Дигофтон

Quick links to important sections

Дигофтон

Treatment option: Pain, Presbyopia, Fatigue

Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Дигофтон

What is Дигофтон? (Digophton)

Property Description
Active ingredient Digitoxin (C41H64O13)
Form Tablets, Solution (Oral and Injectable)
Pharmacological class Cardiac Glycoside
Common use Improvement of heart muscle performance and regulation of rhythm
Origin Naturally occurring compound from the Digitalis purpurea (foxglove) plant

What is Дигофтон and What Class Does It Belong To?

Дигофтон (Digophton) is a prescription-only medication designated for specialized cardiac therapy, fundamentally classified as a Cardiac Glycoside (ATC code C01AA04). This class of agent specifically influences the performance and rhythm of the heart muscle, and the substance is utilized in adult cardiac care to support and regulate the function of a heart that is weakened or has rhythm irregularities. The use of this drug class for cardiac conditions is recognized for managing certain chronic heart conditions.

The term Cardiac Glycoside defines the drug by its core mechanism of inhibiting the Na^+/K^+ ATPase pump, a vital enzyme within cardiac muscle cells. This classification underpins the drug's differentiating feature: its long half-life of approximately seven to eight days, which supports the selection of Digitoxin for maintenance therapy where a sustained therapeutic effect is necessary.

Composition, Origin, and Available Forms

The sole active ingredient in Дигофтон is the chemical compound Digitoxin, a single-ingredient product. Digitoxin is a naturally occurring phytosteroid historically isolated from the leaves of the purple foxglove plant, Digitalis purpurea. This natural origin is defined by its specific chemical structure.

As a pharmaceutical preparation, Дигофтон is available in common dosage form(s), primarily including tablets for oral administration, as well as a specialized solution that may be used for intravenous injection, providing flexibility for healthcare professionals.

The General Purpose of Digitoxin in Cardiac Therapy

The general purpose of Дигофтон is to improve the overall efficiency and rhythm of the heart. This is achieved through a critical dual action: providing a positive inotropic effect (strengthening the force of heart muscle contractions) and inducing a negative chronotropic effect (gently slowing the heartbeat frequency). By enhancing the force of contraction and regulating the rhythm, the medicine aims to optimize cardiac output, which is central to supporting compromised heart function.

What side effects are possible with Дигофтон?

Possible Side Effects and Safety Information

The safety profile of Дигофтон (Digitoxin), a cardiac glycoside, is officially defined by a narrow therapeutic window, meaning the effective concentration is close to the concentration that can cause toxicity, as noted in regulatory labeling. The documented adverse reactions are categorized primarily by the affected body system and frequency, based on data from official government health authorities.

Adverse Reaction Categories and Frequency

Adverse reactions associated with this medicine most frequently involve three System-Organ Classes: Cardiac Disorders, Gastrointestinal Disorders, and Nervous System Disorders.

Classification Examples of Reactions
Common Irregular heart rhythm (arrhythmia), slow heart rate (sinus bradycardia), nausea, vomiting, loss of appetite (anorexia), headache, dizziness, and blurred or color-distorted vision.
Serious Life-threatening cardiac toxicity is documented, including severe forms of heart block and ventricular fibrillation.

Key Safety Constraints and Considerations

The regulatory profile specifies that the risk of toxicity is significantly increased by electrolyte imbalances, particularly low levels of potassium (hypokalemia) or magnesium (hypomagnesemia). Reduced kidney function (renal impairment) is another officially listed consideration, especially for older adults, as it can elevate drug exposure.

Officially documented safety constraints prohibit the use of this medicine in individuals with a known hypersensitivity to digitalis preparations and in patients with pre-existing ventricular fibrillation. Symptoms of toxicity, such as fatigue or nausea, may be non-specific and are officially noted to sometimes be mistaken for worsening symptoms of the underlying heart condition.

Overdose and Emergency Response

Overdose and When to Seek Help — Official Regulatory Information

The official overdose information for Дигофтон (Digitoxin) is centered on recognizing specific toxicity manifestations and initiating immediate emergency care as mandated by regulatory authorities.

