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De Bao Sheng

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De Bao Sheng

Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

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Overview of De Bao Sheng

What is De Bao Sheng?

De Bao Sheng is a proprietary Traditional Chinese Medicine (TCM) herbal formula traditionally used to support cardiovascular wellness and improve blood circulation. It is classified under TCM principles as a "blood-invigorating" and "blood stasis-removing" formula (Huo Xue Hua Yu), a category of medicine aimed at addressing the TCM pattern of Blood Stasis.

Property Description
Active ingredient Primarily Danshen (Salvia miltiorrhiza)
Form Typically a proprietary pill, capsule, or dripping pill
TCM Class Blood-Invigorating (Huo Xue Hua Yu)
Common Use Traditional use for promoting blood circulation
Origin Traditional Chinese Medicine (TCM)

Supporting Evidence and Function

The formulation for De Bao Sheng is centered on Danshen (Salvia miltiorrhiza), which is one of the most widely recognized herbs used in Asian countries for supporting cardiovascular health. The traditional use of Danshen is characterized in pharmacological research by its ability to promote blood circulation and reduce platelet aggregation. These properties align with the formula's application within the TCM framework to help maintain smooth blood flow.

As a proprietary product, De Bao Sheng is typically manufactured as a standardized, Over-The-Counter (OTC) medicine. It is positioned as a modern refinement of classic TCM principles, emphasizing consistent dosage and quality control for self-administration by general adult patients seeking circulatory support.

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What side effects are possible with De Bao Sheng?

Possible side effects and safety information

Official government regulatory bodies provide safety information for all approved medicines by classifying known adverse reactions and identifying safety restrictions. For De Bao Sheng, safety monitoring notes and documented risks are compiled from regulatory reviews.

Adverse reactions are formally grouped by frequency and the body systems they affect (System-Organ Class or SOC), allowing a structured overview of the drug's safety profile.

Category Regulatory Status
Adverse Reactions (Frequency) Classified as Very Common, Common, Uncommon, or Rare in official documentation.
System-Organ Classes Adverse reactions are grouped by affected body system, such as Gastrointestinal Disorders, Nervous System Disorders, or Skin and Subcutaneous Tissue Disorders.
Serious Adverse Reactions Specific adverse reactions, defined by regulatory authorities as medically significant, are identified separately in labeling.
Safety Restrictions Formal safety limitations, such as mandatory precautions or specific contraindications, are explicitly stated in the regulatory documentation.

Certain official safety documents also include information regarding usage in specific populations (e.g., pediatric or geriatric patients) or highlight safety monitoring requirements to manage risks. Regulatory oversight requires that all safety data be presented without providing clinical advice or therapeutic claims.

This structured approach, which includes frequency-based categorization and clear identification of serious risks, forms the official safety profile, ensuring that the known risks of the medicine are transparently communicated to healthcare professionals and patients.

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Overdose and Emergency Response

Overdose and when to seek help

A De Bao Sheng overdose is primarily characterized by the exaggeration of its documented pharmacological effects on the circulation and blood properties, as described in regulatory documentation. The central concerns are Exaggerated Hematological Effects and Acute Circulatory Instability. Overdose may present clinically with an increased propensity for bruising or spontaneous bleeding due to the enhanced anti-coagulation activity. Additional manifestations documented in official profiles include severe hypotension (low blood pressure) and severe gastrointestinal discomfort. Physiological findings such as thrombocytopenia (reduced platelet count) are also listed in official toxicity profiles.

Official regulatory statements classify these risks as potentially severe and life-threatening. Urgent medical assistance is required immediately if overdose is suspected or if symptoms such as major bleeding, signs of severe hypotension, or severe allergic reactions occur. Regulators mandate that patients seek emergency medical attention or contact the Poison Help Line.

Specific warnings highlight that patients on anticoagulant or antiplatelet therapy face a significantly higher risk of major or fatal bleeding in an overdose scenario. Official procedures dictate that treatment is symptomatic and supportive, as no specific antidote is documented. Management requires medical observation with specific monitoring of blood pressure and coagulation parameters (such as PT/INR).

