D-Vi-Sol (Oral)

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D-Vi-Sol (Oral)

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Overview of D-Vi-Sol (Oral)

Property Description
Active ingredient Dihydrotachysterol (DHT)
Form Oral Solution (Liquid drops) in an oil base
Pharmacological class Synthetic Vitamin D Analog / Calcemic Agent
General purpose Management of critical mineral and calcium balance
Origin Synthetic derivative of ergosterol

What Type of Medicine is D-Vi-Sol (Oral)?

D-Vi-Sol (Oral) is a pharmaceutical preparation containing the active ingredient Dihydrotachysterol (DHT), which is classified as a potent Synthetic Vitamin D Analog and a specialized calcemic agent. The purpose of this medicine is to directly regulate and elevate calcium concentrations in the bloodstream to support essential mineral balance. This compound's efficacy for stabilizing blood calcium levels is widely clinically recognized and supported by pharmacological studies.

Dihydrotachysterol is a single-ingredient product designed for oral administration. It is a key differentiating factor that this compound does not require the secondary activation step in the kidneys that native forms of Vitamin D typically require, allowing it to function effectively even when natural activation pathways are compromised.

Composition, Origin, and Form of Dihydrotachysterol

The core active component, Dihydrotachysterol, is a synthetic derivative chemically related to the plant precursor ergosterol. As Dihydrotachysterol is a lipid-soluble compound, the medicine is manufactured as an oral solution in an oil base—a formulation essential for stability and proper absorption within the digestive system.

This specific liquid form ensures a reliable delivery of the active ingredient. The compound's high efficacy and predictable action are linked to its structure, which allows it to directly influence the body's mineral regulatory mechanisms. The medicine is often prescribed in situations where patients require a reliable, high-potency agent for mineral correction.

How D-Vi-Sol Generally Supports Calcium Regulation

The fundamental action of D-Vi-Sol is to serve as a reliable calcium-elevating agent. It achieves this by significantly increasing the amount of calcium absorbed from the intestines and by concurrently influencing the management of phosphate through increased excretion via the kidneys. This integrated approach to managing both minerals is vital. By rapidly and predictably influencing calcium status, Dihydrotachysterol’s general purpose is to maintain the critical mineral equilibrium necessary for essential bodily functions, including nerve signal transmission, muscle activity, and bone structure maintenance.

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What side effects are possible with D-Vi-Sol (Oral)?

Possible side effects and safety information

The official safety profile for Dihydrotachysterol is critically centered on the risk of Hypercalcemia, which is an elevated level of calcium in the blood. As a potent synthetic calcemic agent, adverse reactions are primarily manifestations of Vitamin D Toxicity (Hypervitaminosis D), which is dose- and duration-dependent. The frequency of Hypercalcemia itself is considered a very common risk in regulatory contexts, while the frequency of individual symptoms is often classified as Not Known.

Adverse effects are documented across several System-Organ Classes, notably the Metabolism and Nutrition Disorders, Renal and Urinary Disorders, Gastrointestinal Disorders, and the Nervous System.

Commonly documented symptoms that may appear as signs of developing toxicity include anorexia, nausea, vomiting, weakness, headache, and polyuria (increased urination). These effects are typically linked to overdosage or prolonged exposure to high doses.

Serious Adverse Reactions officially documented relate to organ damage resulting from persistent Hypercalcemia. These include Nephrolithiasis (kidney stones), irreversible Renal Insufficiency, Ectopic Calcification (calcification of soft tissues), and serious Cardiac Arrhythmias.

Safety constraints restrict the use of this medicine in individuals with pre-existing Hypercalcemia of any cause or diagnosed Vitamin D Toxicity. Specific regulatory caution is advised for patients with existing Cardiac or Renal Impairment due to the increased risk of complications arising from calcium imbalance. Furthermore, the drug's effects can persist for two or more months after cessation of treatment.

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Overdose and Emergency Response

Overdose with Dihydrotachysterol is officially documented to result from severe hypercalcemia, an excessively high concentration of calcium in the blood. The clinical manifestations are an extension of this condition and require immediate attention. Early overdose symptoms may include anorexia, nausea, vomiting, weakness, fatigue, and headache. As the severity increases, patients may exhibit more pronounced signs such as polyuria, polydipsia, hypertension, somnolence, and psychosis.

