Claridar

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Claridar

Property Description
Active ingredient Clarithromycin (INN)
Form Film-coated tablets, Oral suspension, Extended-release tablets
Pharmacological class Macrolide antibiotic (Anti-infective agent)
General Purpose Counteracting bacterial proliferation
Origin Semi-synthetic

What Type of Medicine is Claridar (Clarithromycin)?

Claridar is a single-active-ingredient prescription medicine whose core component is the substance Clarithromycin. It is formally classified as an anti-infective agent that belongs to the macrolide antibiotic pharmacological class. The macrolides are a clinically recognized group of drugs known for their distinct activity against a defined range of microbial pathogens. Clarithromycin is a semi-synthetic derivative, having been chemically modified from the natural macrolide compound Erythromycin to improve its properties. This classification confirms that Claridar is designed specifically to address issues caused by bacterial pathogens, such as managing a localized microbial proliferation in soft tissues.

Composition and Available Forms of Claridar

As a single active ingredient product, Claridar's composition relies entirely on Clarithromycin, which is formulated for oral administration and absorbed into the bloodstream for a systemic effect throughout the body. The medicine is manufactured to provide diverse dosage forms, including conventional film-coated tablets and granules for oral suspension, making it adaptable for various patient groups, notably the pediatric population. The availability of both immediate-release and extended-release tablets also provides flexibility in how the active ingredient is delivered over time.

General Purpose and Mechanism Principle

The general purpose of Claridar is to counteract bacterial proliferation when infections are caused by susceptible microorganisms. This objective is achieved through the drug's fundamental mechanism principle, which involves interfering directly with the bacteria's internal machinery. Clarithromycin acts as a protein synthesis inhibitor by binding to the bacterial 50S ribosomal subunit, which prevents the microorganism from manufacturing the essential proteins required for its growth and replication. By halting the growth of the invading bacteria, the medicine supports the body’s natural defenses in resolving the underlying issue.

What side effects are possible with Claridar?

Possible side effects and safety information

The safety profile of Claridar, containing Clarithromycin, is structured around frequency classifications and the specific physiological systems affected, as documented in official regulatory labeling (EMA, FDA). This information is descriptive and not intended as clinical advice.


Adverse Reaction Scope

The most common adverse reactions are categorized under Gastrointestinal Disorders and include diarrhoea, nausea, vomiting, abdominal pain, and a metallic or abnormal taste (dysgeusia). Nervous System and Psychiatric effects such as headache and insomnia are also classified as common.

Classification Examples of Officially Documented Effects
Common Diarrhoea, Dysgeusia, Insomnia, Nausea, Headache
Uncommon Leukopenia, Vertigo, Hypersensitivity, QT interval prolongation
Not Known Torsades de Pointes, Hepatic Failure, Stevens-Johnson Syndrome (SJS)

Serious Adverse Reactions and Safety Constraints

The regulatory profile highlights several serious adverse reactions, which are often classified as 'Not Known' due to their rarity in clinical trials but are documented in post-marketing surveillance. These include severe Cardiac Arrhythmias (such as QT prolongation and Torsades de Pointes) and rare instances of fatal Hepatic Failure and life-threatening skin conditions (e.g., SJS).

Safety Restrictions: Official labeling imposes specific constraints. Claridar is contraindicated in patients with a history of QT prolongation or ventricular cardiac arrhythmia, as well as those with severe hepatic failure combined with renal impairment. Exacerbation of symptoms of Myasthenia Gravis has been reported. Furthermore, the risk of Clostridioides difficile-associated diarrhoea (CDAD) is documented and may occur up to two months after treatment completion.

Overdose and Emergency Response

Overdose and When to Seek Help

The official regulatory documentation for Claridar (Clarithromycin) overdose primarily reports manifestations consistent with gastrointestinal irritation. These typically documented signs include abdominal pain, nausea, vomiting, and diarrhea. Additionally, transient hearing loss has been noted in association with high-dose exposure.

A severe overdose, however, presents the risk of life-threatening outcomes affecting the cardiac and hepatic systems. These serious manifestations include QT prolongation and ventricular arrhythmias, such as Torsade de Pointes, as well as the potential for severe hepatic dysfunction and hepatic failure with fatal outcome. Elderly patients with pre-existing renal problems may be more susceptible to drug-associated cardiac effects.