Overdose Scope

Classification Official Regulatory Statements
Documented Presentations Gastrointestinal symptoms (anorexia, nausea, vomiting), neurological effects (confusion, headache), visual disturbances (altered color perception, blurred vision), and characteristic cardiac arrhythmias (progressive bradyarrhythmias, AV block, ventricular complexes).
Life-Threatening Outcomes The most severe outcomes are defined by severe ventricular arrhythmias and/or significant hyperkalemia (potassium levels exceeding 5.5 mEq/L in adults) [Source 1.5, 2.2].
Antidote A specific antidote, Digoxin Immune Fab (antibody fragments), is established for reversing life-threatening or potentially life-threatening toxicity [Source 1.5, 2.2].
High-Risk Populations Patients of advanced age or with impaired renal function are noted to be at increased risk of toxicity due to reduced clearance [Source 1.2, 1.5].

Immediate Action Required

Regulatory documents mandate that the medication must be immediately withdrawn upon suspicion of toxicity [Source 3.2]. Immediate medical attention or hospitalization is required for any suspected overdose [Source 1.6]. Urgent medical intervention is necessary when life-threatening symptoms—such as severe arrhythmias or hyperkalemia—are present, often involving continuous cardiac monitoring and supportive treatments like electrolyte correction [Source 1.5, 2.2]. The established procedure specifies the use of the antidote for severe toxicity [Source 2.2].

Therapeutic Uses of Дигофтон

What Дигофтон Treats: Main Uses and Benefits


The use of Дигофтон (Digitoxin) is centered on providing specialized therapeutic support in two primary areas of cardiac care, focusing on supporting the function of the heart muscle and assisting with the regulation of its rhythm to contribute to easing symptomatic distress. These uses include managing Chronic Heart Failure and rate management in chronic Atrial Fibrillation or Atrial Flutter.

Therapeutic Domains and Symptom Relief

This medication is relevant in contexts involving heightened systemic burden and functional stress. The use is relevant for managing symptoms related to organ-specific functional stress, which is commonly used to help with symptom clusters related to reduced circulation. This includes persistent fatigue, shortness of breath (dyspnea), and fluid retention and edema that can significantly interfere with daily functioning. It also assists with heart rate moderation, which supports general well-being during symptomatic phases. This supports the patient during difficult episodes by easing distress from a rapid, unstable heart rhythm. It is commonly used when groups of symptoms, particularly fatigue and congestion, appear suddenly or fluctuate, and supportive symptom management is appropriate.


QuickFact

Property Description
Relief for Symptoms related to physical discomfort and systemic imbalance (fatigue, edema, rapid heart rhythm).
Condition Context Chronic conditions where functional stability is affected, such as HFrEF and Chronic AF.
Patient Benefit Assists with maintaining functional stability and contributes to easing the overall symptom load.

Eligibility and Restrictions for Use

The eligibility for Дигофтон (Digitoxin) is determined by official regulatory documentation focusing on existing cardiac health, organ function, and specific physiological states. Use is strictly contraindicated in several patient groups.


Populations with Absolute Contraindications

  • Patients with known Hypersensitivity to Digitoxin or other digitalis glycosides.
  • Patients experiencing Ventricular Fibrillation.
  • Patients with certain supraventricular arrhythmias associated with an Accessory Atrioventricular Pathway (e.g., Wolff-Parkinson-White Syndrome).
  • Patients with Second-Degree or Intermittent Complete Heart Block (in the absence of a pacemaker).

Eligibility and Restriction Rules

Classification Rule and Rationale Status
Age-Group Use is established in Adult Patients. Use in Pediatric Patients is highly specialized and generally not established for general use. Caution Required
Organ Function Eligibility is restricted in Severe Hepatic Impairment, as Digitoxin is primarily metabolized by the liver. Restricted Use
Clinical State Use is generally not recommended immediately following Acute Myocardial Infarction or in cases of active Myocarditis. Not Recommended
Physiological State Use in Pregnancy should only occur when the clinical benefit clearly outweighs possible risk. Conditional Use

Official Eligibility Statements: Regulatory labeling mandates that absolute contraindications related to cardiac conduction must exclude patients from treatment. For others, eligibility is conditional, requiring correction of factors like Electrolyte Imbalances (e.g., Hypokalemia) and careful management due to organ status, such as Severe Hepatic Impairment, as defined in official documents.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory documents classify interactions with Digitoxin into pharmacokinetic and pharmacodynamic categories, defining several restrictions and co-administration conditions.

