Citrol

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Citrol

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Citrol

Property Description
Active ingredient Citalopram (as Citalopram Hydrobromide)
Form Film-coated Tablet, Oral solution
Pharmacological class Selective Serotonin Reuptake Inhibitor (SSRI)
General purpose Modulating central nervous system chemistry for mood stabilization
Origin Synthetic, Bicyclic phthalane derivative

What Type of Medicine is Citrol?

Citrol is a prescription-only psychotropic drug containing the active ingredient Citalopram (as Citalopram Hydrobromide). It belongs to the specific pharmacological class known as a Selective Serotonin Reuptake Inhibitor (SSRI). This classification is characterized by its focused action on the Central Nervous System (CNS) to promote emotional equilibrium. The medicine's role is established in supporting the brain chemistry associated with mood regulation.

The unique profile of Citalopram among SSRIs is its high level of selectivity for inhibiting serotonin reuptake, with minimal affinity for other receptors. This synthetic compound is available as a film-coated tablet and oral solution, with the film-coating being a distinctive feature designed to facilitate smooth oral administration.


Citrol's Active Ingredient and Pharmaceutical Form

The chemical foundation of Citrol is Citalopram, a bicyclic phthalane derivative that is structurally distinct from some other SSRIs. Citalopram is classified as a racemic compound, meaning the active substance is an equal blend of two mirror-image molecules. This racemic structure is a key point of comparison with its purified analogue, Escitalopram.

Citrol is a single-entity product for oral intake. The availability of the oral solution alongside the film-coated tablet offers administration flexibility. The use of Citalopram Hydrobromide ensures pharmaceutical stability, supporting consistent delivery of the active substance within the body.

Regulatory References

  1. Citalopram - StatPearls - NIH

What side effects are possible with Citrol?

Possible Side Effects and Safety Information

The safety profile of Citrol (Citalopram) is formally documented in government regulatory texts, which classify possible adverse reactions by frequency and the body system affected. These classifications reflect how regulatory documents organize and communicate the medicine’s risk profile.

Adverse reactions are categorized using standard frequency bands:

  • Very Common (Affecting ge 1 in 10 individuals): Nausea, dry mouth, somnolence, insomnia, increased sweating, and headache.
  • Common (Affecting ge 1 in 100 to < 1 in 10 individuals): Decreased appetite, agitation, tremor, diarrhea, constipation, fatigue, and sexual dysfunction (e.g., ejaculation disorder).

The official labeling notes that certain effects, such as anxiety and restlessness, may be more frequent at the start of treatment or during dosage adjustments. The risk of Suicidal thoughts and behaviors is also noted to be higher during the initial few months of therapy, particularly in younger adults.

Serious Adverse Reactions and Restrictions

Regulatory documents highlight several serious adverse reactions, which are typically rare. These include Serotonin Syndrome and dose-dependent QT prolongation (a change in the heart's electrical activity) with the potential risk of Torsade de Pointes. Specific contraindications are listed in the official prescribing information, such as avoiding use in individuals with a known congenital long QT syndrome or those taking Monoamine Oxidase Inhibitors (MAOIs), due to heightened safety risks.

Population-specific safety considerations are formally documented. For older adults and patients with hepatic impairment, a lower maximum recommended dose is specified, as these groups may face an increased risk of specific adverse effects, such as Hyponatremia (low sodium levels).

Overdose and Emergency Response

Overdose and When to Seek Help

Official regulatory information describes Citalopram (Citrol) overdose as potentially involving a range of neurological and cardiovascular manifestations, particularly with high-dose ingestion or when taken with other substances.

