Dimetindene

(Systemic use):Endocrine disordes ( primary or secondary adrenocortical insufficiency ).

shock unresponsive to conVentional therapy if adrenocortical insufficiency exists or is suspected, Rheumati

c disorders ( post – traumatic osteoarthritis, synovitis of osteoarthritis, Rheumatoid arthritis, Acute and subacute bursitis.

Epicondylitis, Acute nonspecific tenosynovitis, Acute gouty arthritis, Psoriatic arthritis

Collagen diseases ( systemic lupus erythematosus, Acute rheumatic Carditis, systemic dermatomysitis ), Dermatologic disease ( Pemphigus, Severe erythma multiforme, Exfoliative dermatitis, Severe psoriasis ) ophthalmic diseases, ( in allergic and inflammatory processes involving the eye, such as : Herpes Zoster ophthalmicus, Iritis, iridocy clitis, chorioretinitis, Keratitis ), Gastrointestinal diseases ( ulcerative colitis systemic theropy ) Respiratory diseases ( symptomatic sarcoidosis, Berylliosis ) Hematologic disorders ( Acquired [ autoimmune ] hemolytic anemia ) Neoplastic disease. (Topical use):variety of skin conditions (e.g., insect bites, poison oak/ivy, eczema, dermatitis, allergies, rash, itching of the outer female genitals, anal itching). Hydrocortisone reduces the swelling, itching, and redness that can occur in these types of conditions. This medication is a mild corticosteroid.

(Systemic use) Prior Arthroplasty of joint, Blood Clotting disorders, intra – articular fracture, infection ( periaticular, current or history of ), osteoporosis, unstable joint.(Topical use): variety of skin conditions (e.g., insect bites, poison oak/ivy, eczema, dermatitis, allergies, rash, itching of the outer female genitals, anal itching). Hydrocortisone reduces the swelling, itching, and redness that can occur in these types of conditions. This medication is a mild corticosteroid.

(Systemic use):Combinations containing any of the following medications, depending on the amount present, also may interact with this medication:

Acetaminophen-Alcohol-Anti-inflammatory drugs, nonsteroidal (NSAIDs)- Aminoglutethimide

Amphotericin B,Carbonic anhydrase inhibitors,Anabolic steroids,Androgens,Antacids,Anticholinergics, especially atropine and related compounds

Anticoagulants, coumarin- or indanedione-

Heparin orStreptokinase orUrokinase

Antidepressants, tricyclic

Antidiabetic agents, oral - Insulin -Antithyroid agents-Thyroid hormones-Contraceptives, oral, estrogen-containing.(Topical use): No specific interactions

(Systemic use):Mineralocorticoid adverse effects ( retention of sodium and water, with oedema and hypertension ), increased excretion of potassium with the possibility of hypokalaemic alkalosis, cardiac failure, disturbances of electrolyte balance, osteoporosis, spontaneous fractures, muscle wasting and nitrogen depletion, hyperglycaemia, menstrual irregularities. Immunosuppression, cushingoid symptoms ( with moon-face, hirsutism, buffalo hump, flushing, CHF, psychic disturbances, sudden blindness, Adrenal suppression, avascular necrosis, cataracts, cutaneous or subcutaneous tissue atrophy, growth suppression ( in children ), impaired wound healing, pancreatitis, peptic ulceration or intestinal perforation, tendon rupture and thin, fragile skin.(Topical use):Stinging, burning, irritation, dryness, or redness at the application site may occur. Acne, unusual hair growth, "hair bumps" (folliculitis), skin thinning/discoloration, or stretch marks may also occur.

Dimetindene is an antihistamine/anticholinergic used orally and locally as an antipruritic.