Components:
Treatment option:
Medically reviewed by Oliinyk Elizabeth Ivanovna, PharmD. Last updated on 26.06.2023
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Clotrimazol GSK
Clotrimazol
Clotrimazol GSK venous stomatitis.
Fungal lesions of the skin and mucous membranes caused by dermatophytes, mold and yeast-like fungi, multi-colored lichen, erythrasma, candidiasis vulvovaginitis, trichomoniasis, mycoses complicated by secondary pyoderma, sanitation of the birth canal before childbirth.
Externally, the cream is applied in a thin layer to the affected areas of the skin 2-3 times a day and gently rubbed in. For a lesion the size of a palm, a column of cream 0.5 cm long is enough.
The duration of therapy is individual and depends on the severity and location of the disease. To achieve a complete recovery, do not stop treatment with the cream immediately after the disappearance of acute symptoms of inflammation or subjective complaints. The duration of therapy should be on average about 4 weeks.
With dermatomycosis-3-4 weeks, erythrasma-2-4 weeks, multi-colored lichen-1-3 weeks, candidiasis vulvitis and balanitis-1-2 weeks.
For fungal diseases of the skin of the legs, it is recommended to continue therapy for about 2 weeks after the symptoms of the disease are relieved.
Externally, intravaginally, the ointment is applied in a thin layer to the affected area of the skin 3 times a day until the subjective symptoms disappear, and for another 2 weeks. A single dose is a column of 5 mm per palm-sized surface area. For vaginal infections-enter deep into the vagina with an applicator 1 time per day. With candida vulvovaginitis and candida balanitis-2-3 times a day for 1-2 weeks. The total duration of treatment for dermatomycosis is 3-4 weeks, erythrasma-2-4 weeks, multi-colored lichen-1-3 weeks.
Hypersensitivity to the components of the drug.
Hypersensitivity, pregnancy (I trimester).
WARNINGS
†Do not use if you have abdominal pain, fever, or a foul-smelling vaginal discharge. You may have a condition which is more serious than a yeast infection. Contact your doctor immediately.
†Do not use if this is your first experience with vaginal itch and discomfort. See your doctor.
†If there is no improvement within 3 days, you may have a condition other than a yeast infection. Stop using this product and see your doctor.
†If you may have been exposed to the human immunodeficiency virus (HIV, the virus that causes AIDS) and are now having recurrent vaginal yeast infections, especially infections that don†t clear up easily with proper treatment, see your doctor promptly to determine the cause of your symptoms and to receive proper medical care.
†If symptoms recur within a 2 month period, contact your doctor.
†Do not use during pregnancy except under the advice and supervision of a doctor.
†This medication is for use in the vaginal and vulvar areas only. It is not for use in the mouth or the eyes. In case accidentally swallowed, seek professional assistance or contact a Poison Control Center immediately.
† Keep this and all drugs out of reach of children. This product is not to be used in children less than 12 years of age.
If you have questions about Clotrimazole Vaginal Cream or vaginal yeast infections, contact your doctor.
PRECAUTIONS
No information provided.
See PATIENT INFORMATION section.
The drug is usually well tolerated. In rare cases, with hypersensitivity to the components of the drug, allergic reactions are noted — redness of the oral mucosa, a burning and tingling sensation at the site of application of the drug, urticaria.
If irritation occurs, the drug should be discontinued.
Allergic reactions: hyperemia, itching, rash.
Acute overdose with topical application of the drug Clotrimazol GSK is unlikely and does not lead to a life-threatening situation.
Clotrimazole is an imidazole derivative, a broad-spectrum antifungal agent.
The antimycotic effect is associated with a violation of the synthesis of ergosterol, which is part of the cell membrane of fungi, which causes a change in its structure and properties and leads to cell lysis.
To clotrimazole sensitive dermatophytes, yeast-like fungi (genus Candida, Torulopsis glabrata, Rhodotorula), mold fungi, as well as the causative agent of multi-colored lichen Pityriasis versicolor and the causative agent of erythrasma.
It has an antimicrobial effect against gram-positive (staphylococci and streptococci) and gram-negative bacteria (Bacteroides, Gardnerella vaginalis), as well as in relation to Trichomonas vaginalis.
It has a wide spectrum of action. Active against dermatophytes, yeast fungi of the genus Candida, Corynebacterium minutissimum, Staphylococcus spp., Streptococcus spp., Trichomonas.
When applied topically, clotrimazole adsorption from the mucous membranes is negligible.
It is characterized by a high penetrating power. The concentration in the epidermis is higher than in the dermis and subcutaneous tissue. It has practically no systemic effect.
- Antifungal agents
- Other synthetic antibacterial agents
When used concomitantly with amphotericin B, nystatin, the activity of clotrimazole may decrease.
The effectiveness reduces nystatin.
