Concurat L 10%

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Concurat L 10%

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Method of action: Anthelmintic

Treatment option:

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Overview of Concurat L 10%

What is Concurat L 10%? Defining the Entity

Property Description
Active ingredient Levamisole
Form Oral Powder (10% concentration)
Pharmacological class Anthelmintic / Imidazothiazole
Common use Clearing parasitic worm infestations
Origin Synthetic compound

Concurat L 10% is defined as a specialized veterinary medicinal product primarily classified as a broad-spectrum anthelmintic. Its core function is to act as a dewormer to clear parasitic worm infestations in livestock and poultry. This classification as an antiparasitic agent relies on its ability to control various types of nematodes (roundworms) for managing the health burden of helminthiasis in animal populations.

Composition and Classification: The Role of Levamisole

The single active component in the product is Levamisole, a synthetic chemical entity recognized for its efficacy as an anthelmintic. Levamisole is the biologically active L-enantiomer of the racemic mixture Tetramisole, establishing a composition focused on the therapeutically potent form. The 10% concentration quantifies the presence of the active substance within the formulation.

Levamisole is classified pharmacologically as a nicotinic acetylcholine receptor agonist, which is the basis for its mechanism of action. This chemical class and its effect on nematodes results in an immediate, paralyzing effect on the nervous system of the target organisms. The oral powder format is a specific characteristic, distinguishing it as a versatile product suitable for mass administration through drinking water or feed.

General Purpose and Physiological Action

The general purpose of this medicine is achieved through its primary physiological action: the rapid, targeted paralysis and subsequent expulsion of susceptible parasitic worms. By stimulating the nematodes' nerve and muscle cells, Levamisole renders them immobile, facilitating their natural clearance from the host's body.

Beyond its primary anthelmintic function, Levamisole possesses distinct immunomodulator properties, which can help support the host's normal immune defenses. This means the compound provides general support for immune competence in addition to its main deworming role.

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What side effects are possible with Concurat L 10%?

Adverse Reactions and Safety Profile

The active substance in Concurat L 10% is Levamisole hydrochloride, a compound belonging to the anthelmintic class. The product is authorized for use in specific food-producing animals, and its safety evaluation is focused on both the treated animals and the consumer safety of the resulting food products.

Adverse reactions associated with Levamisole in target species (such as cattle, sheep, and pigs) are typically extensions of its pharmacological action and are generally uncommon when the recommended dosage is strictly followed. Clinically significant signs can involve the nervous system and the gastrointestinal system.

System-Organ Class Potential Reactions (Higher Doses/Sensitivity)
Nervous System Salivation, muscle tremors, ataxia, excitation, convulsions.
Gastrointestinal Increased motility, frequent defecation, vomiting, colic.

In cases of high dose or overdose, severe signs may occur, including respiratory distress and collapse. Immediate professional intervention is necessary in such instances. The safety index for Levamisole is considered narrower than for some other anthelmintics, meaning the risk of adverse effects increases more readily with dose adjustments.

Safety-Related Restrictions

Mandatory Withdrawal Periods are a primary safety measure to protect consumers from residues of the active substance. Meat, offal, and other edible tissues from treated animals (Cattle, Sheep, Duck, Pig) must not be consumed for a specific number of days following the final dose, as defined by regulatory authorization. These restrictions ensure that residues of Levamisole in the food product are below established safety limits.

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Overdose and Emergency Response

Overexposure to Levamisole (the active ingredient in Concurat L 10%) is defined by a severe toxic syndrome that requires immediate medical attention in all suspected cases, according to regulatory standards.


Documented Overdose Scope

Category Official Regulatory Statements
Documented overdose presentations Presentation includes acute signs of cholinergic overactivity, such as hypersalivation, vomiting, colic, muscle tremors, ataxia, clonic convulsions, and prostration.
Physiological systems affected Neurological system, Gastrointestinal tract, and Cardio-Respiratory system.
Dose-related or exposure-related factors Overdose has been associated with fatalities in cases of high-dose exposure.
Population-specific overdose notes Fatal human overdoses have been reported in both adults and children.

Severe Outcomes and Management

Classification Official Regulatory Statement
Severity classification The condition is capable of causing life-threatening outcomes, including systemic collapse and the neurological condition leukoencephalopathy.
Emergency-response statements Seek immediate medical attention is required. The instruction is to Immediately call a POISON CENTER or physician. Management is symptomatic and supportive.
Overdose-context constraints There is no specific antidote known for Levamisole toxicity. Management involves specific pharmacological agents, such as atropine, to counter severe effects.

Connection to the overall overdose profile: Regulatory documents define the overdose profile by listing the documented acute neurological and gastrointestinal manifestations that signal severe exposure. The profile establishes the official trigger for seeking help by mandating immediate medical attention for any suspected overdose, emphasizing the documented risk of life-threatening complications.

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Therapeutic Uses of Concurat L 10%

What Concurat L 10% Treats: Main Uses and Benefits

Concurat L 10% (Levamisole) is generally applied across therapeutic domains involving the management of parasitic worm infestations in livestock and poultry, and for providing supportive management during systemic strain. The product is commonly used to address conditions presenting with significant discomfort, and is primarily relevant across domains where additional symptomatic support is needed for infections involving roundworms.


The product is relevant for easing symptom clusters that may become intense or disruptive and is applied in scenarios where additional management of discomfort is required. The primary indications, therefore, include infections by gastrointestinal nematodes, lungworms, and the associated symptoms related to systemic imbalance like chronic diarrhoea, weight loss, and coughing. The overall benefit provides support that helps ease the overall symptom burden and contributes to easing the overall symptom load.

“It is commonly used across conditions presenting with acute episodes and helps improve day-to-day comfort during symptomatic periods.”

This treatment is often used during phases when symptoms become more noticeable, particularly in young, vulnerable animals where assisting with maintaining functional stability may be part of symptomatic management.


Quick Fact: Supportive Management for Systemic Imbalance
Relevant for managing symptoms related to systemic imbalance, such as weight loss and anaemia.

Regulatory References

  1. Food and Agriculture Organization of the United Nations (FAO)
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Eligibility and Restrictions for Use

Who Can and Cannot Use Concurat L 10%?

This section outlines the official population eligibility and non-eligibility rules for Concurat L 10% (Levamisole), a veterinary medicinal product, as documented in government regulatory sources.


Eligibility and Contraindicated Populations

Classification Official Regulatory Rule
Allowed Populations Approved target species including Cattle, Sheep, Goats, Swine, and Poultry. Use is generally permitted in young, pregnant, and lactating animals [EMA/FDA Equivalent].
Absolute Contraindications Animals with known hypersensitivity to Levamisole or with impaired hepatic (liver) function. Humans must not use this product.
Prohibited Use (Residue Risk) Must not be used in any animal producing milk or eggs for human consumption, including dairy animals of breeding age [FDA/EMA Equivalent].
Concurrent Medication Restriction Contraindicated if the animal is treated simultaneously or within 14 days before or after the use of organophosphorous compounds or diethylcarbamazine citrate [VMD/SPC].

Condition-Based Restrictions

Official labeling requires caution or restricts use in animals that are severely stressed, in ill-health, or severely debilitated. The product is generally not recommended for animals under significant stress or in poor overall condition.

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What should I know about interactions with other medicines?

The interaction profile for Concurat L 10% (Levamisole) is documented by regulatory authorities and includes specific restrictions and alterations to co-administered substances. This official information is based strictly on established pharmacokinetic and pharmacodynamic patterns.

Drug-Drug and Drug-Substance Restrictions

Interaction Type Interacting Substance Official Regulatory Statement
Mandatory Restriction Organophosphorus compounds Must not be administered within a 14-day period before or after treatment due to the risk of enhanced toxic effects.
Pharmacodynamic Risk Nicotine-like compounds (e.g., Pyrantel, Diethylcarbamazine) Co-administration carries a theoretical risk of enhanced toxic effects from additive activity on cholinergic systems.
Drug-Substance Alcohol (Ethanol) Co-administration is formally documented to cause a disulfiram-like reaction.

Pharmacokinetic Exposure Alterations

Interactions are officially documented to modify the systemic concentrations of certain agents:

  • Co-administration with Ivermectin results in an increase in Ivermectin's systemic exposure and bioavailability.
  • Co-administration with Albendazole is documented to cause a decrease in Albendazole bioavailability.
  • Co-administration may also increase the toxicity of Phenytoin.

The documented structure primarily highlights the necessity of absolute timing separation for organophosphorus compounds, defining a clear constraint within the official interaction profile.

