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Method of action:
Treatment option:
Medically reviewed by Oliinyk Elizabeth Ivanovna, PharmD. Last updated on 26.06.2023
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Molsidomine
CHD (prevention of angina attacks), congestive heart failure (in combination with cardiac glycosides and/or diuretics).
Inside, regardless of the meal, do not chew, drink enough liquid.
For the prevention of angina attacks: 1-4 mg 2-3 times a day, if necessary-8 mg (Table retard) 1-2 times a day, in particularly severe cases — 3 times. Relief of angina attacks: sublingual administration is 1-2 mg.
Hypersensitivity, cardiogenic shock, hypotension (sBP below 100 mmHg), glaucoma (especially angle-closure), vascular collapse, low left ventricular filling pressure, pregnancy (first trimester), breastfeeding.
From the nervous system and sensory organs: headache, dizziness.
From the cardiovascular system and blood (hematopoiesis, hemostasis): lowering blood pressure, collapse.
From the gastrointestinal tract: nausea.
Allergic reactions: skin rash, itching, bronchospasm.
Symptoms: severe headache, sharp drop in blood pressure, tachycardia.
Treatment: symptomatic therapy.
Absorbed quickly and almost completely, bioavailability-60-70%. Cmax (4.4 mcg / ml) is reached after 1 h. It does not bind to plasma proteins. In the liver, it is converted to pharmacologically active derivatives-SIN-1 and SIN-1A, eventually releasing NO. T1/2 - 0.85-2.35 hours. It is excreted in the form of metabolites mainly by the kidneys (90%), through the intestine (9%).
- Nitrates and nitrate-like agents
Molsidomine enhances the effect of vasodilators. Alcohol increases the effect. Acetylsalicylic acid enhances the antiplatelet activity.
