Coforta

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Coforta

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Coforta

Property Description
Active Ingredients Butafosfan, Cyanocobalamin (Vitamin B12)
Form Solution for Injection
Pharmacological Class Metabolic Tonic and Roborant
Target Audience Veterinary Use (e.g., cattle, horses, swine)
Origin Combination: Synthetic Butafosfan + Semi-synthetic B Vitamin

Coforta: A Metabolic Tonic and Combination Roborant

Coforta is classified as a metabolic tonic and a roborant, defined as a general restorative agent designed to support and strengthen the body's systems, and is strictly intended for veterinary use. This specialized product is manufactured as a sterile solution for injection, which is administered via the parenteral route to allow rapid systemic availability of its components. Its classification is officially recognized as a mineral supplement combination under the ATCvet code QA12CX99.

Coforta is one of the most widely known branded preparations containing Butafosfan, frequently employed to support animals during common stress periods, such as recovery from transportation or post-partum exhaustion.


Composition: Butafosfan, Cyanocobalamin, and Origin

The preparation is a distinctive combination product containing two essential active pharmaceutical ingredients: the organic phosphorus compound Butafosfan and Cyanocobalamin (Vitamin B12). Butafosfan is a unique synthetic derivative of phosphonic acid, which provides a source of organic phosphorus known to influence the body's energy pathways. Butafosfan assists in stimulating liver function and maintaining general metabolism in domestic animals.

Cyanocobalamin is an essential B vitamin derivative required for key biochemical pathways. This combination pairs the immediate metabolic support of the phosphorus compound with the long-term hematopoietic support (red blood cell production) provided by the B vitamin.


General Purpose: Support for Vigor and Metabolic Stability

Coforta's general purpose is to broadly promote the restoration of vitality and metabolic stability when animals face challenging periods. The two active compounds synergistically enhance the efficient utilization of energy substrates and support healthy red blood cell production, assisting the body in recovering its natural capacity for function. The combined action of this supplement formulation is clinically recognized for aiding the animal's systems in achieving physiological balance after systemic challenge.

What side effects are possible with Coforta?

Possible Side Effects and Safety Information

The official regulatory safety profile for the Butafosfan and Cyanocobalamin combination product (Coforta) indicates a low incidence of adverse reactions in the target animal species. Documented safety concerns primarily involve potential immune responses and events related to the parenteral administration route.


Adverse Reaction Frequencies

Adverse reactions are classified according to frequency in regulatory documents:

  • Rare (1 to 10 animals per 10,000 treated): May include local reactions such as injection site pain or swelling, particularly following subcutaneous administration.
  • Very Rare (less than 1 animal per 10,000 treated): Circulatory shock is the most serious reaction documented, noted to be associated with rapid intravenous injection.

These effects are generally classified under General Disorders and Administration Site Conditions or Vascular Disorders.


Safety Constraints and Special Considerations

Use of the product is strictly contraindicated in animals with a known hypersensitivity or allergy to Butafosfan, Cyanocobalamin (Vitamin B12), or any of the excipients. The potential for anaphylactic reactions is a fundamental safety concern associated with the use of injectable B vitamins.

Specific regulatory notes apply to certain populations:

  • Cats: The excipient benzyl alcohol requires that the dose be strictly adhered to and caution be exercised due to species-specific metabolic differences.
  • Dogs with Chronic Renal Insufficiency: Use requires a formal benefit-risk assessment by a professional.

This safety structure emphasizes that risk mitigation depends primarily on confirming the absence of known hypersensitivity and ensuring correct, non-rapid administration technique.

Overdose and Emergency Response

Overdose and when to seek help

The regulatory profile for products containing Butafosfan and Cyanocobalamin (such as Coforta) indicates a low acute toxicity and a lack of specific, reported overdose symptoms at high dose multiples in key species. The official profile defines risk based on procedural issues and protocols for human exposure.

Domain Official Regulatory Statement
Documented Manifestations: No adverse effects were reported in cattle at up to five times the recommended dose. In dogs, only a transient slight swelling at the injection site was noted following high doses. Overdose symptoms are officially documented as "None known."
Severe Outcomes: Circulatory shock is documented as a very rare adverse event linked to too rapid intravenous injection, and is not classified as a typical dose-volume overdose symptom.
Data Gaps: Official overdose data are explicitly not available for horses and for dogs administered the product via the intravenous or intramuscular routes.