Property Official Regulatory Statement
Documented Overdose Presentations Symptoms may include seizures, somnolence, agitation, tremor, nausea, and vomiting. More severe outcomes include serotonin syndrome and coma [NIH/FDA sources].
Physiological Systems Affected The overdose profile highlights risks to the Central Nervous System and the Cardiovascular System, including specific heart rhythm abnormalities like QT interval prolongation and Torsade de Pointes [FDA sources].
Population-Specific Notes The maximum recommended daily dose is restricted for elderly patients (over 60) and those with hepatic impairment due to the increased risk of QT prolongation [FDA sources].
Emergency-Response Statement Call the poison control helpline immediately in case of suspected overdose. Call emergency services (911) if the individual has collapsed, is experiencing trouble breathing, or cannot be awakened [MedlinePlus source].
When Immediate Medical Help Is Required Seek immediate medical attention for severe symptoms such as chest pain, fainting, fast or irregular heartbeat, severe muscle stiffness or twitching, or confusion [FDA/MedlinePlus sources].

No specific antidote is known for Citalopram overdose; therefore, management focuses on providing symptomatic and supportive treatment while closely monitoring vital signs and the ECG. The severity classification in official documents notes the potential for life-threatening outcomes, particularly in cases involving multiple substances.

Therapeutic Uses of Citrol

What Citrol Treats: Main Uses and Benefits

Citrol (Citalopram) is generally applied in contexts where additional symptomatic support is needed across key psychotherapeutic domains, providing support that helps ease the overall symptom burden during periods of heightened symptoms. The medication provides supportive relief when symptoms interfere with routine activities. Citalopram is indicated for the treatment of Major Depressive Disorder (MDD) in adults. It is relevant in clinical settings marked by heightened patient distress, commonly used to help with symptom clusters that may become intense or disruptive, including MDD, Panic Disorder, Obsessive-Compulsive Disorder (OCD), and specific behavioral disturbances.

The medicine is relevant for managing symptoms that cluster into patterns requiring supportive relief, such as persistent sadness, loss of pleasure, recurrent panic attacks, and intrusive thoughts. Citrol assists with maintaining functional stability and supports patients during episodes of heightened discomfort across these therapeutic areas.


Quick Fact: Symptomatic Support for Mood Disturbances Citrol is applied in conditions where symptoms may intensify temporarily, supports patients during difficult episodes by easing distress, and may assist with managing patterns of low mood and reduced motivation.

Eligibility and Restrictions for Use

Who Can and Cannot Use Citrol?

Citrol (Citalopram) eligibility is determined by official regulatory criteria, defining groups who are permitted, restricted, or strictly prohibited from use.

Contraindicated Populations (Must Not Use)
Patients with known hypersensitivity to Citalopram or its ingredients.
Patients currently taking or within 14 days of discontinuing Monoamine Oxidase Inhibitors (MAOIs).
Patients currently taking Pimozide or with a history of QT interval prolongation or Congenital Long QT Syndrome.
Age-Group and Condition Restrictions
Pediatric Patients (Under 18): Use is not approved as safety and efficacy have not been established.
Older Adults (Aged 65+) and patients with hepatic (liver) impairment: Use is restricted, requiring a lower maximum dose due to altered drug clearance and cardiac risk.
Pregnancy/Lactation: Use is cautioned; third-trimester exposure is associated with neonatal risks, and the medicine is excreted into breast milk.

Regulatory criteria mandate caution for patients with a history of seizure disorder or bleeding disorders, and for those with electrolyte imbalances, to manage associated risks.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Citrol’s interaction profile is documented by government regulatory agencies and is categorized based on pharmacokinetic (PK) and pharmacodynamic (PD) risk.

Contraindicated Combinations

Co-administration is formally prohibited with: Monoamine Oxidase Inhibitors (MAOIs), including Linezolid and Intravenous Methylene Blue; Pimozide; and all medicinal products known to prolong the QT-interval. A mandatory minimum of 14 days must elapse between discontinuing an MAOI and initiating Citrol, or vice versa.

Pharmacodynamic and Metabolic Interactions

Interaction Type Interacting Products/Substances
Serotonergic Risk (PD) Other serotonergic agents (e.g., Triptans, Fentanyl, Tramadol, Lithium, Tryptophan, St. John's Wort).
Bleeding Risk (PD) Drugs that interfere with hemostasis (e.g., NSAIDs, Aspirin, Warfarin).
Clearance Reduction (PK) Potent inhibitors of the CYP2C19 and CYP3A4 enzymes (e.g., Omeprazole, Cimetidine, Ketoconazole).

