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Делагил

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Делагил

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

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Overview of Делагил

Quick Facts

Property Description
Active Ingredient Chloroquine (as Phosphate)
Form Tablets (for oral use)
Pharmacological Class Antiprotozoal / Antimalarial (4-Aminoquinoline)
General Purpose Combating parasitic infection and reducing inflammation
Origin Synthetic Compound

What is Delagil: Definition and Composition

Delagil is a synthetic medicinal product containing the active ingredient Chloroquine, supplied as Chloroquine phosphate. This drug is a 4-aminoquinoline derivative, defining its chemical structure and synthetic origin. As a single-ingredient product, or monotherapy, Delagil's function is attributed solely to Chloroquine, which is an established International Nonproprietary Name (INN) for this compound and is listed on the World Health Organization's (WHO) Model List of Essential Medicines.

Pharmacological Class and General Purpose

Delagil primarily belongs to the pharmacological class of antiprotozoal and antimalarial agents, specifically within the Aminoquinolines subgroup (ATC Code P01BA01). Its core utility is in combating parasitic infections by disrupting key metabolic processes within the targeted single-celled organisms, such as those that cause malaria. Beyond its established antiparasitic role, Chloroquine is also clinically recognized for its immunosuppressive and anti-inflammatory actions, which provides the general benefit of helping to manage conditions involving overactive immune responses and chronic systemic inflammation.

Dosage Form: Oral Tablets

Delagil is supplied in the solid pharmaceutical form of tablets, intended for oral administration, ensuring a systemic effect. This traditional, non-flavored route allows the active ingredient, Chloroquine, to be consistently absorbed through the gastrointestinal tract and distributed throughout the body. The tablet form provides a stable and predictable mechanism for the ingestion of the required dose of the active substance.

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What side effects are possible with Делагил?

Possible Side Effects and Safety Information

Делагил (chloroquine phosphate) is generally well-tolerated at recommended dosages, particularly for short-term use. However, like all medications, it can cause side effects. Patients should be aware of both common and rare, potentially serious adverse reactions.

Common Side Effects (typically mild and often resolved by taking the medicine with food or milk):

  • Gastrointestinal disturbances, including nausea, vomiting, diarrhea, and stomach cramps.
  • Headache.
  • Skin reactions, such as itching (pruritus) and skin rash.

Serious Adverse Reactions (require immediate medical attention):

System Side Effect
Ocular (Eye) Retinal toxicity (retinopathy), which can be irreversible and lead to permanent vision loss, especially with long-term use or high doses. Symptoms include blurred vision, difficulty reading, or changes in color vision. Regular eye exams are crucial.
Cardiovascular Heart rhythm changes (e.g., QT interval prolongation), which can lead to life-threatening conditions like ventricular arrhythmias. Symptoms include a fast or irregular heartbeat, fainting, or severe dizziness.
Neurological/Psychiatric Seizures, acute extrapyramidal disorders (involuntary movements), or psychiatric symptoms such as mood changes, anxiety, or suicidal thoughts.
Hematologic Rare but serious blood disorders, including aplastic anemia or agranulocytosis.
Metabolic Severe hypoglycemia (low blood sugar), which may present as sweating, shakiness, confusion, or rapid heartbeat.

Precautions:

Chloroquine should be used with caution, or may be contraindicated, in patients with pre-existing retinal or visual field changes, certain cardiac conditions, liver or kidney impairment, or psoriasis. An overdose is extremely dangerous and can be fatal; the medication must be kept strictly out of the reach of children.

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Overdose and Emergency Response

Overdose Scope

Property Description
Documented overdose presentations: Neurological symptoms include headache, drowsiness, and convulsions. Severe systemic signs include hypotension, visual disturbances, and documented QRS/QT prolongation on an ECG.
Physiological systems affected: Cardiovascular system, Central Nervous System (CNS), Respiratory system, and Metabolic (electrolyte/glucose) balance.
Dose-related or exposure-related factors: Symptoms can manifest rapidly, often within 30 minutes of acute ingestion.
Population-specific overdose notes: Accidental ingestion of one or two tablets has resulted in fatalities in children, indicating a profound severity risk in the pediatric population.
Emergency-response statements: Treatment must be prompt and is symptomatic and supportive. Required procedural steps include immediate gastric lavage and the administration of activated charcoal.
When immediate medical help is required: Immediate medical attention must be sought upon any suspected overdose due to the rapid onset and risk of sudden and early respiratory or cardiac arrest.

Overdose Classifications (High-Level)

Property Description
Severity classification: Potentially life-threatening and associated with fatal outcomes (cardiac arrest and respiratory arrest).
Regulatory basis: Based on official warnings and prescribing information from major government regulatory bodies.
Overdose-context constraints: No specific antidote is known; management relies solely on officially described supportive measures and monitoring.

Resulting Overdose Structure

Official overdose statements:

  • Severe outcomes officially documented include sudden and early respiratory arrest, cardiac arrest, ventricular arrhythmias, and fatal cardiomyopathy.
  • Neurological manifestations such as convulsions and coma, and ECG changes are critical, regulator-listed signs of severe toxicity.
  • Immediate medical attention is required due to the rapid onset and life-threatening nature of the acute toxicity.
  • Continuous cardiac monitoring and close observation for at least six hours are required for stabilizing patients who survive the acute phase.

Connection to the overall overdose profile (2–4 sentences): Regulatory documents define the Delagil overdose profile by emphasizing the severe, rapid-onset risk to the cardiovascular and central nervous systems. This acute toxicity, characterized by documented symptoms like hypotension and QRS widening, dictates the regulatory mandate for prompt emergency response and intensive supportive care. The explicit absence of a known antidote confirms that management must strictly follow the procedural and monitoring steps outlined in the official prescribing information.

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Therapeutic Uses of Делагил

What Делагил Treats: Main Uses and Benefits

Delagil (Chloroquine) is applied across two distinct therapeutic domains, offering support for conditions involving parasitic infections and chronic inflammatory processes. Within these therapeutic domains, the medication is commonly used to help manage the symptoms associated with the acute episodes of malaria and may be part of prophylactic strategies. It is also relevant for easing symptoms in chronic conditions characterized by periods of heightened symptoms, such as Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA).

Symptom Management Focus

The medication supports the body in addressing the underlying cause of infection, which helps with easing the sudden, severe symptoms related to systemic imbalance like high fever and chills. In chronic conditions, it contributes to easing symptom clusters that may become intense or disruptive, helping with manifestations such as joint stiffness, swelling, and inflammatory skin lesions. The medication's role is commonly aligned with the intent to support the patient during difficult episodes by easing distress and helping to maintain functional stability. This supportive relief is applied when symptoms interfere with routine activities.


Quick Fact Block

Quick Fact: Support for Symptoms Related to Chronic Inflammation Quick Fact: May Assist with Symptoms Associated with Acute Infection
Domain: Chronic inflammatory conditions (RA, SLE) Domain: Protozoal infections (Malaria, Amebiasis)
Benefit: Helps manage disruptive symptoms and contributes to improved day-to-day comfort. Benefit: May assist with maintaining a sense of stability when acute symptoms are noticeable.
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Eligibility and Restrictions for Use

Who Can and Cannot Use Делагил? (Official Eligibility)

The eligibility for Delagil (Chloroquine) is strictly defined by regulatory documents based on patient conditions and age. Use is established for adults and children for malaria treatment and prophylaxis. However, specific conditions may prohibit or limit its use.

Absolute Non-Eligibility (Contraindications)

Condition
Hypersensitivity to Chloroquine or any 4-aminoquinoline compound.
Pre-existing retinal or visual field changes (unless for acute malaria).

Restricted and Conditional Use

Use is highly restricted and requires specific caution for patients with certain pre-existing conditions:

  • Cardiac Disease: Caution is mandatory in patients with pre-existing cardiac conditions, history of ventricular arrhythmias, or certain electrolyte imbalances (due to cardiotoxicity risk).
  • Organ Function Impairment: Patients with hepatic disease, alcoholism, or impaired renal function require caution due to slower drug clearance.
  • Metabolic/Skin Disorders: Caution is required for patients with G6PD deficiency, Porphyria, or Psoriasis, as the medicine may exacerbate these conditions.

Age and Physiological Limitations

  • Pediatric Use: While approved for malaria, the safety and efficacy for treating extraintestinal amebiasis are not established in children.
  • Pregnancy: Use is generally permitted for malaria when the clinical benefit outweighs the potential hazard.
  • Lactation: The medicine is compatible with breastfeeding, but the amount transferred is insufficient to protect the infant from malaria.
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What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory documents detail specific interactions for chloroquine, the active substance in Делагил, based on its pharmacokinetic properties and the potential for cardiotoxicity. The most critical interaction involves co-administration with other medications known to prolong the QT interval, which is generally discouraged due to the increased risk of severe ventricular arrhythmias and torsades de pointes.

Interactions can also affect the concentration of co-administered drugs. Chloroquine can increase the systemic exposure of cyclosporine and digoxin, requiring clinical monitoring for potential toxicity. Conversely, drugs that inhibit CYP450 enzymes, such as cimetidine, may increase chloroquine levels, while certain CYP450 inducers may decrease them.

Administration with specific classes of drugs requires caution. When used concurrently with insulin or other antidiabetic medications, close monitoring of blood glucose levels is necessary due to the documented risk of hypoglycemia. Practical restrictions also exist for absorption-related interactions; antacids, kaolin, and ampicillin require spaced administration to avoid reducing the bioavailability of chloroquine or ampicillin.

Interaction Type Practical Implication
QT-Prolonging Drugs Avoid co-administration due to additive risk of serious cardiac arrhythmias.
CYP450 Inhibitors Requires monitoring as they may increase chloroquine concentrations.
Antidiabetic Drugs Requires monitoring for potential hypoglycemia.
Antacids/Kaolin Administration must be separated by several hours to ensure adequate absorption.
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Mechanism of Action

The action of Делагил (Chloroquine) is defined by two primary, distinct mechanistic domains: targeted toxicity against the parasite and broad modulation of the human immune system.


Enzyme Inhibition and Cellular Toxicity in Parasites

This domain covers the drug's specific antiparasitic mechanism, where it becomes trapped in the parasite's acidic food vacuole. It functions as an inhibitor of Heme Polymerase and binds to toxic free heme. This molecular interference prevents the necessary detoxification process, causing the accumulation of highly destructive compounds that result in parasite cell lysis and the cessation of parasitic proliferation.


Immunomodulation via Intracellular pH Shift

This domain covers the drug's interaction with human immune cells, acting as a lysosomotropic agent to elevate the pH of internal acidic vesicles. This pH shift impairs the processing of antigens and their subsequent presentation via MHC Class II molecules, ultimately leading to a downregulation of CD4^+ T-cell activation. Furthermore, the drug acts as an inhibitor of Toll- like Receptor 9 ( TLR9), limiting the production of pro-inflammatory cytokines, which results in the dampening of inflammatory signaling within those pathways.

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Dosage and Administration Information

Official Administration Guidelines

Delagil (Chloroquine) is officially approved for oral administration as a tablet. The guidelines for its use are defined by standard clinical documentation, which often refer to the dose in terms of Chloroquine base equivalent, rather than the phosphate salt, to ensure dosing precision. The usage pattern is dependent on the therapeutic objective, requiring different administration schedules for prevention versus acute treatment.

For malaria prophylaxis (suppressive use), the standard regimen for adults is 300 mg of Chloroquine base taken once weekly on a consistent day. The administration must begin 1 to 2 weeks prior to entering the exposed area, continue throughout the stay, and must be maintained for four consecutive weeks after departure. If the initiation of prophylaxis is delayed, the official label provides a procedural instruction allowing for an initial adult loading dose of 600 mg base, administered in two divided doses six hours apart.

In scenarios requiring treatment for acute, uncomplicated malaria, the administration shifts to a rapid, 3-day course utilizing divided doses. The entire dose course follows an initial loading dose of 600 mg base, followed by specific subsequent doses over the next 48 hours.

Administration should occur with food to assist with tolerance. A critical contextual instruction is the requirement to separate Chloroquine intake from antacids or Kaolin by at least four hours, as these agents can interfere with proper absorption. For pediatric patients, the dose is calculated based on body weight, using a 5 mg base per kilogram rule for weekly suppression, without exceeding the adult maximum.

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Recent Clinical Evidence

Research Evidence / Overview of Studies for Делагил

1. Evidence Overview for Systemic Lupus Erythematosus (SLE)

Research exploring the use of this substance in Systemic Lupus Erythematosus (SLE), a condition characterized by fluctuating or episodic manifestations, was conducted using both Randomized Controlled Trials (RCTs) and large-scale long-term observational cohort studies. Researchers monitored key outcomes related to systemic or functional imbalance, specifically looking at changes in disease activity scores (e.g., SLEDAI) and the rate of flare-ups or episodic changes. The studies also explored long-term concerns by tracking the accumulation of organ damage over many years. The populations included adults with an established diagnosis of SLE.

Studies reported patterns observed in the measured outcomes, with findings indicating that consistent patterns suggesting a lower frequency of heightened symptom activity were described across various populations. Furthermore, evidence describes how symptoms evolved in the observed populations, and patterns related to the long-term accumulation of organ damage were described as less extensive in certain cohorts.

2. Evidence Overview for Rheumatoid Arthritis (RA)

Research for Rheumatoid Arthritis (RA) was evaluated in various study settings, including RCTs and intermediate-term observational settings. Studies explored outcomes reflecting daily functioning and activity level in adults with RA presenting with varying symptom burdens. Researchers monitored specific outcomes related to physical discomfort, such as joint tenderness and swelling counts, along with objective markers related to inflammatory states in the body.

Findings describe patterns observed in the studies related to the management of specific manifestations over defined time intervals. Studies report how symptoms evolved in the observed populations, and research highlights changes measured during the study period for inflammatory markers. However, the evidence quality varies across studies, and findings related to the substance's ability to prevent or slow long-term joint damage progression were reported as mixed or inconsistent.

3. Evidence Overview for Malaria (Acute Treatment and Prevention)

Research examined the substance for the treatment of acute malaria infection and historical research also explored its use for prevention (prophylaxis). For acute infection, Therapeutic Efficacy Studies examined temporary physiological imbalance, examining measures of parasite clearance and the resolution of acute symptoms like fever. These studies primarily focused on individuals in areas where the Plasmodium parasites were known to be sensitive to the substance.

Studies monitored changes in parasite counts and the resolution of clinical recovery in the observed populations where the parasite remains sensitive. Evidence suggests that the effectiveness is now highly conditional on the geographic location because the global prevalence of drug-resistant strains (particularly P. falciparum) severely limits the applicability of the data.

Key Studies & References

  1. Chloroquine (MedlinePlus Drug Information)
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Frequently Asked Questions (FAQ)

Common questions about Делагил (FAQ)


Q: What is Делагил prescribed for most often?

Official regulatory documents state that this medication is approved for treating certain types of parasitic infections, specifically the suppression of malaria. Additionally, the drug is indicated for the management of autoimmune conditions, including rheumatoid arthritis and systemic lupus erythematosus (SLE). These are the main labeled uses described in the official product information.


Q: Is Делагил used for pain relief?

The medication is not formally classified as an analgesic (pain reliever). However, its primary function involves anti-inflammatory and immunosuppressive actions. By reducing inflammation associated with conditions like rheumatoid arthritis, it may contribute indirectly to a reduction in joint pain and swelling.


Q: Can Делагил be taken for many years?

Extended use of the medication over a prolonged period, typically five years or more, is associated with a greater risk of potentially irreversible retinal damage, known as retinopathy. For this reason, official safety information describes the need for regular, mandatory eye monitoring if the drug is used long-term.


Q: Is blurred vision a common side effect of Делагил?

Some transient, mild visual disturbances have been reported, particularly when treatment begins. However, official safety documents also list blurred vision as a key symptom of the more serious adverse event, retinopathy. The product information indicates that any visual changes should be reported to a healthcare provider.


Q: How often do people get a rash from Делагил?

Skin reactions, including rashes and itching (pruritus), are frequently reported adverse effects according to official product information. Although these are common, the precise incidence rates can vary among different groups of patients studied.


Q: Does Делагил affect my liver?

Regulatory information indicates that the drug is processed in the liver. Official warnings describe that caution is required for individuals with pre-existing hepatic disease or alcoholism. Official documents also list the potential for hepatotoxicity (liver damage) and abnormal liver function tests as possible adverse events.


Q: Can I drink alcohol while taking Делагил?

Official warnings note that caution is described for patients with alcoholism or existing impaired liver function. Alcohol use may potentially increase the risk of certain adverse reactions or affect how the drug is cleared from the body.


Q: What foods interact with Делагил?

Official administration guidelines describe that the medication is typically administered with a meal or a glass of milk. This is specifically intended to help reduce gastrointestinal upset and assist with tolerance. No specific foods are typically listed in regulatory documents for complete avoidance.


Q: What does the long-term research say about the safety profile of Делагил?

The primary long-term safety concern described in regulatory warnings is the risk of irreversible retinal damage. Official safety information also mentions that extended, high-dose therapy has been associated with reports of a potentially serious heart condition called cardiomyopathy.


Q: What does "contraindication" mean for Делагил?

A contraindication is a circumstance or condition that regulatory bodies state makes the use of the drug not appropriate or potentially harmful. For this medication, an example of a contraindication is pre-existing retinal or visual field changes.


Q: How is Делагил usually packaged (e.g., tablet size)?

The medication is supplied in tablet form as the phosphate salt, often in strengths equivalent to 150 mg or 300 mg of the active ingredient (chloroquine base). Official documents detail the specific color, shape, and inactive ingredients used in the product.


Q: How long does it take for Делагил to start showing an effect?

Due to the drug’s extremely slow onset of action, clinical improvement for chronic conditions like rheumatoid arthritis may not be apparent immediately. Official information indicates that patients may not notice the expected effects for several weeks, or potentially up to six months, after beginning treatment.


Q: Does Делагил affect your sleep?

Official documents list insomnia (trouble sleeping) as one of the reported adverse events. Other central nervous system effects that may impact rest, such as nervousness, anxiety, and confusion, are also mentioned in the product information.


Q: Is it normal to feel tired when starting Делагил?

Unusual tiredness or weakness, medically termed fatigue or asthenia, is reported as a potential side effect in official patient information. This effect is reported to be generally mild and may resolve within the first few weeks of therapy.


Q: Will hair loss stop after I stop taking Делагил?

Alopecia (hair loss) is listed as a possible adverse reaction to the medication. This side effect is generally described in official documentation as being reversible upon discontinuation of treatment.


Q: Does Делагил cause weight gain or loss?

According to some official patient information, weight loss is listed as a possible adverse event, although the incidence rate is unknown. Weight gain is not typically reported as a side effect in regulatory documents.


Q: Is it safe to take Делагил with anti-inflammatory drugs?

The regulatory label does not typically list specific contraindications with common over-the-counter NSAIDs (like ibuprofen). However, the co-administration of any drug requires evaluation, and drug combinations are typically reviewed by a healthcare professional.


Q: What happens if I miss taking a day of Делагил?

Official patient instructions usually describe a procedure for addressing a missed dose. This procedure typically involves taking the missed dose promptly or skipping it, depending on the timing of the next scheduled dose.


Q: What happens in the body when Делагил starts to leave the system?

Official clinical pharmacology data indicates that the drug has an extremely long terminal elimination half-life, meaning it takes a long time for the active substance to be fully cleared. The regulatory texts note that this process can take approximately one to two months, and the drug is primarily eliminated unchanged through the urine.

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How should Делагил be stored and disposed of?

Official Storage and Handling Requirements

Делагил (Chloroquine phosphate) tablets must be stored at Controlled Room Temperature, which is defined by regulatory agencies as 20 C to 25 C (68 F to 77 F). The official label requires that the medication be dispensed and stored in a tight, light-resistant container to maintain its stability. It must be kept away from excessive heat and moisture.

Child-Safety and Disposal

Due to the significant risk of accidental overdose, the medication must be stored with a child-resistant closure and kept out of the sight and reach of children at all times. For disposal of unused or expired tablets, the regulatory preferred method is to take them to a community drug take-back program. If this is unavailable, the drug may be mixed with an undesirable substance (e.g., used coffee grounds, dirt) and sealed in a container before being discarded in the household trash, with all personal information scratched off the packaging.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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