Diclocin

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Diclocin

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Diclocin

Property Description
Active Ingredients Diclofenac, Paracetamol (Acetaminophen)
Form Tablet (Oral), Solution for injection (Parenteral)
Pharmacological Class NSAID / Analgesic Combination
Common Purpose Short-term relief of pain, inflammation, and fever
Origin Synthetic (Chemically manufactured)

What is Diclocin and What is its Composition?

Diclocin is defined as a fixed-dose combination pharmaceutical preparation, distinguished by the simultaneous inclusion of two distinct synthetic active chemical substances: Diclofenac and Paracetamol (Acetaminophen). As a combination product, it is positioned to manage conditions where both pain and inflammation are present. This medicine is typically supplied for oral administration in the form of a tablet, although an aqueous solution for injection may also be available. The primary ingredients, Diclofenac (a phenylacetic acid derivative) and Paracetamol, define the composition, which is structurally different from single-active-ingredient analgesics.


Diclocin's Pharmacological Class and Type

Diclocin is categorized as a dual-action agent, combining a Non-steroidal Anti-inflammatory Drug (NSAID) with an Analgesic/Antipyretic agent. The Diclofenac component belongs to the NSAID class, which acts against inflammation by restricting the production of prostaglandins. Within this combination, Diclofenac functions as a peripheral anti-inflammatory agent. The Paracetamol component provides complementary antipyretic (fever-reducing) and central pain-relieving effects. This classification defines its core function and positions Diclocin as an agent for combined symptomatic management.


What is the General Therapeutic Purpose of the Combination?

The general therapeutic purpose of this fixed-dose combination is to provide comprehensive, short-term relief from discomfort that involves a mix of pain, inflammation, and fever simultaneously, such as following an acute strain or minor injury. The strategy of combining an anti-inflammatory like Diclofenac with an analgesic like Paracetamol offers an integrated approach. The dual mechanism restricts the production of chemical messengers responsible for inflammation and simultaneously elevates the central pain threshold, thereby optimizing the management of complex symptomatic states.

Regulatory References

  1. WHO Essential Medicines List

What side effects are possible with Diclocin?

Possible Side Effects and Safety Information

Diclocin (diclofenac) is a non-steroidal anti-inflammatory drug (NSAID) and is associated with serious, potentially life-threatening risks, as documented by governmental regulatory agencies.

Serious Adverse Reactions (Boxed Warnings)

  • Cardiovascular Thrombotic Events: Use of Diclocin may increase the risk of serious cardiovascular (CV) thrombotic events, including myocardial infarction (heart attack) and stroke, which can be fatal. This risk may increase with the duration of use and in patients with pre-existing heart disease or CV risk factors. It is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.
  • Gastrointestinal (GI) Events: NSAIDs cause an increased risk of serious GI adverse events, including inflammation, bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur without warning, and the risk is higher in elderly patients.

Common Adverse Reactions

Commonly reported side effects (occurring in greater than 2% of users) typically involve the gastrointestinal and nervous systems. These include abdominal pain, nausea, dyspepsia, diarrhea, flatulence, headache, and dizziness.

Safety Restrictions and Other Serious Risks

System-Organ Class Serious Risk / Restriction
Hepatobiliary Hepatotoxicity (liver damage), sometimes fatal; elevated liver enzymes.
Renal/Urogenital Renal toxicity, including acute renal failure and papillary necrosis. Avoid use in patients with advanced renal disease.
Immune/Skin Severe, sometimes fatal, anaphylactic reactions; serious skin reactions like Stevens-Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), and DRESS.
Contraindications Known hypersensitivity to Diclocin or other NSAIDs/aspirin (history of asthma, urticaria, or allergic-type reactions); established congestive heart failure (NYHA class II-IV), ischemic heart disease, peripheral arterial disease, or cerebrovascular disease.

Diclocin should be used at the lowest effective dose for the shortest duration possible to minimize potential risks, which are often dose- and duration-dependent. Use in pregnancy is generally avoided from about 30 weeks gestation due to the risk of premature closure of the fetal ductus arteriosus.

