Cozim-Q

Used for nutritional supplementation, also for treating dietary shortage or imbalance. (Acromegaly; Gigantism; Hyperammonemia; Hypophysectomy; Panhypopituitarism; Pituitary dwarfism; chromophobe adenoma; pituitary trauma; postsurgical craniopharyngioma; problems of growth and stature; urea cycle disorders;)

is indicated as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe ( ≥ 500 mg/dL) hypertriglyceridemia.

Oral

Selenium (Cozim-Q) deficiency

Adult: 100-500 mcg of Selenium (Cozim-Q) daily.

Intramuscular

Selenium (Cozim-Q) deficiency

Adult: 100-500 mcg of Selenium (Cozim-Q) daily.

Intravenous

Selenium (Cozim-Q) deficiency

Adult: 100-500 mcg of Selenium (Cozim-Q) daily.

R & D - Ubidecarenone (Cozim-Q) (Origin) is used as a heart energizer and antioxidant to fight against free radicals in the body. It serves as an energy booster for patients suffering from high-cholesterol, hypertension, congestive heart failure (CHF), and other heart related problems.

Treating patients who have very high triglyceride levels. It is used in addition to a low-fat diet.

Omega-3 fatty acids (Cozim-Q) is a lipid-regulating agent. Exactly how it works is not known. It may decrease the production of triglycerides in the liver.

Selenium (Cozim-Q) is mineral that is found in soil and occurs naturally in certain foods (such as whole grains, Brazil nuts, sunflower seeds, and seafood). Selenium (Cozim-Q) is not produced in the body, but it is needed for proper thyroid and immune system function.

Selenium (Cozim-Q) is used to treat or prevent Selenium (Cozim-Q) deficiency.

Selenium (Cozim-Q) has been used in alternative medicine as an aid to treat Hashimoto's thyroiditis (an autoimmune disorder of the thyroid), and to treat high cholesterol.

Not all uses for Selenium (Cozim-Q) have been approved by the FDA. Selenium (Cozim-Q) should not be used in place of medication prescribed for you by your doctor.

Selenium (Cozim-Q) may also be used for purposes not listed in this product guide.

Ubiquinone is a vitamin-like substance that is made naturally in the body. Ubiquinone is also known as Coenzima, Ubidcarenone, Ubidécarénone, and Ubiquinol.

Ubiquinone has been used in alternative medicine as a likely effective aid in treating coenzyme Q-10 deficiency, or reducing the symptoms of mitochondrial disorders (conditions that affect energy-production in the cells of the body).

Ubiquinone is also possibly effective in preventing migraine headaches, lowering blood pressure, preventing a second heart attack, or slowing the progression of early Parkinson's disease. Ubiquinone is also possibly effective in improving symptoms in people with congestive heart failure, nerve problems caused by diabetes, Huntington's disease, muscular dystrophy, or macular degeneration (age-related vision loss).

Ubiquinone has also been used to treat Alzheimer's disease, high cholesterol, or amyotrophic lateral sclerosis (Lou Gehrig's disease). However, research has shown that ubiquinone may not be effective in treating these conditions.

Research also has shown that ubiquinone is not likely to be effective in increasing athletic performance.

Other uses not proven with research have included treating asthma, COPD, cancer, diabetes, certain heart problems, fibromyalgia, hepatitis C, kidney problems, high blood pressure during pregnancy, muscle problems caused by taking "statin" cholesterol medicine, and other conditions.

Ubiquinone is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Ubiquinone may also be used for purposes not listed in this product guide.

Dosage depends on the severity of the catabolic state & amino acid requirement. Daily dose: 10-20ml/kg body wt equiv to 1-2g amino acids/kg body wt. Maximum daily dosage not >2g amino acids/kg body wt.

Selenium (Cozim-Q) Injection provides 40 mcg Selenium (Cozim-Q)/mL. For metabolically stable adults receiving TPN, the suggested additive dosage level is 20 to 40 mcg Selenium (Cozim-Q)/day. For pediatric patients, the suggested additive dosage level is 3 mcg/kg/day.

