Clavulin 875

Quick links to important sections

Clavulin 875

Treatment option:

Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Clavulin 875

Property Description
Active Ingredients Amoxicillin and Clavulanic Acid
Pharmacological Class beta-Lactam Antibacterial Agent
Form Film-coated Tablet
Route of Administration Oral (Systemic)
Origin Semi-synthetic (Amoxicillin) / Synthesized (Clavulanic Acid)
Classification Fixed-Dose Combination Product

What is Clavulin 875 (Co-amoxiclav) and What Type of Drug is It?

Clavulin 875, officially known by its non-proprietary name Co-amoxiclav, is a prescription-only medicine that functions as a broad-spectrum beta-lactam antibiotic for systemic use against bacterial infections. This formulation is clinically recognized for its action against susceptible pathogens and is used for addressing various infections.

The drug belongs to the penicillin class, specifically designated as a combination penicillin-class antibacterial and beta-lactamase inhibitor. It is formulated as a fixed-dose combination product, typically a film-coated tablet intended for oral administration, providing a systemic treatment option. It is closely associated with the formulation marketed under the trade name Augmentin.

Composition: The Role of Amoxicillin and Clavulanic Acid

The active agents in Clavulin 875 are the core semi-synthetic penicillin, Amoxicillin, and the chemically synthesized protective agent, Clavulanic Acid. The combination is utilized because Clavulanic Acid acts as a beta-lactamase inhibitor, neutralizing the defensive enzymes that some resistant bacteria produce to deactivate Amoxicillin. This mechanism enhances the drug's utility compared to single-agent penicillin derivatives.

General Purpose of this Combination Antibacterial Agent

The overarching purpose of this combination is to provide an antimicrobial defense against bacterial infections, including those that display resistance. The synergistic effect of the two agents enhances the bactericidal action and extends the clinical utility of the Amoxicillin component. This protected action allows the drug to interfere with bacterial cell wall synthesis, a key step in neutralizing the source of the infection. A typical use scenario involves addressing common infections where bacterial resistance is a potential factor.

What side effects are possible with Clavulin 875?

Possible Side Effects and Safety Information

The following safety information is derived from official governmental regulatory documents (e.g., FDA, EMA) and outlines the known risks associated with Clavulin 875 (amoxicillin/clavulanate).

Adverse Reactions by Frequency

Adverse reactions are formally classified by their reported frequency of occurrence:

Classification Examples of Documented Reactions
Common Diarrhea, Nausea, Vomiting, Mucocutaneous candidiasis.
Uncommon/Rare Dizziness, Headache, Transient increases in liver enzymes (ALT/AST), Skin rash, Urticaria.

Serious Adverse Reactions

Although rare, certain reactions are documented as clinically significant and may require immediate medical attention:

  • Hypersensitivity: Severe allergic reactions, including anaphylaxis, angioedema, and Severe Cutaneous Adverse Reactions (SCARs) such as Stevens-Johnson Syndrome (SJS).
  • Hepatotoxicity: Liver dysfunction, including hepatitis and cholestatic jaundice, which may occur during or several weeks after treatment has stopped.
  • Gastrointestinal: Clostridioides difficile-associated diarrhea (CDAD), which can range from mild to severe colitis.

Safety Restrictions and Limitations

Clavulin 875 is contraindicated and must not be used in the following circumstances, based on regulatory labeling:

  • Patients with a history of serious allergic reactions (e.g., anaphylaxis) to penicillins or other beta-lactam antibiotics.
  • Patients with a prior history of cholestatic jaundice or hepatic dysfunction associated with the use of amoxicillin/clavulanate.

Population-Specific Considerations: Patients with pre-existing severe renal impairment or suspected infectious mononucleosis require specific caution or dosage adjustment, as directed by the prescribing information.

Overdose and Emergency Response

Official Overdose Manifestations

Clavulin 875 (Co-amoxiclav) overdose information is based on formal regulatory documentation. Acute manifestations of an overdose are primarily characterized by gastrointestinal symptoms, including nausea, vomiting, and diarrhoea, which may lead to a disturbance of the fluid and electrolyte balances.

A more serious concern documented in official labeling is Amoxicillin crystalluria, a specific physiological finding that can result in acute renal injury (renal failure). This risk is associated with exposure to high doses of the medication, particularly when urine output is reduced. Additionally, overdose may present with convulsions (fits), a risk officially noted to be increased in patients with impaired renal function.

