Colme (Cyanamid)

Clear colorless solution with a faint smell of acetic acid.

Chronic alcoholism (treatment and prevention of relapses).

Inside, 36-75 mg (12-25 drops) 2 times a day (after 12 hours) according to an individual scheme.

increased individual sensitivity,

severe heart disease,

diseases of the respiratory tract and kidneys (with reduced function),

severe liver disease,

pregnancy,

the period of breastfeeding.

Taking the drug is accompanied by good health, if alcohol is not consumed. Sometimes there may be fatigue, drowsiness, skin rashes, tinnitus, transient leukocytosis.

Reaction to alcohol: when used simultaneously with alcohol, the following symptoms appear: severe hyperemia of the skin, "pulsation" in the head and neck, nausea, tachycardia, difficulty breathing, weakness, blurred vision, profuse sweating, chest pain. In more severe cases — vomiting, decreased blood pressure, respiratory depression, a collaptoid state. The nature and severity of the symptoms depend on the amount of alcohol consumed.

Symptoms: not described, may increase the side effect.

Treatment (in case of taking too large doses of the drug): gastric lavage, symptomatic therapy aimed at maintaining the functions of the liver, respiration and cardiovascular system. It is necessary to monitor the hematocrit index, if necessary, to transfuse blood.

It inhibits acetaldehyde dehydrogenase, which is involved in the metabolism of ethyl alcohol.

Promotes an increase in the concentration of the metabolite of ethyl alcohol-acetaldehyde, which causes negative sensations (flushes of blood to the face, nausea, tachycardia, shortness of breath, etc.), which make it unpleasant to drink alcohol, which leads to a conditioned reflex aversion to the taste and smell of alcoholic beverages.

The sensitizing effect of cyanamide on alcohol appears earlier (after about 45-60 minutes) and lasts shorter (about 12 hours) than the effect of disulfiram. Also, unlike disulfiram, cyanamide does not have a hypotensive effect.

• Remedies for the correction of disorders in alcoholism, substance abuse and drug addiction

The effect is enhanced by acetaldehyde dehydrogenase inhibitors (metronidazole, isoniazid, phenytoin, etc.), co-administration with them should be avoided. Do not prescribe simultaneously with disulfiram or earlier than 10 days after its cancellation. Incompatible with drugs aldehyde of nature (paraldehyde, chloral derivative).

In a place protected from light, at a temperature not exceeding 25 °C.

Keep out of reach of children.

Do not use after the expiration date indicated on the package.

in ampoules of dark glass of 15 ml, in a cell plastic tray of 4 pcs., complete with a dispenser bottle (dropper), in a pack of cardboard 1 pallet.

For dosing, you should break the ampoule containing the drug solution, pour the contents into the bottle enclosed in the package, and put it on the dropper bottle. The bottle should be kept tightly closed.

N07BB Drugs used for alcohol dependence

• F10. 2 Alcohol dependence syndrome