Overdose and Emergency Response

Overdose and When to Seek Help

Overdose Symptoms

The most common symptoms of a Diclocin (diclofenac) overdose involve the gastrointestinal system and may include nausea, vomiting, stomach pain, and gastrointestinal bleeding. Less frequently, more severe overdose may lead to central nervous system effects such as drowsiness, seizures, confusion, or coma. Other serious effects can include acute renal failure or respiratory depression.

Emergency Actions

Management of a Diclocin overdose consists primarily of symptomatic and supportive care. There is no specific antidote for diclofenac overdose. For symptomatic patients, or following the ingestion of a large amount (e.g., 5 to 10 times the usual dose), actions like administering activated charcoal and/or an osmotic cathartic may be indicated if the patient is seen within approximately four hours of ingestion. Procedures like forced diuresis or hemodialysis are generally not considered useful due to the drug’s high protein binding.

When to Seek Immediate Medical Help

Seek emergency medical help right away if you or someone you are with has an overdose. Immediate medical attention is also required if a person experiences symptoms of a serious cardiovascular event (e.g., chest pain, shortness of breath, weakness, or slurred speech) or signs of serious liver injury (e.g., jaundice, right upper quadrant tenderness, flu-like symptoms). Contact a Poison Control Center immediately for specific treatment guidance and instructions.

Therapeutic Uses of Diclocin

What Diclocin Treats: Main Uses and Benefits

Diclocin is used in situations involving symptoms related to physical discomfort and is applied across domains where additional symptomatic support is needed. It is commonly used when short-term symptomatic assistance is needed to manage acute or disruptive symptom patterns. This combination is indicated for the management of symptoms including inflammation, fever, headache, arthritis, and dysmenorrhea.


The combination is relevant in conditions involving inflammatory or irritative processes, such as musculoskeletal injuries like sprains and strains, and acute flare-ups of chronic conditions including osteoarthritis and rheumatoid arthritis. It is also applied in managing temporary, intense discomforts, including dental pain and certain types of headache.

“The medication helps ease the overall symptom burden, providing support during difficult episodes.”

This application provides support that helps ease the overall symptom burden, and may assist with maintaining comfort when symptoms momentarily interfere with routine activities. It is frequently applied when symptoms become noticeable in acute, self-limiting discomforts or in conditions involving recurrent or episodic manifestations like menstrual cramps.

Quick Fact: Relief for Acute Pain and Inflammation
The combination is commonly used for managing conditions that require simultaneous support for both pain and fever/inflammation in adults, and is applied when short-term symptomatic assistance is needed.

Eligibility and Restrictions for Use

Diclocin (Diclofenac/Paracetamol combination) eligibility is strictly defined by regulatory authorities based on contraindications and patient risk profile.


Contraindicated Populations

Use of Diclocin is prohibited for patients with the following official exclusions:

  • Hypersensitivity: Known allergy to Diclofenac, Paracetamol, aspirin, or any other NSAID.
  • GI Disease: Active gastrointestinal ulceration, bleeding, or perforation.
  • Severe Organ Dysfunction: Severe hepatic (liver) or severe renal (kidney) insufficiency.
  • Cardiovascular Disease: Established congestive heart failure (NYHA class II–IV), ischaemic heart disease, peripheral arterial disease, or cerebrovascular disease.
  • Surgical Setting: In the setting of coronary artery bypass graft (CABG) surgery.

Age and Reproductive Status

Population Eligibility Status (Regulatory Basis)
Pediatric Patients Not Recommended/Contraindicated generally under 15 years of age.
Late Pregnancy Contraindicated in the second and third trimesters.
Lactation Contraindicated during breastfeeding.

Restricted Use

Caution and close surveillance are mandated for older adults, patients with a history of GI disorders (e.g., ulcerative colitis), or those with cardiovascular risk factors (e.g., hypertension) where use must be limited to the shortest duration and lowest effective dose.

What should I know about interactions with other medicines?

Diclocin (Diclofenac) may interact with numerous other medications, increasing the risk of adverse effects, particularly those related to the gastrointestinal tract and kidneys. Patients should inform their healthcare provider of all prescription and non-prescription drugs, vitamins, and herbal supplements they are taking.