Required Emergency Actions

In all cases where an overdose of Clavulin 875 is suspected, the regulatory mandate is to seek immediate medical attention or contact a doctor, pharmacist, or nurse immediately. There is no specific antidote documented for this combination product. Management consists of symptomatic and supportive treatment, which may include efforts to maintain adequate fluid intake and urinary output to reduce the risk of crystalluria. Haemodialysis is an officially described procedure that can assist in removing the active components from the body.

Therapeutic Uses of Clavulin 875

What Clavulin 875 Treats: Main Uses and Benefits

Clavulin 875 (Co-amoxiclav) is commonly used across conditions presenting with bacterial infections, especially in scenarios where supportive symptom management is needed and bacterial resistance may be a factor. This medication is applied across therapeutic domains involving the ears, lungs, sinus, skin, and urinary tract. It provides core therapeutic support by addressing the underlying pathogen, which helps support the easing of the overall symptom load.

The medication is relevant for managing symptoms that interfere with daily comfort during acute episodes such as community-acquired pneumonia (CAP), acute bacterial rhinosinusitis, acute otitis media, and infections of the skin and soft tissue. It is considered relevant in conditions involving inflammatory or irritative processes, such as infections resulting from animal bites or those affecting patients with underlying conditions like diabetes.

Quick Fact: Relief for Inflammatory Symptoms

Quick Fact: Relief for Inflammatory Symptoms This medication helps address groups of symptoms that may become intense, such as fever, persistent cough, and localized pain.

Patient Benefit Summary

“It is applied in clinical settings that involve acute or unstable symptom patterns, helping patients cope more steadily with difficult episodes.”

By addressing the bacterial source of the condition, Clavulin 875 contributes to improved day-to-day comfort, providing support that helps ease the overall symptom burden and may assist with maintaining functional stability during periods of heightened distress.

Regulatory References

  1. NIH MedlinePlus overview

Eligibility and Restrictions for Use

Clavulin 875 (amoxicillin and clavulanate potassium) is an antibiotic used to treat specific bacterial infections in adults and pediatric patients weighing 40 kilograms (kg) or more. Its use is determined by a healthcare provider based on the type and severity of the infection.

Who Cannot Use Clavulin 875?

The medication is contraindicated in several specific circumstances to ensure patient safety:

  • Allergy or Hypersensitivity: Individuals with a history of a severe allergic reaction (e.g., anaphylaxis, Stevens-Johnson syndrome) to amoxicillin, clavulanate potassium, or other beta-lactam antibiotics, such as penicillins or cephalosporins.
  • Liver Problems: Patients with a history of cholestatic jaundice or other hepatic dysfunction specifically associated with previous use of amoxicillin and clavulanate potassium.
  • Mononucleosis: Its use is generally avoided in patients with or suspected of having infectious mononucleosis due to an increased risk of developing a skin rash.

Use with Caution

Clavulin 875 should be used with caution and may require dose adjustment or close monitoring in patients with pre-existing conditions, including severe kidney disease (creatinine clearance less than 30 mL/min) and existing liver impairment.

What should I know about interactions with other medicines?

This section outlines documented interactions with other medicines and products, strictly based on authoritative regulatory documentation.

Documented Pharmacokinetic and Pharmacodynamic Interactions

The co-administration of this medicine with certain agents may alter its effectiveness or increase the risk of specific drug-related effects. Official documents classify these interactions based on the need for monitoring or avoidance.

Interacting Medicine Category Key Interaction Description Regulatory Constraint
Probenecid (Uricosuric) Inhibits the renal excretion of amoxicillin, leading to prolonged and increased blood concentrations of the amoxicillin component. Co-administration is generally not recommended.
Oral Anticoagulants (e.g., Warfarin) May be associated with an increase in International Normalized Ratio (INR) and prolongation of prothrombin time due to the antibiotic component. Requires careful monitoring of Prothrombin Time/INR and potential anticoagulant dose adjustment.
Allopurinol Increases the risk of developing a skin rash (allergic skin reaction) associated with amoxicillin. Use with caution and monitor for rash.
Oral Contraceptives May reduce the efficacy of hormonal contraceptives. Patients should be advised to use non-hormonal barrier methods of contraception.

Interaction-Related Special Considerations

Regulatory agencies advise that this product should be avoided in patients with suspected infectious mononucleosis. Additionally, to ensure proper absorption of clavulanate, administration is often recommended at the start of a meal.

Mechanism of Action

Clavulin 875 operates through a synergistic, two-part molecular strategy to produce cell death in susceptible bacteria, targeting both the bacterial defense mechanism and its core structural integrity.