Population and Exposure Constraints

Concomitant use with CYP2C19 inhibitors is expected to decrease Citrol clearance, resulting in increased plasma concentrations. This risk is also significantly elevated in CYP2C19 Poor Metabolizers and Elderly Patients (age 60+), leading to specific population-based restrictions. Official guidance also cautions against the co-administration of alcohol.

Mechanism of Action

How Citrol Works: Understanding its Mechanism of Action

Citrol affects physiological responses through engagement with specific signaling mechanisms and regulatory pathways. This action occurs across distinct mechanistic domains and results in the modulation of heightened physiological pathway activity.


Modulating Receptor-Mediated Signaling

Citrol acts within systems involving receptor- or enzyme-mediated signaling, specifically by engaging mechanisms that regulate dysregulated processes. It affects systems where specific transmitters or mediators dominate, initiating or suppressing signaling sequences that lead to specific downstream effects. This modification of early molecular steps affects mediator activity, influencing the establishment of a resultant physiological set-point.


Regulating Heightened Physiological Pathways

The drug's mechanism includes modulating key pathways associated with heightened physiological responses. It is relevant in contexts involving rapid modulation of physiological responses, affecting the regulation of processes driven by distinct signaling patterns. Citrol modifies these pathways, influencing feedback regulation within cascades where multiple layers of activation occur. The resulting pathway activity contributes to the adjustment of physiological responses, influencing the compound’s systemic profile.

Dosage and Administration Information

How to Use Citrol

Citrol (Citalopram) administration follows standardized protocols to ensure proper usage. The medicine is for oral intake, available as a film-coated tablet and an oral solution. Both forms allow for flexible intake and may be taken with or without food.


Official Dosing Regimens

The standard adult dosing schedule for the primary indication typically begins with an initial dose of 20 mg once daily. Doses are administered as a single daily dose. The usual maintenance range is between 20 mg and 40 mg daily, with a maximum recommended dose of 40 mg per day.

Population Group Maximum Recommended Daily Dose
Older Adults (Age > 60) 20 mg
Hepatic Impairment 20 mg

Administration and Procedural Rules

Any adjustments to the dose must be introduced gradually, usually in increments of 10 mg or 20 mg, and only after a minimum interval of at least one week has passed at the current dose. This titration schedule is utilized to align the patient's usage with established procedural steps. For consistency, the daily dose should generally be taken at the same time each day.

In cases of a missed dose, the procedure is generally to skip the missed dose and resume the schedule with the next planned dose; doubling the dose is not advised. When ending treatment, the medicine is not to be stopped abruptly. Instead, treatment cessation requires a gradual dose reduction (tapering) over a period of at least one to two weeks to follow established clinical procedures.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Citrol

This overview summarizes the formal research base for Citrol, focusing on the design and documented observations of clinical studies reported in official and peer-reviewed scientific literature. The findings describe group patterns observed in research settings, but research does not determine whether an individual will respond similarly.


Research Evidence for Major Depressive Disorder (MDD)

Research exploring Major Depressive Disorder (MDD) in adults includes short-term, placebo-controlled randomized clinical trials (RCTs). These studies were used in research exploring how symptoms change over time during the acute phase of treatment, typically lasting between two and eight weeks. Pooled analyses of these trials reported measured differences in symptom scores and response rates between the active treatment group and the placebo group. Studies exploring the achievement of full symptom resolution, or remission, in the short-term acute treatment phase have reported variable findings across various research reports.

Comparative research has explored Citrol alongside other treatments in its class, with studies exploring outcomes that were comparable between Citrol and many newer medications for acute MDD. Research explored comparisons with its purified analog, escitalopram, with some studies reporting variability in measured symptom scores and response rates between the two agents.


Evidence for Panic Disorder and Obsessive-Compulsive Disorder (OCD)

Studies for Panic Disorder utilized randomized, controlled research designs, monitoring the frequency of panic attacks over defined time intervals. Findings describe patterns observed where the measured change in the number of panic attacks was noted in the active treatment group compared to placebo. However, the evidence base is less expansive than the evidence base for MDD.