Laboratory findings that confirm overdose commonly show elevated serum calcium (hypercalcemia), along with hyperphosphatemia, azotemia, and metabolic alkalosis. Prolonged or severe hypercalcemia is associated with life-threatening systemic complications, specifically metastatic soft tissue calcification in the kidneys, heart, and arteries, and potential permanent renal damage. In the most severe cases, the condition can lead to coma or death.

Regulatory labeling mandates that any suspected overdose requires the immediate cessation of the medication. Due to the risk of severe outcomes, patients must seek immediate medical attention. Management is formally designated as symptomatic and supportive, utilizing procedures like aggressive intravenous hydration and diuretics to correct the mineral imbalance, as no specific antidote is known. Continuous hospital monitoring is required to assess for potential cardiac and renal complications.

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Therapeutic Uses of D-Vi-Sol (Oral)

What D-Vi-Sol (Oral) Treats: Main Uses and Benefits

The therapeutic use of Dihydrotachysterol (DHT) may be part of symptomatic management in scenarios involving mineral imbalances. This is relevant in clinical settings where supportive calcium management is appropriate.

This medication is relevant in conditions characterized by periods of heightened symptoms, such as Hypoparathyroidism (post-surgical or chronic), as well as metabolic bone issues like Rickets and Osteomalacia. It may be applied in addressing symptom clusters related to neuromuscular irritability, including tingling, numbness, muscle twitching, and the involuntary muscle spasms known as tetany.

Dihydrotachysterol provides support that helps ease the overall symptom burden associated with these manifestations and assists with maintaining functional stability. It is often used during phases when symptoms become more noticeable or when the body's mineral regulation processes require additional support.

“This supportive therapy is relevant in contexts involving heightened systemic burden associated with calcium deficiency.”


Quick Fact: Relief for Neuromuscular Irritability
This medication is commonly used to help manage the cluster of symptoms associated with Hypocalcemia, contributing to easing the overall symptom load associated with discomfort like tingling and the painful contraction of muscles in tetany.
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Eligibility and Restrictions for Use

Official Eligibility and Contraindications

D-Vi-Sol (Dihydrotachysterol) eligibility is strictly defined by regulatory authorities due to its potent effect on calcium levels. Use is contraindicated and explicitly prohibited in patients with pre-existing Hypercalcemia (high blood calcium levels), Hypervitaminosis D (Vitamin D toxicity), or a history of Malabsorption Syndrome.


Age and Condition Restrictions

Population Group Eligibility Status and Restriction
Pediatric Patients Allowed, but dosage must be individualized; strict restriction is required in infants with Idiopathic Hypercalcemia.
Older Adults (Geriatric) Conditional Use; cautious dose selection is necessary, especially if decreased hepatic, renal, or cardiac function is present.
Pregnancy Category C (FDA); use is justified only if the potential benefit outweighs the possible risks, as use can lead to fetal damage and hypercalcemia in the newborn.
Lactation Contraindicated in breastfeeding mothers (per European labeling) as the drug is excreted in breast milk and may cause infant hypercalcemia.
Comorbidities Use requires essential maintenance of normal serum phosphorus levels in patients with Hyperphosphatemia (e.g., Renal Osteodystrophy) to prevent complications.
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What should I know about interactions with other medicines?

Interactions with other medicines and products

Interactions with D-Vi-Sol (Cholecalciferol/Vitamin D3) primarily involve substances that affect its absorption in the gut or those that pose a risk of combined toxicity, specifically hypercalcemia.


Pharmacokinetic Interactions (Exposure Modification)

Mechanism Interacting Substances Practical Implication
Decreased Absorption Bile Acid Sequestrants (e.g., Cholestyramine), Mineral Oil (Laxatives), Orlistat These drugs can significantly reduce the amount of Vitamin D absorbed by the body. Dose separation is typically required to mitigate this effect.
Increased Catabolism Anticonvulsants (e.g., Phenytoin, Phenobarbital) Certain seizure medications may increase the breakdown of cholecalciferol, potentially lowering its circulating effectiveness.

Pharmacodynamic Interactions (Additive Effects)

Mechanism Interacting Substances Practical Implication
Increased Calcium Risk Thiazide Diuretics, Calcium Supplements These combinations increase the risk of hypercalcemia (excessive calcium in the blood) due to additive effects on calcium retention or intake.

Contraindications and Restrictions

Co-administration with other Vitamin D analogs or high-dose Vitamin D supplements is generally restricted to prevent the significant risk of Hypervitaminosis D. Furthermore, the use of Phosphate Binders requires careful monitoring of serum calcium and phosphate levels to manage the combined effect on mineral balance.

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Mechanism of Action

The action of D-Vi-Sol (Dihydrotachysterol, DHT) commences with its conversion in the liver into an active metabolite that functions as a VDR agonist on the nuclear Vitamin D Receptor (VDR). By binding to the VDR, this molecule initiates a genomic cascade where the receptor complex modulates the transcription of specific genes at the Vitamin D Response Elements (VDREs). This core mechanistic domain is responsible for translating the drug’s presence into durable cellular changes necessary for systemic mineral management.

The gene modulation cascade directly results in the increased synthesis of calcium transport proteins, such as Calbindin, primarily in the small intestine. This enhancement of the intestinal lining's capacity to absorb calcium from the diet is the primary mechanism leading to an increase in plasma calcium concentration. Concurrently, the VDR activation promotes phosphate excretion via the kidneys and influences calcium exchange at the bone surface, establishing an integrated physiological consequence that results in the modulation of mineral equilibrium dynamics.

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Dosage and Administration Information

How Dihydrotachysterol (Oral) is Used

Dihydrotachysterol (Oral) is administered exclusively via the oral route, available either as a tablet or as an oral solution concentrate (0.2 mg per mL). The liquid form requires precise measurement using a calibrated dropper to ensure the dose accuracy specified in the prescription.

The administration protocol is structured as a two-phase process: a temporary, higher initial dose is followed by a long-term maintenance dose. For adults, the initial dose typically ranges from 0.8 mg to 2.4 mg once daily for several days. This transitions to a maintenance range of 0.2 mg to 1.0 mg once daily, which must be adjusted to meet the patient’s ongoing needs. The average daily maintenance dose is reported as 0.6 mg.

Dosing for pediatric patients (infants and children) follows a separate set of labeled guidelines, where the initial and maintenance dose levels are distinct from those used for adults. Treatment in all age groups is conditioned upon regular determinations of blood calcium levels, as dosage must be carefully individualized and periodically reevaluated.

A key procedural constraint involves co-administration: the medicine must be used concurrently with an adequate intake of supplemental calcium, as detailed in the patient’s overall treatment plan. Dose adjustments, if necessary, are typically made at intervals of 4 to 8 weeks based on laboratory results to maintain the targeted calcium balance.

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Recent Clinical Evidence

Research evidence / Overview of studies for D-Vi-Sol (Oral)

Evidence for Use in Hypoparathyroidism (Chronic Hypocalcemia Management)

The research on Dihydrotachysterol (D-Vi-Sol) for chronic hypoparathyroidism primarily consists of long-term observational studies, cross-sectional registry analyses, and older comparative controlled trials. Research has explored its use in adults with the condition, often caused by surgical procedures. Studies monitored key biomarkers related to systemic imbalance, such as tracking the stability of blood calcium and phosphate concentrations over time. Observational studies described that intensive laboratory monitoring was necessary to manage mineral homeostasis.

However, a notable limitation is the lack of high-quality, contemporary Randomized Controlled Trials (RCTs). Comparative evidence is lacking against newer standard therapies. The long-term effects are not fully established with the rigor of modern prospective trials. This means that while Dihydrotachysterol is a compound evaluated in studies exploring mineral balance, evidence related to patient-reported outcomes or quality of life remains insufficient.


Evidence for Use in Rickets and Osteomalacia (Metabolic Bone Issues)

For metabolic bone issues, the evidence base includes historical comparative controlled trials and various observational studies. Research examined outcomes related to physical structure, such as tracking changes in radiographic abnormalities in children with rickets and assessing levels of bone mineralization in adults with osteomalacia. Studies reported that the medicine was evaluated in regimens where researchers explored the management of mineral imbalance associated with defective bone formation.

Research highlights changes measured during the study period, and the reported normalization of specific serum markers were patterns observed in patients receiving the medicine. A limitation is the reliance on older controlled trials and observational data, limiting the certainty of applying the findings across a wide range of patients. Data for long-term outcomes on the durability of bone healing remain insufficient in the formal trial literature.


Evidence for Use in Chronic Renal Insufficiency and Osteodystrophy

Research exploring Dihydrotachysterol's use in chronic renal insufficiency includes prospective, randomized, comparative trials against other active Vitamin D analogs. These studies primarily focused on biomarkers related to systemic imbalance, examining the stability of serum calcium and phosphate levels. Research in this setting described that frequent laboratory monitoring was necessary due to observed instances of elevated calcium levels. Follow-up durations were typically limited (often six months to one year) relative to the lifelong nature of chronic kidney disease.