️ Irreversible Deactivation of Bacterial Defense

The Clavulanic Acid component acts as a molecular shield by targeting and irreversibly inhibiting the beta-lactamase enzymes. These enzymes are produced by resistant bacteria to hydrolyze and destroy beta-lactam antibiotics. By neutralizing this defense, Clavulanic Acid restores the activity of Amoxicillin, which is necessary for the Amoxicillin mechanism to proceed effectively.


Covalent Blockade of Cell Wall Construction

The Amoxicillin component, now protected from degradation, binds covalently to Penicillin-Binding Proteins (PBPs), which are bacterial enzymes essential for cross-linking the cell wall's peptidoglycan layer. This blockade disrupts the final assembly of the rigid cell wall, resulting in structural failure and the activation of bacterial autolytic enzymes.


Synergistic Osmotic Lysis

The combined failure of cell wall construction and activated autolysis results in the inability of the bacterial cell to maintain osmotic stability, triggering osmotic lysis (cell rupture and death). This killing of susceptible pathogens defines the drug's bactericidal action.

Dosage and Administration Information

Instructions for Use

This section outlines the administration guidelines for Clavulin 875 (amoxicillin and clavulanate potassium).


Dosing and Administration

Instruction Component Requirement
Route of Administration Oral (Tablet)
Standard Adult Dose One 875 mg/125 mg tablet
Dose Frequency Every 12 hours (Twice Daily)
Timing Relative to Meals Take at the start of a meal to enhance the absorption of clavulanate and minimize potential gastrointestinal intolerance.
Duration of Therapy The full prescribed course is to be completed, even if symptoms improve early.

Special Administration Rules

  • Tablet Handling: The tablet is to be swallowed whole and should not be crushed or chewed.
  • Age and Weight: This 875 mg strength is intended for Adults and Pediatric Patients weighing 40 kg or more. It is not appropriate for patients under 40 kg.
  • Kidney Impairment: Patients with severe kidney dysfunction (Glomerular Filtration Rate < 30 mL/min) are not to receive the 875 mg tablet and require an alternative regimen.
  • Missed Dose: If a dose is missed, it is taken as soon as remembered. If it is almost time for the next scheduled dose, the missed one is skipped to return to the regular schedule. Two doses are not to be taken at the same time.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Amoxicillin/Clavulanate (Clavulin 875)

Evidence for use in Acute Bacterial Sinusitis and Otitis Media

Research has examined the use in individuals with sinus infections and middle ear infections caused by susceptible bacteria. These studies, primarily Randomized Controlled Trials (RCTs), were conducted during periods of increased symptom activity and monitored measurements related to physical discomfort and systemic imbalance. The findings describe patterns observed in the studies related to how patient-reported experiences changed over defined time intervals. However, follow-up durations were limited, and results apply only to the specific populations studied.

Evidence for use in Lower Respiratory Tract Infections

The medication was evaluated in studies focusing on outcomes related to systemic or functional imbalance caused by lower respiratory tract infections. These studies involved short-term RCTs and research monitored symptoms such as cough, difficulty breathing, and fever. Studies reported measurements related to the status of these respiratory outcomes and the overall daily functioning of the participants. The certainty remains low regarding sustained observations, as follow-up durations were limited, and comparative evidence is sometimes lacking.

Evidence for use in Skin and Soft Tissue Infections

Studies explored conditions involving periods of heightened symptoms, specifically bacterial infections of the skin. Research observed how symptoms evolved in study populations, focusing on outcomes linked to inflammatory states. Data show patterns related to how outcomes reflecting daily functioning changed during the short course of the study. Limited information exists regarding long-term recurrence after the acute phase has been evaluated.

Evidence for use in Urinary Tract Infections (UTIs)

Research explored temporary physiological imbalance caused by bacterial UTIs. Studies tracked outcomes linked to irritative states and monitored physiological strain. Findings describe patterns related to symptom intensity over the defined time interval. The certainty remains low regarding sustained observations, and comparative evidence is often lacking.


Long-term Studies and Follow-up

Existing research focuses on acute, short-term evaluations. Follow-up durations were limited across the key studies for all indications. Therefore, long-term effects are not fully established, and there is limited information for long-term outcomes regarding sustained non-recurrence of infection.

Evidence in Special Populations

Data for certain groups remain insufficient. While studies were conducted involving children, results apply only to the specific pediatric populations studied. Data are still emerging for groups such as older adults with multiple chronic conditions. Subgroup findings for these specific populations are often uncertain due to small sample sizes.