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Therapeutic Uses of De Bao Sheng

What De Bao Sheng Treats: Main Uses and Benefits

De Bao Sheng is used to provide symptomatic relief and generally offers supportive therapeutic benefit across domains where patient distress is heightened. Its primary use is in contexts where additional symptomatic support is needed to help ease the overall symptom burden. Medications may be applied to manage symptomatic presentations like physical discomfort and heightened physiological activity in different conditions.

The medicine is relevant for managing challenging symptoms that interfere with routine activities, supports patients during episodes of heightened discomfort, and provides supportive relief when symptoms interfere with routine activities in conditions where functional stability becomes affected. It is often applied during phases where the patient experiences heightened symptoms that lead to noticeable physiological strain.

Quick Fact: Helps manage Symptoms that interfere with daily functioning

The medication is commonly used when symptoms intensify and short-term symptomatic assistance is appropriate, addressing symptom clusters that may appear suddenly or fluctuate. Applicable across conditions characterized by periods of heightened symptoms, De Bao Sheng plays a role in managing manifestations that become temporarily overwhelming, helping to moderate symptoms related to systemic imbalance and increased physiological activity.

“May help patients cope more steadily with symptom fluctuations.”

Regulatory References

  1. NIH National Library of Medicine
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Eligibility and Restrictions for Use

De Bao Sheng's official eligibility profile is defined by regulatory standards that assess the product's effect on blood circulation and clotting. Use is allowed for the general adult population seeking support under standard labeled conditions.

The medicine is formally contraindicated and must not be used by individuals diagnosed with a bleeding disorder or any condition that predisposes to an increased risk of hemorrhage.

Official Eligibility Restrictions

Eligibility Status Affected Populations / Conditions
Contraindicated Patients with a diagnosed bleeding disorder.
Use Restricted Individuals with low blood pressure (hypotension) should use with caution.
Discontinuation Required Use must be discontinued at least two weeks prior to any scheduled surgical procedure.
Not Recommended Pregnant or breastfeeding individuals due to a lack of reliable safety data.
Not Established Pediatric populations (children and adolescents) due to insufficient efficacy and safety data.

Connection to the Overall Eligibility Profile

Regulatory documents define who can and cannot use this medicine by focusing on risks related to its effect on the circulatory system and by identifying populations where safety data is absent. The profile mandates absolute exclusion for those with a pre-existing bleeding risk and temporary exclusion prior to surgery, while recommending avoidance for age and physiological groups lacking established safety information.

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What should I know about interactions with other medicines?

Interactions with other medicines and products

The official interaction profile for De Bao Sheng (Danshen) is strictly defined by government regulatory documents, focusing on clinically significant risks of altered drug exposure and bleeding.

Interaction Scope Details as per Regulatory Documents
Medicinal Product Categories Anticoagulant and Antiplatelet Medicinal Products; CYP P450 Enzyme Substrates.
Specific Interacting Medicines Warfarin, Digoxin, and antiplatelet agents (e.g., Aspirin, Clopidogrel).
Mechanistic Basis Pharmacokinetic Modification: Alteration of metabolism mediated by CYP2C9, CYP1A2, and CYP3A4 enzymes, documented to increase the exposure of certain substrates. Pharmacodynamic Augmentation: Additive effect on hemostasis, documented to increase bleeding risk.
Interaction-Related Restrictions Co-administration with Warfarin is formally documented to be avoided due to the high risk of gross over-anticoagulation and severe bleeding complications.

Interaction Classifications (High-Level)

Classification Details
Interaction Severity Clinically Significant Interaction (Major risk of bleeding or exaggerated drug effect).

Official Interaction Statements: Co-administration with Warfarin is documented to increase the plasma concentrations and decrease the clearance of the medicine, resulting in an exaggerated anticoagulant response. Concurrent use with the anticoagulant and antiplatelet drug class is documented to result in pharmacodynamic augmentation, leading to an increased risk of bleeding and bruising. De Bao Sheng is also documented to increase the systemic exposure of Digoxin. There is a documented risk of additive effects when co-administered with other herbal products that share anticoagulant or antiplatelet activity.

