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Citragel

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Citragel

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

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Overview of Citragel

Property Description
Active Ingredients Calcium Citrate Malate, Colecalciferol (Vitamin D3)
Form Oral Gel
Pharmacological Class Mineral and Vitamin Supplement, Bone Metabolism Regulator
Common Use Supporting Bone Mineral Density; correcting deficiency states
Origin Synthetic/Derived Combination

What is Citragel and What Type of Supplement is It?

Citragel is a combination supplement and pharmaceutical preparation classified as a Mineral and Vitamin Supplement used to support bone health and address specific nutritional deficits. It is formally categorized within the pharmacological class of Bone Metabolism Regulators. The preparation is distinctively formulated as an oral gel, designed for easy oral administration, which differentiates it from standard solid-dose tablets.


The Composition: Understanding Calcium Citrate Malate and Colecalciferol

The efficacy of Citragel is derived from its dual active ingredients: Calcium Citrate Malate (CCM) and Colecalciferol (commonly known as Vitamin D3). The chemical composition of Vitamin D3 is a naturally occurring form of Vitamin D.

This specific composition is vital because CCM possesses high bioavailability, a factor critical to mineral supplementation. Calcium citrate malate is among the most effective forms for increasing bone mineral density. This specific form of calcium is clinically recognized for its utilization by the body. The active components are suspended in an Aqueous Gel Base, facilitating the preparation's smooth delivery, further emphasizing patient convenience and optimized absorption.


What is the General Purpose of Citragel?

The general purpose of Citragel is to correct and prevent deficiency states of Calcium and Vitamin D to support the preservation of Bone Mineral Density (BMD). This preparation acts as a fundamental supportive agent, ensuring the required levels of nutrients are available to maintain the structural integrity of the skeleton, a typical use scenario for managing Osteopenia.

By delivering Calcium Citrate Malate for optimized mineral supply and Colecalciferol for enhanced mineral uptake, the preparation supports the body’s natural processes for Mineral Homeostasis Regulation. Its primary utility is ensuring that the foundational nutrients required for healthy bone mineralization are consistently and efficiently replenished, thereby assisting in the maintenance of long-term skeletal health.

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What side effects are possible with Citragel?

Possible side effects and safety information

The safety profile for Citragel, a combination of Calcium Citrate Malate and Colecalciferol, is organized by regulatory bodies according to frequency and affected body system. Adverse reactions are primarily classified as Gastrointestinal Disorders and Metabolism and Nutrition Disorders.


Official Adverse Reactions and Frequencies

Classification System-Organ Class Officially Documented Effects
Uncommon Metabolism and Nutrition Disorders Hypercalcaemia (high blood calcium levels), Hypercalciuria (high urinary calcium excretion)
Rare Skin and Subcutaneous Tissue Disorders Pruritus (itching), Rash, Urticaria (hives)
Common Gastrointestinal Disorders Constipation, Flatulence, Nausea, Vomiting, Abdominal pain

Regulatory Safety Constraints and Special Considerations

Official labeling describes several safety constraints. The preparation is contraindicated and must not be used in individuals with pre-existing conditions such as Hypercalcaemia, Hypercalciuria, Nephrolithiasis (kidney stones), Hypervitaminosis D (Vitamin D overdosage), or Severe Renal Impairment.

Serious adverse reactions documented in regulatory sources include the development of renal calculi (kidney stones) as a potential consequence of hypercalcaemia, as well as severe hypersensitivity reactions. The official safety profile notes an increased risk of hypercalcaemia in specific patient groups, including those who are immobilized and individuals with Sarcoidosis. Furthermore, long-term treatment at high dosages is explicitly associated with an increased possibility of developing hypercalciuria and hypercalcaemia.

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Overdose and Emergency Response

Overdose and when to seek help

The official overdose profile for combination supplements containing Calcium and Colecalciferol (Vitamin D3) is documented by regulatory bodies as leading to conditions of Hypercalcaemia (excess calcium in the blood) and Hypervitaminosis D (Vitamin D toxicity).