What is Still Uncertain about Amoxicillin/Clavulanate (Clavulin 875)

Comparative evidence is lacking for certain indications. The long-term effects are not fully established, as follow-up durations were limited in the acute studies, and research does not determine whether an individual will respond similarly. Findings describe group patterns, and research highlights what is known about short-term changes—and what remains uncertain.

Key Studies & References

  1. Label: AMOXICILLIN AND CLAVULANATE POTASSIUM tablet, film coated - DailyMed
  2. Antibiotic treatment of acute and recurrent otitis media in children: an Italian intersociety Consensus
  3. Complicated Urinary Tract Infections (cUTI): Clinical Guidelines for Treatment and Management (IDSA)

Frequently Asked Questions (FAQ)

Common questions about Clavulin 875 (FAQ)


Q: How quickly does Clavulin 875 start working after the first dose?

Official regulatory documents indicate that the active components of Clavulin 875 are generally well absorbed in the stomach and intestines. While official information indicates the active components reach peak concentrations quickly, the time it takes to notice improvement in symptoms can vary widely depending on the type and severity of your infection.


Q: How long do the side effects of Clavulin 875 usually last?

Most common side effects, such as nausea or diarrhea, are typically temporary and usually subside once the prescribed course of the medication is completed. It is important to know that rare but serious side effects, such as drug-induced liver injury, may begin or persist for several weeks after stopping treatment. Severe or persistent symptoms are a reason to seek guidance from a healthcare professional.


Q: Can Clavulin 875 interact with birth control pills?

Yes, official product information mentions a potential interaction between this medication and combined oral estrogen/progesterone contraceptives (birth control pills). The antibiotic component can affect intestinal flora, which may lead to reduced reabsorption of estrogen. This might lower the effectiveness of the hormonal contraceptive.


Q: Are there any common foods or drinks to avoid while taking Clavulin 875?

The official product information advises taking Clavulin 875 at the start of a meal to help reduce potential upset stomach and maximize absorption of one of the active ingredients. However, regulatory documents do not list specific foods or non-alcoholic drinks that must be avoided while using this medication.


Q: What are the signs of an allergic reaction to Clavulin 875?

Signs of a serious allergic reaction may include developing a rash or hives, or experiencing swelling of the face, mouth, or throat (known as angioedema). Discontinuation of the medication and immediate medical attention is necessary if any severe reaction occurs.


Q: Why do some people experience yeast infections after taking Clavulin 875?

Clavulin 875 is designed to fight bacterial infections, but it is an antibacterial agent and may disrupt the natural balance of microorganisms in the body. This disruption may lead to an overgrowth of non-susceptible organisms like yeast. The occurrence of yeast infections (mucocutaneous candidiasis) is officially listed as a common adverse reaction.


Q: Can Clavulin 875 affect the results of blood tests?

Yes, regulatory documents note that this medication may affect the results of certain laboratory tests. Specifically, high concentrations of the amoxicillin component in the urine may lead to false-positive results in specific non-enzymatic urine glucose tests. Additionally, the drug may lead to temporary changes in liver enzyme levels (ALT/AST) and can prolong prothrombin time (INR) in patients taking blood thinners.


Q: Is Clavulin 875 safe for older adults or the elderly?

Official product information suggests that dosing for the elderly should generally be approached cautiously. This is due to the higher likelihood of reduced kidney, liver, or heart function, as well as the potential for other co-existing medical conditions or medications. These factors are typically considered by a healthcare professional when determining the appropriate regimen.


Q: Can Clavulin 875 be crushed or split?

According to the official instructions for use, the tablet must be swallowed whole. It should not be crushed, split, or chewed. This ensures the correct delivery and absorption of the active ingredients.


Q: What should I report to my doctor while taking Clavulin 875?

If signs of a severe allergic reaction (like swelling or rash), severe diarrhea that contains blood or mucus, or signs of liver problems (such as persistent vomiting or yellowing of the skin/eyes) are experienced, immediate guidance from a healthcare professional is necessary. These symptoms are considered serious and require prompt medical attention.


Q: What is the difference between the 875mg and 500mg doses of Clavulin?

The 875 mg tablet contains a higher amount of the antibiotic amoxicillin compared to the 500 mg strength. Official guidelines typically reserve the higher dose for treating more severe infections or for specific types of infections, such as those affecting the lower respiratory tract. The appropriate dose is typically determined by a healthcare professional based on the specific infection being treated.


Q: Does Clavulin 875 interact with common over-the-counter pain relievers?

Official drug labels do not list direct interactions with common non-prescription pain relievers like acetaminophen or ibuprofen. However, regulatory information notes that non-steroidal anti-inflammatory drugs (NSAIDs, which include ibuprofen) can sometimes increase the risk of bleeding when taken alongside certain antibiotic-induced changes.


Q: What kind of infections does the '875' dose treat?

The 875 mg dose is indicated for the treatment of several types of bacterial infections in adults. These typically include lower respiratory tract infections, acute bacterial sinusitis (sinus infections), certain skin structure infections, and urinary tract infections, provided they are caused by susceptible bacteria.


Q: Can Clavulin 875 be used for skin infections?

Yes, official regulatory indications confirm that this medication is used for the treatment of skin and skin structure infections when they are caused by bacteria that are susceptible to the drug's components.


Q: Is Clavulin 875 effective against common colds or the flu?

No. Clavulin 875 is specifically an antibacterial agent. According to official limitations of use, it is not effective against and is not indicated for the treatment of viral infections, such as the common cold or influenza (the flu).


Q: Can Clavulin 875 cause difficulty sleeping?

Difficulty sleeping (insomnia) is not listed as a common side effect in official documents. However, general central nervous system effects, such as dizziness and headache, have been reported in rare or uncommon cases.


Q: Is it normal to feel tired or dizzy while on Clavulin 875?

Official information lists dizziness as an uncommon or rare side effect. While unusual tiredness is not listed as a common effect, severe or persistent fatigue could, in rare cases, be associated with more serious adverse reactions like liver problems.


Q: Are there any long-term side effects associated with Clavulin 875?

The existing clinical research primarily focuses on acute, short-term evaluations of the drug. Therefore, official documents state that long-term effects are not fully established. However, rare instances of liver dysfunction have been documented to occur several weeks after a patient has stopped taking the medication.


Q: How long after stopping Clavulin 875 can I expect side effects to subside?

Common gastrointestinal side effects generally resolve within a few days after you complete the prescribed course. For rare but serious side effects, such as cholestatic jaundice, the onset can be delayed, and symptoms may sometimes persist for several weeks after the medication has been discontinued.


Q: What is the risk of antibiotic resistance with Clavulin 875?

Like all antibiotics, using Clavulin 875 carries a risk of contributing to the development of drug-resistant bacteria. Official guidelines emphasize that this drug should only be used to treat infections proven or highly suspected to be caused by susceptible bacteria, which helps maintain its long-term effectiveness.


Q: What is the maximum number of days Clavulin 875 is typically taken for?

The length of treatment varies depending on the specific infection being treated, but many clinical trials and guidelines support courses that range between 5 and 14 days. Official regulatory documents emphasize that the full prescribed course must always be completed.


Q: Why is Clavulin 875 a prescription-only medication?

This medication is classified as a prescription-only antibacterial agent. Its use requires professional medical supervision for several reasons: to ensure accurate diagnosis of a susceptible bacterial infection, to monitor for potentially serious adverse reactions like severe allergies, and to responsibly manage the community risk of antibiotic resistance.


Q: What is the evidence or research supporting the effectiveness of Clavulin 875?

Clinical studies and research have demonstrated that Clavulin 875 is effective in treating various bacterial infections. This includes infections of the lower respiratory tract, sinuses, skin, and urinary tract. Its effectiveness is especially noted against certain bacteria that produce beta-lactamase enzymes, which the clavulanate component helps overcome.

How should Clavulin 875 be stored and disposed of?

Storage and Disposal of Clavulin 875 mg Tablets

Clavulin 875 mg tablets must be stored according to specific regulatory requirements to maintain product integrity.

Storage Conditions

Requirement Official Condition
Temperature Store at controlled room temperature, typically 20 C to 25 C (68 F to 77 F), and not above 25 C or 30 C.
Protection Keep in the original container, tightly closed, and protect from moisture and excess heat.
Child Safety Must be kept out of the sight and reach of children.
Stability Note Tablets in certain packs must be used within 14 or 30 days of opening, depending on the specific storage temperature listed in the labeling.

Disposal Requirements

Unused or expired medication must not be disposed of via wastewater or household trash.

Disposal must follow local guidelines, typically by using an authorized drug take-back program or by consulting a pharmacist for instruction.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

Equivalent of Clavulin 875 found in:

A-Z Index: