Components:
Medically reviewed by Kovalenko Svetlana Olegovna, PharmD. Last updated on 26.06.2023
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Top 20 medicines with the same components:
Indication
Clobetasol Topical (Clobenex gm Cream)® Spray, 0.05% is a super-high potent topical corticosteroid formulation indicated for the treatment of moderate to severe plaque psoriasis affecting up to 20% body surface area (BSA) in patients 18 years of age or older. The total dosage should not exceed 50 g (59 mL or 2 fl. oz.) per week. Do not use more than 26 sprays per application or 52 sprays per day. Treatment should be limited to 4 consecutive weeks.
Patients should be instructed to use Clobetasol Topical (Clobenex gm Cream)® Spray, 0.05% for the minimum amount of time necessary to achieve the desired results see [Dosage and Administration (2)].
Use in patients under 18 years of age is not recommended because safety has not been established and because numerically high rates of HPA axis suppression were seen with other clobetasol propionate topical formulations.
Limitations of Use
Clobetasol Topical (Clobenex gm Cream)® Spray, 0.05% should not be used on the face, axillae, or groin. Clobetasol Topical (Clobenex gm Cream)® Spray, 0.05% should not be used if there is atrophy at the treatment site. Clobetasol Topical (Clobenex gm Cream)® Spray, 0.05% should not be used in the treatment of rosacea or perioral dermatitis.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Clotrimazole Topical (Clobenex gm Cream) Cream: Clotrimazole Topical (Clobenex gm Cream) cream is an antifungal cream used to treat skin infections caused by dermatophytes, fungi, yeasts, moulds, etc [eg, athlete's foot, jock itch, ringworm of the body, cutaneous candidiasis (candida infection of the skin which may occur in diaper areas in babies, in armpits, groins or areas under the breasts)], pityriasis versicolor (commonly called white spots).
Clotrimazole Topical (Clobenex gm Cream) cream can also be used for erythrasma (a skin infection caused by the bacteria Corynebacterium minutissimum and usually affects areas with skin folds eg, the groin, armpits, between toes).
Clotrimazole Topical (Clobenex gm Cream) cream can also be used for female fungal infections of the vaginal area. It can also be used in males where inflammation is present in the penis, caused by yeast fungi (Candida vulvitis and Candida balanitis).
Clotrimazole Topical (Clobenex gm Cream)
Topical Powder:
Skin infections caused by fungi (eg, dermatophytes, yeasts, moulds) is treated with an antifungal product (eg, Clotrimazole Topical (Clobenex gm Cream) cream).Clotrimazole Topical (Clobenex gm Cream) powder may be used as an adjuvant to the previously mentioned treatment or as a follow-up treatment (prevention of reinfection) of the previously mentioned fungal infections (dermatomycoses) and erythrasma.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.To reduce the development of drug-resistant bacteria and maintain the effectiveness of Neomycin Topical (Clobenex gm Cream) tablets and other antibacterial drugs, Neomycin Topical (Clobenex gm Cream) tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Suppression of Intestinal Bacteria
Neomycin Topical (Clobenex gm Cream) tablets are indicated as adjunctive therapy as part of a regimen for the suppression of the normal bacterial flora of the bowel, e.g., preoperative preparation of the bowel. It is given concomitantly with erythromycin enteric-coated base.
Hepatic Coma (Portal-Systemic Encephalopathy)
Neomycin Topical (Clobenex gm Cream) has been shown to be effective adjunctive therapy in hepatic coma by reduction of the ammonia-forming bacteria in the intestinal tract. The subsequent reduction in blood ammonia has resulted in neurologic improvement.
Clobetasol is a topical (for the skin) steroid. It reduces the actions of chemicals in the body that cause inflammation, redness, and swelling.
Clobetasol Topical (Clobenex gm Cream) is used to treat the inflammation and itching caused by a number of skin conditions such as allergic reactions, eczema, and psoriasis.
Clobetasol Topical (Clobenex gm Cream) may also be used for purposes not listed in this medication guide.
Clotrimazole Topical (Clobenex gm Cream) is an antifungal medication that fights infections caused by fungus.
Clotrimazole Topical (Clobenex gm Cream) (for the skin) is used to treat skin infections such as athlete's foot, jock itch, ringworm, and yeast infections.