Overdose scope

Property Official Regulatory Statement
Documented overdose presentations Overconsumption results in Hypercalcaemia and Hypervitaminosis D.
Physiological systems affected Gastrointestinal (nausea, vomiting, constipation); Renal (polyuria, polydipsia, irreversible renal damage); Systemic (fatigue, confusion, muscle weakness); Cardiovascular (cardiac arrhythmias).
Dose-related or exposure-related factors Toxicity can arise from acute, massive single doses or from chronic, prolonged excessive intake.
Population-specific overdose notes Overdose is explicitly warned against during pregnancy due to the documented risk of foetal complications, including mental retardation and aortic stenosis.
Emergency-response statements The first mandated action is to stop taking the supplement immediately. Subsequent management includes rehydration and specialized supportive treatment.
When immediate medical help is required Individuals must seek immediate medical attention and contact emergency services immediately if severe signs of overconsumption, such as severe confusion or cardiac arrhythmias, are suspected.

Overdose classifications (high-level)

Property Official Regulatory Statement
Severity classification Overdose can lead to severe systemic outcomes including irreversible renal damage, soft tissue calcification, and, rarely, death.
Regulatory basis Descriptions are consistently based on the established clinical findings of Hypercalcaemia and Hypervitaminosis D.
Overdose-context constraints No specific antidote is known for this toxicity. Management relies entirely on symptomatic and supportive care.

Resulting overdose structure

Official regulatory documents define the overdose profile by outlining the clinical manifestations of Hypercalcaemia and Hypervitaminosis D, which include symptoms such as anorexia, nausea, and fatigue. The profile explicitly requires the immediate discontinuation of the product and mandates that individuals seek immediate medical attention when severe symptoms or signs of toxicity are evident. This structure provides official, label-based guidance on recognizing and responding to overconsumption risk, noting that no specific antidote is known and treatment is symptomatic and supportive.

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Therapeutic Uses of Citragel

What Citragel Treats: Main Uses and Benefits

The therapeutic application of Citragel is focused on providing essential nutritional support to mitigate symptoms and clinical issues arising from insufficient intake or absorption of Calcium and Vitamin D. The primary utility is to address conditions of deficiency and support long-term skeletal health.


Managing Bone Thinning and Skeletal Fragility

Citragel is considered relevant for managing the nutritional components of conditions such as Osteoporosis and Osteopenia, which are characterized by a progressive reduction in bone mineral density. The preparation contributes to the maintenance of bone mass over time, and by providing necessary nutrients, may assist with reducing the long-term risk of fragility fractures.

It is commonly used to help manage symptomatic Vitamin D deficiency, low blood calcium (hypocalcemia), and is applicable as supportive therapy for bone diseases like Osteoporosis and Osteomalacia.


Correcting Deficiencies and Alleviating Muscle Spasms

By supporting the replenishment of these vital nutrient levels, Citragel may assist with easing neuromuscular symptoms such as involuntary muscle cramps or spasms, which supports improved comfort and assists with maintaining functional stability.

Quick Fact: Relief for Muscle Symptoms The preparation supports the management of muscle cramps and spasms that are commonly associated with low blood calcium levels (hypocalcemia).


Foundational Support for High-Risk Groups

Citragel is generally used as adjunctive support for patient groups with high mineral requirements or heightened risk of bone loss, including postmenopausal women, the elderly, and individuals with conditions that impair nutrient absorption. This targeted supplementation supports general well-being during symptomatic phases and may assist with maintaining long-term skeletal stability.

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Eligibility and Restrictions for Use

Who Can and Cannot Use Citragel?

Citragel's eligibility profile is based strictly on regulatory safety data for high-dose calcium and Vitamin D supplements, with Adults and the Elderly being the established populations for use in deficiency states.