Research exploring Obsessive-Compulsive Disorder (OCD) monitored outcomes using specialized scales to quantify changes in the severity of obsessions and compulsions. Studies reported that the doses used in trials studying OCD symptoms were often observed to be higher than the doses used in trials for MDD. Evidence is limited concerning long-term follow-up beyond the initial acute period.


Long-Term and Maintenance Studies

Maintenance studies utilized designs where patients who had achieved initial stability were then observed over defined time intervals, often lasting six to 12 months or longer. Research describes that measured outcomes regarding the rate of symptom recurrence were observed between patients continuing treatment and those discontinuing and switching to placebo. These findings help contextualize how symptoms evolved during the longer periods following acute stabilization.


Study Quality, Limitations, and Research Gaps

Reviews of the research base have noted that the overall quality of reporting in some older trials was variable. Key limitations in the research include that data for certain groups remain limited, and there is limited information for long-term outcomes extending beyond the one-year follow-up in the maintenance trials. Research reports noted that findings related to symptom remission based on published trials alone were variable, with researchers often suggesting that evaluation of unpublished data is necessary for a more complete understanding.

Key Studies & References

  1. Citalopram (StatPearls) - National Institutes of Health (NIH) Review

Frequently Asked Questions (FAQ)

Common questions about Citrol (FAQ)


Q: Is Citrol used for conditions other than its primary approved purpose?

Regulatory documents list the specific conditions for which Citrol is formally approved and for which efficacy has been studied, such as Major Depressive Disorder (MDD), Panic Disorder, and Obsessive-Compulsive Disorder (OCD). The official indications do not list uses for any other conditions.

Q: How quickly can a person generally expect to notice the effects of Citrol?

Official patient information often states that it may take several weeks after starting treatment before an individual notices any improvement in their symptoms. It is also noted that some patients may feel an increase in anxiety or restlessness when they first begin taking the medication.

Q: Is there a generic version of Citrol available?

Yes, regulatory listings from agencies like the FDA confirm that generic versions of Citalopram Hydrobromide, the active ingredient in Citrol, are available from multiple manufacturers.

Q: What kind of monitoring or tests are usually needed when taking Citrol?

Regulatory guidance notes that certain tests, such as ECG monitoring (checking the heart's electrical activity) and monitoring electrolyte levels in the blood, are relevant for patients with risk factors for changes in heart rhythm. This is due to the potential for dose-dependent QT prolongation, a risk factor noted in official warnings.

Q: How long does Citrol typically stay in the system after the last dose?

According to the official drug information, the drug's plasma half-life is approximately 35 hours after administration. The half-life refers to the time it takes for the concentration of the medicine in the bloodstream to be reduced by half. Complete elimination typically takes several half-lives.

Q: Can Citrol affect a person's mood or energy levels?

Official documents list changes to energy and mood as potential effects. These can include common side effects like somnolence (drowsiness) and fatigue, as well as insomnia (trouble sleeping). Less commonly, some people may experience agitation or restlessness, particularly when first starting the medicine.

Q: What are the signs of a serious allergic reaction to Citrol?

Official warnings highlight the risk of hypersensitivity reactions (severe allergic responses). The symptoms of a serious, related condition called Serotonin Syndrome are also highlighted, and can include confusion, hallucinations, agitation, fever, and severe dizziness. Patients are advised in official warnings to seek medical attention if symptoms of a serious reaction occur.

Q: Are there any known food restrictions while using Citrol?

Official regulatory guidance states that Citrol may be taken with or without food. Its absorption and effectiveness are not dependent on mealtimes, meaning there are no specific food restrictions for this medicine.

Q: Is Citrol a type of antibiotic?

No, Citrol is not an antibiotic. It is classified as a Selective Serotonin Reuptake Inhibitor (SSRI), a type of psychotropic drug designed to help regulate mood and emotional equilibrium by acting on the central nervous system.

Q: Does Citrol affect blood pressure?

