a swift attenuation of the acidic chemical irritation.


Physical Alteration of Luminal Gas Surface Tension

The antiflatulent component, Simethicone, acts as a surfactant to physically modify the gas-liquid interface surface tension of the gastrointestinal contents. This action causes small, tenacious gas bubbles entrapped in mucus to coalesce into larger, consolidated gas volumes , thereby facilitating their physiological expulsion.


️ Motility Compensation Through Opposing Actions

The formulation integrates the counteracting properties of its two antacid components: the astringent, water-adsorbing effect of Aluminum Hydroxide and the osmotic, water-attracting effect of Magnesium Hydroxide. This synergy supports a more physiologically neutral outcome on bowel fluid balance and motility, maintaining a more balanced influence on bowel function compared to single agents.

Dosage and Administration Information

How to Use Diovol Plus: Administration Guidelines

Diovol Plus, a fixed-dose combination product containing aluminum hydroxide, magnesium hydroxide, and simethicone, is administered exclusively via the oral route. The medication is available in two dosage forms: oral suspension and chewable tablets. Adherence to specific administration procedures is necessary to ensure proper use according to established standards.


Standard Dosage and Frequency

The standard adult dose (for patients 12 years and older) typically ranges from 10 mL to 20 mL for the standard oral suspension concentration, or 2 to 4 tablets of the chewable form. Dosing is intended for intermittent use (as needed) or on a scheduled regimen, generally up to four times per day, with doses separated by a minimum of 4 to 6 hours. It is generally advised that the dosage must not exceed 80 mL of the liquid or 12 tablets in any 24-hour period.


Administration Requirements and Duration

For the liquid suspension, the product must be shaken well before measurement, and the dose must be accurately measured using a calibrated device. Chewable tablets must be chewed thoroughly before swallowing. The timing of administration is flexible, often directed for use after meals and at bedtime.

This product is intended for short-term symptomatic use. Continuous administration at the maximum dose must not extend beyond two weeks unless specifically directed by a healthcare professional. Furthermore, the antacid components necessitate a procedural constraint: to prevent interference with absorption, other oral medications should be administered with a 2-hour interval from the time Diovol Plus is taken.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Diovol Plus


Evidence for Acute Acid and Gas-Related Digestive Discomfort

The basis for the combination's availability was explored in historical regulatory processes and is rooted in a historical consensus. These ingredients have been used in research exploring how symptoms change over time and are generally recognized by regulators for their established uses. The evidence for the antacid components is foundational, focused on their ability to rapidly change stomach acid levels (gastric pH). The antiflatulent component research has explored studies examining patient-reported outcomes describing perceived discomfort related to gas.

Research for this specific fixed-dose combination has studied outcomes related to physical discomfort, specifically the feeling of heartburn, sour stomach, and concurrent bloating or abdominal pressure. The evidence primarily stems from trials assessing short-term or episodic symptom patterns. While the foundational evidence for the individual components is robust, comparative evidence is lacking for the specific triple-combination product in modern, large-scale randomized trials.


Research on the Impact on Other Medications (Drug-Drug Interactions)

Diovol Plus was studied for its potential to affect the absorption of other orally administered medications. This research involves controlled pharmacokinetic (PK) studies where healthy adult volunteers were observed in specific scenarios. Research explored scenarios where the antacid's rapid change in stomach environment was observed. Data suggest patterns related to changes in how the body processes the co-administered medication.

These PK studies do not determine whether an individual will respond similarly to the product's main purpose of relieving acid and gas symptoms. The results apply only to the populations studied and the specific drugs tested during the research.


Long-Term Studies and Follow-Up

Research exploring short-term symptom changes is the most common form of evidence for this product category. Most studies that monitor patient responses for acid and gas relief involve follow-up durations that were limited, often to a few hours or, at most, a few weeks. Long-term outcomes for the specific fixed combination are not fully established, as the research is designed to characterize response to episodic or acute changes in comfort.

Key Studies & References MedlinePlus: Antacids (Patient Instructions)

Frequently Asked Questions (FAQ)

Common questions about Diovol Plus (FAQ)

Q: How quickly should I expect Diovol Plus to start working?

Official product information describes the mechanism of action as a rapid, non-systemic chemical buffering of acid in the stomach. This chemical process is designed to provide a swift attenuation (reduction) of the burning sensation and acidic irritation. While specific timeframes in minutes are not usually included on the label, the mechanism itself is generally recognized as being quick-acting.

Q: Does Diovol Plus interact with common pain relievers like ibuprofen?

Regulatory safety documents for this class of medicine warn that antacids can interfere with the absorption of many orally administered medications. Although specific non-prescription pain relievers like ibuprofen are generally not listed individually, the official guidance requires administering other oral medications with a 2-hour interval from the antacid to help mitigate the potential for interference.

Q: Are there any specific foods or drinks to avoid while using Diovol Plus?

Yes, the official regulatory label includes a specific warning about co-administration with citrate-containing substances, which includes certain foods, beverages, or drug formulations. The reason for this warning is that combining citrate with the aluminum component may increase systemic aluminum exposure, which carries a risk of toxicity.

Q: Can I take Diovol Plus if I am taking prescription blood pressure medication?

Regulatory labeling requires that the antacid be separated from most other oral prescription medications by at least two hours. This mandatory timing separation helps to mitigate the risk of reduced absorption of the co-administered drug, including medications like those used for blood pressure.