Contraindicated Populations (Absolute Exclusion)

The medicine is contraindicated and must not be used in patients with an existing high mineral load, specifically hypercalcaemia (high blood calcium), hypercalciuria (excessive urinary calcium), or hypervitaminosis D (Vitamin D toxicity). Use is also prohibited in individuals with severe renal impairment, a history of kidney stones (nephrolithiasis), or known hypersensitivity to the active substances.

Age and Condition-Based Restrictions

Pediatric Use is generally not recommended or contraindicated for children and adolescents below the label’s specified age threshold (e.g., 12 years), typically due to the high component strength. Conditional use is required for individuals with mild to moderate renal impairment or conditions like sarcoidosis, necessitating careful supervision and monitoring of serum and urinary calcium levels.

Pregnancy and Lactation Eligibility

Use during pregnancy is conditional and restricted to correcting a documented deficiency, with regulatory guidance demanding strict avoidance of overdose. Use while lactating is often not recommended or requires specific caution due to the passage of metabolites into breast milk.

These constraints define who can and cannot use the medicine, focusing regulatory restrictions primarily on pre-existing mineral status and organ function to ensure patient safety.

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What should I know about interactions with other medicines?

Interactions with other medicines and products

This section details officially documented interaction patterns for products containing Calcium Citrate and Colecalciferol (Vitamin D3), focusing strictly on information found in government regulatory documentation.


Potential Reduction of Co-administered Drug Exposure

Co-administration with Citragel can significantly reduce the systemic absorption of certain medicines through a mechanism known as chelation or binding in the gastrointestinal tract. Regulatory labeling mandates timing separation to mitigate this effect for several medicinal products:

  • Antibiotics: Calcium may reduce the efficacy of Tetracycline and Quinolone antibiotics. These must be administered at least two hours before or four to six hours after Citragel.
  • Bisphosphonates (e.g., Alendronate): Must be taken at least 30 minutes before Citragel to ensure proper absorption.
  • Levothyroxine (Thyroid Hormone): Administration must be separated by at least four hours.

Risk of Additive Toxicity

Interacting Substance/Class Official Interaction Outcome
Vitamin D Analogs (e.g., Calcitriol) Additive toxicity, specifically a high risk of hypercalcaemia (excessive blood calcium levels). Combination is formally restricted.
Thiazide Diuretics May reduce the excretion of calcium, contributing to the risk of hypercalcaemia.
Cardiac Glycosides (e.g., Digoxin) Hypercalcaemia may increase the toxicity of the glycoside, potentially leading to cardiac arrhythmias.

Interaction with Diet and Supplements

Foods high in Oxalic or Phytic Acid (e.g., spinach, whole cereals) can inhibit calcium absorption. Additionally, other vitamin or mineral supplements containing high levels of calcium or Vitamin D increase the overall risk of toxicity.

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Mechanism of Action

How Citragel Works

Citragel's mechanism of action is rooted in its dual role as an alkalinizing modulator and a mineral complexing agent primarily within the urinary tract.

Modulating Urinary Chemistry via Alkalinization

Following systemic metabolism, the drug introduces an alkaline load that is managed by renal excretion. This process increases the pH of the urine (decreases its acidity), a physiological change that enhances the solubility of acid-sensitive mineral components in the urinary fluid.

Reducing Active Minerals via Complexation

Concurrently, the citrate component functions as a chelator. It binds directly with free, ionized calcium (Ca^2+) within the urine, forming highly soluble complexes. This reduction in active calcium concentration limits the primary building block required for mineral aggregation and crystal formation. The combined physiological consequences of increased solubility and reduced active mineral concentration create an unfavorable environment for solid precipitation, acting on mineral crystallization kinetics.

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Dosage and Administration Information

Administration Scope

Detail Official Instruction
Route of administration Oral administration only, consistent with the formulation as a gel/solution.
Dosing schedule The typical maintenance dose is generally 1000 mg to 2000 mg of elemental Calcium and 800 IU to 2000 IU of Colecalciferol daily. Maximum daily intake must not be exceeded.
Timing in relation to meals The dose should be taken with or immediately after a meal to enhance the absorption of both active components.
Preparation requirements The container must be shaken well before use, and the prescribed quantity must be precisely measured using the provided device.
Age-group administration rules Use in children is typically not recommended without specific guidance, and severe renal impairment may require caution or dose adjustment.
Missed-dose rules If a dose is missed, take it as soon as remembered unless it is near the time for the next scheduled dose, in which case the missed dose must be skipped. Do not double the dose.
Special procedural conditions The total daily dose may be administered either once daily or divided into 2 or 3 doses to optimize elemental calcium absorption, particularly if the total dose is high.

Instruction Classifications (High-Level)

Classification Detail
Administration method type Oral (Liquid/Gel)
Frequency pattern Daily (once or divided doses)
Use-context constraints Must be taken with food; dose limits must be strictly observed.

Resulting Procedural Structure

Official step sequence:

  • Verify the exact dose amount and shake the product container well.
  • Measure the dose precisely using the dedicated measuring device.
  • Administer the measured dose orally with or immediately after a meal.
  • Repeat administration once daily or as divided doses according to the official schedule.

Connection to the Overall Use Protocol

This official protocol establishes Citragel as a daily oral supplement intended for long-term use at specific elemental calcium and Vitamin D ranges. The instructions mandate specific timing relative to food and preparation steps (shaking and precise measurement) to ensure the medicine is correctly utilized, thereby standardizing the approach across various clinical settings.

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Recent Clinical Evidence

Citragel: Recent Clinical Evidence

The evidence for the use of Calcium Citrate Malate and Colecalciferol (Vitamin D3)—the active ingredients in Citragel—is largely derived from formal research. This includes Randomized Controlled Trials (RCTs) and meta-analyses that combine findings from multiple studies. Research has primarily explored two areas: research exploring long-term bone structure and research exploring nutritional deficits.


Evidence for Nutritional Support in Bone Health

Researchers have conducted numerous large-scale RCTs and systematic reviews to explore the combination of calcium and Vitamin D supplementation. Research examined outcomes related to physical discomfort, such as changes in Bone Mineral Density (BMD), and the overall rate of bone loss in the observed populations. Studies also monitored the incidence of outcomes reflecting daily functioning or activity level, such as fractures.

Findings from this body of work describe patterns observed in the studies related to BMD in certain high-risk groups receiving the combination supplement. However, results varied, and evidence is limited regarding the outcomes on fracture incidence across all study groups, particularly those who were not already severely deficient. Direct, long-term fracture data linked specifically to the Calcium Citrate Malate (CCM) salt combination remains limited.


Evidence for Correcting Calcium and Vitamin D Deficiency States

The research exploring this use involves RCTs and bioavailability studies. These studies monitored outcomes related to systemic or functional imbalance by tracking key blood measures, or biomarkers. Specifically, data show patterns related to concentrations of serum 25-hydroxyvitamin D [25(OH)D] and levels of serum calcium and Parathyroid Hormone (PTH), which help regulate mineral balance.

The findings indicate patterns related to changes in serum 25(OH)D concentrations following administration of Colecalciferol. Bioavailability research specifically analyzed Calcium Citrate Malate absorption efficiency. Research describes the combination's use in study contexts involving fluctuating or unstable symptoms, such as muscle cramps, which was observed in some studies to be associated with low calcium levels.


Areas of Research Uncertainty and Study Gaps

Key limitations in the research include that follow-up durations were limited in many deficiency-correction studies. Findings were mixed when evaluating the outcomes on fracture incidence, meaning research does not determine whether an individual will respond similarly. Furthermore, the limited information for long-term outcomes, specifically regarding the Calcium Citrate Malate form, means that comparative evidence against other calcium salts is lacking in terms of definitive fracture reduction over many years.

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Frequently Asked Questions (FAQ)

Common questions about Citragel (FAQ)


Q: How quickly should I expect to notice anything after starting Citragel?