In the event of an overdose, treatment is symptomatic and supportive, and no specific antidote is known. Regulatory guidance mandates that individuals must call the poison control helpline or emergency services immediately. Urgent medical attention is required if there are signs of collapse, seizure, trouble breathing, or the appearance of signs and symptoms of hepatitis (e.g., jaundice or dark urine). Furthermore, hemodialysis is unlikely to be of significant benefit in removing Claridar from the system.

Therapeutic Uses of Claridar

What Claridar Treats: Main Uses and Benefits

Claridar is applied in addressing conditions marked by increased discomfort and provides therapeutic support focused on assisting with the bacterial burden and easing related symptoms. This medication is commonly prescribed for a wide range of infections caused by designated, susceptible bacteria.

Scope of Symptom Management

Claridar is relevant for managing infections of the respiratory tract (like bacterial sinusitis, bronchitis, pharyngitis, and pneumonia), skin and soft tissues (such as cellulitis), and is applied in addressing specific gastrointestinal pathogens (like H. pylori in ulcer therapy). It helps address groups of symptoms that may become intense or disruptive, including persistent cough, throat pain, fever, and symptoms related to inflammatory or irritative states.

“It may also provide supportive relief for patients who require an anti-infective but have a known allergy to penicillin.”

This medication is considered relevant in contexts involving heightened systemic burden, assisting the patient during symptomatic phases. It contributes to easing the overall symptom load during periods of heightened symptoms and supports the patient during difficult episodes by helping manage distress.

Quick Fact: Relief for Acute Discomfort Claridar is commonly used when symptoms related to physical discomfort, like fever and localized inflammation, are caused by susceptible bacterial infections, providing supportive relief that assists with maintaining functional stability.

Regulatory References

  1. NIH MedlinePlus overview

Eligibility and Restrictions for Use

Claridar (Clarithromycin) eligibility is strictly defined by regulatory documents, establishing absolute contraindications and specific limitations based on a patient's intrinsic characteristics. The medicine is contraindicated for patients with a known hypersensitivity to any macrolide antibiotic or a history of clarithromycin-associated cholestatic jaundice or hepatic dysfunction. Absolute prohibition also applies to patients with a history of QT prolongation, ventricular arrhythmias, or uncorrected hypokalemia or hypomagnesemia. Furthermore, use is prohibited in cases of severe hepatic failure combined with renal impairment.

Eligibility for use is conditional in certain populations. Patients with severe renal impairment or impaired hepatic function require special caution. For age groups, adults and adolescents (12 years and older) are eligible for tablets, while children 6 months of age and older should use the oral suspension, as the tablet form is not recommended for those under 12. Safety and efficacy are not established for infants younger than 6 months. Use during pregnancy is not recommended unless no suitable alternatives exist, and use during lactation requires a formal risk-benefit weighing.

What should I know about interactions with other medicines?

Claridar Interactions with other medicines and products

Claridar (Clarithromycin) is officially classified as a strong inhibitor of the CYP3A4 enzyme and an inhibitor of the P-glycoprotein (P-gp) transporter. This dual action leads to documented pharmacokinetic interactions that primarily increase the systemic exposure (AUC and Cmax) of many co-administered medicinal products.


Formal Regulatory Restrictions

Co-administration of Claridar is contraindicated with several drugs due to the potential for significantly elevated plasma concentrations and serious adverse reactions, as specified in regulatory labeling.

  • Cardiotoxic Agents: Combination with Pimozide, Astemizole, Cisapride, and Terfenadine is prohibited due to the high risk of severe cardiac arrhythmias, including QT interval prolongation.
  • Ergot Derivatives: Co-administration with Ergotamine and Dihydroergotamine is prohibited due to the risk of acute ergot toxicity, characterized by vasospasm.
  • Statins: Co-administration with Lovastatin or Simvastatin is contraindicated due to the significantly increased risk of myopathy and rhabdomyolysis.
  • Colchicine: This combination is strictly contraindicated in patients with pre-existing renal and/or hepatic impairment due to the risk of fatal toxicity.

Timing and Exposure Rules

Regulatory documents stipulate that oral Claridar and Zidovudine doses must be separated by at least 4 hours to prevent a documented reduction in Zidovudine plasma concentration. Additionally, the extended-release formulation has a documented interaction with food, which increases its peak plasma concentration.

Mechanism of Action

Targeted Inhibition of Bacterial Protein Manufacturing

Claridar's core mechanism involves its binding to the bacterial 50S ribosomal subunit , specifically at the peptide exit tunnel. This molecular blockade prevents the bacteria from completing protein synthesis and elongating its essential polypeptide chains. This bacteriostatic action limits the proliferation of the pathogen, which is a key physiological consequence of ribosomal blockade.


Modulation of Host Inflammatory Signaling

The mechanism extends beyond the bacteria to include the host's immune pathways. Claridar acts to suppress the signaling cascade of NF-κB, a crucial transcription factor, thereby reducing the gene expression and release of various proinflammatory cytokines such as IL-8. This secondary effect contributes to the modulation of inflammatory signaling within affected tissues.


Sustained Anti-Microbial Action via Active Metabolite

The mechanism is maintained and enhanced by a process known as metabolite synergy. The parent compound and its major breakdown product, 14-(R)-hydroxyclarithromycin, both possess anti-microbial activity and target the same ribosomal subunit. This combined action ensures a sustained blockade of the target pathway, contributing to the overall physiological response.

Dosage and Administration Information

How to Use Claridar: Official Administration Guidelines

Claridar (Clarithromycin) administration is governed by a defined set of instructions detailed in official prescribing information. The medication is primarily for oral use through immediate-release tablets, extended-release tablets, and oral suspension. An intravenous (IV) formulation is also approved for administration in specific clinical settings.


Dosing and Frequency Patterns

The standard regimen for immediate-release forms is typically 250 mg or 500 mg twice daily (every 12 hours). The extended-release tablets are administered as 1000 mg (1 gram) only once daily (every 24 hours). The total duration of treatment generally ranges from 7 to 14 days, though specific infections, such as those caused by Streptococcus pyogenes, require a mandatory minimum course of 10 days.


Administration Conditions and Adjustments

Condition/Population Official Instruction Constraint Type
IR Forms/Suspension Can be taken with or without food. Intake Timing
Extended-Release Tablets Must be taken with food; swallow whole and do not crush or chew. Physical Integrity
Pediatric Patients Use the oral suspension; dosing is based on weight at 15 mg/kg/day divided every 12 hours. Age/Dose Calculation
Severe Renal Impairment The total daily dosage must be reduced by one-half. Dose Modification

For H. pylori eradication, Claridar is administered as a three-times-daily regimen as part of a combination therapy with other agents, never as monotherapy.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Claridar

Evidence for Acute Bacterial Infections (Respiratory and Skin)

The research base for Claridar consists of short-term Randomized Controlled Trials (RCTs). These studies were used to explore their application in conditions associated with acute or disruptive episodes, such as community-acquired pneumonia, pharyngitis, or infections of the skin. Researchers focused on outcomes related to physical discomfort and systemic imbalance, designing the trials to measure changes in symptoms like fever and cough, alongside laboratory confirmation of bacteriological status (testing for the presence or absence of the targeted bacteria).

However, the research so far indicates that follow-up durations were limited, typically only covering the 5 to 14 days of the treatment course. Therefore, there is limited information for long-term endpoints or relapse frequency over months or years.


Evidence for Addressing Specific Gastrointestinal Pathogens

Claridar was studied for its application within multi-drug regimens aimed at addressing the Helicobacter pylori pathogen, which is associated with acute or disruptive episodes of duodenal ulcer disease. A primary measurement monitored in these studies was the rate of H. pylori eradication, confirmed several weeks after treatment was completed.

Early studies reported measurements related to the pathogen status when the compound was used in specific multi-drug regimens. However, research describes patterns related to the prevalence of resistance to this class of antibiotic worldwide. Because the susceptibility of the bacteria to the compound may vary significantly by region, the findings were mixed regarding eradication outcomes when comparing different countries or time periods.


Long-Term Studies and Extended Follow-up Research

Research has also explored outcomes long after the short-term study period has finished, including large-scale Randomized, Placebo-Controlled Trial (RCT). Researchers monitored endpoints like all-cause mortality and cardiovascular mortality up to 10 years after patients had completed their short study course. The key long-term RCT data showed patterns related to long-term mortality in the specific subgroup of patients who already had stable coronary heart disease.

However, the long-term effects are not fully established across the general population because the central study specifically included patients with existing heart disease, and the general applicability of these results to patients without that comorbidity is not established.

Key Studies & References

  1. Clarithromycin: MedlinePlus Drug Information (General Indications and Safety)
  2. Macrolides - StatPearls (Overview of Antibiotic Class and General Use)
  3. The prevalence of clarithromycin-resistant Helicobacter pylori isolates: a systematic review and meta-analysis

Frequently Asked Questions (FAQ)

Common questions about Claridar (FAQ)


Q: How long does Claridar typically take before I start to notice anything?

A: Evidence from clinical use indicates that for many acute infections, patients may begin to notice a reduction in symptoms within a few days of starting the compound. However, the time until significant relief can vary and may take up to a week or more for certain specific types of infections.


Q: Is Claridar a new drug, or has it been around for a while?

A: According to official documentation, this compound has been authorized for use by regulatory bodies for several decades, with its initial approval occurring in the early 1990s. While formulations and prescribing information are routinely updated, the medicine itself has an established history.


Q: How quickly does Claridar leave your system?

A: Official pharmacological data describes how the body processes the compound. The time required for half of the medicine to be eliminated from the body—known as the half-life—ranges from approximately 3 to 7 hours, depending on the dose administered.


Q: Can Claridar affect the way birth control works?

A: Some macrolide antibiotics have been mentioned in studies regarding a potential effect on oral contraceptives. Official guidance indicates that Claridar does not stop contraceptive pills from working, but official guidance indicates that side effects like severe diarrhea or vomiting may potentially reduce the effectiveness of protection.


Q: Does Claridar interact with common pain relievers like Tylenol or Advil?

A: Regulatory information indicates that Claridar can affect the way the body processes certain pain relievers, specifically mentioning drugs like acetaminophen (Tylenol). This interaction could potentially lead to increased concentrations of the pain reliever in the body.


Q: Is Claridar approved in countries other than the US?

A: Yes, official regulatory documents from multiple international health agencies, including the EMA (Europe), Health Canada, and the TGA (Australia), are publicly available. This indicates that the compound is authorized for use in numerous regions outside of the United States.


Q: How does Claridar relate to similar medications like [Related Class Drug]?

A: Official information describes Claridar as belonging to the macrolide class of antibiotics. This group of medicines is characterized by its action of binding to the 50S ribosomal subunit of susceptible bacteria to inhibit the manufacturing of essential proteins.


Q: Is Claridar suitable for people who have kidney issues?

A: Regulatory guidance specifies that for individuals with severe kidney impairment, the official dosage recommendations specify that a dose adjustment may be necessary. This is because the compound is primarily removed from the body by the kidneys, and impairment can lead to increased concentrations.


Q: Is Claridar supposed to be taken for a short time or long-term?

A: The compound is most often prescribed as a short-course treatment, typically lasting 7 to 14 days, for acute bacterial infections. However, official documents indicate that it is also approved for use over extended periods in specific combination regimens for conditions like MAC infection.


Q: Can I stop taking Claridar suddenly, or should I talk to my doctor first?

A: Official patient guidance emphasizes the importance of completing the entire prescribed course of treatment, even if symptoms begin to improve quickly. Completing the full course is important to minimize the risk of the infection returning and to limit the development of antibiotic resistance.


Q: Is it possible to be allergic to Claridar?

A: Yes, official regulatory labeling documents the occurrence of hypersensitivity reactions associated with the compound. These reactions can range from uncommon allergic responses to severe, acute reactions like anaphylaxis, and the regulatory documents emphasize that severe reactions should be medically addressed without delay.


Q: How do I know if the side effects I am having are serious?

A: Regulatory materials describe certain symptoms as potentially indicating serious adverse reactions, such as blistering skin or changes in heart rhythm. Official guidance indicates that such events warrant immediate professional medical review.


Q: Is Claridar considered a high-risk medication during pregnancy?

A: Official guidance describes that the safety of the compound for use during pregnancy has not been established. The label information states its use is generally not recommended unless the anticipated health benefits are judged to outweigh the potential risks to the developing fetus.


Q: What does the official guidance say about using Claridar while breastfeeding?

A: Official guidance states that small amounts of the compound are known to be excreted into human breast milk. Due to the potential for the compound to cause side effects in the breastfed infant, official guidance notes that special consideration is warranted.


Q: Is the research on Claridar still ongoing, or are studies complete?

A: Research involving the compound continues, with clinical trial registries documenting ongoing studies. These trials may be examining interactions with other substances and the use of the compound in various patient populations.


Q: What type of patients were included in the main clinical trials for Claridar?

A: The main efficacy trials primarily included adult and pediatric patients diagnosed with acute bacterial infections, such as those affecting the respiratory tract or skin. Other studies have included healthy adult volunteers and specific patient groups, such as those with stable coronary heart disease.


Q: Does taking Claridar require any special monitoring or blood tests?

A: Regulatory information describes that certain patients may be subject to specialized monitoring or blood tests, due to the noted association with hepatic dysfunction, elevated liver enzymes, and the risk of affecting heart rhythm.


Q: Is it necessary to avoid driving while taking Claridar?

A: Documented adverse reactions include central nervous system effects such as dizziness, vertigo (a spinning sensation), and blurred vision. Official information indicates that if patients experience these effects, exercising caution when performing tasks that require concentration, such as driving or operating machinery, is appropriate.


Q: Does Claridar have any known effects on mood or energy levels?

A: Official documentation lists adverse reactions that affect the nervous system and psychological state, including common effects like insomnia and, less commonly, reports of anxiety, confusion, or other changes in mental status.


Q: What is the general safety classification of Claridar according to regulatory bodies?

A: The compound is classified as a macrolide antibiotic and its use is subject to specific regulatory constraints outlined in its prescribing information. These include formal contraindications that restrict its use in patients with certain cardiac conditions or severe liver and kidney impairment.


Q: Is there a generic version of Claridar available?

A: Yes, regulatory agencies have approved generic versions of the compound. The availability of generic alternatives is often detailed in official drug listings and formularies.


Q: Does Claridar cause weight gain or weight loss?

A: Official post-marketing surveillance reports note that weight loss has been listed as an adverse event. Weight gain is not listed among the commonly documented side effects in the compound's official labeling.


Q: Can I take Claridar if I have diabetes or high blood pressure?

A: Regulatory information includes a specific warning regarding the risk of significantly decreased blood sugar levels when the compound is administered with insulin or certain oral diabetes medications. The full safety information should be consulted regarding pre-existing conditions.


Q: Are there any long-term effects of taking Claridar that I should know about?

A: Regulatory documents include a warning based on long-term studies that observed a potential pattern of increased all-cause mortality in a select subgroup of patients with stable coronary heart disease for several years following a short course of treatment. The full context is described in the research section.


Q: Does the time of day I take Claridar matter?

A: Official patient guidance often suggests the practice of taking the compound at approximately the same time each day. This approach is intended to help maintain consistent levels of the medication in the body.


Q: Are there any specific populations, like older adults, who need special consideration with Claridar?

A: Official documentation notes that older adults may have an increased susceptibility to certain drug-associated effects. Regulatory guidance indicates that special consideration is warranted, particularly regarding effects on the heart’s electrical activity (known as the QT interval).


Q: Can Claridar cause skin reactions or rashes?

A: Official regulatory materials document that the compound can cause skin reactions, including both common rashes and, rarely, severe, life-threatening conditions such as Stevens-Johnson Syndrome (SJS). The documents emphasize that severe or blistering rashes require immediate medical review.

How should Claridar be stored and disposed of?

Claridar (Clarithromycin) requires strict adherence to labeled storage and disposal rules to maintain its integrity and ensure safety.

Dosage Form Mandatory Storage Conditions Prohibited Conditions
Tablets Store at room temperature (68 F to 77 F or 20 C to 25 C), protected from light, heat, and moisture. Do not store in a high-moisture area like the bathroom.
Oral Suspension (Mixed) Store at room temperature (59 F to 86 F or 15 C to 30 C). Do not refrigerate or freeze the liquid suspension.

All forms must be kept in the original container, tightly closed, and stored out of the sight and reach of children. The mixed oral suspension must be discarded after 14 days to ensure stability. Unused or expired medication should be disposed of via a drug take-back program or by mixing with an undesirable substance before discarding in the household trash. Do not flush the medicine down the toilet unless directed by specific product labeling.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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