Pharmacokinetic Interactions: Exposure Modification

The most prominent interactions are those that alter Digitoxin plasma concentrations. Substances that increase exposure (raising the serum level) are primarily P-Glycoprotein (P-gp) and CYP3A inhibitors, including antiarrhythmics like Amiodarone and Quinidine, as well as certain Macrolide antibiotics. The official label documents that this inhibition of clearance and/or absorption-transport increases the risk of toxicity.

Conversely, Enzyme Inducers such as Rifampicin and Phenytoin accelerate the drug's hepatic breakdown, leading to a documented lowering of the Digitoxin serum concentration.

Pharmacodynamic and Timing Constraints

  • Electrolyte-Influencing Agents (e.g., Kaliuretic Diuretics, Corticosteroids) are officially documented to intensify glycoside toxicity by inducing hypokalemia or hypomagnesemia, requiring careful management.
  • The co-administration of Intravenous Calcium Salts is formally contraindicated due to the documented potential for severe reinforcement of cardiac toxicity.
  • Binding Agents (e.g., Cholestyramine, Activated Charcoal) are documented to decrease Digitoxin absorption and must be separated: Digitoxin intake is required to occur at least two hours prior to the binding agent administration.

Population-Specific Notes

Regulatory cautions note that the potential for interaction-related severity is higher in the elderly due to age-related decline in renal clearance, which impacts overall drug elimination. The drug requirement may also be officially reduced in cases of coexisting severe hepatic and renal impairment.

Mechanism of Action

Targeting Na^+/ K^+-ATPase

This domain centers on the sodium-potassium adenosine triphosphatase ( Na^+/ K^+-ATPase) enzyme. By inhibiting this enzyme, Дигофтон interrupts the normal electrochemical gradient across the cell membrane, which drives an intracellular accumulation of sodium ions ( Na^+).


Regulation of Na^+/ Ca^2+ Exchanger and Ca^2+ Flux

The resulting increase in intracellular Na^+ concentration affects the function and equilibrium of the Na^+/ Ca^2+ exchanger (NCX). This leads to a reduced outward flux of calcium ions ( Ca^2+) and a subsequent elevation of intracellular Ca^2+ concentration, thereby increasing calcium availability.


Consequence on Myocardial Contractile Process

This elevated intracellular Ca^2+ directly influences the contractile machinery by increasing calcium binding to troponin. This molecular change affects the excitation-contraction coupling process, resulting in a modification of the force and velocity of myocardial contraction.

Dosage and Administration Information

The official use of Дигофтон, a cardiac glycoside, is structured as a two-phase protocol to safely establish and sustain the therapeutic effect. The medicine is approved for administration by two primary routes: oral (tablets and solutions) for long-term use, and intravenous (IV) injection, which is generally reserved for situations requiring rapid effects or when oral administration is impractical, often requiring a supervised setting.

The dosing regimen is highly individualized and is divided into an initial Loading Dose (Digitalization) followed by a Maintenance Dose that is continued long-term. The Loading Dose is calculated and administered in divided portions over 24 to 48 hours to quickly achieve the required drug level. This is then transitioned to the Maintenance Dose, which is typically taken once daily to replace the amount of drug eliminated from the body. Oral doses should be taken consistently at the same time each day, without dependence on meals.

Dosing is adjusted based on individual physiological factors. Doses require careful reduction in older adults and in patients whose kidney function is reduced, as this affects how the drug is cleared from the body. Furthermore, to guide the initial loading and long-term maintenance, Therapeutic Drug Monitoring (TDM) is employed. This involves laboratory checks of drug serum concentrations (trough levels) to verify that the administered dose is both effective and appropriate for the patient's individual clearance rate. The IV formulation must be administered slowly, usually over at least five minutes, and may require dilution before use.

Recent Clinical Evidence

Evidence for Use in Chronic Heart Failure

Research for Дигофтон (Digitoxin) has primarily focused on large-scale Randomized Controlled Trials (RCTs) in adults with heart failure with reduced ejection fraction (HFrEF). These studies explored outcomes related to major events, including hospitalization and all-cause death. Research observed patterns related to hospitalization for heart failure in the Digitoxin group compared to the control group. However, when researchers examined the outcome of all-cause death alone, the data did not provide sufficient statistical certainty to establish a clear pattern of difference. The largest dedicated trial also experienced lower enrollment than planned, impacting findings for some secondary outcomes.

Evidence for Rate Control in Chronic Atrial Fibrillation

Digitoxin was studied for rate management in chronic Atrial Fibrillation (AF) using randomized comparative trials against other rate control agents. Research examined outcomes related to physical discomfort and functional status. Trials reported that Digitoxin and comparator agents were able to reach similar heart rate values. Evidence remains limited regarding long-term outcomes for AF, as there is a lack of large-scale RCTs specifically for outcomes like stroke prevention in AF alone.

Long-Term Research and Study Duration

The research includes studies with intermediate to long-term follow-up, typically around three years. This follow-up duration monitored changes in hospitalization frequency and mortality. However, long-term effects are not fully established beyond these observation periods, meaning there is limited information for outcomes that exceed the duration of the largest trials.

Evidence in Specific Patient Groups & Uncertainties

Research has explored Digitoxin in patient cohorts, including older adults and those with different severity strata of heart failure. However, data for certain groups remain insufficient. For example, certainty remains low regarding the patterns observed in patients with severe kidney impairment. Findings in observational studies have been mixed, highlighting that evidence quality varies and that research provides context about group patterns but not individual predictions.

Key Studies & References Digitoxin in Patients with Heart Failure and Reduced Ejection Fraction (The DIGIT-HF Trial)

Frequently Asked Questions (FAQ)

Common questions about Дигофтон (FAQ)


Q: What is the main difference between Дигофтон and similar medicines?

Regulatory documents describe Digitoxin (the active ingredient in Дигофтон) as having a distinctive and long half-life, which is approximately seven to eight days. This sustained presence in the body is a key differentiating characteristic compared to other cardiac glycosides. Additionally, official sources note that Digitoxin's primary elimination route is hepatic metabolism (processed by the liver), unlike other similar medicines which are mainly cleared by the kidneys.


Q: Is Дигофтон used for other conditions besides the main ones listed?

Official product information is limited to approved indications, such as supporting heart function in Heart Failure and managing heart rate in conditions like Atrial Fibrillation. According to regulatory labels, the medicine is not indicated for the treatment of any other conditions.


Q: How quickly does Дигофтон start working?

The initial administration involves a Loading Dose (or Digitalization) phase, which is administered over 24 to 48 hours. This process is designed to bring drug levels into the therapeutic range. The full stabilization of the medication's benefit is often part of the subsequent long-term maintenance phase.


Q: Can Дигофтон cause weight gain or weight loss?

Official regulatory documents for cardiac glycosides mention that side effects can include unusual weight gain or swelling. This symptom is noted on the label because it may be associated with underlying health changes. Weight loss is not commonly cited in regulatory safety information.


Q: Is it normal to feel tired after starting Дигофтон?

Official information lists drowsiness and extreme fatigue as potential effects. Furthermore, regulatory texts note that non-specific symptoms of toxicity, which may include tiredness, can sometimes be mistaken for symptoms of the patient's underlying heart condition.


Q: Are there any foods or drinks I should avoid while using Дигофтон?

Due to the drug's mechanism, regulatory guidance often stresses that maintaining proper electrolyte balance, particularly potassium, is important for the underlying heart condition being treated. Binding agents, which can include certain high-fiber foods, are officially documented to decrease the medicine’s absorption and may need to be managed with timing constraints.


Q: Can Дигофтон affect my sleep?

Official regulatory texts for this class of medicine list central nervous system (CNS) effects as potential adverse reactions. These effects can sometimes include psychiatric disturbances like insomnia (difficulty sleeping) or general nervousness, particularly if drug levels are elevated or potentially toxic.


Q: Can Дигофтон be used during pregnancy or while breastfeeding?