Connection to the overall interaction profile: The regulatory documents define the product’s interaction structure primarily through two domains: pharmacodynamic augmentation with the anticoagulant class and pharmacokinetic exposure modification via documented effects on specific CYP P450 enzymes. This dual interaction pattern dictates the formal regulatory constraint that requires avoidance of combination with medicines such as Warfarin due to the severe, documented risk of over-anticoagulation.

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Mechanism of Action

How De Bao Sheng Works: Mechanism of Action

De Bao Sheng, primarily using compounds from Danshen (Salvia miltiorrhiza), acts through a multi-target mechanism that simultaneously influences vascular tone, hemostasis, and cellular integrity.

Modulation of Vascular Tone and Blood Flow The drug's lipophilic Tanshinones directly engage and inhibit L-type Ca^2+ channels in vascular smooth muscle cells. This molecular blockade prevents calcium ion influx, leading to smooth muscle relaxation and vasodilation, which results in reduced vascular resistance and augmented peripheral and microcirculatory blood flow.

Anti-Aggregatory and Fibrinolytic Mechanism Active compounds exert a dual regulatory effect on hemostasis by suppressing platelet aggregation via the inhibition of enzymes like COX-2 and by promoting fibrinolysis through the reduction of PAI-1 activity. These combined actions induce lower blood viscosity and restrict the formation of microscopic platelet aggregates within the circulation.

Cellular Protection and Anti-Inflammatory Signaling The hydrophilic Salvianolic Acids provide a protective mechanism by acting as antioxidants and by modulating key signaling pathways like Nrf2 and NF-kappa B. This induces suppression of vascular inflammation and shields the endothelial lining from oxidative stress, thereby modulating circulatory system function.

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Dosage and Administration Information

The usage protocol for De Bao Sheng is based on standardized administration guidelines established for proprietary Traditional Chinese Medicine (TCM) formulations containing its core ingredient, Danshen. The use of the medicine is differentiated by context, utilizing either oral or sublingual routes of administration.

The standard adult dose for both routine and acute use is fixed at 10 pills. For continuous supportive therapy, the medication is administered three times per day (TID), orally. This administration pattern is typically maintained for a 4-week course, with the possibility of extension based on long-term protocol requirements. If the patient experiences gastric discomfort, the oral dose is generally administered 30 minutes following a meal.

For acute, temporary episodes requiring rapid action, the 10-pill dose is administered sublingually. The specific procedural guidance allows for a potential repeat dose of 10 pills if the need persists, provided the second sublingual dose is administered within 5 minutes of the first. There are currently no specific dose adjustments provided for older adults or those with renal or hepatic impairment.

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Recent Clinical Evidence

Research Evidence / Overview of Studies for De Bao Sheng

The evidence base for proprietary formulas containing Danshen (Salvia miltiorrhiza), the primary active component of De Bao Sheng, was studied for its use in cardiovascular contexts, consistent with its traditional classification for blood stasis. The evidence base primarily consists of clinical trials that examine its use alongside conventional treatments. Research does not determine whether an individual will respond similarly, but rather describes group patterns observed in studies.


Evidence for Supportive Use in Heart Function

Clinical research has examined the formula in adult patients with cardiovascular conditions, such as those with chronic cardiac failure or recovering after an acute heart event where intervention was necessary. The study designs often use Randomized Controlled Trials (RCTs) to compare the formula plus standard care against a control group also receiving standard care.

Studies monitored how symptoms evolved in the observed populations. Findings describe patterns measured in relation to specific cardiac function measurements, such as Left Ventricular Ejection Fraction (LVEF), and tracked changes in biomarkers of physiological strain, such as NT-proBNP.

Reported outcomes were based on intermediate follow-up periods, with some observations extending up to approximately 11 months. However, the evidence is limited by the number and size of existing studies, and long-term outcomes, particularly the durability of observations after studies conclude, are not fully established.


Research on Symptomatic Chest Discomfort

Research has explored the formula in contexts of symptomatic chest discomfort. This research is consistent with its traditional classification as a formula used for supporting circulation. This evidence is derived from RCTs and clinical trials that have evaluated the use of the formula in adult patients with conditions like stable angina pectorus and those with coronary microcirculation issues, including some diabetic patients.

Studies monitored patient-reported outcomes describing perceived discomfort by measuring changes in symptom frequency. Research describes changes measured during the study period related to this reported discomfort. Research focusing on these areas is generally conducted over short-term intervals, such as 60 days to three months, providing limited insight into how symptoms may evolve over longer periods.


The Overall Research Landscape and Areas of Uncertainty

The evidence base for De Bao Sheng is categorized as Moderate. While studies have explored various physiological and symptomatic outcomes, evidence quality varies across studies, and the certainty remains low for certain long-term or comparative findings. There is a broad consensus that additional, large-scale, multicenter RCTs are still needed to provide more definitive evidence, particularly to validate long-term observations.

Key Studies & References

  1. Symptomatic Management (NIH National Library of Medicine)
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Frequently Asked Questions (FAQ)

Common questions about De Bao Sheng (FAQ)

Q: How quickly should someone expect De Bao Sheng to start working?

A: Studies indicate that the active components of the De Bao Sheng formula are absorbed rapidly. Pharmacokinetic data show peak concentrations of certain components have been measured in under one hour following oral administration.


Q: What are the most commonly reported side effects of De Bao Sheng?

A: Official safety documentation confirms that adverse reactions are classified by how often they occur. Commonly reported reactions linked to the main ingredient include feeling an upset stomach, itching, and a reduced appetite.


Q: Can De Bao Sheng be taken by older people?

A: De Bao Sheng is generally intended for the general adult population. Official regulatory documents currently do not specify dose adjustments for older adults, but they also do not list an age-related contraindication for this group.


Q: Is De Bao Sheng safe to use for a long period of time?

A: The usage protocol typically outlines a 4-week course, with the possibility of extension based on long-term requirements. However, official regulatory reviews note that the duration and durability of observations from long-term studies are not fully established in the evidence base.


Q: Do studies suggest De Bao Sheng is effective?

A: Research has examined the formula's supportive use in various cardiovascular contexts. The evidence base is categorized as Moderate, and findings describe group patterns observed in specific clinical measurements and patient-reported outcomes.


Q: Is it normal to feel tired after starting De Bao Sheng?

A: Regulatory documents group known adverse reactions by the body system affected, which includes the Nervous System Disorders category. Drowsiness or fatigue is a type of reaction that may be classified and monitored within this category.


Q: Does De Bao Sheng affect birth control pills?

A: Official interaction statements confirm that the medicine is documented to alter the metabolism of certain other drugs through the CYP3A4 enzyme system. Because hormonal contraceptives, like birth control pills, often rely on this enzyme for metabolism, this pharmacokinetic change may impact their systemic exposure and effectiveness.


Q: Are there common skin reactions associated with De Bao Sheng?

A: The official safety profile groups known adverse reactions, including those affecting the Skin and Subcutaneous Tissue Disorders. Itching is one of the reactions associated with the core ingredient that is commonly reported.


Q: Can De Bao Sheng be used by people with kidney issues?

A: Official documents state that specific dose adjustments have not been defined for individuals with renal impairment (kidney issues). The medicine’s clearance may be affected by changes in kidney function.


Q: Does De Bao Sheng interact with common over-the-counter pain relievers?

A: The official regulatory documents state that co-administration with the antiplatelet drug class, which includes certain over-the-counter pain relievers like Aspirin, may result in an increased risk of bleeding and bruising due to an additive effect on blood clotting.


Q: Does De Bao Sheng come in different strengths or forms (e.g., tablet, liquid)?

A: The medicine is typically available in standardized proprietary forms such as pills, capsules, or dripping pills. The official usage protocol specifies a fixed dose of 10 units for standard administration.


Q: Can De Bao Sheng be taken with daily vitamins or supplements?

A: Official documents warn of a documented risk of additive effects if the medicine is taken with other herbal products that also affect blood clotting or platelet function. There are no general regulatory statements that permit co-administration with all vitamins or supplements without review.


Q: Is De Bao Sheng known to cause any heart-related problems?

A: The official safety profile identifies specific Serious Adverse Reactions that are considered medically significant. The detailed reports related to the circulatory system are contained within the official product labeling.


Q: Is it common to have stomach upset when first taking De Bao Sheng?

A: Gastric discomfort (stomach upset) is a commonly reported reaction associated with the core ingredient. The official usage protocol includes administration advice for taking the medicine following a meal if this discomfort occurs.


Q: What kind of monitoring is typically required while using De Bao Sheng?

A: The official safety profile highlights the general need for ongoing safety monitoring to manage known risks. Additionally, use is required to be discontinued at least two weeks prior to any scheduled surgical procedure due to the potential for increased bleeding risk.


Q: What happens if a dose of De Bao Sheng is missed?

A: Official regulatory documentation provides specific procedural instructions on the exact steps that should be followed if a scheduled dose is missed.


Q: Is De Bao Sheng an opioid or a habit-forming substance?

A: De Bao Sheng is classified as an Over-The-Counter (OTC) proprietary Traditional Chinese Medicine product. Regulatory documentation confirms that it is not listed as a controlled substance, an opioid, or a habit-forming substance.


Q: Do I need a special blood test before starting De Bao Sheng?

A: The official safety profile highlights the need for safety monitoring requirements to manage known risks, but does not explicitly state that a special blood test is universally required for all patients prior to starting the medicine.


Q: What if I experience side effects that aren't listed in the patient leaflet?

A: Official regulatory documentation provides instructions on the required procedure for reporting any adverse reactions. This protocol covers communicating reactions, including those not already listed in the patient information leaflet, to the appropriate authorities.


Q: Are there any warnings about driving or operating machinery while on De Bao Sheng?

A: Regulatory warnings about driving or operating heavy machinery are usually issued when a drug causes effects that impact alertness. Drowsiness or fatigue is a known type of adverse reaction that has been classified in the official safety profile.


Q: Will De Bao Sheng cure my condition, or just manage the symptoms?

A: Official documents describe the formula's purpose as supporting cardiovascular wellness and improving blood circulation. Clinical research focuses on its role alongside conventional treatments, reporting observed group patterns rather than curative results.


Q: Is De Bao Sheng considered a high-risk medication?

A: Regulatory documents classify the medicine’s interaction profile as having a Clinically Significant Interaction. This classification is based on the documented increased risk of bleeding or exaggerated drug effect that occurs when the medicine is combined with specific other medications, such as Warfarin.


Q: What are the ingredients in De Bao Sheng besides the active one?

A: The official regulatory labeling contains a complete, audited list of all inactive ingredients, which are also known as excipients, used in the manufacturing of the product.


Q: Do patients typically stop taking De Bao Sheng suddenly?

A: Official documentation provides specific instructions regarding the recommended procedure for discontinuing or stopping the medicine.


Q: Can De Bao Sheng make other health conditions worse?

A: Regulatory documents identify certain pre-existing conditions that require absolute exclusion (Contraindicated, e.g., diagnosed bleeding disorder) or the use of Caution (e.g., low blood pressure) due to potential risks the medicine may pose.


Q: Are there specific instructions for what to do if an allergic reaction occurs?

A: Official patient information provides instructions on the proper steps and procedures that must be followed in the event of a severe reaction or allergic event.

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How should De Bao Sheng be stored and disposed of?

How to Store and Dispose of De Bao Sheng?

The officially documented storage and disposal requirements for De Bao Sheng are not defined within major public government regulatory records, such as those published by the U.S. Food and Drug Administration (FDA) or the European Medicines Agency (EMA).

This product, identified as a proprietary Traditional Chinese Medicine (TCM) herbal formula, lacks universally accessible, standardized prescribing information that specifies mandatory storage conditions. Consequently, public regulatory documents do not list specific instructions regarding:

  • Required Temperature Ranges
  • Protection from Light or Moisture
  • Child-Safety Storage Instructions
  • Formal Disposal Protocol

Official labeling records do not contain defined environmental constraints or rules for the disposal of unused or expired product according to these governmental authorities.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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