Clotrimazole Topical (Clobenex gm Cream) may also be used for purposes not listed in this medication guide.
Neomycin Topical (Clobenex gm Cream) belongs to the family of medicines called antibiotics. Neomycin Topical (Clobenex gm Cream) preparations are used to help prevent infections of the skin. Neomycin Topical (Clobenex gm Cream) may be used for other problems as determined by your doctor.
Neomycin Topical (Clobenex gm Cream) preparations are available without a prescription.
Note: For proper dispensing of foam, hold the can upside down and depress the actuator.
Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate) Foam should be applied to the affected area twice daily, once in the morning and once at night. Invert the can and dispense a small amount of Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate) Foam (up to a maximum of a golf-ball-size dollop or one and a half capfuls) into the cap of the can, onto a saucer or other cool surface, or to the lesion, taking care to avoid contact with the eyes. Dispensing directly onto hands is not recommended (unless the hands are the affected area), as the foam will begin to melt immediately upon contact with warm skin. When applying Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate) Foam to a hair-bearing area, move the hair away from the affected area so that the foam can be applied to each affected area. Pick up small amounts with fingertips and gently massage into affected area until the foam disappears. Repeat until entire affected area is treated.
Apply the smallest amount possible that sufficiently covers the affected area(s). No more than one and a half capfuls of foam should be used at each application. Do not apply to face or intertriginous areas.
Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate) Foam is a super-high-potency topical corticosteroid; therefore, treatment should be limited to 2 consecutive weeks and amounts greater than 50 g/week should not be used. Use in pediatric patients under 12 years of age is not recommended. Unless directed by a physician, Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate) Foam should not be used with occlusive dressings.
Instructions for applying Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate) Foam
Apply Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate) Foam twice a day, once in the morning and once at night. Apply only enough to cover the affected areas. Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate) Foam should not be applied to the groin, armpits, or other skin fold areas.
To use Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate) Foam:
Before applying Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate) Foam for the first time, break the tiny plastic piece at the base of the can's rim by gently pushing back (away from the piece) on the nozzle.
Turn the can upside down.
Push the button to squirt a small amount of Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate) Foam into the cap of the can, onto a saucer or other cool surface, or your affected skin area. This amount should be no more than 1 ½ capfuls, about the size of a golf ball.
Do not squirt Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate) Foam directly onto your hands (unless your hands are the affected areas), because the foam will begin to melt right away on contact with your warm skin. If your fingers are warm, rinse them in cold water first. (Be sure to dry them thoroughly before handling the foam.)
If the can seems warm or the foam seems runny, run the can under cold water.
Using your fingertips, gently massage Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate) Foam into the affected areas until the foam disappears.
If you are treating areas with hair such as the scalp, move any hair away so that the foam can be applied directly to the affected areas.
Repeat the process until the affected areas are treated.
Keep the foam away from your eyes, as it will sting and may cause eye problems if there is frequent contact with your eyes. If the foam gets in your eyes, rinse them well with cold water right away. If the stinging continues, contact your doctor right away.
Wash your hands after applying Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate) Foam. Throw away any of the unused medicine that you squirted out of the can.
How supplied
Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate) Foam is supplied in 100 g (NDC 63032-031-00) and 50 g (NDC 63032- 031-50) aluminum cans.
Store at controlled room temperature 68-77°F (20-25°C).
WARNING
FLAMMABLE. AVOID FIRE, FLAME OR SMOKING DURING AND IMMEDIATELY FOLLOWING APPLICATION. Keep out of reach of children. Contents under pressure. Do not puncture or incinerate container. Do not expose to heat or store at temperatures above 120°F (49°C).
Manufactured for : Connetics Corporation, Palo Alto, CA 94304, USA. For additional information: 1-888-500-DERM or visit, www.Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate).com. VersaFoam-HF is a trademark, and the V logo, the interlocking C design, Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate) and Connetics are registered trademarks, of Connetics Corporation. January 2006. FDA revision date: 7/11/2006
Usual Adult Dose for Tinea Corporis:
Apply Clotrimazole Topical (Clobenex gm Cream) in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 4 weeks, depending on the nature and severity of the infection.
Usual Adult Dose for Tinea Cruris:
Apply Clotrimazole Topical (Clobenex gm Cream) in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 weeks, depending on the nature and severity of the infection.
Usual Adult Dose for Tinea Pedis:
Apply Clotrimazole Topical (Clobenex gm Cream) in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 4 to 8 weeks, depending on the nature and severity of the infection.
Usual Adult Dose for Cutaneous Candidiasis:
Apply Clotrimazole Topical (Clobenex gm Cream) in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 to 4 weeks, depending on the nature and severity of the infection.
Usual Adult Dose for Tinea Versicolor:
Apply Clotrimazole Topical (Clobenex gm Cream) in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 to 4 weeks, depending on the nature and severity of the infection.
Usual Adult Dose for Vaginal Candidiasis:
Regimen 1: 100 mg (one 100 mg vaginal suppository) intravaginally once a day for 7 consecutive days alone or in combination with topical application of 1% clotrimazole cream to affected area two times daily for 7 consecutive days.
Regimen 2: 200 mg (one 200 mg vaginal suppository) intravaginally once a day for 3 consecutive days alone or in combination with topical application of 1% clotrimazole cream to affected area two times daily for 7 consecutive days.
Regimen 3: 500 mg (one 500 mg vaginal suppository) intravaginally once.
Regimen 4: One applicatorful of 1% clotrimazole vaginal cream intravaginally once daily (preferably at bedtime) for 7 consecutive days.
Regimen 5: One applicatorful of 2% clotrimazole vaginal cream intravaginally once daily (preferably at bedtime) for 3 consecutive days.
Studies have shown the three and seven day courses of clotrimazole to be equally effective. Patient compliance may be increased with a three day course. Patients who fail to achieve a cure with a single 500 mg dose should be treated with a 3 or 7 day course of clotrimazole.
Weekly or monthly clotrimazole vaginal suppositories appear to be effective topical regimens for chronic suppressive therapy in female patients with HIV.
Usual Pediatric Dose for Tinea Corporis:
> 3 years: Apply Clotrimazole Topical (Clobenex gm Cream) in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 4 weeks, depending on the nature and severity of the infection.
Usual Pediatric Dose for Tinea Cruris:
> 3 years: Apply Clotrimazole Topical (Clobenex gm Cream) in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 weeks, depending on the nature and severity of the infection.
Usual Pediatric Dose for Tinea Pedis:
> 3 years: Apply Clotrimazole Topical (Clobenex gm Cream) in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 4 to 8 weeks, depending on the nature and severity of the infection.
Usual Pediatric Dose for Cutaneous Candidiasis:
> 3 years: Apply Clotrimazole Topical (Clobenex gm Cream) in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 to 4 weeks, depending on the nature and severity of the infection.
Usual Pediatric Dose for Tinea Versicolor:
> 3 years: Apply Clotrimazole Topical (Clobenex gm Cream) in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 to 4 weeks, depending on the nature and severity of the infection.
Usual Pediatric Dose for Vaginal Candidiasis:
> 12 years: Regimen 1: 100 mg (one 100 mg vaginal suppository) intravaginally once a day for 7 consecutive days alone or in combination with topical application of 1% clotrimazole cream to affected area two times daily for 7 consecutive days.
Regimen 2: 200 mg (one 200 mg vaginal suppository) intravaginally once a day for 3 consecutive days alone or in combination with topical application of 1% clotrimazole cream to affected area two times daily for 7 consecutive days.
Regimen 3: 500 mg (one 500 mg vaginal suppository) intravaginally once.
Regimen 4: One applicatorful of 1% clotrimazole vaginal cream intravaginally once daily (preferably at bedtime) for 7 consecutive days.
Studies have shown the three and seven day courses of clotrimazole to be equally effective. Patient compliance may be increased with a three day course. Patients who fail to achieve a cure with a single 500 mg dose should be treated with a 3 or 7 day course of clotrimazole.
Weekly or monthly clotrimazole vaginal suppositories appear to be effective topical regimens for chronic suppressive therapy in female patients with HIV.
