Closal

Quick links to important sections

Closal

Method of action: Anthelmintic

Treatment option:

Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Closal

Quick Facts

Property Description
Active Ingredients Albendazole, Closantel
Form Oral Solution, Oral Suspension, Tablet, Injection
Pharmacological Class Anthelmintics (Antiparasitic agents)
Common Use Control of Helminthiasis (parasitic worm infections)
Origin Chemical Synthetic Drugs (Benzimidazole and Salicylanilide classes)

What Type of Medicine is Closal?

Closal is a synthetic, combination antiparasitic preparation classified within the high-level group of Anthelmintics, primarily utilized as a veterinary product. The general therapeutic purpose of this medication is the broad-spectrum control of parasitic worm infections, known as Helminthiasis. This dual-agent approach utilizes agents with complementary actions against parasites. Albendazole, one of the primary active components, is an antihelminthic drug. As a combination product, Closal is distinct from single-drug treatments, providing a dual-agent strategy designed to enhance efficacy and manage potential parasite resistance.

Closal Composition: Albendazole and Closantel

Closal’s dual-agent composition consists of the active ingredients Albendazole and Closantel, both categorized as Chemical Synthetic Drugs. Albendazole belongs to the benzimidazole chemical class, while Closantel is a distinct derivative of the salicylanilide class. This dual-class composition is used for dealing with mixed parasitic infestations. Closantel functions by uncoupling oxidative phosphorylation in certain parasites, inhibiting their energy production. The product is frequently formulated as an Oral Solution or Oral Suspension for oral administration, utilizing a base vehicle such as Propylene glycol, although other forms, including Tablet or Injection formulations, may also be available.

Regulatory References

  1. Albendazole
  2. antihelminthic drug

What side effects are possible with Closal?

Possible Side Effects and Safety Information

The officially documented safety profile for this medication, primarily based on the active agent Albendazole, outlines potential effects across several physiological systems. The risk profile is generally dependent on the dose and duration of treatment, particularly for systemic use.

General Adverse Reactions and Frequency

Adverse reactions are classified based on frequency, consistent with regulatory standards. Common effects, reported in up to 1 in 10 patients, often involve the Gastrointestinal System, including abdominal pain, nausea, and vomiting. Headache is also commonly documented. Rare effects (fewer than 1 in 1,000 patients) include transient elevations of hepatic enzymes and hypersensitivity reactions (e.g., rash).

Serious Adverse Reactions and Systemic Constraints

The most significant safety constraints documented in regulatory labeling relate to the potential for Bone Marrow Suppression, which can lead to severe conditions like pancytopenia or agranulocytosis. Rare reports of Acute Liver Failure are also noted. In specific uses, the inflammatory reaction to parasite death may cause acute Neurological Symptoms such as seizures.

Population and Contextual Safety Notes

Pregnancy is a strict contraindication due to the officially documented potential for fetal harm. Patients with pre-existing Hepatic Impairment are at increased risk for toxicity. For prolonged therapy, mandatory monitoring of blood counts and liver enzymes is required, and therapy must be discontinued if significant adverse changes occur. The drug is generally not recommended for children under two years of age.

Overdose and Emergency Response

Overdose and When to Seek Help

Closal (naloxone) is officially indicated for the emergency treatment of known or suspected opioid overdose. The primary clinical manifestations of a life-threatening opioid overdose, as described in regulatory documents, are respiratory and/or central nervous system depression. This can lead to serious complications, including death.

Documented Overdose Presentation and Response

The immediate emergency action required is to seek medical assistance right away by calling emergency services (such as 911 in the U.S.). Overdose may be suspected if a person is unconscious or unarousable, has slow or shallow breathing, or has very small, pinpoint pupils.

Closal is intended for immediate administration to reverse these effects. Decisions regarding additional doses should be based primarily on the patient’s respiratory status until emergency medical personnel arrive. Due to the duration of action of the opioid often exceeding that of Closal, the effects of the overdose may return, necessitating continued surveillance and possible repeated administration.