Q: Does Diovol Plus affect the absorption of other vitamins or minerals?

Official documents do identify substances whose absorption can be affected by the metal components, and they specifically name iron supplements. The antacid components can bind to certain minerals in the digestive tract, a process known as chelation, which may lead to reduced systemic availability.

Q: Can Diovol Plus be used by children, and is there a weight limit?

Official product labeling establishes the standard non-self-medication age limit at 12 years and older. Regulatory documents explicitly state that use in children under 12 years of age requires consultation with a healthcare professional before use. A specific weight limit is not usually specified on the label.

Q: What did the official studies conclude about the effectiveness of Diovol Plus?

Official regulatory texts define the intended purpose as providing symptomatic relief for heartburn, acid indigestion, and gas. The evidence is generally described as foundational, focusing on the active components' ability to rapidly change stomach acid levels and lessen gas-related discomfort.

Q: What should I do if I accidentally take more Diovol Plus than I intended?

Regulatory labeling states that if an overdose is suspected, professional help or a poison control center should be contacted immediately. This warning is included on the official label regarding the use of more medication than intended.

Q: Does Diovol Plus lose effectiveness if it is near its expiry date?

The expiration date listed on the product packaging is the specific time limit up to which the manufacturer establishes the period of full potency and acceptable quality. This expectation applies only when the product has been stored according to the specified conditions (e.g., room temperature, away from moisture).

Q: Can I use Diovol Plus at the same time as a proton pump inhibitor (PPI)?

The regulatory label mandates a 2-hour separation between the antacid and all other oral medications to prevent potential interference with absorption. This general principle applies to all simultaneously administered oral drugs, including those in the proton pump inhibitor (PPI) class.

Q: What is the purpose of the calcium and magnesium components?

The product’s active ingredients include Magnesium Hydroxide (and Aluminum Hydroxide), which function as antacids. Regulatory monographs state their purpose is the chemical neutralization of stomach acid while simultaneously providing a balancing influence on bowel motility compared to single-agent antacids. Calcium is not listed as an active component in the provided product information.

Q: Does Diovol Plus interact with birth control pills?

Regulatory safety information for this class of drug requires a 2-hour interval between the antacid and all other oral medications. This separation is necessary to prevent potential binding and reduced systemic exposure, a general principle that applies to many oral medications, including oral contraceptives.

Q: Can I take Diovol Plus if I have a history of stomach ulcers?

Official safety information suggests patients consult a healthcare professional before use if they have underlying or chronic digestive symptoms, such as persistent stomach pain or a history of severe discomfort.

Q: Are there different formulations, like liquid versus chewable tablets, and how do they differ?

Official labeling states that the product is available as both an oral suspension and chewable tablets. The primary difference noted in the directions is the administration procedure: the suspension must be shaken well and measured, while the tablets must be chewed thoroughly before swallowing.

Q: Has Diovol Plus been approved by government health agencies?

Yes, the product formulation is regulated by government health authorities under established Over-the-Counter (OTC) Monographs or equivalent regulatory systems. This means the product is recognized by health authorities for its stated indications when used according to the label directions.

Q: What is the difference between antacids and other acid-reducing medicines?

Official sources describe antacids as working by rapid, non-systemic chemical buffering, which means they quickly neutralize acid directly in the stomach to raise the pH. This mechanism differs from systemic acid reducers (like H2 blockers or PPIs), which are absorbed into the body to alter the physical production of acid.

Q: Does Diovol Plus have any known long-term side effects?

Regulatory documents warn that the product is intended for short-term use and that prolonged administration (exceeding two weeks) requires professional medical consultation. This extended use may carry an increased risk of systemic mineral imbalances, such as hypophosphatemia (low phosphate levels) and potential magnesium toxicity in at-risk populations.

Q: What does 'contraindication' mean in the context of Diovol Plus?

The term contraindication is used in regulatory documents to define specific conditions, such as severe kidney impairment, where the product must not be used. This restriction is mandatory because using the medicine under these conditions carries a risk of severe adverse effects that significantly outweighs any potential benefit.

Q: Can I use Diovol Plus if I am diabetic (sugar content concern)?

The Inactive Ingredients section on the product label will confirm whether the formulation contains sucrose or other sugars. While some variations of this medicine have been historically positioned as sucrose-free options, users monitoring sugar intake should consult the current, specific product label.

Q: Does Diovol Plus address symptoms like burping or gas pains?

Yes, the product is officially indicated for the relief of gas and the associated discomfort. The anti-flatulent component, Simethicone, works to facilitate the physiological expulsion of trapped gas from the digestive system, which includes addressing symptoms like burping and gas pains.

How should Diovol Plus be stored and disposed of?

How to Store and Dispose of Diovol Plus?

Diovol Plus storage and disposal instructions are defined by regulatory labeling to ensure product stability and public safety.

Required Storage Conditions

Diovol Plus must be stored at room temperature, typically 15 C to 30 C. The product must be protected from excessive heat, moisture, and direct sunlight.

Formulation Constraint Requirement
Oral Suspension Do not allow it to freeze
All Forms Keep the container tightly closed

Safety and Disposal

The medicine must be stored in a secure location and kept out of the reach of children and pets. For disposal, any unused or expired Diovol Plus should be returned to a pharmacy for proper disposal through established drug take-back programs.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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