In adults, Selenium (Cozim-Q) deficiency states resulting from long-term TPN support, Selenium (Cozim-Q) as selenomethionine or selenious acid, administered intravenously at 100 mcg/day for a period of 24 and 31 days, respectively, has been reported to reverse deficiency symptoms without toxicity.

Aseptic addition of Selenium (Cozim-Q) Injection to the TPN solution under laminar flow hood is recommended. Selenium (Cozim-Q) is physically compatible with the electrolytes and other trace elements usually present in amino-acid/dextrose solution used for TPN. Frequent monitoring of plasma Selenium (Cozim-Q) levels is suggested as a guideline for subsequent administration. The normal whole blood range for Selenium (Cozim-Q) is approximately 10 to 37 mcg/100 mL.

Parenteral drug products should be inspected visually for particulate matter and discoloration, whenever solution and container permit.

Oral

Heart failure

Adult: 50-150 mg daily in 2-3 divided doses.

Oral

Angina pectoris

Adult: 150-600 mg daily in divided doses.

See also:
What is the most important information I should know about Omega-3 fatty acids (Cozim-Q)?

hypersensitivity

See also:
What is the most important information I should know about Selenium (Cozim-Q)?

Selenium (Cozim-Q) Injection should not be given undiluted by direct injection into a peripheral vein because of the potential for infusion phlebitis.

See also:
What is the most important information I should know about Ubidecarenone (Cozim-Q)?

Young children, pregnant or lactating women or those with severe liver or kidney diseases.

Use Omega-3 fatty acids (Cozim-Q) as directed by your doctor. Check the label on the medicine for exact dosing instructions:

• An extra patient information leaflet is available with Omega-3 fatty acids (Cozim-Q). Talk to your pharmacist if you have questions about this information.
• Some medicines may need to be taken with food. For some medicines, it does not matter. Check with your pharmacist about how to take Omega-3 fatty acids (Cozim-Q).
• Swallow Omega-3 fatty acids (Cozim-Q) whole. Do not break, open, crush, dissolve, or chew before swallowing. If you cannot swallow Omega-3 fatty acids (Cozim-Q) whole, tell your doctor. You may need a different medicine.
• Omega-3 fatty acids (Cozim-Q) works best if it is taken at the same time(s) each day.
• Do NOT change your dose or stop taking Omega-3 fatty acids (Cozim-Q) without talking to your doctor.
• If you miss a dose of Omega-3 fatty acids (Cozim-Q), take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Omega-3 fatty acids (Cozim-Q).

Use Selenium (Cozim-Q) lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Shake well before each use.
• Remove jewelry before using Selenium (Cozim-Q) lotion.
• Do not use on broken or inflamed skin or scalp.
• To use Selenium (Cozim-Q) lotion on the scalp - Massage 1 or 2 teaspoonfuls of the medicine on the wet scalp. Leave on the scalp for 2 to 3 minutes. Rinse scalp thoroughly. Wash hands well after treatment. If you are using Selenium (Cozim-Q) lotion before or after bleaching, tinting, or permanent waving of hair, rinse hair for at least 5 minutes in cool running water.
• To use Selenium (Cozim-Q) lotion on the skin - Apply a sufficient amount to cover affected areas of the body. Lather well with a small amount of water. Leave the medicine on the skin for 10 minutes. Rinse thoroughly in the shower. Wash hands well after treatment.
• If you miss a dose of Selenium (Cozim-Q) lotion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once

Ask your health care provider any questions you may have about how to use Selenium (Cozim-Q) lotion.

L-arginine (Cozim-Q) is used for congestive heart failure, chest pain, high blood pressure, and coronary artery disease. L-arginine (Cozim-Q) is also used for recurrent pain in the legs due to blocked arteries, decreased mental capacity in the elderly, erectile dysfunction, male infertility. L-arginine (Cozim-Q) for preventing the common cold, improving kidney function after a kidney transplant, high blood pressure during pregnancy (pre-eclampsia), improving athletic performance, boosting the immune system, and preventing inflammation of the digestive tract in premature infants.

Selenium (Cozim-Q) is used as a dietary supplement mainly in the treatment of Selenium (Cozim-Q) deficiency affecting young women and children with Keshan disease. It is also used for treatment of osteoarthiritis associated with poor Selenium (Cozim-Q) levels in body called Kashin-Beck Disease. Selenium (Cozim-Q) supplements are also used in patients with HIV/ AIDS to maintain the adequate Selenium (Cozim-Q) levels.

Coenzyme Q10 has been used for heart problems (e.g., heart failure, angina), high blood pressure, Parkinson's disease, gum disease, and certain diseases passed down through families (Huntington's disease, muscular dystrophy). It has also been used for preventing migraine headaches and for preventing cell damage that may occur after surgery or treatment with certain anti-cancer drugs. If you have or think you have any of the conditions listed above, consult your doctor for advice on proper care and treatment.

Coenzyme Q10 is a substance that your body normally makes. Your body uses it to help keep in good health.

Some herbal/diet supplement products have been found to contain possibly harmful impurities/additives. Check with your pharmacist for more details about the brand you use.

The FDA has not reviewed this product for safety or effectiveness. Consult your doctor or pharmacist for more details.

How to use Ubidecarenone (Cozim-Q)

This product is taken by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.

If you are using a liquid or powder form, carefully measure your dose using a medication-measuring device or spoon. Do not use a household spoon because you may not get the correct dose. If your liquid form is a suspension, shake the bottle well before measuring each dose. If your liquid comes in a tube/ampule, take the dose immediately after opening and discard any left over liquid. Follow the manufacturer's directions for mixing the powder form.

If you are using chewable tablets or wafers, chew each dose thoroughly before swallowing.

If you are using a tablet made to dissolve in the mouth, dry your hands before handling the tablet. Place each dose on the tongue and allow to dissolve completely, then swallow it with saliva or water.

Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

If your condition persists or worsens, or if you think you may have a serious medical problem, seek immediate medical attention.

Anticoagulants or Other Drugs Affecting Coagulation

Some studies with omega-3-acids demonstrated prolongation of bleeding time. The prolongation of bleeding time reported in these studies has not exceeded normal limits and did not produce clinically significant bleeding episodes. Clinical studies have not been done to thoroughly examine the effect of LOVAZA and concomitant anticoagulants. Patients receiving treatment with LOVAZA and an anticoagulant or other drug affecting coagulation should be monitored periodically (e.g., aspirin, NSAIDS, warfarin, coumarin).

See also:
What other drugs will affect Selenium (Cozim-Q)?

Baloxavir Marboxil: Polyvalent Cation Containing Products may decrease the serum concentration of Baloxavir Marboxil. Avoid combination

Bictegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Bictegravir. Management: Administer bictegravir under fasting conditions at least 2 hours before or 6 hours after polyvalent cation containing products. Coadministration of bictegravir with or 2 hours after most polyvalent cation products is not recommended. Consider therapy modification

Bisphosphonate Derivatives: Polyvalent Cation Containing Products may decrease the serum concentration of Bisphosphonate Derivatives. Management: Avoid administration of oral medications containing polyvalent cations within: 2 hours before or after tiludronate/clodronate/etidronate; 60 minutes after oral ibandronate; or 30 minutes after alendronate/risedronate. Exceptions: Pamidronate; Zoledronic Acid. Consider therapy modification

Deferiprone: Polyvalent Cation Containing Products may decrease the serum concentration of Deferiprone. Management: Separate administration of deferiprone and oral medications or supplements that contain polyvalent cations by at least 4 hours. Consider therapy modification

Dolutegravir: Selenium (Cozim-Q) may decrease the serum concentration of Dolutegravir. Management: Administer dolutegravir at least 2 hours before or 6 hours after oral Selenium (Cozim-Q). Administer the dolutegravir/rilpivirine combination product at least 4 hours before or 6 hours after oral Selenium (Cozim-Q). Consider therapy modification

Eltrombopag: Polyvalent Cation Containing Products may decrease the serum concentration of Eltrombopag. Management: Administer eltrombopag at least 2 hours before or 4 hours after oral administration of any polyvalent cation containing product. Consider therapy modification

Elvitegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Elvitegravir. Management: Administer elvitegravir 2 hours before or 6 hours after the administration of polyvalent cation containing products. Consider therapy modification