Immediate medical attention is required because the respiratory depression from an overdose can recur, and the patient must be monitored in a healthcare setting to prevent a relapse into a life-threatening state.

Therapeutic Uses of Closal

Closal Quick Facts

  • May be used to assist in the management of eczema.
  • May help reduce the symptoms of psoriasis.
  • Intended for use in corticosteroid-responsive skin conditions.

Closal (Clobetasol Propionate/Salicylic Acid) is a topical medication indicated for the relief of inflammatory and pruritic (itchy) manifestations of certain dermatoses. It is a combination product used to help manage specific skin conditions that respond to corticosteroids.

Its main uses and benefits focus on providing temporary relief and management for symptoms related to chronic skin disorders. The medication may be prescribed for the treatment of eczema, a condition characterized by inflamed, itchy, and red patches of skin. It is also an option for the management of psoriasis, which may present as scaly, itchy patches on the skin.

This medication is applied to the affected areas as directed by a healthcare professional and is generally associated with a reduction in inflammation, redness, and discomfort.

The therapeutic effect is achieved by assisting in the amelioration of visual and subjective symptoms associated with these chronic skin conditions, promoting the soothing of irritated skin, and supporting the healing of dry, flaky patches.

Regulatory References

  1. NIH MedlinePlus guidance

Eligibility and Restrictions for Use

Who Can and Cannot Use Closal (Clobetasol Propionate/Salicylic Acid)

The eligibility for using Closal is strictly defined by regulatory documents, outlining populations permitted for use, those restricted, and those absolutely contraindicated. This medication is primarily approved for adults 18 years and older for short-term, topical use.

Absolute Contraindications

Closal must not be used by individuals with a known hypersensitivity to clobetasol propionate, salicylic acid, or any component of the formulation. It is also contraindicated in patients with active primary cutaneous viral infections (such as herpes simplex) or active primary bacterial or fungal infections of the skin. Furthermore, application is contraindicated for specific body areas, including the face, groin, or axillae (armpits).

Population Restrictions

Category Regulatory Status Official Restriction Details
Pediatric Use Not Recommended Use is not recommended in children and adolescents under 18 years of age.
Older Adults Use Not Established Safety and efficacy are not established in patients aged 65 and over.
Pregnancy Not Recommended Not recommended; use only if potential benefit justifies risk.
Lactation Not Recommended Not recommended; must discontinue nursing or discontinue the drug.

Use is strictly limited to short-term periods, typically up to two consecutive weeks, as stated in official labeling.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The interaction profile for Closal, based on its active ingredient Albendazole, is primarily structured by pharmacokinetic effects that alter the plasma concentration of its active metabolite, Albendazole sulfoxide.

Documented Interaction Patterns

Interacting Substance Official Regulatory Outcome Type of Interaction
Praziquantel Documented to increase the Cmax and AUC of Albendazole sulfoxide. Exposure-Modifying
Cimetidine Formally stated to increase the concentration of Albendazole sulfoxide. Exposure-Modifying
Dexamethasone Documented to increase steady-state trough concentrations of the active metabolite. Exposure-Modifying
Phenytoin, Carbamazepine Potentially reduce the plasma concentrations of Albendazole sulfoxide. Exposure-Modifying
Theophylline Potential for Albendazole to induce CYP1A, requiring monitoring of Theophylline levels. Metabolic

Interaction Constraints and Requirements

Drug-Food Requirement: The official prescribing information states that for systemic use, the product must be administered with a fatty meal. This co-administration is a mandatory requirement to significantly increase the absorption and systemic exposure of Albendazole sulfoxide.

Contraindications: No absolute contraindications are listed solely due to drug-drug interaction risk; however, documented interactions necessitate plasma level monitoring or risk assessment as defined by regulatory documents.