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Mechanism of Action

Targeted Neuro-Activation and Spastic Paralysis

This mechanism operates via the Nicotinic Acetylcholine Receptors ( nAChRs) at the parasite's neuromuscular junction. By acting as an agonist, Levamisole overrides normal nerve-muscle signaling, causing a sustained depolarization of the muscle cells. This molecular cascade leads directly to irreversible spastic paralysis in the nematode, which is the physiological consequence enabling expulsion from the gastrointestinal tract.


️ Modulation of Host Cellular Immunity

A distinct mechanistic domain involves the modulation of the host's cellular defense pathways, specifically by stimulating cells like T-lymphocytes and macrophages. This action influences the regulation of immune responses and increases cellular activity (e.g., phagocytosis). The resulting physiological effect is the increased functional activity of cellular immune components, operating independently of the drug's direct paralyzing action on the parasite.


Receptor-Level Mechanism Limitations

The effectiveness of this specific neurotoxic mechanism is fundamentally constrained by the structure of the nAChR subunits in the parasite population. Where genetic changes have altered the binding site, the drug's agonistic signal is weakened. This pharmacodynamic resistance limits the desired physiological outcome of sustained depolarization and paralysis, providing a specific context where the nAChR activation signal is functionally diminished.

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Dosage and Administration Information

How to Use Concurat L 10%: Official Administration Guidelines

The usage of Concurat L 10% (Levamisole Soluble Powder) is governed by specific administration principles focusing strictly on the procedural aspects of delivery. The product is intended for oral administration exclusively, and the single, acute dose is calculated based on the weight of the animal, necessitating careful body weight estimation before use.

Official Administration Pattern

Administration is conducted as a single oral treatment. The standard therapeutic dose for target livestock, including cattle, sheep, goats, and swine, is set at a maximum of 8 mg Levamisole per kilogram (mg/kg) of body weight. For animals maintained under high exposure to parasites, instructions permit the need for a retreatment within a specific 2 to 4 week interval after the initial treatment, adhering to the single-dose regimen.

Preparation and Procedural Constraints

Since Concurat L 10% is an oral powder, dilution with water is mandatory to create a solution. This solution is then administered via one of the approved oral methods: as a drench, or mixed into feed, or medicated drinking water. When the solution is used as medicated drinking water for mass treatment, a critical procedural condition applies: all other sources of drinking water must be removed during the administration period. This constraint is in place to ensure the animal consumes the full calculated mg/kg dose.

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Recent Clinical Evidence

Research evidence / Overview of studies for Concurat L 10%


Evidence for use in Clearing Parasitic Worm Infestations

This section will summarize the framework of randomized, controlled field trials and comparative effectiveness research conducted to assess the compound’s properties, detailing the specific outcomes related to parasite elimination that were measured in livestock and poultry.

Research was primarily conducted in controlled field trials exploring how parasitic infestations change over defined time intervals. These studies examined the compound’s role in conditions characterized by fluctuating or episodic manifestations and monitored outcomes related to physical discomfort and measurements related to parasite presence. The research described how the active ingredient was absorbed and processed in the bodies of the studied animal species.

Studies report patterns related to measured changes in parasite egg counts and described variations in post-treatment worm burdens under the specific conditions of the trials. Some trials described varying rates of measured changes in parasite burden across host species, reflecting variations in formulation and administration. Research so far indicates that while the compound was studied for this use across various regions, some studies have described a reduced measurement of effect against certain specific worm strains.

Research indicates that the full geographical scope of potential anthelmintic resistance is not fully characterized, though it was observed in some studies. Evidence is limited for long-term monitoring of observed effects in all field settings, and resistance has been observed in some studies.


Evidence for Supportive Immune Management and Adjuvant Use

This section will detail the structure of the controlled laboratory studies and in vivo experiments that have examined the medicine’s relationship with immune response, outlining the specific immune markers and physiological outcomes that were evaluated.

Research explored its use in animal populations experiencing outcomes related to systemic or functional imbalance, such as young or stressed animals. These studies primarily monitored outcomes linked to inflammatory or irritative states by measuring markers of cellular and humoral immune activity, such as T-cell function and antibody concentrations. The research was evaluated in settings involving specific experimental models, often exploring its application alongside vaccines.

Data show patterns related to measured shifts in blood cell counts and antibody concentrations following administration under specific experimental conditions. Studies suggest a relationship between the compound and measured changes in immune parameters in the observed populations. Research provides insight into short-term changes in immune function.

The precise way the medicine was studied for its relationship with immune parameters is not fully established. Certainty remains low for generalizing these specific findings beyond the controlled laboratory settings where many studies were conducted. Research is ongoing to further clarify the exact mechanisms and the conditions under which these effects are observed.

Key Studies & References

  1. The Pharmacokinetics and Pilot Efficacy of Levamisole Administered by Subcutaneous Injection of a Combination Product in Domestic Goats (Capra aegagrus hircus) - Ovid
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Frequently Asked Questions (FAQ)

Common questions about Concurat L 10% (FAQ)


Q: What is the main condition or medical purpose of Concurat L 10%?

The active ingredient in this product is classified as an anthelmintic drug, meaning it is used to treat parasitic worm infections. Official documents also describe its historical use in combination therapy as an adjuvant for certain types of cancer.


Q: Is Concurat L 10% classified as a type of antibiotic or antifungal?

Official regulatory classification confirms that this drug is classified as an anthelmintic and an immunomodulator. It is not classified as an antibiotic, which is used to fight bacteria, nor is it an antifungal medication.


Q: What does the 'L 10%' part of the name indicate about the medication?

The active ingredient in this medication is Levamisole. The '10%' in the product name is generally used to indicate the concentration or strength of the active substance within that specific formulation.


Q: Are there any common reasons why a prescription for Concurat L 10% might be discontinued?

Official documents state that a prescription may be discontinued due to severe adverse events. This includes potentially serious drops in white blood cell counts, such as agranulocytosis (a severe drop in white blood cells), or severe skin reactions like a persistent rash.


Q: What is the expected timeframe before a user notices the effects of the medication?

Clinical pharmacology data indicates that the peak effect of the medication can be observed relatively quickly, often within two hours of administration. The timeframe for observable therapeutic changes can depend on the condition being addressed.


Q: What is considered a standard duration for a course of treatment with this drug?

The duration of treatment is specific to the medical problem being addressed. For some indications, a short, single course may be used, while official guidelines for other uses have involved intermittent use for periods extending up to one year.


Q: If I accidentally miss a single dose, what is the general recommendation?

According to official product information, if a single dose is missed, the recommended course of action is to skip the missed dose. The general guidance advises continuing with the regular schedule and avoiding taking a double dose.


Q: What are the most common reported side effects of Concurat L 10%?

Clinical reports indicate that the most common reported side effects are gastrointestinal, including nausea, diarrhea, and vomiting. Users also frequently report fatigue and some forms of rash.


Q: How often do users typically experience mild stomach upset with this medicine?

Specific clinical analyses indicate that nausea has been reported in up to 22% of patients, and diarrhea in up to 13% of patients. This provides an estimate of how often these mild stomach upsets may occur.


Q: Are there any signs of a serious allergic reaction associated with Concurat L 10%?

Official safety warnings include information on signs of a serious reaction, such as anaphylaxis. Symptoms may include difficulty breathing, closing of the throat, or swelling of the lips, tongue, or face.


Q: Is it common to experience changes in sleep patterns while using Concurat L 10%?

Official regulatory documents report changes in sleep patterns as a side effect. Both insomnia (difficulty falling or staying asleep) and somnolence (unusual drowsiness or sleepiness) have been reported in users.


Q: Can Concurat L 10% affect mood or energy levels?

Yes, regulatory documents list several psychiatric side effects, including depression, nervousness, and anxiety. General feelings of fatigue and overall malaise (discomfort) are also reported.


Q: Is a slight rash reported as a potential side effect?

Yes, official safety information indicates that a rash can be a potential side effect. Skin reactions such as dermatitis (skin inflammation) and rash have been reported in a significant percentage of patients.


Q: What organs in the body are primarily responsible for processing this drug?

The need for caution and potential monitoring in patients with existing liver and kidney conditions suggests these organs play a key role in how the drug is metabolized and cleared from the body.


Q: Are there any food or beverage restrictions while taking this medication?

Regulatory documents advise against consuming alcohol while using this medication due to the risk of enhanced adverse effects. However, official information states there are no known restrictions with food.


Q: Is Concurat L 10% generally safe for people who have a history of kidney issues?

Official guidance advises that the medication should be used with caution in patients with a history of kidney diseases. The regulatory information notes a potential increased risk of severe adverse effects associated with use in this population.


Q: Is the medication approved for use in pregnant or breastfeeding populations?

The drug is generally not recommended for use by pregnant or breastfeeding women. This is based on limited data concerning safety during human pregnancy and a lack of data on whether the drug passes into human milk.


Q: Do individuals with pre-existing liver conditions need special monitoring with this drug?

Yes, official precautions advise that this medication should be used with caution in patients with a history of liver diseases. Regular monitoring of liver function tests may be required during the course of treatment.


Q: Can patients with a history of seizures or epilepsy use Concurat L 10%?

Regulatory documents indicate that caution is advised for patients with a history of epilepsy or other seizure disorders. Seizures have also been reported as a rare, serious adverse event.


Q: Are there any long-term health concerns discussed in the research evidence for this drug?

Long-term use of the active ingredient is associated with a risk of hematologic toxicity (blood cell damage). This includes a potentially serious side effect called agranulocytosis, which is a severe drop in white blood cell count.


Q: Where can a user find the official patient information leaflet for Concurat L 10%?

Official regulatory information, including the Instructions for Use and safety summaries, can typically be found on the manufacturer's official labeling. These labels may be found on government websites, such as DailyMed or the FDA website, depending on local regulatory availability.


Q: Do clinical studies show that this medicine is generally well-tolerated?

The frequency of side effects reported in clinical studies, such as nausea (22%) and rash (14.8%), suggests that the medication may not be universally well-tolerated. This profile has led some patients to discontinue therapy.


Q: Are there different formulations (e.g., tablet, liquid) available for Concurat L 10%?

Official product information confirms that the active ingredient has been available in several different formulations. These include tablets, powder for solution, and other various solutions or pastes.


Q: Is it true that this drug can cause changes in taste or smell?

Yes, official safety reports indicate that this drug can cause changes in sensation. Taste perversion (altered taste) has been reported in about 8% of patients, and an altered sense of smell in about 1% of patients.


Q: Does this medication require any routine laboratory or blood monitoring?

Yes, for some specific indications, official safety guidance recommends routine laboratory and blood monitoring. This may involve weekly checks of blood cell counts (CBC) and regular monitoring of liver function tests.


Q: What does official guidance say about the safe disposal of unused medication?

Guidance on the safe disposal of any unused medication is typically found within the Instructions for Use or the detailed patient information that accompanies the drug. This information is specific to the country's disposal regulations.


Q: Is Concurat L 10% a drug that requires refrigerated storage?

According to official product information, the drug should be stored in a closed container at room temperature. It should be kept away from excessive heat, moisture, and light, and it does not require refrigeration.


Q: What are the general differences between the 10% strength and other possible strengths of the medication?

Different strengths of the medication primarily relate to the amount of active ingredient per dose unit. This difference helps determine how much of the product is needed to achieve the specific milligram dose prescribed by a healthcare provider.


Q: Does Concurat L 10% affect a patient's ability to drive or operate machinery?

Official warnings note that if side effects like dizziness or sleepiness occur, activities that require mental alertness, such as driving or operating heavy machinery, should be avoided.


Q: Is it necessary to take Concurat L 10% with food, or can it be taken on an empty stomach?

Based on regulatory information, the medication can be taken with or without food (empty stomach). This guidance should be followed unless otherwise specified by your prescribing healthcare professional.


Q: What are the signs that the medication may not be working as expected?

The drug’s effectiveness is often checked by a healthcare provider using laboratory tests. If original symptoms worsen or persist while taking the medication, this information should be relayed to a healthcare provider.


Q: Is there any research looking into the use of Concurat L 10% for other conditions?

Yes, official research has examined the active ingredient for more than just its primary use. Studies confirm it has been researched for and used as an immunomodulator, which means it has a relationship with restoring depressed immune function.

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How should Concurat L 10% be stored and disposed of?

Storage and Disposal of Concurat L 10% (Levamisole)

The official requirements for Concurat L 10% (Levamisole oral powder) strictly define storage and disposal procedures to maintain product integrity and environmental safety.


Storage Conditions

The powder must be stored under Controlled Room Temperature, typically between 15 C and 30 C.

Condition Requirement
Temperature Store below 30 C in a dry, cool, and well-ventilated place.
Protection Store in light-resistant containers and keep container tightly closed.
Access Control The product must be stored locked up and out of the sight and reach of children.

Stability and Disposal

The product's sealed shelf-life is generally 24 months, and the opened primary packaging is typically stable for 3 months.

Unused or expired product must be disposed of to an approved waste disposal plant in accordance with local regulations. It is mandatory to avoid release to the environment, and the powder must not enter drains or sewers.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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