Other NSAIDs and Aspirin

Do not take Diclocin with other Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), such as ibuprofen or naproxen, or with aspirin (unless a low dose is specifically prescribed by a doctor for cardiovascular protection). Combining Diclocin with these medicines significantly increases the risk of serious gastrointestinal problems like bleeding, ulcers, and perforation.

Anticoagulants and Antiplatelet Drugs

Using Diclocin with blood thinners (anticoagulants like warfarin, or antiplatelet drugs like clopidogrel) increases the risk of major bleeding events. Close monitoring and dose adjustment by a healthcare provider are essential if this combination is unavoidable.

Other Significant Interactions

Medicine Class Examples Potential Interaction Result
Antihypertensives ACE inhibitors (e.g., lisinopril), ARBs (e.g., losartan), Diuretics (e.g., furosemide) May reduce the effectiveness of blood pressure medicines and increase the risk of kidney damage or heart failure.
SSRIs/SNRIs Selective Serotonin Reuptake Inhibitors, Serotonin-Norepinephrine Reuptake Inhibitors Increased risk of gastrointestinal bleeding.
Corticosteroids Prednisone, Dexamethasone Increased risk of gastrointestinal ulcers and bleeding.
Lithium Medication for bipolar disorder May increase lithium levels, leading to toxicity.
Methotrexate Used for cancer and inflammatory diseases May increase the concentration and toxicity of methotrexate.

Alcohol and Tobacco

Avoid consuming alcohol and using tobacco while taking Diclocin, as both can significantly increase the risk of serious gastrointestinal bleeding and ulceration.

Mechanism of Action

How Diclocin Works at the Biological Level

Dual Inhibition of Prostaglandin Synthesis

This mechanism involves the non-selective competitive inhibition of Cyclooxygenase (COX) enzymes by Diclofenac and the central inhibition of COX by Paracetamol. Diclofenac targets both COX-1 and COX-2 peripherally, blocking the conversion of arachidonic acid into prostanoids, specifically prostaglandin E2 ( PGE2). This primary molecular action results in diminished local vascular permeability and reduced sensitization of peripheral nociceptors at the site of tissue response.

Modulation of Central Nociceptive and Thermoregulatory Pathways

Paracetamol's distinct action occurs predominantly within the Central Nervous System (CNS). It modulates key pain processing centers and may engage the descending serotonergic pathway. The central reduction of PGE2 results in an elevation of the body's pain threshold and the alteration of the hypothalamic set point for thermoregulation. The combined action provides concurrent modulation of both peripheral inflammatory mediators and central nociceptive signaling through two complementary mechanisms.

Dosage and Administration Information

How Diclocin is Used: Administration Guidelines

Diclocin, a fixed-dose combination (FDC) containing Diclofenac and Paracetamol, is administered via the oral route using the tablet form. General clinical guidelines suggest that the medication should be utilized for the shortest duration necessary to control symptoms, consistent with its primary purpose for short-term symptomatic relief.


Standard Dosage and Frequency

The standard adult dose is generally one tablet (typically 50 mg Diclofenac / 500 mg Paracetamol). Administration is typically scheduled in divided doses, commonly two to three times daily. The total intake must never exceed three tablets in a 24-hour period, which corresponds to a maximum of 150 mg of Diclofenac and 1500 mg of Paracetamol via the FDC. This limit is set to mitigate the risk of Paracetamol overdose.


Administration Conditions and Population Rules

For proper administration, the tablet should be swallowed whole with a drink and is preferably taken with or after food to mitigate potential gastrointestinal irritation. The tablet must not be crushed, broken, or chewed. Standard practice involves avoiding any other medical product containing Paracetamol simultaneously while using this combination. Regarding specific populations, the dosage for older adults is typically reduced compared to the standard adult regimen, and the FDC is not indicated for children. Furthermore, for individuals with impaired hepatic function, the daily Paracetamol dose may be restricted to a maximum of 2 grams, highlighting the role of dose management in organ impairment.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Diclocin

Evidence for Use in Acute Post-Operative Pain

Research exploring the combination of Diclofenac and Paracetamol has been heavily focused on studies evaluating acute pain that follows surgical procedures. Studies were conducted during periods of increased symptom activity, primarily utilizing short-term Randomized Controlled Trials (RCTs) and Meta-analyses of these trials. This research examined outcomes related to physical discomfort in adults who had undergone procedures such as dental extractions and cesarean sections. The evidence base for this area is broadly described as having a High evidence level.