Official warnings note that Citrol can cause dose-dependent QT prolongation, which is an alteration of the heart's electrical activity. This is a risk factor for serious cardiac events, although general blood pressure changes are not commonly highlighted in the official side effect profile.

Q: Can Citrol interact with medicines used for depression or anxiety?

Yes, official documents explicitly prohibit combining Citrol with Monoamine Oxidase Inhibitors (MAOIs). Additionally, using it with other serotonergic agents (which includes many medicines for depression and anxiety) carries an increased risk of Serotonin Syndrome.

Q: Are there specific times of day that Citrol is meant to be taken?

Official guidance emphasizes that the daily dose should be taken at the same time each day for consistency. Official patient guidance on administration sometimes notes that taking the dose in the morning may be related to managing sleep difficulty (insomnia).

Q: Can a person with kidney disease take Citrol?

Official regulatory guidance states that a dose adjustment is not typically required for patients with mild to moderate kidney problems (renal impairment). The use of Citrol in patients with severe kidney disease has generally not been well-studied.

Q: What is the definition of a serious side effect listed for Citrol?

Serious adverse reactions highlighted in official regulatory documents are typically rare but significant. these include Serotonin Syndrome, certain heart rhythm changes like QT prolongation and Torsade de Pointes, and an increased risk of bleeding, seizures, or the activation of mania/hypomania.

Q: Has Citrol been studied in children?

Regulatory documents state that Citrol is not approved for use in patients under 18 years of age. This is because the safety and efficacy of the medication have not been established in this specific pediatric population.

Q: Does Citrol require a prescription?

Yes, Citrol is classified in official documents as a prescription-only drug, meaning it cannot be obtained without a valid prescription from an authorized healthcare professional.

Q: Are there any known interactions between Citrol and herbal teas?

Official drug interaction warnings specifically state that the herbal product St. John's Wort must not be taken with Citrol due to the heightened risk of developing Serotonin Syndrome. General information on other specific herbal teas is not provided in regulatory documentation.

Q: Does Citrol affect the results of any common laboratory tests?

Citrol is associated with the risk of causing Hyponatremia (abnormally low sodium levels) in some patients. This change in sodium levels is an adverse reaction that would be detected by a blood test, but it is not the medicine directly interfering with the test procedure.

Q: Does Citrol interact with birth control pills?

Based on official drug interaction information, Citalopram is generally reported to have no known or clinically significant interaction with common hormonal birth control pills. The full medication list should be reviewed with a healthcare professional, according to standard guidance.

Q: What is the purpose of the patient information leaflet that comes with Citrol?

The leaflet is a government-mandated document that provides patients with necessary scientific information about the drug. It describes the approved uses, its potential risks and side effects, and important instructions for safe and effective use of the medicine.

Q: What should be done in the event of an overdose of Citrol?

Regulatory documents describe potential symptoms of overdose, such as vomiting, seizures, or changes in heart rhythm. Official guidance on overdosage states that this is a serious event and patients should seek immediate medical attention.

Q: Does Citrol affect fertility in males or females?

Non-clinical data from animal studies suggest that Citalopram may potentially impact sperm quality. The official information notes that it is currently unknown if this observation translates to reduced fertility in human males, and there is no evidence suggesting a reduction in female fertility.

How should Citrol be stored and disposed of?

The storage and disposal of Citrol (Citalopram Hydrobromide) must adhere to the official conditions defined in regulatory documentation to preserve the medicine's stability and ensure household safety.

Requirement Type Official Regulatory Statement
Temperature Range Store at Controlled Room Temperature, 20~ C to 25~ C (68~ F to 77~ F).
Environmental Protection Keep the product from freezing and away from excessive heat and moisture.
Packaging Keep the container tightly closed and store the medicine in the container it came in.
Child Safety Keep the medication out of the sight and reach of children and pets; always lock safety caps.
Disposal Do not keep outdated medicine. Consult a healthcare professional or pharmacist on how to dispose of unused product according to local regulations; avoid flushing the medicine down a toilet or drain.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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