When Urgent Medical Help is Required

The primary mandatory action requiring immediate attention is accidental human exposure. In the event of accidental self-injection, the person must seek medical advice immediately and show the package leaflet or label to the attending physician.

Official regulatory documents state that no specific antidote is known for this combination, and management is supportive. The administration must always be performed very slowly to mitigate the documented risk of circulatory shock.

Therapeutic Uses of Coforta

What Coforta Treats: Main Uses and Benefits

Coforta is applied across domains where additional symptomatic support is needed to address symptoms related to systemic imbalance and temporary functional strain. The product is relevant for easing symptoms that are linked to systemic or temporary functional stress, such as symptoms that create noticeable physiological strain.

The combination is commonly used when short-term symptomatic assistance is needed for general systemic discomfort. It is applicable for conditions presenting with symptom clusters that may become intense or disruptive, such as symptoms of fatigue, low stamina, general weakness, and poor appetite.

It is often used during phases when symptoms become more noticeable, such as during recovery from illness, stress, or periods of overexertion. It helps address symptom clusters and supports the patient during difficult episodes by easing distress. The use of this combination is relevant for easing symptoms that interfere with daily functioning.


Quick Fact: Support for Low Stamina

Regulatory References

  1. Health Products Regulatory Authority (HPRA)

Eligibility and Restrictions for Use

Coforta is authorized exclusively for veterinary use. The official eligibility profile, as defined by governmental regulatory documents, establishes which animal populations are permitted to use the product and those who must avoid it.

Contraindications

The medicine must not be used in any animal with a documented hypersensitivity to its active substances—Butafosfan or Cyanocobalamin—or to any of its excipients, such as Benzyl alcohol. The product is strictly not for human use.

Eligible and Restricted Populations

Coforta is approved for use across target species including Cattle, Horses, Swine, Sheep, Goats, Dogs, and Cats, and is also eligible for juvenile groups such as Calves and Foals.

Eligibility is conditional in several circumstances:

  • Maternal Status: Use in pregnant or lactating Mares, Bitches, and Queens is restricted; its safety is not established and requires a veterinarian’s professional benefit-risk assessment. Use in cows is permitted.
  • Organ Function: Treatment of dogs with chronic renal insufficiency is conditional upon a specific benefit-risk evaluation.
  • Species Caution: Use in cats requires specific caution and strict dose adherence due to metabolic limitations related to the excipient, Benzyl alcohol.

What should I know about interactions with other medicines?

The official interaction profile for Coforta is defined by statements in government regulatory documents regarding both the combination product and the established profile of the Cyanocobalamin component.

Interaction Scope and Classification

The Summary of Product Characteristics for the Butafosfan and Cyanocobalamin solution explicitly states that no specific interactions with other medicinal products are known. This high-level classification is recorded in the regulatory basis established by European authorities.

Procedural and Component Constraints

A mandatory procedural constraint is that the solution must not be physically mixed with other veterinary medicinal products in the absence of documented compatibility studies. While formal drug-drug interactions for the combination are absent, interactions involving the Cyanocobalamin component are officially documented.

Exposure and Diagnostic Interactions

The official labeling for Cyanocobalamin outlines several exposure-modifying and diagnostic interactions. Substances such as colchicine and para-aminosalicylic acid, along with heavy alcohol intake lasting longer than two weeks, are associated with a potential to produce malabsorption of the Cyanocobalamin component. Furthermore, specific interacting medicines, including most antibiotics, methotrexate, and pyrimethamine, are officially listed as substances that can invalidate folic acid and vitamin B12 diagnostic blood assays.

Connection to the Profile

The regulatory documents establish that the product's official interaction structure is characterized by an absence of known drug interactions but is subject to a procedural restriction on mixing and component-specific effects on diagnostic tests and absorption.