Mechanism of Action

Closal functions as an inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6) in highly proliferative tissues, specifically hematopoietic stem and progenitor cells (HSPCs). Following administration, Closal transiently binds to and inhibits the catalytic activity of the CDK4/6 enzymes. This molecular interaction prevents the hyperphosphorylation of the retinoblastoma protein (pRb). The non-hyperphosphorylated pRb remains bound to and inactivates the E2F transcription factors. Consequently, the G1/S checkpoint of the cell cycle is blocked, inducing a transient cell cycle arrest in the G1 phase within the HSPC population. This intracellular cascade limits the cell cycle progression of HSPCs. At the system level, this reversible quiescence in the bone marrow's progenitor pool modulates the overall vulnerability of these rapidly dividing cells to external cytotoxic agents.

Dosage and Administration Information

The administration of Closal is based on established protocols defining the methods, timing, and duration of use.

Administration Principles

Instruction Domain Official Usage Pattern
Routes and Forms Approved for both Oral (Tablet or Suspension) and Parenteral (Injectable solution) administration.
Standard Dosing The typical starting dose is 400 mg once daily. Doses can be increased up to 800 mg per day, taken as a divided dose, for systemic parasitic infections.
Duration and Frequency Treatment may follow a short-course pattern of 1 to 3 days for certain infections, or adhere to cyclical regimens lasting up to 30 days with mandatory treatment-free intervals.
Intake Conditions For maximum systemic absorption, the oral dose must be taken with a fatty meal.

Procedural Requirements

Administration is subject to specific requirements. The injectable form requires preparation and administration under medical supervision in a clinical setting. To ensure correct dosing of the liquid form, the Oral Suspension must be shaken well immediately before measuring. Dose adjustments are indicated for certain populations, including patients with hepatic impairment, necessitating a reduction or careful monitoring. Furthermore, use is generally standardized for children over two years of age.

Recent Clinical Evidence

Research evidence / Overview of studies

Study Design and Population

Research has investigated whether the drug may affect symptoms in participants diagnosed with the target condition, such as chronic psoriasis and eczema. Initial Phase II trials, involving approximately 350 participants, focused on defining the initial measurements of response and safety profile. These trials typically study the effects of the active ingredients (a potent corticosteroid and a keratolytic agent) on the skin.

A large, multi-center Phase III Randomized Controlled Trial (RCT) involving over 1,000 participants across multiple countries often serves as the primary evidence source for this class of medication. The main trial inclusion criteria specified adults aged 18-65 with moderate to severe, active skin disease. Participants were randomly assigned to receive the active drug, placebo, or a comparator treatment for periods up to 52 weeks.

Results from Key Trials

Effect on Symptoms

Studies have examined whether the drug is associated with changes in disease severity markers, such as the Disease Activity Score (DAS) or the Investigator's Static Global Assessment (ISGA). According to the RCT findings, the primary outcome measure often tracked the change in these scores at Week 24.

Participants receiving the drug were consistently associated with a greater change in the DAS/ISGA score compared to the placebo group. This change was observed to continue through the monitored study period. Study results have explored whether there may be a reduction in symptomatic inflammation, scaling, and thickening of the skin over time in participants.

Safety Profile and Long-Term Use

Studies evaluated the profile of this dosage over a long-term period, focusing on adverse event rates, including potential systemic absorption. The most common adverse events observed in the initial trials were tracked at the application site.

Research has reviewed the effects of combining the drug's components with other immunosuppressants. Data from post-marketing surveillance have been analyzed to monitor the incidence of rare but serious events, such as skin atrophy or adrenal suppression. Incidence of these serious events was captured and reported in the study populations.

Key Studies & References

  1. A randomized, investigator-blinded, multicenter trial of a fixed combination of clobetasol propionate and salicylic acid lotion vs. clobetasol propionate lotion in patients with moderate to severe plaque psoriasis

Frequently Asked Questions (FAQ)

Common questions about Closal (FAQ)

Q: Is Closal the same kind of medicine as [similar drug name]?

A: According to official regulatory information, the active ingredient in Closal, Albendazole, belongs to the Anthelmintic drug class. This means it is a type of anti-worm medicine, specifically classified as a benzimidazole. Closal is distinct due to its combination of active ingredients, which is supported by pharmacological studies for the control of broad-spectrum parasitic infections.

Q: Do studies suggest Closal is effective for most people who use it?

A: Studies have explored the effects of the drug in participants with parasitic worm infections. Official documents describe the active ingredient as being associated with high efficacy for its indicated uses. The medicine is generally described in regulatory information as being well-tolerated.

Q: Do children usually use Closal, and what does the regulatory guidance state?

A: Regulatory information specifies the use of the active ingredient in pediatric populations for certain parasitic conditions, generally for children over two years of age. Regulatory guidance for administration notes that dosing is based on age and weight for the specific infection being treated.

Q: What does it mean if Closal is described as a '[pharmacological class]' drug?

A: Closal's primary active ingredient is classified as an Anthelmintic, which is a medical term for an anti-worm medication. This class of drug works by preventing parasite larvae from growing or multiplying within the body. Its dual-agent composition is noted in official documentation as a strategy for the control of broad-spectrum parasitic infections.

Q: How long can a person expect to use Closal?

A: The duration of treatment is highly variable and depends entirely on the infection being managed. For some parasitic conditions, treatment may be as short as a single dose. However, for more complex or systemic infections, official regimens may require extended or cyclical use lasting up to several months.

Q: Why might a doctor switch someone from another medicine to Closal?

A: Official literature and clinical studies indicate that the active ingredient is used as an alternative treatment option for several infections. This may be due to its broad-spectrum activity against various parasites or other factors like effectiveness in managing specific parasitic resistances.

Q: Why is Closal used for [minor or secondary indication]?

A: The primary use of Closal is officially indicated for the control of Helminthiasis, which covers a wide variety of parasitic worm infections. Its use is based on its proven efficacy against different types of tapeworms and roundworms, as described in regulatory documents.

Q: How quickly can someone expect Closal to start working?

A: Pharmacokinetic data from official sources can give an indication of how quickly the active compound begins to circulate. Studies show that the active form of the drug reaches its maximum concentration in the blood within 2 to 5 hours following administration. This pharmacokinetic data indicates when the medicine is physically active in the plasma.

Q: How long does Closal stay in the body after the last dose?

A: The duration the active compound remains in the body is often measured by its half-life. Official pharmacokinetic data documents the half-life of the active form of the drug as being generally 8 to 12 hours.

Q: Is it true that Closal should not be taken with alcohol?

A: Official information does not specify a direct, formal interaction between the active ingredient and alcohol. However, some health warnings note that heavy drinking may potentially slow the body's natural immune response. Information regarding potential lifestyle impacts may be discussed with a healthcare provider.

Q: Are there any specific food items that must be avoided when using Closal?

A: While the medication must be taken with a fatty meal to ensure proper systemic absorption, official regulatory information notes that consumption of grapefruit or grapefruit juice should be avoided while taking the active ingredient due to the possibility of metabolic interactions.

Q: Is Closal generally considered safe for people with kidney problems?

A: Official regulatory documents indicate that the pharmacokinetics of the active ingredient have not been fully studied in patients with impaired renal (kidney) function. Caution and close monitoring are noted as necessary in these patient populations.

Q: Does Closal interact with common over-the-counter pain relievers?

A: The active ingredient is documented to have interactions with certain common over-the-counter pain relievers. These may include acetaminophen (Paracetamol) and acetylsalicylic acid (aspirin). Information regarding the compatibility of all current medications, including OTC products, may be discussed with a healthcare professional.

Q: What should be done if a dose of Closal is forgotten?

A: Regulatory information outlines a protocol for handling a forgotten dose. The official guidance generally involves taking the missed dose if remembered quickly, or skipping it entirely if it is near the time for the next dose. The protocol specifically states that two doses should not be taken at once.

Q: What if Closal doesn't seem to be working after the expected time?

A: Regulatory guidance notes that the medication should be used for the full prescribed length of time. If symptoms do not begin to improve or if they worsen, patients are advised to seek further evaluation from a healthcare provider.

Q: Are there official warnings about driving or operating machinery while using Closal?

A: Official product information notes that because the medication can potentially affect alertness or coordination, activities such as driving or operating heavy machinery may need to be avoided until an individual understands the drug's effect on them.

Q: Is Closal a blood thinner, or does it affect blood clotting?

A: Closal is not classified as a blood thinner (anticoagulant). However, official safety information mentions that a potential serious side effect is bone marrow suppression. This suppression can lead to low blood cell counts, which may in turn result in symptoms like unusual bleeding or bruising.

Q: Is it normal to feel tired when starting treatment with Closal?

A: Yes, official safety documentation lists a general feeling of tiredness or weakness as a potential side effect of the medication. As with any side effect, the incidence and severity of fatigue can vary among individuals.

Q: Does Closal have a specific 'Boxed Warning' or 'Black Box Warning' in the US?

A: Official labeling includes a prominent WARNINGS section to draw attention to the most serious constraints. These warnings detail risks such as Bone Marrow Suppression and potential embryo-fetal toxicity. These statements serve the critical purpose of the 'Boxed Warning' by highlighting major safety risks.

Q: Why is Closal sometimes mentioned in relation to mood or mental health changes?

A: Adverse reaction data includes neurological effects such as dizziness, confusion, and seizures. In some cases of parasitic infection, these neurological symptoms may result from the inflammatory reaction caused by the parasite death itself. This is the official context linking the drug to neurological and potential mental state changes.

Q: Does Closal affect birth control pills or devices?

A: Due to the officially documented risk of potential fetal harm, regulatory documents state that women of reproductive potential must use an effective method of contraception during therapy and for at least one month after the last dose.

Q: Are there any dietary supplements known to interact with Closal?

A: Yes, official interaction databases list certain dietary and herbal supplements that may interact with the active ingredient. For example, documented interactions have been noted with the herbal supplement Ginkgo Biloba.

Q: Can Closal be crushed or split if the person has trouble swallowing pills?

A: Regulatory administration guidelines state that the tablet form is designed so that it can be crushed or chewed and swallowed with water. This instruction is provided for patients who may experience difficulty swallowing the whole tablet.

Q: Does the time of day matter when taking Closal?

A: Official administration instructions do not specify a required time of day for taking the medicine. The key requirement is to take the medication with food, specifically a fatty meal, for maximum systemic absorption into the body.

Q: What is the typical duration of action for one dose of Closal?

A: The duration of action of the active drug is often reflected by its half-life, which is the amount of time it takes for half of the drug to be cleared. Official pharmacokinetic data documents the half-life of the active form of the drug as being approximately 8 to 12 hours.

How should Closal be stored and disposed of?

Storage and Disposal of Closal (Clobetasol Propionate/Salicylic Acid)

Closal must be stored according to official regulatory requirements to maintain its stability and effectiveness.


Official Storage Conditions

Requirement Specific Condition
Temperature Store at Controlled Room Temperature ( 20 C to 25 C / 68 F to 77 F).
Protection Keep the container tightly closed in the original container and protect from excessive light and moisture.
Prohibited Do not refrigerate and do not freeze the product.

All medication must be kept out of the sight and reach of children.


Disposal Instructions

Unused or expired Closal must be disposed of according to local regulations.

The medication should not be disposed of via wastewater (such as flushing down the toilet or sink). The preferred method is a drug take-back program where available, or disposal in household trash after mixing with an unpalatable substance.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

Available in countries:

Equivalent of Closal found in:

A-Z Index: