Components:
Method of action:
Treatment option:
Medically reviewed by Kovalenko Svetlana Olegovna, PharmD. Last updated on 12.03.2022
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Coldistan
Diphenhydramine, Naphazoline Hydrochloride
Acute, seasonal or year-round allergic conjunctivitis, irritation of the conjunctiva during the use of contact lenses, from exposure to sunlight, cigarette smoke, contact with water in a swimming pool, etc.
Conjunctival, adults and children over 2 years — 1-2 drops, but not more often than every 6-8 hours.
The drug should not be used for more than 3-5 days without the consent of an ophthalmologist.
Hypersensitivity to the components of the drug and adrenomimetic agents, narrow-angle glaucoma.
Most often-temporary symptoms from the conjunctiva: burning, itching, ophthalmalgia, vision disorder, redness of the conjunctiva, possibly-dilation of the pupil or an increase in intraocular pressure. A case of corneal opacity in a patient who instilled the drug in the conjunctival sac for 7 days at least 10 times a day is described. After discontinuation of the drug, the opacity disappeared.
Very rarely — drowsiness, palpitations, high blood pressure, headache, dizziness, nausea.
The appearance of any general reactions or prolonged local irritation requires discontinuation of the drug.
Prolonged or too frequent administration of the drug in young children can lead to central nervous system inhibition, hypothermia, coma, prolonged pupil dilation. Naphazoline can cause a sudden decrease in blood pressure and tachycardia.
There are no data concerning acute overdose of drops injected topically into the conjunctival sac.
The full local effect of naphazoline is detected after 5 minutes from the moment of topical application of the drug. Its action lasts up to 8 hours, and with frequent use of a large amount-up to 6 hours.
Naphazoline can be absorbed from the mucous membranes, causing general symptoms, although such an effect in adults after administration of the drug in the conjunctival sac is unlikely. General reactions mainly occur in elderly patients and in young children.
- Alpha-adrenomimetics in combinations
- H1- antihistamines in combinations
- Ophthalmic products in combinations
The use of drugs containing naphazoline in patients treated with tricyclic antidepressants may increase its vasoconstrictive effect. Concomitant use of MAO inhibitors with naphazoline may lead to a hypertensive crisis.