Mechanism of Action

The mechanism operates through a coordinated dual-action, targeting core cellular processes for energy generation and substrate conversion. The Butafosfan component functions as a direct organic phosphorus donor that readily participates in cellular reactions, supporting the critical step of ATP synthesis and the phosphorylation of metabolic intermediates in pathways like glycolysis. The immediate supply of organic phosphorus to the cell's energy infrastructure reduces the magnitude of metabolic fatigue and supports phosphorylation-dependent processes within tissues, including smooth and cardiac muscle fibers. The Cyanocobalamin (B12) component is converted into cofactors necessary to activate two essential enzymes: Methylmalonyl-CoA Mutase (MCM) and Methionine Synthase (MS). Activation of MCM enables the conversion of propionate into glucose precursors, a reaction that contributes to the regulation of energy substrate balance. MS activation supports the DNA synthesis required for hematopoiesis. The combined mechanism provides both enzyme cofactors and substrate to enhance the overall efficiency of the liver's metabolic machinery. This effect extends to the modulation of regulatory factors, such as LXRalpha, which influences the pathways governing the breakdown of fat reserves, adjusting the physiological response associated with metabolic stress.

Dosage and Administration Information

How to Use Coforta: Official Administration Guidelines

Coforta is provided as a Solution for Injection, and its proper usage is governed by specific administration constraints and dosing schedules established guidelines. The medicine is administered exclusively via the Intramuscular (IM) or Subcutaneous (SC) injection routes.

The dosage protocol is highly species and age-dependent, necessitating different volumetric amounts for adult animals versus young animals (e.g., Cattle versus Calf).

Administration Scope Official Guideline
Route of Administration Intramuscular (IM) and Subcutaneous (SC) injection only.
Dosing Schedule Volumetric dosing varies by species. For acute supportive needs, the dose is typically higher (e.g., 5-25 mL for cattle/horses); for chronic support, the amount is reduced to approximately half the acute dose.
Frequency Pattern Acute Support: The full dose may be repeated daily if required. Chronic Support: The half dose is repeated at extended intervals, typically every one to two weeks or less.
Procedural Condition Injection volumes greater than 20 mL must be administered in parts, utilizing several injection sites (IM), or administered entirely via the SC route. Intramuscular injection must be made into the muscle tissue on the side of the neck.
Use-Context Constraint Administration is restricted to use by or under the supervision of a veterinary surgeon.

These official guidelines establish that Coforta is strictly a parenteral product, with administration restricted to intramuscular and subcutaneous routes. Dosage is governed by species-specific volume ranges, which are further divided based on the animal's age category (e.g., Pig versus Suckling Pig). The established protocols define two distinct time patterns for use: a high-frequency, daily repetition for acute supportive needs, and a lower-frequency, reduced-volume pattern for chronic or ongoing supportive use. This structured approach specifies both the technical requirements for injection, such as managing large volumes, and the necessary level of professional oversight required.

Recent Clinical Evidence

Research evidence / Overview of studies for Coforta

Evidence for Support During Metabolic Challenges in Cattle

Studies focused on high-producing dairy cows, a population dealing with conditions involving periods of heightened symptoms related to energy imbalance, such as subclinical ketosis. Research examined the product's use in these animals through both small, highly controlled trials and larger field observations. The primary outcomes related to systemic or functional imbalance that were monitored included blood levels of specific indicators like beta-hydroxybutyrate (BHBA) and Non-Esterified Fatty Acids (NEFA), which are measures of a cow's energy status.

When researchers analyzed the data, some trials described patterns where the study group had measurements of these metabolic biomarkers that differed from control groups. However, when monitoring outcomes reflecting daily functioning or activity level, specifically milk production, findings were mixed. Data show patterns related to milk yield have been heterogeneous across the available studies. Follow-up durations were limited in most research, meaning long-term changes are not fully established.


Research on Postpartum Recovery and Reproductive Markers

Studies explored the combination product in cows experiencing the postpartum period, which are conditions associated with acute or disruptive episodes. These trials primarily monitored outcomes linked to inflammatory or irritative states, such as the rate at which the uterus returns to its normal state (involution), and tracked metrics related to the timing of the reproductive cycle.

Studies observed some patterns where a faster rate of uterine involution was associated with the administration of the product in some studies. However, when examining final outcomes describing episodic or acute changes related to reproductive success, such as confirmed pregnancy rates, the reported observations have varied considerably. Direct, sustained evidence regarding final reproductive outcomes data are still emerging.


Gaps in Evidence and Areas of Uncertainty

The research highlights what is known—and what is still uncertain—about the product. Across the different indications, evidence quality varies across studies, and findings were mixed regarding key functional outcomes. These inconsistencies can be attributed to several research limitation frames, including the fact that sample sizes were modest in many trials and that environmental and management factors vary widely across field studies. Comparative evidence is lacking for many potential applications, and data for certain groups remain insufficient.

Key Studies & References

  1. Butaphosphan and Cyanocobalamin Supplementation in Semen Extender on Chilled Boar Sperm Quality and Life Span
  2. Effects of Adjunctive Treatment with an Injectable Combination of Butaphosphan and Cyanocobalamin to Individual Antimicrobial BRD Therapy on Hematological and Biochemical Parameters in Male Holstein-Friesian White Veal Calves
  3. Efficacy of a Butafosfan and Vitamin B12 Combination (Catosal®) on Biochemical and Hematological Blood Parameters in Dogs Tre
  4. Use of Butaphosphan with Cyanocobalamin in High Producing Cows and Associations with Milk Yield and Dry Matter Intake

Frequently Asked Questions (FAQ)

Common questions about Coforta (FAQ)


Q: What is the difference between Coforta and other vitamin B supplements?

Official documents describe Coforta as a combination of two active ingredients: Butafosfan, which is a unique organic phosphorus compound, and Cyanocobalamin (Vitamin B12). Most standard B vitamin supplements typically contain only one or more B vitamins. The inclusion of the phosphorus component, which supports energy metabolism, is what distinguishes this formulation.

Q: Is Coforta meant for long-term use?

Official guidelines establish distinct dosing patterns for the product. These include a high-frequency daily repetition for acute supportive needs, and a reduced-frequency, lower-volume repetition for chronic or ongoing supportive use. This structured approach allows for its use according to the lower-frequency pattern for chronic support.

Q: Is it common for people to feel nauseous after starting Coforta?

The official safety profile for the combination product specifies a limited list of rare and very rare adverse events. The documentation does not list nausea among the officially reported reactions.

Q: Can Coforta cause changes in blood pressure readings?

The official safety profile includes circulatory shock as a documented, very rare, and serious vascular reaction. This event is noted to be associated with rapid administration via the intravenous route. The safety profile focuses on this specific, rare event associated with administration technique.

Q: Are there any foods or drinks officially advised against while using Coforta?

Official labeling states that heavy alcohol intake lasting longer than two weeks is associated with a potential to produce malabsorption of the Cyanocobalamin component. No specific food items are advised against in the official documentation.

Q: Is Coforta safe to use during pregnancy according to regulatory bodies?

Official eligibility documents confirm that use in pregnant cows is permitted. However, for pregnant mares, bitches, and queens, safety is not established. Use in these populations is conditional upon a professional benefit-risk assessment.

Q: Is Coforta safe to use while breastfeeding according to regulatory bodies?

Official eligibility documents confirm that use in lactating cows is permitted. However, for lactating mares, bitches, and queens, safety is not established. Use in these populations is conditional, requiring a professional benefit-risk assessment.

Q: What are the signs of a possible allergic reaction to Coforta?

The official safety profile notes that use is strictly contraindicated in cases of known hypersensitivity (allergy). The most serious documented immune response listed is circulatory shock, classified as a very rare adverse reaction.

Q: Are there studies available that look at Coforta's long-term safety?

Official research summaries indicate that the follow-up durations were limited in most available studies. The documentation notes that long-term changes and effects over extended periods are not fully established.

Q: How does the action of Coforta compare to that of regular Vitamin B12 injections?

Coforta is described as having a dual mechanism of action. It combines Cyanocobalamin (Vitamin B12), which supports red blood cell production, with Butafosfan. Butafosfan is a unique organic phosphorus compound that acts as a donor to support immediate cellular energy metabolism (ATP synthesis).

Q: Does Coforta have different uses in different countries?

As an officially authorized product, its specific intended uses, classification (e.g., mineral supplement combination), and eligible species are defined by the regulatory documents of the country or region where it is marketed and approved. Therefore, minor differences may be observed between regional labels.

Q: How quickly do people generally expect to notice an effect from Coforta?

The product is a solution for injection designed for rapid systemic availability. Research studies examining its metabolic effects typically monitor initial changes in key metabolic indicators within a period of three to ten days after administration.

Q: Does Coforta interact with vitamins or other dietary supplements?

Regulatory documents include a procedural constraint that the solution must not be physically mixed with other medicinal products without documented compatibility studies. The product's specific interaction profile does not list general vitamins or dietary supplements.

Q: Does Coforta contain any common allergens like gluten or soy?

The official product composition lists the active ingredients and the major excipient, Benzyl alcohol. Regulatory documents do not explicitly declare the absence of trace allergens like gluten or soy.

Q: Is Coforta known to affect blood sugar levels?

The product's mechanism of action is described in official documents as influencing metabolic pathways. Specifically, it supports the efficient utilization of energy substrates and the conversion of precursors into glucose. These actions contribute to the regulation of energy substrate balance.

Q: Why is Coforta sometimes mentioned alongside neurological conditions?

The product contains Cyanocobalamin (Vitamin B12), which is an essential nutrient. Deficiency of B12 is recognized in wider medical documentation as potentially leading to neurological complications.

Q: Is there a risk of building up too much of the components of Coforta in the body?

Research related to the Butafosfan component notes that successive doses are administered because of its relatively short plasma half-life. Cyanocobalamin (B12) is a water-soluble vitamin.

Q: What is the typical duration of Coforta's presence in the body after administration?

The official dosing schedule, which requires daily repetition for acute support, is informed by the relatively short plasma half-life of the Butafosfan component.

Q: Is Coforta considered a controlled substance anywhere?

Regulatory documents classify this product as a Prescription Drug (Rx) or a product restricted to veterinary professional supervision. It is not listed as a scheduled controlled substance.

Q: Does Coforta's effectiveness change if it's taken with or without food?

Since the official administration route is exclusively via injection (intramuscular or subcutaneous), the product bypasses the digestive system. This means that the product's effectiveness is not affected by the animal's feeding schedule.

Q: What does the research say about Coforta's supporting role in recovery from illness?

Official research studies have focused on the product's supportive role during specific conditions involving metabolic stress, such as postpartum recovery in dairy cattle and other periods of high physiological challenge.

Q: Why do some users report a temporary change in urine color after using Coforta?

A component of the product, Cyanocobalamin (Vitamin B12), is water-soluble. Official medical literature recognizes that the metabolic byproducts of B vitamins can cause a temporary, noticeable change in urine color.

Q: Is Coforta a generic drug, or does it have multiple brand names?

Coforta is listed in regulatory documents as a brand name product. The combination of its two active ingredients, Butafosfan and Cyanocobalamin, is recognized as the generic name for this formulation.

Q: What is the non-directive guidance for using Coforta while traveling?

Official storage guidelines require that the product be kept protected from light, stored below 30 C, and that it must not be frozen. Maintaining these conditions during transportation is required to preserve the product's integrity.

How should Coforta be stored and disposed of?

How to Store and Dispose of Coforta?

The storage and disposal of the Coforta solution for injection must follow strict regulatory guidelines to maintain product stability and ensure environmental safety.

Storage Conditions

Requirement Official Regulatory Instruction
Temperature Store below 30 C; do not freeze or expose to temperatures below 0 C.
Light Protection Must be protected from light; keep the vial in the original outer carton.
Container Keep the container tightly closed and sealed until use.
Child Safety Keep out of the sight and reach of children and away from food.

Stability and Disposal

The product label specifies stability limitations once the multi-dose vial is entered. The remaining solution must be discarded within 28 days of the first use.

Disposal must adhere to specific environmental rules. Unused or expired product must not be discarded via wastewater or household waste. It must be returned through local take-back schemes or pharmaceutical waste collection points in accordance with governmental requirements.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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