Colsamin

Colsamin

Dexamethasone, Neomycin

Infections of the eye and its appendages:

blepharitis,

conjunctivitis,

keratoconjunctivitis,

keratitis,

iridocyclitis,

prevention of postoperative inflammation of the anterior part of the eye.

Into the conjunctival sac.

With a mild infectious process-1-2 drops of the drug are instilled every 4-6 hours. In the case of a severe infectious process, the drug is instilled every hour, as the phenomena of inflammation decrease, the frequency of instillations of the drug decreases. Before use, the bottle with drops should be shaken.

individual hypersensitivity to any of the components of this drug,

viral diseases of the eye (including keratitis caused by herpes simplex, chickenpox),

mycobacterial infection of the eye,

tubercular diseases of the eye,

acute herpes zoster,

fungal diseases of the eye,

condition after removal of a foreign body of the cornea,

purulent infection of the mucous membrane of the eye and eyelids caused by microorganisms resistant to the action of neomycin, purulent corneal ulcer.

With caution prescribed for glaucoma, cataracts.

Local. Allergic reaction, accompanied by itching and swelling of the eyelids, as well as redness of the conjunctiva. Side effects caused by the steroid component: increased intraocular pressure with possible subsequent development of glaucoma, damage to the optic nerve and visual fields (when using the drug for more than 10 days, monitoring of intraocular pressure is necessary), posterior subcapsular cataract, slowing down the healing process of wounds. Topical use of steroids in diseases that cause thinning of the cornea or sclera can lead to their perforation.

Secondary infection

The development of secondary infection is observed after the use of combined drugs containing glucocorticosteroids in combination with antibiotics. With prolonged use of steroids, the development of fungal infections of the cornea is possible. The appearance of non-healing ulcers on the cornea after prolonged treatment with steroid drugs may indicate the development of fungal invasion. Secondary bacterial infection can occur as a result of suppression of the protective reaction of the patient's body.

Neomycin - has a bactericidal effect, disrupting protein synthesis in the microbial cell. Active in relation to Staphylococcus aureus, Corynebacterium diphtheriae, Streptococcus viridans, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Aerobacter aerogenes, Haemophilus influenzae. It is not very effective against streptococci. It does not affect pathogenic fungi, viruses, and anaerobic flora. The resistance of microorganisms to neomycin develops slowly and to a small extent.

Polymyxin V. The mechanism of action is mainly due to the blockade of the permeability of the cytoplasmic membrane of bacterial cells. Active in relation to P. aeruginosa, Aerobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, Koch-Weeks bacillus.

Dexamethasone - GCS. It has anti-inflammatory, anti-allergic and desensitizing effects. It has an anti-exudative effect. Dexamethasone effectively suppresses inflammatory processes.

The combination of dexamethasone with antibiotics can reduce the risk of developing an infectious process.

When applied topically, systemic absorption is low.

• Glucocorticosteroids in combinations
• Ophthalmic products in combinations

Interaction with other drugs is not currently known.

In the case of use with other local ophthalmic drugs, the interval between their use should be at least 10 minutes.