Usual Adult Dose for Bowel Preparation
1 g orally every hour for 4 doses followed by 1 g every 4 hours for 5 doses
Alternate dosing: 6 g/day orally divided every 4 hours for 2 to 3 days
Usual Adult Dose for Hepatic Encephalopathy
4 to 12 g/day orally divided every 4 to 6 hours for 5 to 6 days
Usual Adult Dose for Hepatic Coma
4 to 12 g/day orally divided every 4 to 6 hours for 5 to 6 days
Usual Adult Dose for Diarrhea
3 g/day orally in 4 divided doses
Usual Pediatric Dose for Bowel Preparation
The safety and efficacy of Neomycin Topical (Clobenex gm Cream) in children less than 18 years of age has not been established. However, the use of Neomycin Topical (Clobenex gm Cream) may be appropriate is some situations.
Less than 1 month: 50 mg/kg/day orally divided every 6 hours
1 year to 18 years: 50 to 100 mg/kg/day orally divided every 6 hours
Usual Pediatric Dose for Hepatic Encephalopathy
The safety and efficacy of Neomycin Topical (Clobenex gm Cream) in children less than 18 years of age has not been established. However, the use of Neomycin Topical (Clobenex gm Cream) may be appropriate is some situations.
1 month to 18 years: 50 to 100 mg/kg/day orally divided every 6 to 8 hours for 5 to 6 days
Usual Pediatric Dose for Hepatic Coma
The safety and efficacy of Neomycin Topical (Clobenex gm Cream) in children less than 18 years of age has not been established. However, the use of Neomycin Topical (Clobenex gm Cream) may be appropriate is some situations.
1 month to 18 years: 50 to 100 mg/kg/day orally divided every 6 to 8 hours for 5 to 6 days
Usual Pediatric Dose for Diarrhea
The safety and efficacy of Neomycin Topical (Clobenex gm Cream) in children less than 18 years of age has not been established. However, the use of Neomycin Topical (Clobenex gm Cream) may be appropriate is some situations.
Less than 1 month: 50 mg/kg/day orally divided every 6 hours
1 year to 18 years: 50 mg/kg/day orally divided every 6 hours for 2 to 3 days
Renal Dose Adjustments
Patients with impaired renal function have a high risk of developing nephrotoxicity and ototoxicity with oral Neomycin Topical (Clobenex gm Cream). Use of a less nephrotoxic medication may be a consideration for this patient.
Liver Dose Adjustments
In chronic hepatic insufficiency, it may be necessary to give Neomycin Topical (Clobenex gm Cream) 4 g daily for an indefinite period, if less toxic drugs cannot be used.
Dose Adjustments
Caution should be used when administering Neomycin Topical (Clobenex gm Cream) to patients with renal impairment. Dose reduction should be considered in these patients.
Precautions
To minimize the risk of toxicity use the lowest possible dose and the shortest possible treatment period to control the condition. Treatment periods of longer than 2 weeks are not recommended.
Do not use in patients with intestinal obstruction.
Do not use in patients with inflammatory or ulcerative gastrointestinal disease due to the potential for increased gastrointestinal absorption of the drug.
Patients should be monitored for nephrotoxicity and ototoxicity.
Neomycin Topical (Clobenex gm Cream) should be used with caution in patients with hearing impairment, renal impairment or neuromuscular disorders.
Dialysis
Patients with impaired renal function have a high risk of developing nephrotoxicity and ototoxicity with oral Neomycin Topical (Clobenex gm Cream). Use of a less nephrotoxic medication may be a consideration for this patient.
See also:
What is the most important information I should know about Clobetasol Topical (Clobenex gm Cream)?
Hypersensitivity to clobetasol propionate or to any of the excipients of Clobetasol Topical (Clobenex gm Cream).
Scalp Application: Infections of the scalp.
Cream/Ointment: Primary skin lesions caused by infection with fungi or bacteria; primary cutaneous viral infections (eg, herpes simplex, chickenpox); rosacea; acne vulgaris; pruritus without inflammation; perianal and genital pruritus; perioral dermatitis.
Use in children: Clobetasol Topical (Clobenex gm Cream) is contraindicated in children <1 year.
Children are more likely to develop local and systemic side effects of topical corticosteroids and in general, require shorter courses and less potent agents than adults.
Care should be taken when using Clobetasol Topical (Clobenex gm Cream) to ensure the amount applied is the minimum that provides therapeutic benefit.
See also:
What is the most important information I should know about Clotrimazole Topical (Clobenex gm Cream)?
Clotrimazole Topical (Clobenex gm Cream) Cream: Hypersensitivity to clotrimazole, cetostearyl alcohol or to any other components of Clotrimazole Topical (Clobenex gm Cream) Cream.
Clotrimazole Topical (Clobenex gm Cream)
Topical Powder:
Hypersensitivity to clotrimazole or to any other components of Clotrimazole Topical (Clobenex gm Cream) Powder.See also:
What is the most important information I should know about Neomycin Topical (Clobenex gm Cream)?
Neomycin Topical (Clobenex gm Cream) oral preparations are contraindicated in the presence of intestinal obstruction and in individuals with a history of hypersensitivity to the drug.
Patients with a history of hypersensitivity or serious toxic reaction to other aminoglycosides may have a cross-sensitivity to Neomycin Topical (Clobenex gm Cream). Neomycin Topical (Clobenex gm Cream) oral preparations are contraindicated in patients with inflammatory or ulcerative gastrointestinal disease because of the potential for enhanced gastrointestinal absorption of Neomycin Topical (Clobenex gm Cream).
Use Clobetasol Topical (Clobenex gm Cream) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Wash your hands before using Clobetasol Topical (Clobenex gm Cream). If your fingers are warm, rinse them in cold water and dry before you apply Clobetasol Topical (Clobenex gm Cream).
- Use the smallest amount of medicine necessary to cover the affected area.
- Turn the can upside down and squirt a small amount of foam (up to the size of a golf ball or about 1½ capfuls) into the cap of the can, onto a clean saucer, or onto another cool, clean surface. You may also squirt it directly onto the affected area. Do not squirt the medicine directly into the hand because it will start to melt immediately upon touching warm skin.
- If you are applying Clobetasol Topical (Clobenex gm Cream) to the scalp, move the hair away from the affected area and gently rub the medicine into the affected area until the foam disappears. Repeat until the entire affected area of the scalp is treated.
- If you are applying Clobetasol Topical (Clobenex gm Cream) to other areas, gently rub the medicine into the skin until it disappears.
- Throw away any unused medicine that has been squirted out of the can.
- Wash your hands immediately after using Clobetasol Topical (Clobenex gm Cream), unless your hands are a part of the treated area.
- Do not use Clobetasol Topical (Clobenex gm Cream) on your face, groin, or underarms unless your doctor tells you otherwise.
- Do not use Clobetasol Topical (Clobenex gm Cream) over large areas of the body without first checking with your doctor.
- Do not bandage or wrap the affected area unless directed to do so by your doctor.
- If the can seems warm or the foam seems runny, rinse the can with cool water.
- If you miss a dose of Clobetasol Topical (Clobenex gm Cream), apply it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Clobetasol Topical (Clobenex gm Cream).
Use Clotrimazole Topical (Clobenex gm Cream) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Clotrimazole Topical (Clobenex gm Cream). Talk to your pharmacist if you have questions about this information.
- Clotrimazole Topical (Clobenex gm Cream) is for vaginal use only. Do not use it rectally or take by mouth.
- Suppositories - Using the applicator provided, insert 1 suppository high into the vagina at bedtime for 7 days.
- Clotrimazole Topical (Clobenex gm Cream) comes with one applicator to be used for all 7 days of treatment. Do not throw away applicator after use. Separate the pieces of the applicator and wash with warm, soapy water immediately after use. Rinse thoroughly. Make sure the applicator is completely dry before the next use.
- External cream - Squeeze a small amount of cream onto your finger and gently spread the cream onto the itchy, irritated skin outside the vagina as directed by your doctor or on the packaging.
- Wash your hands immediately after using Clotrimazole Topical (Clobenex gm Cream).
- To clear up your infection completely, use Clotrimazole Topical (Clobenex gm Cream) for the full course of treatment. Keep using it even if you feel better in a few days.
- If you miss a dose of Clotrimazole Topical (Clobenex gm Cream), use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Clotrimazole Topical (Clobenex gm Cream).
Use Neomycin Topical (Clobenex gm Cream) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Neomycin Topical (Clobenex gm Cream) by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Take Neomycin Topical (Clobenex gm Cream) with plenty of water to avoid dehydration.
- Do not take Neomycin Topical (Clobenex gm Cream) for more than 2 weeks unless advised to do so by your health care provider.
- Take Neomycin Topical (Clobenex gm Cream) on a regular schedule to get the most benefit from it.
- To clear up your infection completely, use Neomycin Topical (Clobenex gm Cream) for the full course of treatment. Keep using it even if you feel better in a few days.
- If you miss a dose of Neomycin Topical (Clobenex gm Cream), take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If more than one dose is missed, contact your health care provider.
Ask your health care provider any questions you may have about how to use Neomycin Topical (Clobenex gm Cream).
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Clobetasol Topical (Clobenex gm Cream) is used to treat itching, redness, dryness, inflammation, and discomfort of various scalp and skin conditions, including immune-mediated skin disease with red scaly patches (psoriasis).
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Clotrimazole Topical (Clobenex gm Cream) is used for the treatment of fungal infections of the vagina, mouth, ear and skin, such as athlete's foot, jock itch, ringworm, thrush, or otitis externa (inflammation of outer ear).
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Neomycin Topical (Clobenex gm Cream) is used topically to prevent or treat skin infections caused by bacteria.
See also:
What other drugs will affect Clobetasol Topical (Clobenex gm Cream)?
Aldesleukin: Corticosteroids may diminish the antineoplastic effect of Aldesleukin. Avoid combination
Corticorelin: Corticosteroids may diminish the therapeutic effect of Corticorelin. Specifically, the plasma ACTH response to corticorelin may be blunted by recent or current corticosteroid therapy. Monitor therapy
Deferasirox: Corticosteroids may enhance the adverse/toxic effect of Deferasirox. Specifically, the risk for GI ulceration/irritation or GI bleeding may be increased. Monitor therapy
Hyaluronidase: Corticosteroids may diminish the therapeutic effect of Hyaluronidase. Management: Patients receiving corticosteroids (particularly at larger doses) may not experience the desired clinical response to standard doses of hyaluronidase. Larger doses of hyaluronidase may be required. Consider therapy modification
Ritodrine: Corticosteroids may enhance the adverse/toxic effect of Ritodrine. Monitor therapy
See also:
What other drugs will affect Clotrimazole Topical (Clobenex gm Cream)?
Simultaneous administration of Clotrimazole Topical (Clobenex gm Cream) with amphotericin B, nystatin, natamycin activity of clotrimazole decreases.
See also:
What other drugs will affect Neomycin Topical (Clobenex gm Cream)?
Acarbose: Neomycin Topical (Clobenex gm Cream) may enhance the adverse/toxic effect of Acarbose. Neomycin Topical (Clobenex gm Cream) may decrease the metabolism of Acarbose. Monitor therapy
Amphotericin B: May enhance the nephrotoxic effect of Aminoglycosides. Monitor therapy
Arbekacin: May enhance the nephrotoxic effect of Aminoglycosides. Arbekacin may enhance the ototoxic effect of Aminoglycosides. Monitor therapy
Ataluren: May enhance the adverse/toxic effect of Aminoglycosides. Specifically, an increased risk of nephrotoxicity may occur with the concomitant use of ataluren and aminoglycosides. Avoid combination
Bacitracin (Systemic): Neomycin Topical (Clobenex gm Cream) may enhance the nephrotoxic effect of Bacitracin (Systemic). Avoid combination
BCG (Intravesical): Antibiotics may diminish the therapeutic effect of BCG (Intravesical). Avoid combination
BCG Vaccine (Immunization): Antibiotics may diminish the therapeutic effect of BCG Vaccine (Immunization). Monitor therapy
Bisphosphonate Derivatives: Aminoglycosides may enhance the hypocalcemic effect of Bisphosphonate Derivatives. Monitor therapy
Botulinum Toxin-Containing Products: Aminoglycosides may enhance the neuromuscular-blocking effect of Botulinum Toxin-Containing Products. Monitor therapy
Capreomycin: May enhance the neuromuscular-blocking effect of Aminoglycosides. Monitor therapy
CARBOplatin: Aminoglycosides may enhance the ototoxic effect of CARBOplatin. Especially with higher doses of carboplatin. Monitor therapy
Cardiac Glycosides: Aminoglycosides may decrease the serum concentration of Cardiac Glycosides. This effect has only been demonstrated with oral aminoglycoside administration. Monitor therapy
Cefazedone: May enhance the nephrotoxic effect of Aminoglycosides. Monitor therapy
Cephalosporins (2nd Generation): May enhance the nephrotoxic effect of Aminoglycosides. Monitor therapy
Cephalosporins (3rd Generation): May enhance the nephrotoxic effect of Aminoglycosides. Monitor therapy
Cephalosporins (4th Generation): May enhance the nephrotoxic effect of Aminoglycosides. Monitor therapy
Cephalothin: May enhance the nephrotoxic effect of Aminoglycosides. Monitor therapy
Cephradine: May enhance the nephrotoxic effect of Aminoglycosides. Monitor therapy
CISplatin: May enhance the nephrotoxic effect of Aminoglycosides. Monitor therapy
Colistimethate: Aminoglycosides may enhance the nephrotoxic effect of Colistimethate. Aminoglycosides may enhance the neuromuscular-blocking effect of Colistimethate. Management: Avoid coadministration of colistimethate and aminoglycosides whenever possible due to the risk of nephrotoxicity and neuromuscular blockade. If coadministration cannot be avoided, monitor renal and neuromuscular function. Consider therapy modification
CycloSPORINE (Systemic): Aminoglycosides may enhance the nephrotoxic effect of CycloSPORINE (Systemic). Monitor therapy
Distigmine: Aminoglycosides may diminish the therapeutic effect of Distigmine. Monitor therapy
Foscarnet: May enhance the nephrotoxic effect of Aminoglycosides. Avoid combination
Lactobacillus and Estriol: Antibiotics may diminish the therapeutic effect of Lactobacillus and Estriol. Monitor therapy
Loop Diuretics: May enhance the adverse/toxic effect of Aminoglycosides. Specifically, nephrotoxicity and ototoxicity. Monitor therapy
Mannitol (Systemic): May enhance the nephrotoxic effect of Aminoglycosides. Avoid combination
Mecamylamine: Aminoglycosides may enhance the neuromuscular-blocking effect of Mecamylamine. Avoid combination
Methoxyflurane: Aminoglycosides may enhance the nephrotoxic effect of Methoxyflurane. Avoid combination
Neuromuscular-Blocking Agents: Aminoglycosides may enhance the therapeutic effect of Neuromuscular-Blocking Agents. Monitor therapy
Nonsteroidal Anti-Inflammatory Agents: May decrease the excretion of Aminoglycosides. Data only in premature infants. Monitor therapy
Oxatomide: May enhance the ototoxic effect of Aminoglycosides. Monitor therapy
Penicillins: May decrease the serum concentration of Aminoglycosides. Primarily associated with extended spectrum penicillins, and patients with renal dysfunction. Exceptions: Amoxicillin; Ampicillin; Bacampicillin; Cloxacillin; Dicloxacillin; Nafcillin; Oxacillin; Penicillin G (Parenteral/Aqueous); Penicillin G Benzathine; Penicillin G Procaine; Penicillin V Benzathine; Penicillin V Potassium. Consider therapy modification
Regorafenib: Neomycin Topical (Clobenex gm Cream) may decrease serum concentrations of the active metabolite(s) of Regorafenib. Monitor therapy
Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate. Management: Consider using an alternative product for bowel cleansing prior to a colonoscopy in patients who have recently used or are concurrently using an antibiotic. Consider therapy modification
SORAfenib: Neomycin Topical (Clobenex gm Cream) may decrease the serum concentration of SORAfenib. Monitor therapy
Tenofovir Products: Aminoglycosides may increase the serum concentration of Tenofovir Products. Tenofovir Products may increase the serum concentration of Aminoglycosides. Monitor therapy
Vancomycin: May enhance the nephrotoxic effect of Aminoglycosides. Monitor therapy
Vitamin K Antagonists (eg, warfarin): Neomycin Topical (Clobenex gm Cream) may enhance the anticoagulant effect of Vitamin K Antagonists. Monitor therapy
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What are the possible side effects of Clobetasol Topical (Clobenex gm Cream)?
In a controlled pharmacokinetic study, 5 of 13 subjects experienced reversible suppression of the adrenals at any time during the 14 days of Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate) Foam therapy to at least 20% of the body surface area. Of the 13 subjects studied, 1 of 9 with psoriasis were suppressed after 14 days and all 4 of the subjects with atopic dermatitis had abnormal cortisol levels indicative of adrenal suppression at some time after starting therapy with Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate) Foam.
Table 3: Subjects with reversible HPA axis suppression at any time during treatment
Dermatosis | Clobetasol Topical (Clobenex gm Cream) |
Psoriasis | 1 of 9 |
Atopic Dermatitis* | 4 of 4 |
*Clobetasol Topical (Clobenex gm Cream) is not indicated for non-scalp atopic dermatitis, as the safety and efficacy of Clobetasol Topical (Clobenex gm Cream) in non-scalp atopic dermatitis has not been established. Use in children under 12 years of age is not recommended. |
Systemic absorption of topical corticosteroids has produced reversible adrenal suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in some patients.
In a controlled clinical trial (188 subjects) with Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate) Foam in subjects with psoriasis of the scalp, there were no localized scalp adverse reactions reported in the Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate) Foam treated subjects. In two controlled clinical trials (360 subjects) with Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate) Foam in subjects with psoriasis of non-scalp regions, localized adverse events that occurred in the Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate) Foam treated subjects included application site burning (10%), application site dryness ( < 1%), and other application site reactions (4%).
In larger controlled trials with other clobetasol propionate formulations, the most frequently reported local adverse reactions have included burning, stinging, irritation, pruritus, erythema, folliculitis, cracking and fissuring of the skin, numbness of the fingers, skin atrophy, and telangiectasia (all less than 2%).
The following additional local adverse reactions have been reported with topical corticosteroids, but they may occur more frequently with the use of occlusive dressings and higher potency corticosteroids such as Clobetasol Topical (Clobenex gm Cream) (clobetasol propionate) Foam. These reactions are listed in an approximate decreasing order of occurrence: dryness, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, striae, and miliaria.
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What are the possible side effects of Clotrimazole Topical (Clobenex gm Cream)?
Applies to Clotrimazole Topical (Clobenex gm Cream): topical cream, topical lotion, topical solution
In addition to its needed effects, some unwanted effects may be caused by Clotrimazole Topical (Clobenex gm Cream) (the active ingredient contained in Clotrimazole Topical (Clobenex gm Cream)). In the event that any of these side effects do occur, they may require medical attention.
Severity: Moderate
If any of the following side effects occur while taking Clotrimazole Topical (Clobenex gm Cream), check with your doctor or nurse as soon as possible:
- Skin rash, hives, blistering, burning, itching, peeling, redness, stinging, swelling, or other sign of skin irritation not present before use of this medicine
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What are the possible side effects of Neomycin Topical (Clobenex gm Cream)?
Allergic reaction, Itching, Skin redness, Eye infection, Skin rash, Fever
Clobetasol Topical (Clobenex gm Cream) scalp application also contains the following excipients: Carbomer, isopropyl alcohol, sodium hydroxide and purified water.
Clobetasol Topical (Clobenex gm Cream) cream also contains the following excipients: Glyceryl monostearate, cetostearyl alcohol, chlorocresol, sodium citrate, monohydrated citric acid, purified water, Arlacel 165, beeswax substitute 6621 and propylene glycol.
Clobetasol Topical (Clobenex gm Cream) ointment also contains the following excipients: Propylene glycol, white soft paraffin and sorbitan sesquioleate.
Each gram of cream and topical powder contains clotrimazole 0.01 g.
Clotrimazole Topical (Clobenex gm Cream) Cream is odourless, can be washed off and does not stain.
A component of Neomycin Topical (Clobenex gm Cream) that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed). Neomycin Topical (Clobenex gm Cream) is a bactericidal aminoglycoside antibiotic that binds to the 30S ribosome of susceptible organisms. Binding interferes with mRNA binding and acceptor tRNA sites and results in the production of non-functional or toxic peptides.