Comparison to Single-Agent Pain Relievers

This sub-section details research where the fixed combination was specifically evaluated against its two individual components, Diclofenac alone or Paracetamol alone. The studies monitored the same key outcomes related to physical discomfort, monitoring measured severity of physical discomfort over defined, short time intervals. Research describes how the combination was studied when compared to the individual substances.


Evidence for Use in Acute Inflammatory Pain

Research has explored whether the combination was relevant for conditions involving inflammatory or irritative states, such as symptoms associated with musculoskeletal injuries or acute flare-ups of chronic conditions like arthritis. The studies explored here were predominantly Short-term RCTs with follow-up durations typically ranging from 3 to 7 days. Studies monitored outcomes reflecting daily functioning or activity level and examined patient-reported outcomes describing perceived discomfort. Findings indicated mixed data patterns across the diverse group of inflammatory conditions studied. The research base in this area is broadly described as having a Moderate evidence level.


What Remains Uncertain in the Research Landscape

Comparative evidence is lacking to distinguish the fixed-dose combination from the simultaneous, separate administration of Diclofenac and Paracetamol. Furthermore, evidence quality varies across studies, and the results apply only to the populations studied. There is limited information for long-term outcomes related to the sustained use of the combination, as research is primarily focused on short-term symptom patterns.

Frequently Asked Questions (FAQ)

Common questions about Diclocin (FAQ)

Q: Why is Diclocin prescribed for skin infections?

A: Official information indicates that Diclocin is prescribed for the short-term relief of pain, inflammation, and fever. While it does not treat the underlying bacterial cause of an infection, it can be used to manage the associated symptoms, such as the swelling and discomfort that occur with inflammatory conditions or certain tissue responses.

Q: Is it true that Diclocin can cause stomach upset?

A: Yes, common side effects often affect the digestive system. Regulatory documents list gastrointestinal issues like abdominal pain, nausea, dyspepsia (indigestion), and diarrhea as frequently reported issues. This is why official guidelines often suggest taking the medication with or after food.

Q: Can taking Diclocin make you feel tired or drowsy?

A: According to official product information, side effects affecting the nervous system, such as drowsiness, dizziness, and fatigue, have been reported. Because effects like drowsiness or dizziness have been reported, official guidance suggests users be aware of how the medication affects them before undertaking tasks like driving or operating machinery.

Q: What happens if you miss a dose of Diclocin?

A: Regulatory patient information generally states that a missed dose may be taken when remembered, unless it is almost time for the next scheduled dose. If so, the missed dose should be skipped to avoid taking too much medication, and the regular schedule should be continued. It is important to never double the dose to make up for one that was forgotten.

Q: Does Diclocin cause issues with birth control pills?

A: The Paracetamol component of Diclocin is generally considered to have no significant interaction risk with oral contraceptives (birth control pills) when taken at the usual therapeutic doses. However, information regarding any potential interaction with the Diclofenac component should be reviewed with a healthcare professional.

Q: Can Diclocin be used to treat dental abscesses?

A: Diclocin is officially indicated for the short-term relief of pain and inflammation. While it is commonly used to manage the pain and swelling associated with dental conditions, it is important to note that, as an anti-inflammatory, it does not treat the underlying bacterial infection that causes an abscess.

Q: Are there any long-term side effects associated with Diclocin use?

A: Official regulatory guidance emphasizes that Diclocin should be used for the shortest duration possible. This is intended to minimize the risk of serious side effects, such as cardiovascular (heart attack, stroke) and gastrointestinal (bleeding, ulceration) adverse events, which may increase with prolonged use.

Q: Is it normal to experience mild diarrhea when first starting Diclocin?

A: Diarrhea is listed in official documents as one of the common side effects associated with this medication, meaning it is a frequently reported experience, especially when first starting the drug.

Q: Can Diclocin make you more sensitive to the sun?

A: Some reports have associated the Diclofenac component with photosensitivity reactions, which is an increased sensitivity to sunlight. Due to reports of photosensitivity, guidance suggests users consider precautions such as limiting excessive sun exposure or using protective clothing.

Q: Are there any studies or research papers proving Diclocin's effectiveness?

A: Yes, regulatory approvals are based on data from clinical trials. Official documents reference the clinical trials and Randomized Controlled Trials (RCTs) that were conducted to establish the efficacy and safety of the fixed-dose combination in managing pain and inflammation.

Q: Does Diclocin have any impact on blood sugar levels?

A: While it is not a primary effect, official adverse reaction reports indicate that changes in blood sugar, specifically high blood sugar (hyperglycemia), have been listed as rare or uncommon reactions associated with the Diclofenac component.

Q: Do any common cold or flu medicines interact with Diclocin?

A: Yes, many common cold and flu relief products contain Paracetamol (Acetaminophen). Regulatory warnings emphasize that using Diclocin with any other product containing Paracetamol is contraindicated because this combination significantly increases the risk of exceeding the safe daily limit for Paracetamol.

Q: Is Diclocin used for conditions other than bacterial infections?

A: Yes, Diclocin is classified as a pain reliever and anti-inflammatory agent. Its therapeutic purpose is to manage symptoms like pain, swelling, and fever. It is not indicated to treat bacterial infections or any infectious cause.

Q: Can Diclocin cause changes in mood or anxiety?

A: Official adverse reaction reports include nervous system effects that extend to psychological symptoms. Less common effects reported include feelings of anxiety, depression, nervousness, and confusion.

Q: Why is it important to finish the full course of Diclocin?

A: Diclocin is prescribed for short-term, acute relief. The duration of use is determined to ensure effective management of pain and inflammation and prevent a rapid return of symptoms. It is generally advised to follow the duration specified by the prescriber.

Q: Is it possible to take Diclocin if you are allergic to penicillin?

A: Yes, Diclocin is chemically different from penicillin. Regulatory contraindications only prohibit its use for known allergies to Diclofenac, Paracetamol, aspirin, or other NSAIDs (Non-Steroidal Anti-Inflammatory Drugs).

Q: Can people with a history of C. difficile colitis take Diclocin?

A: Official warnings mandate that the drug must be used with extreme caution in patients with a history of gastrointestinal disorders. Due to the high risk of serious gastrointestinal side effects (like bleeding and perforation), a healthcare professional must determine if the potential benefits outweigh the risks prior to use.

Q: Is it okay to take antacids close to the time of taking Diclocin?

A: Some antacids have the potential to change the rate at which the Diclofenac component is absorbed, which could delay or reduce its initial effectiveness. Consultation with a healthcare professional is recommended to determine the optimal timing of doses if you regularly take antacids.

Q: Can a person develop a resistance to Diclocin over time?

A: The term 'resistance' primarily applies to antibiotics, but Diclocin is an anti-inflammatory and pain reliever. The concern is not about resistance, but about the increased risk of serious side effects (like cardiovascular or GI events) associated with long-term or continued use, which is why it is prescribed for short-term relief only.

Q: Does Diclocin come in a liquid suspension form?

A: The fixed-dose combination product Diclocin is typically approved and supplied as an oral tablet. While solutions for injection may exist, the availability of a specific liquid suspension for oral use depends entirely on the formulation approved by your local regulatory agency.

How should Diclocin be stored and disposed of?

Storage and Disposal Requirements

Diclocin (Diclofenac and Paracetamol tablets) must be stored at room temperature, which regulatory agencies define as below 25 C (77 F). To maintain the product's stability, the tablets must be protected from both light and moisture and kept in their original, tightly closed container.


Official Constraints

Storage Component Requirement
Temperature Store below 25 C (Do not exceed 77 F).
Protection Keep protected from light and moisture.
Child Safety Must be kept out of the reach and sight of children.

For disposal, the medicine should be returned using a drug take-back program or mail-back envelope. If no program is available, mix the tablets with an undesirable substance (like coffee grounds or dirt) and seal the mixture in a container before discarding it in the household trash. Do not flush the medication unless specifically instructed by the label. Always scratch out personal information on the label before disposal.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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