Key Studies & References

  1. Hypoparathyroidism, Efficacy of Active Vitamin D Analogs: Systematic Review and Meta-Analysis of Randomized Controlled Trials
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Frequently Asked Questions (FAQ)

Common questions about D-Vi-Sol (Oral) (FAQ)


Q: Can D-Vi-Sol cause an upset stomach or digestive issues?

Regulatory documents list nausea and vomiting as documented symptoms that may appear with developing toxicity or overdose. Additionally, potential signs of excessive calcium in the blood (hypercalcemia) can include changes in bowel habits such as constipation, abdominal cramps, or general digestive distress.


Q: What does the research say about the effectiveness of liquid vitamin D drops like D-Vi-Sol?

Studies and official information indicate that the research has primarily focused on the drug's effects on mineral equilibrium dynamics, tracking the stability of blood calcium and phosphate concentrations. For some uses, official summaries note a lack of high-quality, modern controlled studies, and research findings are primarily based on observational trials.


Q: Does D-Vi-Sol affect how calcium is absorbed in the body?

Yes, the fundamental action of D-Vi-Sol is described as influencing calcium levels. It does this by significantly increasing the amount of calcium absorbed from the intestines to help stabilize critical mineral balance in the bloodstream.


Q: What happens if D-Vi-Sol is exposed to light or heat?

According to the official product information, D-Vi-Sol must be protected from direct light, excess heat, and freezing during storage. Protecting the medicine from these environmental factors is intended to maintain its stability and mitigate the risk of degradation or loss of efficacy.


Q: Can D-Vi-Sol be used for purposes other than those described in the main uses?

Official regulatory documents only describe the use of D-Vi-Sol (Dihydrotachysterol) in the management of specific conditions such as Hypoparathyroidism, certain forms of Rickets and Osteomalacia, and conditions related to Chronic Renal Insufficiency. Information regarding other potential uses is not addressed in the approved product labeling.


Q: Are there any reported interactions between D-Vi-Sol and common baby medications?

Official documents describe interactions with certain categories of medicines, such as specific Anticonvulsants (like Phenytoin or Phenobarbital) or Thiazide Diuretics. These interactions are noted because they can modify drug exposure or increase the risk of hypercalcemia (excess calcium in the blood).


Q: Is D-Vi-Sol the same thing as just Vitamin D drops?

No, D-Vi-Sol is classified as a Synthetic Vitamin D Analog containing the active ingredient Dihydrotachysterol. This compound is chemically distinct from native forms of Vitamin D, like Cholecalciferol (Vitamin D3), which are typically found in common Vitamin D supplements. The official labeling describes the two as separate compounds.


Q: Is there a taste or flavor to D-Vi-Sol drops?

According to regulatory sources, the perception of a metallic taste in the mouth is listed as a symptom that can be associated with developing toxicity or overdose.


Q: What are the typical long-term concerns, if any, with using D-Vi-Sol?

Serious, long-term adverse reactions are associated with persistent elevated calcium levels (Hypercalcemia). These include organ damage such as irreversible Renal Insufficiency, Nephrolithiasis (kidney stones), and calcification of soft tissues. The drug’s potent effects on mineral balance can also persist for two or more months after treatment is stopped.


Q: Is D-Vi-Sol linked to any allergic reactions?

Yes. Official documentation describes a need for immediate medical attention if signs of a serious allergic reaction, such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, are observed.


Q: Can D-Vi-Sol affect the results of blood tests?

Yes. The medicine is described as regulating blood concentrations of calcium and phosphate, which are two critical lab values. Due to its potent action, treatment is conditioned upon regular determinations of blood calcium levels to allow for accurate dosage adjustment.


Q: Has D-Vi-Sol been studied in children beyond infancy?

Yes. Official eligibility allows for use in Pediatric Patients (which includes both infants and children) with separate, individualized dosing guidelines. Research evidence has examined outcomes in children with rickets.


Q: Does D-Vi-Sol need to be taken with food?

Official product information does not explicitly mandate taking the dose with food. However, the medicine must be used concurrently with an adequate intake of supplemental calcium. As Dihydrotachysterol is a lipid-soluble compound, its absorption is understood to be related to the presence of bile.


Q: Can D-Vi-Sol cause changes in appetite?

Anorexia (loss of appetite) is listed in official documents as a commonly documented symptom. This symptom may appear as a sign of developing toxicity or overdose.


Q: Are there specific food ingredients that might interact with D-Vi-Sol?

Regulatory sources advise that treatment may require adjustment of dietary intake concerning foods containing natural or added calcium, phosphate, and vitamin D. Consumption of grapefruit and grapefruit juice may also alter the drug's blood levels and effects.


Q: Does D-Vi-Sol have to be taken at the exact same time every day?

Official instructions specify that the drug is to be taken once daily to maintain consistent mineral balance. Regulatory documents do not mandate taking the medicine at a specific time of day (e.g., morning or evening).


Q: What is the typical timeframe doctors suggest using D-Vi-Sol?

The administration protocol is structured as a temporary, higher initial dose followed by a long-term maintenance dose. The total timeframe is not fixed or predefined but must be highly individualized and periodically reevaluated based on the patient’s ongoing needs and mineral status.


Q: Why is the active ingredient in D-Vi-Sol measured in International Units (IU)?

The potent active ingredient, Dihydrotachysterol, is typically measured and labeled in milligrams (mg) or a concentration of mg per mL in official documents. International Units (IU) is a measurement unit that is commonly used for native Vitamin D compounds, not Dihydrotachysterol itself.


Q: What is the consistency of D-Vi-Sol drops?

Official compositional information states that the medicine is manufactured as an oral solution that is administered as liquid drops. Since Dihydrotachysterol is a lipid-soluble compound, the solution is formulated in an oil base for proper stability and absorption.


Q: Does D-Vi-Sol interact with any herbal products?

Official documents describe interactions with certain pharmaceutical agents and dietary components. For all unlisted products, including herbal remedies and supplements, general regulatory guidance notes that consultation with a healthcare professional may be needed before combining them with D-Vi-Sol.


Q: Can D-Vi-Sol be used in children with certain chronic health issues?

Yes, its use is described for the management of mineral imbalance in conditions like Renal Osteodystrophy in pediatric patients. Use is conditional on the essential maintenance of normal serum phosphorus levels to prevent complications.


Q: Does D-Vi-Sol need to be refrigerated?

No. Official storage conditions state that the medicine must be stored at room temperature, typically between 15 C and 30 C. The product is specifically required to be protected from freezing.


Q: Are there any known issues with giving D-Vi-Sol at night?

Official administration instructions specify taking the drug once daily. Regulatory documents do not specify any restrictions or requirements regarding the time of day (e.g., morning versus night) for administration.


Q: Are the research findings on D-Vi-Sol considered long-term or short-term?

Official summaries indicate that the research base includes a combination of both. Some studies are long-term observational trials; however, controlled trials often had limited follow-up durations (e.g., six months to one year), and the full long-term effects for some uses are not fully established.


Q: How is the need for D-Vi-Sol generally determined by health professionals?

The need for the drug is typically determined by a diagnosis of a condition that requires active calcium elevation, such as hypoparathyroidism. The specific dose and ongoing need for the drug are then adjusted based on regular determinations of blood calcium levels.


Q: Are there any known interactions between D-Vi-Sol and iron supplements?

Official interaction tables do not specifically list iron supplements. However, general guidance suggests caution when combining the drug with any supplements, and consulting a healthcare professional is noted as necessary.


Q: Can D-Vi-Sol be given to infants who are partially formula-fed?

The medicine is officially labeled for use in Pediatric Patients (including infants) when indicated for a covered condition like rickets or hypoparathyroidism. Eligibility is conditional on the diagnosis and is not determined by the method of infant feeding.


Q: What are the inactive ingredients listed in D-Vi-Sol?

Official compositional information focuses on the active component. The documentation states that the lipid-soluble active ingredient, Dihydrotachysterol, is manufactured as an oral solution in an oil base.

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How should D-Vi-Sol (Oral) be stored and disposed of?

How to Store and Dispose of D-Vi-Sol (Oral)


Storage Conditions

D-Vi-Sol (Dihydrotachysterol Oral Solution) must be stored at room temperature, typically between 15°C and 30°C. It is required to be kept in its original container with the cap tightly closed to protect it from degradation. The product must be protected from freezing and stored away from direct light, excess heat, and moisture.

Safety and Disposal

Regulatory requirements mandate that the medicine be stored out of the reach of children and pets. For disposal of unused or expired drops, if a take-back program is unavailable, the liquid should be removed from its original container, mixed with an undesirable substance (such as dirt), placed in a sealed bag, and then thrown into the household trash.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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