Official documentation states that use during pregnancy is conditional; it should only be considered when the clinical benefit to the patient is judged to clearly outweigh any possible risks. For breastfeeding, the medicine is described as passing into the milk in small amounts. Official documents note that this is not typically expected to result in adverse effects in the infant, but individual decisions require professional judgment.


Q: Does alcohol change the effect of Дигофтон?

Patient counseling information for related cardiac glycosides advises that alcohol may intensify effects such as drowsiness or dizziness caused by the medication. Regulatory information notes that alcohol consumption should be discussed professionally due to this potential additive effect.


Q: Are there any known interactions between Дигофтон and herbal supplements?

While specific herbal supplements are not always individually listed in regulatory documents, official warnings exist for all substances that affect heart rhythm, potassium levels, or the drug’s metabolism. Certain herbal products can fall into these categories, potentially altering the drug's effect or increasing the risk of toxicity.


Q: Is there a generic version of Дигофтон available?

Official documents identify the active substance in this medication as Digitoxin. Regulatory bodies list multiple approved manufacturers and forms of the active ingredient, indicating that generic versions of Digitoxin are available. However, the specific product name 'Дигофтон' may be a brand name.


Q: What is a 'contraindication' for Дигофтон?

A contraindication is a documented condition or factor that absolutely forbids the use of a medicine because regulatory sources indicate it would cause harm or high risk. For Дигофтон, official labels list specific contraindications, such as the presence of pre-existing ventricular fibrillation.


Q: How does Дигофтон relate to lifestyle changes for the condition it treats?

Regulatory guidance confirms the medication is used as part of a comprehensive management strategy. This strategy often involves addressing the underlying heart condition through measures like diet and weight management, as advised by health professionals.


Q: Can Дигофтон affect my ability to drive or operate machinery?

Official information advises that the medication may cause side effects such as dizziness or drowsiness. Official information indicates that if these effects occur, activities like driving or operating machinery should be avoided until the patient's individual response to the medication is understood.


Q: Can I take Дигофтон if I have a chronic stomach condition?

The drug's official safety profile includes common Gastrointestinal Disorders such as nausea and vomiting. If a patient has a pre-existing chronic stomach condition, careful monitoring is indicated, as the drug's side effects can sometimes complicate or overlap with the symptoms of the existing condition.


Q: Can Дигофтон cause mood changes or depression?

Regulatory texts for cardiac glycosides sometimes list central nervous system effects including confusion, nervousness, and in rare instances, psychiatric disturbances. These potential adverse reactions are generally observed when drug levels are elevated or potentially toxic.


Q: How soon after starting Дигофтон will my doctor assess the results?

Monitoring for the drug begins during the initial 24 to 48 hour Loading Dose period. Official protocols mandate that Therapeutic Drug Monitoring (TDM)—involving laboratory blood checks—be performed to confirm drug levels and guide the transition to the long-term maintenance dose.


Q: What are the ingredients in Дигофтон besides the main active substance?

Official regulatory labels detail both the active ingredient (Digitoxin) and the inactive ingredients (excipients) used in the formulation. Common inactive components listed include substances like cellulose, starch, magnesium stearate, and lactose.


Q: Is Дигофтон gluten-free or lactose-free?

Official composition information indicates that the oral tablet formulation of the medicine often contains lactose (or anhydrous lactose) as an inactive ingredient. Regulatory warnings indicate that due to the presence of lactose, the product should be avoided by patients with rare hereditary problems, such as Lapp lactase deficiency or galactose intolerance.

How should Дигофтон be stored and disposed of?

Storage and Disposal Requirements for Digoxin (Дигофтон)

Official regulatory documents define strict conditions for the storage and disposal of Digoxin to maintain product stability and ensure public safety.

Condition Type Required Standard
Temperature Controlled Room Temperature (20 C to 25 C).
Protection Store protected from light and moisture.
Packaging Keep in the original container; liquid solution must be kept tightly closed.
Safety Must be stored out of the sight and reach of children.

For disposal, unused or expired Digoxin is considered a high risk for accidental poisoning. The preferred method is through a drug take-back program. If this is not immediately available, official guidance recommends disposal by flushing down the toilet or sink, due to the critical risk of fatal harm from accidental ingestion.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

Available in countries:

Equivalent of Дигофтон found in:

A-Z Index: