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Medically reviewed by Militian Inessa Mesropovna, PharmD. Last updated on 26.06.2023

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Mild to moderate pain and fever, Symptomatic treatment of headache, neuralgia, toothache, painful affections of the joints, fever and flu-like syndromes.
Aspirin (Couldina) is in a group of drugs called salicylates (sa-LIS-il-ates). It works by reducing substances in the body that cause pain, fever, and inflammation.
Chlorpheniramine (Couldina) is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.
Phenylephrine (Couldina) is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).
Aspirin (Couldina), Chlorpheniramine (Couldina), and Phenylephrine (Couldina) is a combination medicine used to treat fever, body aches, runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.
Aspirin (Couldina), Chlorpheniramine (Couldina), and Phenylephrine (Couldina) may also be used for purposes not listed in this medication guide.
Usual Adult Dose for Nasal Congestion:
ASA/Chlorpheniramine (Couldina)/Phenylephrine (Couldina) 325 mg-2 mg-7.8 mg oral tablet, effervescent:
2 tablets dissolved in 4 ounces of water every 4 hours not to exceed 8 tablets daily.
Usual Pediatric Dose for Nasal Congestion:
ASA/Chlorpheniramine (Couldina)/Phenylephrine (Couldina) 325 mg-2 mg-7.8 mg oral tablet, effervescent:
12 years or older: 2 tablets dissolved in 4 ounces of water every 4 hours not to exceed 8 tablets daily.
See also:
What is the most important information I should know about Couldina?
Use with caution in:
Asthma.
Decreased kidney function.
Decreased liver function.
Elderly people.
History of peptic ulcers.
Not to be used in:
Blood clotting disorder (haemophilia).
Breastfeeding.
Children and adolescents under 16 years of age, unless on the advice of a doctor.
Gout.
People in whom Aspirin (Couldina) or other NSAIDs, eg ibuprofen, cause allergic reactions such as asthma attacks, itchy rash (urticaria), nasal inflammation (rhinitis) or swelling of the lips, tongue and throat (angioedema).
Peptic ulcer.
Severely decreased kidney function.
Severely decreased liver function.
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Use Couldina as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Couldina by mouth with or without food.
- Do not chew or swallow the tablet. Place the tablet in a glass and add 4 oz/120 mL of water. Allow the tablet to dissolve completely, then drink all of the liquid. Rinse the container with an additional small amount of water and drink the contents to ensure the entire dose is taken.
- If you miss a dose of Couldina and you are taking it on a regular schedule, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Couldina.
See also:
What other drugs will affect Couldina?
People taking anticoagulant medicines used to prevent the blood clotting, eg warfarin, should not take Aspirin (Couldina) to relieve pain or inflammation. This is because Aspirin (Couldina) can irritate the stomach lining, as well as increasing the effects of warfarin, both of which increase the likelihood of bleeding. There may be an increased risk of bleeding if Aspirin (Couldina) is taken with other ’blood-thinning’ (antiplatelet) medicines such as clopidogrel or ticlopidine. Aspirin (Couldina) reduces the rate at which the body can remove the medicine methotrexate. The two should not usually be used together. There is an increased risk of side effects if Aspirin (Couldina) is taken with other non-steroidal anti-inflammatory drugs (NSAIDs), eg ibuprofen, diclofenac, indometacin. For this reason, Aspirin (Couldina) should not be taken with any other NSAID. There may be an increased risk of bleeding or ulceration of the stomach or intestines if Aspirin (Couldina) is taken with corticosteroids, eg prednisolone, dexamethasone. There may be an increased risk of side effects if Aspirin (Couldina) is taken with acetazolamide. Cholestyramine may reduce the absorption of paracetamol from the gut. Metoclopramide and domperidone may increase the absorption of paracetamol from the gut. Long-term or regular use of paracetamol may increase the anti-blood-clotting effect of warfarin and other anticoagulant medicines, leading to an increased risk of bleeding. Regular monitoring of blood clotting times should be performed if paracetamol is used regularly with these medicines. This effect does not occur with occasional pain-killing doses.
See also:
What are the possible side effects of Couldina?
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Skin rashes
Irritation to the lining or movements of the gut
Allergic reactions such as skin rash, swelling of the lips, tongue and throat (angioedema) or narrowing of the airways (bronchospasm)
Ulceration or bleeding of the stomach or intestines
Worsening of asthma
The side effects listed above may not include all of the side effects reported by the drug’s manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.