PenicillAMINE: Polyvalent Cation Containing Products may decrease the serum concentration of PenicillAMINE. Management: Separate the administration of penicillamine and oral polyvalent cation containing products by at least 1 hour. Consider therapy modification

Raltegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Raltegravir. Management: Administer raltegravir 2 hours before or 6 hours after administration of the polyvalent cations. Dose separation may not adequately minimize the significance of this interaction. Consider therapy modification

Trientine: Polyvalent Cation Containing Products may decrease the serum concentration of Trientine. Management: Avoid concomitant administration of trientine and oral products that contain polyvalent cations. If oral iron supplements are required, separate the administration by 2 hours. If other oral polyvalent cations are needed, separate administration by 1 hour. Consider therapy modification

See also:
What other drugs will affect Ubidecarenone (Cozim-Q)?

If you are taking this product under your doctor's direction, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

Before using this product, tell your doctor or pharmacist of all prescription and nonprescription medications you may use, especially of: drugs for high blood pressure, "blood thinners" (e.g., warfarin), drugs for diabetes, drugs for high cholesterol (e.g., atorvastatin, lovastatin).

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Abdominal bloating, Abdominal pain, Abnormality of blood, Allergy, Decreased blood pressure, Diarrhoea, Gout, Airway inflammation, Worsening of asthma

See also:
What are the possible side effects of Omega-3 fatty acids (Cozim-Q)?

Body as a Whole: Enlarged abdomen, asthenia, body odor, chest pain, chills, suicide, fever, generalized edema, fungal infection, malaise, neck pain, neoplasm, rheumatoid arthritis, and sudden death.

Cardiovascular System: Arrhythmia, bypass surgery, cardiac arrest, hyperlipemia, hypertension, migraine, myocardial infarct, myocardial ischemia, occlusion, peripheral vascular disorder, syncope, and tachycardia.

Digestive System: Anorexia, constipation, dry mouth, dysphagia, colitis, fecal incontinence, gastritis, gastroenteritis, gastrointestinal disorder, increased appetite, intestinal obstruction, melena, pancreatitis, tenesmus, and vomiting.

Hematologic-Lymphatic System: Lymphadenopathy.

Infections and Infestations: Viral infection.

Metabolic and Nutritional Disorders: Edema, hyperglycemia, increased ALT, and increased AST.

Musculoskeletal System: Arthralgia, arthritis, myalgia, pathological fracture, and tendon disorder.

Nervous System: Central nervous system neoplasia, depression, dizziness, emotional lability, facial paralysis, insomnia, vasodilatation, and vertigo.

Respiratory System: Asthma, bronchitis, increased cough, dyspnea, epistaxis, laryngitis, pharyngitis, pneumonia, rhinitis, and sinusitis.

Skin: Alopecia, eczema, pruritus, and sweating.

Special Senses: Cataract.

Urogenital System: Cervix disorder, endometrial carcinoma, epididymitis, and impotence.

See also:
What are the possible side effects of Selenium (Cozim-Q)?

Applies to Selenium (Cozim-Q) sulfide topical: topical cream, topical foam, topical lotion, topical shampoo, topical suspension

As well as its needed effects, Selenium (Cozim-Q) sulfide topical may cause unwanted side effects that require medical attention.

Severity: Moderate

If any of the following side effects occur while taking Selenium (Cozim-Q) sulfide topical, check with your doctor or nurse as soon as possible:

Less common or rare:

• Skin irritation

Minor Side Effects

Some Selenium (Cozim-Q) sulfide topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:

• Unusual dryness or oiliness of hair or scalp

• Increase in normal hair loss

See also:
What are the possible side effects of Ubidecarenone (Cozim-Q)?

This product usually has very few side effects. Nausea, loss of appetite, upset stomach, or diarrhea may rarely occur. If any of these effects persist or worsen, contact your doctor promptly.

A very serious allergic reaction to this product is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

An essential amino acid that is physiologically active in the L-form. [PubChem]

Each capsule contains Co-enzyme Q10 25 mg and 50 mg, respectively.

Ubidecarenone (Cozim-Q) also contains fractionated coconut oil as an inactive ingredient.