Coquelusedal

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Coquelusedal

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Coquelusedal

Property Description
Active ingredients Gelsemium, Grindelia, Melaleuca Oil (Niaouli Oil)
Form Suppository
Pharmacological class Antitussive combination, Adjunctive treatment
General purpose Symptomatic support for acute bronchial discomfort
Origin Primarily herbal (Phytotherapy)

Coquelusedal: Definition and Unique Positioning

Coquelusedal is a combination medicine classified as an antitussive combination intended for symptomatic support during benign acute bronchial conditions. Its role is to help alleviate related discomforts, rather than treating the underlying cause.

The medicine is provided in the suppository dosage form, utilizing the rectal route primarily for ease of administration in specific target audiences, such as infants and children, who may struggle with oral medication. Furthermore, Coquelusedal is explicitly differentiated into forms for Adults, Children, and Infants, ensuring the composition is appropriately tailored to the age group.

Composition and Herbal Origin

The medicine's identity is defined by its four botanical active ingredients, derived from herbal sources (Phytotherapy). The formulation includes soft hydroalcoholic extracts of Gelsemium and Grindelia, alongside the essential oil of Melaleuca quinquenervia, commonly known as Niaouli Oil.

Niaouli oil contributes the terpene derivative 1,8-cineole, a compound recognized for its local effects on mucous membranes and associated with balsamic properties. The combination of these extracts and essential oils distinguishes the formulation from single-ingredient remedies used for respiratory discomfort, providing a broad approach to temporary symptom relief.

General Purpose: Symptomatic Relief

The overall general purpose of Coquelusedal is to leverage the synergistic properties of its ingredients to help alleviate irritation associated with acute bronchial discomfort. The extracts are incorporated for their traditionally recognized calming action, while the Niaouli Oil contributes a known balsamic effect to the respiratory passages. The medicine functions as an adjunct treatment aimed at making the temporary symptoms of acute bronchial conditions more tolerable.

What side effects are possible with Coquelusedal?

Possible Side Effects and Safety Information

This section outlines the officially documented adverse effects and safety characteristics of Coquelusedal (Gelsemium, Grindelia, Niaouli Oil), based strictly on governmental regulatory sources, such as the French national drug agency (ANSM) and related regulatory summaries.

Documented Adverse Reactions

Side effects documented in regulatory labeling primarily fall into two categories: local reactions related to the suppository route and systemic risks related to the terpene derivative component (Niaouli Oil).

System-Organ Class Type of Adverse Reaction
General & Administration Site Irritation of the anus or rectum (Local effect)
Skin & Subcutaneous Tissue Skin irritation (Due to excipients like propylene glycol)
Nervous System Convulsions, agitation, or confusion (Serious systemic effects)

Serious and Exposure-Related Safety Notes

Serious Neurological Risk: The presence of the terpene derivative Niaouli Oil poses a risk of neurological accidents, specifically convulsions, in infants and children if the recommended duration of treatment or dosage is exceeded. Overdosage in adults, particularly the elderly, may lead to agitation or confusion of ideas.

Duration-Related Patterns: The frequency and intensity of local irritation are documented to increase with prolonged duration of use. The medication's rectal route is intended to be used for the shortest possible time to minimize local toxicity.

Safety Constraints for Specific Populations

Safety labeling specifies strict limitations for certain groups:

  • Infants and Children: Coquelusedal is contraindicated in children under 30 months of age and in any child with a history of epilepsy or febrile seizures.
  • Pregnancy and Lactation: Use is not recommended or discouraged during pregnancy and breastfeeding due to a lack of safety data and the potential transfer of undesirable terpene derivatives to the nursing infant.

Contraindications and Restrictions

Official restrictions include the following:

  • The medication is contraindicated if there is a recent history of anorectal lesions (rectitis, anitis, or rectal bleeding).
  • It is contraindicated for use concurrently with any other products (medicines or cosmetics) containing terpene derivatives.

Overdose and Emergency Response

Overdose and when to seek help

The official documentation regarding overdose for Coquelusedal addresses risks associated with its active components, the terpene derivative (Niaouli Oil) and Gelsemium.

Documented Manifestations and Life-Threatening Risks

The primary risk specifically outlined in the product labeling relates to the potential for neurological events. Overdose, or use exceeding the recommended duration, is associated with the accumulation of the terpene derivative component, leading to a risk of convulsions and other neurological disorders. This risk is explicitly stated as a concern for infants and children.

Toxicity from the Gelsemium component presents a separate, more severe risk. As documented in official toxicological literature, overdose may rapidly progress to life-threatening systemic poisoning, including respiratory depression and subsequent circulatory failure.

Required Emergency Actions

The mandated instruction provided in the product's official information following a suspected overdose is to Consult your doctor. Due to the documented potential for severe outcomes—including seizures or signs of respiratory compromise—urgent medical attention is required.

Management relies entirely on symptomatic treatment and supportive care because no specific antidote is known for the toxic components. Severe cases necessitate observation and specialized respiratory support in a monitored setting.

Therapeutic Uses of Coquelusedal

What Coquelusedal Treats: Main Uses and Benefits

The primary role of Coquelusedal is to offer symptomatic support for the distress generally associated with acute, benign bronchial conditions, acting as an adjunctive measure during periods of illness. It is commonly used when symptoms create noticeable interference with general comfort. The medication serves as a supportive therapeutic option in situations involving acute, time-limited respiratory discomfort.

Managing Irritative Cough and Bronchial Discomfort

This supportive combination is considered relevant across domains where additional symptomatic support is needed, primarily to address symptoms related to irritative states in the respiratory tract. It may assist with managing symptom clusters that become intense or disruptive, such as the bothersome irritative cough or the general feeling of bronchial distress. This offers symptomatic relief that may assist patients in managing difficult episodes.

Adjunctive Support for Acute Respiratory Episodes

The medicine may be considered relevant in conditions characterized by periods of heightened symptoms, specifically those acute episodes associated with colds or flu-like viral states. It is commonly used when short-term symptomatic assistance is needed across different age groups, including Infants, Children, and Adults. This focus supports the patient during episodes of heightened discomfort and may assist with maintaining functional stability during symptomatic phases.


Quick Fact: Used for Managing Symptoms of Bronchial Discomfort Coquelusedal is applied in scenarios where short-term symptomatic assistance is needed to manage the acute manifestations of lower respiratory tract irritation.

Regulatory References

  1. Base de Données Publique des Médicaments

Eligibility and Restrictions for Use

Who Can and Cannot Use Coquelusedal?

Eligibility to use Coquelusedal is strictly defined by regulatory documents based on age, medical history, and physiological status.

Contraindications and Restrictions

Population/Condition Eligibility Status Regulatory Context
History of Epilepsy/Convulsions Contraindicated Risk of neurological accidents due to terpene derivatives.
Children under 30 months Contraindicated Safety concerns regarding terpene derivatives, particularly for the Children’s formulation.
Pregnancy or Breastfeeding Not Recommended Risk of neurological complications in the fetus/infant via systemic exposure.
Anal or Rectal Lesions/Proctitis Contraindicated Local safety constraint due to the suppository route of administration.

Age-Specific Use

Coquelusedal formulations are differentiated by age to ensure safety related to the terpene derivative content:

  • Coquelusedal Nourrissons (Infants): Reserved for infants/children up to 30 months of age.
  • Coquelusedal Enfants (Children): Reserved for children from 30 months to 15 years.

Summary

Official regulatory information restricts the use of Coquelusedal based on neurological risks associated with its ingredients and local safety requirements of the suppository. Individuals with specific pre-existing conditions or physiological states are formally excluded or advised against use.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Contraindicated Combinations: Terpene Derivatives

The official interaction profile of Coquelusedal is strictly focused on the presence of terpene derivatives (specifically from Niaouli Oil), which creates a risk of additive systemic exposure. The co-administration of Coquelusedal with any other product containing terpene derivatives is formally classified as a contraindicated combination by regulatory authorities.

This prohibition applies to both medicinal products and cosmetics containing substances such as camphor, cineole, menthol, terpineol, and essential oils of eucalyptus and turpentine, regardless of their route of administration (oral, rectal, cutaneous, or pulmonary).

Pharmacodynamic and Population Risk

This restriction is imposed due to the risk of additive accumulation of the terpene derivative in the body, including the brain. This pharmacodynamic interaction is officially documented as increasing the risk of neurological disorders, such as convulsions, particularly in the sensitive populations of infants and children.

Interaction Classification Official Regulatory Information
Severity Classification Contraindicated Combination (Additive Risk for Neurological Toxicity)
Mechanistic Basis Risk of additive systemic exposure and accumulation of terpene derivatives
Timing-based Rule Must not be used at the same time (prohibited co-administration)

Exclusions

Regulatory documents explicitly state that interactions with food, drink, and other conventional herbal products are generally not applicable or specifically addressed beyond the mandatory prohibition of other terpene-containing products.

Mechanism of Action

The mechanism involves central and peripheral actions that modulate defined neurochemical and inflammatory pathways.

Central Modulation of the Cough Reflex

This domain involves the Gelsemium component acting on inhibitory Glycine receptors within the central nervous system (CNS), specifically in the medulla's cough center. This interaction functionally enhances inhibitory neural tone, a mechanistic process leading to an elevation of the activation threshold within the cough reflex pathway.

️ Peripheral Reduction of Airway Inflammation

The extracts, including Grindelia and 1,8-cineole, exert local action by modulating core inflammatory regulators, such as the NF-kappaB transcription factor and the COX-2 enzyme, in the bronchial lining. This mechanism causes a reduction in the synthesis of local pro-inflammatory mediators, resulting in decreased signal transduction from the bronchial tissues.

Modulation of Mucociliary Function

The 1,8-cineole component directly affects the respiratory tract's internal environment. Its mechanism involves stimulating the ciliary beat frequency and decreasing the viscosity of secretions on the mucous membranes. This process leads to an increase in the functional capacity of the mucociliary escalator, influencing the removal of secretions from the air passages.

Dosage and Administration Information

How to Use Coquelusedal: Administration Guidelines

The administration of Coquelusedal is governed by guidelines regarding the route, dose, frequency, and duration of use. The medicine is provided solely in a suppository form and is designated for the rectal route of administration.


Dosage and Age-Specific Forms

Coquelusedal is distinguished by three distinct, age-specific formulations, and the choice of product must align with the patient's age group to ensure appropriate compositional use. The maximum approved daily administration for all patient groups is two suppositories within a 24-hour period.

Population Age Range Standard Dosing Limit
Infants Up to 30 months 1 to 2 suppositories per day
Children 30 months to 15 years 1 to 2 suppositories per day
Adults 15 years and older 1 to 2 suppositories per day

Duration and Procedural Constraints

The overall treatment course is designated to be short-term. It is specified that the administration via the rectal route must be used for the shortest possible duration necessary. For the Children and Adults formulations, the course of use is restricted to a maximum of three days. There are no specific instructions regarding the timing of administration in relation to meals or any required preparation steps, such as dilution or reconstitution.

Recent Clinical Evidence

Coquelusedal is a pharmaceutical product traditionally used as an adjunctive treatment for benign acute bronchial disorders in both children (infant and child formulations) and adults. The formulation typically consists of a combination of plant extracts with antitussive properties, which may include soft hydroalcoholic extracts of Grindelia and Gelsemium.

Efficacy and Therapeutic Use

Clinical evidence supporting the efficacy of Coquelusedal largely stems from its traditional use and regulatory classifications, which position it for the symptomatic relief of acute cough and associated bronchial congestion. The components, such as Grindelia and Gelsemium, are classified for their properties aimed at soothing the respiratory system. The medication is commonly administered via the rectal route as a suppository, with specific formulations tailored to different age groups, including infants (up to 30 months) and older children (30 months to 15 years), and adults (15 years and over).

Age Group Key Active Ingredients (Example) Primary Use
Infant (up to 30 months) Grindelia extract, Gelsemium extract Adjunctive treatment for benign acute bronchial disorders
Child (30 months to 15 years) Grindelia extract, Gelsemium extract, Niaouli essence Adjunctive treatment for benign acute bronchial disorders
Adult (15 years and over) Grindelia extract, Gelsemium extract, Niaouli essence Adjunctive treatment for benign acute bronchial disorders

Safety and Administration

Regulatory warnings emphasize the importance of adhering strictly to the prescribed dosage and a short duration of treatment, typically limited to three days. This precaution is particularly relevant for the formulations containing niaouli essential oil, a terpene derivative present in the Child and Adult versions, which, in excessive doses, poses a theoretical risk of neurological events, such as convulsions, in infants and children. Contraindications include known allergies to the components and recent history of anorectal injury due to the route of administration. Patients are advised to consult a healthcare professional if symptoms persist, worsen, or are accompanied by fever or purulent sputum, as this may indicate a chronic or more serious underlying condition.

Frequently Asked Questions (FAQ)

Common questions about Coquelusedal (FAQ)


Q: What is the difference between Coquelusedal and typical cough syrups?

Coquelusedal is classified as an antitussive combination, and a primary difference from typical cough syrups is its dosage form. According to official product information, Coquelusedal is provided as a suppository and is administered through the rectal route. The rectal route of administration is specified in official product information, which is a key distinction from oral cough syrups.

Q: Do people use Coquelusedal for any conditions other than cough and cold?

Regulatory documents define the product's official purpose strictly. The medicine is indicated solely for use as an adjunctive (supportive) treatment for benign acute bronchial disorders. Official product information does not include indications or recommendations for use in any other health conditions.

Q: Is it normal to feel a mild sensation after using Coquelusedal?

The official product labeling for the rectal route of administration mentions the potential for local reactions. Official safety information lists irritation of the anus or rectum as a documented adverse effect. Regulatory documents advise that the product should be used for the shortest possible duration to minimize the risk of such local issues, which can increase with prolonged use.

Q: Can Coquelusedal be used if someone has a fever?

Special warnings in the official product information advise seeking professional consultation if a fever is present, or if other specific accompanying symptoms occur. These warnings include seeking professional advice if a fever is present, if symptoms worsen, or if purulent sputum (thick, often colored mucus) is noticed.

Q: What does official guidance say about using Coquelusedal for a dry cough versus a wet cough?

The medicine is indicated for use in managing the symptoms of benign acute bronchial disorders. Its intended use is defined as symptomatic support for acute bronchial disorders. The mechanism of action is described as encompassing both a soothing effect on the cough reflex (antitussive) and a mechanism that helps with the removal of secretions.

Q: Is Coquelusedal ever described as having pain-relieving properties?

Official regulatory information classifies Coquelusedal as an antitussive combination product. The documentation for the medicine's formal classification and primary purpose does not designate the product as an analgesic (pain reliever).

Q: Does Coquelusedal interact with medications for asthma or allergies?

Official regulatory warnings focus heavily on one critical interaction: the prohibition of concurrent use with any other product containing terpene derivatives (e.g., cineole, camphor). Beyond the mandatory prohibition of terpene derivatives, specific interactions with non-terpene-containing medications often used for asthma or allergies are not detailed in the product label.

Q: What kind of research has been done on the ingredients in Coquelusedal?

Official product information notes the product's use is designated based on its traditional use in addressing acute respiratory symptoms. The official documents detail the mechanisms of action of the components, but generally do not contain summaries or detailed statistics from full clinical trials in the Patient Information Leaflet.

Q: Is there any information about Coquelusedal being studied in adults?

The product is officially regulated, formulated, and indicated for use in an Adults formulation, designated for individuals aged 15 years and older. The product's official indication and formulation for adults confirm its regulatory scope includes this age group.

Q: What are the components in Coquelusedal that help with respiratory issues?

Coquelusedal is a combination medicine whose active ingredients are extracts of Gelsemium and Grindelia, along with Niaouli Oil. These components are combined to provide properties aimed at modulating the cough reflex, soothing the respiratory system, and creating a balsamic effect in the air passages.

Q: Is Coquelusedal a type of anti-inflammatory medicine?

The official classification of the medicine is an antitussive combination. This classification is used for medicines that help relieve cough symptoms, and the product is not primarily classified as an Anti-Inflammatory Agent.

Q: Is Coquelusedal considered a decongestant?

Official documents classify the medicine as an antitussive combination. The regulatory documentation does not classify the product as a decongestant, although one of its mechanisms involves affecting the respiratory tract's internal environment.

Q: Do studies suggest Coquelusedal can affect sleep?

Official regulatory warnings list potential serious systemic side effects, which are neurological in nature, including convulsions, agitation, and confusion, particularly in cases of overdose. The official safety labeling does not include drowsiness or common sleep disturbances among its documented adverse effects.

Q: Does Coquelusedal contain any ingredients that can cause drowsiness?

Official regulatory safety information lists potential neurological risks, such as convulsions, agitation, and confusion, particularly when the recommended dose is exceeded or for sensitive populations. Official safety labeling does not include drowsiness among its documented adverse effects.

Q: Does the efficacy of Coquelusedal depend on the type of infection causing the cough?

Coquelusedal is intended for the symptomatic support of acute bronchial disorders, meaning it helps relieve the discomfort of the cough itself. Official special warnings advise that a medical consultation be sought when symptoms are accompanied by purulent sputum, which may indicate a need for diagnosis of the underlying cause.

Q: Can Coquelusedal be used by patients with existing gastrointestinal issues?

Official regulatory documents contain a specific contraindication related to the product’s route of administration. The medicine is contraindicated if a patient has a recent history of anorectal lesions, such as rectitis, anitis, or rectal bleeding. The labeling does not address contraindications for general upper gastrointestinal issues.

Q: Are there documented cases of Coquelusedal interacting with blood thinners?

The official interaction profile is highly specific, listing a formal prohibition only against the concurrent use of any products containing terpene derivatives. The regulatory documents do not provide information or warnings regarding any interactions between Coquelusedal and anticoagulants (blood thinners).

Q: What does the research say about the long-term use of Coquelusedal?

Regulatory documents mandate that the overall treatment course must be short-term and is formally restricted to a maximum of three days for older children and adults. Official safety warnings advise against using the product for a longer duration due to the risk of accumulation of terpene derivatives and local irritation at the site of administration.

Q: Can Coquelusedal be used if a patient is already taking multivitamins?

The official interaction profile focuses strictly on the risk of additive exposure from products containing terpene derivatives. Regulatory documents state that interactions with common food, drink, and other conventional herbal products are generally not applicable or specifically addressed beyond the mandatory prohibition of other terpene-containing products.

Q: Is Coquelusedal considered an expectorant or a cough suppressant?

The product is officially classified as an antitussive combination by regulatory agencies. This classification is used for medicines that combine properties to help relieve cough symptoms, including both action on the cough reflex and effects on respiratory secretions.

How should Coquelusedal be stored and disposed of?

The official regulatory documentation for Coquelusedal suppositories specifies strict conditions for storage and disposal to ensure product integrity and environmental safety.

Storage Conditions

Requirement Official Statement
Maximum Temperature Store at a temperature not exceeding 25, C.
Freezing Restriction The product must not be frozen.
Child Protection Must be kept out of the reach and sight of children.
Flammable Warning Do not bring this product near a flame due to the presence of flammable terpene derivatives.

Disposal Instructions

To comply with environmental protection rules, unused or expired Coquelusedal must not be thrown away with household waste or into drains. The mandated procedure is to ask a pharmacist how to properly dispose of the medicine.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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