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Medically reviewed by Fedorchenko Olga Valeryevna, PharmD. Last updated on 22.03.2022
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Indicated for use in smoking cessation.
Cytisine is contraindicated in hypertensive patients, severe atherosclerosis, pregnancy, and lactation.
There are no data for any clinically significant drug interactions of Cytisine with other drugs.
The most frequent adverse reactions after the beginning of the treatment using Cytisine are: changes in taste and appetite, dry mouth, headache, increased irritability, nausea, constipation, tachycardia, slightly elevated blood pressure. These reactions disappear during the treatment.
Cytisine is an alkaloid that is found naturally in several plant genera such as Laburnum and Cytisus of the family Fabaceae. Recent studies have shown it to be a more effective and significantly more affordable smoking cessation treatment than nicotine replacement therapy. Also known as baptitoxine or sophorine, Cytisine has been used as a smoking cessation treatment since 1964, and is relatively unknown in regions outside of central and Eastern Europe. Cytisine is a partial nicotinic acetylcholine agonist with a half-life of 4.8 hours. Recent Phase III clinical trials using Cytisine (a brand of Cytisine marketed by Sopharma AD) have shown similar efficacy to varenicline, but at a fraction of the cost.