Studies and official information indicate that the process of raising Vitamin D levels, which is one of the main goals of treatment, may take several weeks to months. The Colecalciferol component needs time to be converted into its active form in the body. Consequently, any improvement in symptoms that are associated with a mineral deficiency may become noticeable as levels are normalized, a process that can take time.


Q: What is the longest period of time people typically use Citragel for?

The preparation is officially described for long-term use to help maintain the body's mineral balance and bone health. However, regulatory documents caution that using high dosages over long periods of continuous treatment is associated with an increased possibility of having high calcium levels in the urine (hypercalciuria) and blood (hypercalcaemia), which necessitates monitoring by a healthcare professional.


Q: If I have a history of kidney problems, is Citragel generally still an option?

Official information states that severe renal impairment (serious kidney problems) is a contraindication and means the product must not be used. For individuals with mild to moderate renal impairment, the use is conditional. Close monitoring of calcium levels in both the blood and urine is necessary, as described in official documents.


Q: Are the side effects of Citragel usually mild, or can they be serious?

Officially documented effects include both common, generally mild reactions like constipation and nausea, and other, rarer events. Regulatory documents describe serious adverse reactions such as the development of renal calculi (kidney stones) as a potential consequence of high calcium levels. They also note the possibility of severe hypersensitivity reactions (allergic-type responses).


Q: If I miss a dose of Citragel, does that affect how it works overall?

The primary goal of this preparation is the long-term correction and maintenance of mineral balance in the body. Therefore, official guidelines for the active ingredients suggest that a single missed dose is not expected to significantly affect the overall long-term outcome of the treatment.


Q: Does taking Citragel affect the results of common lab tests, like blood work?

Yes, taking this preparation is intended to change the levels of key minerals in your body. Official guidance states that patients must have monitoring of serum and urinary calcium levels. This is because the active ingredients are designed to directly affect the concentration of these minerals, which are measured in standard lab tests.


Q: How does Citragel affect people who have existing heart conditions?

Regulatory safety documents note that caution is required, particularly if a person is taking Cardiac Glycosides (a class of heart medicine, such as Digoxin). Elevated calcium levels (hypercalcaemia), which is an uncommon side effect, may increase the toxicity of these heart medicines, potentially leading to an abnormal heart rhythm (cardiac arrhythmias).


Q: Why is it described that Citragel should be used for a specific period of time?

The official purpose of Citragel is to correct and prevent specific deficiency states of Calcium and Vitamin D. Although it is described for long-term supportive use, treatment is typically initiated to address a documented mineral imbalance. For this reason, the continuation of use is typically re-evaluated once the documented deficiency has been corrected.


Q: How does the effectiveness of Citragel compare between younger and older adults in studies?

Clinical research primarily involved studies on Adults and the Elderly, as these are the main populations at risk of the target deficiency states. Evidence indicates the preparation's ability to help correct deficiencies in both groups. However, official summaries of the evidence show that results related to long-term outcomes, such as fracture incidence, varied across the observed populations.


Q: What are the official warnings about driving or operating machinery while on Citragel?

Authoritative sources explicitly state that the active ingredient, Colecalciferol (Vitamin D3), is not expected to impair or affect an individual's ability to drive or operate machinery. The official safety profile lists gastrointestinal effects like nausea and vomiting, but no specific warning related to driving or alertness is mandated.


Q: What official information is available regarding Citragel and mood changes?

The official adverse reaction lists provided in regulatory documents do not list mood changes, anxiety, or depression as reported side effects. While some general sources note confusion as a possible symptom of hypercalcaemia (excessively high blood calcium), this is classified as an uncommon side effect of the preparation.


Q: What are the official guidelines for stopping Citragel use?

Official patient information notes that consultation with a healthcare professional is advised before making a decision to permanently stop the preparation. The safety profile notes that if high calcium levels occur, medical supervision may necessitate the temporary discontinuation of treatment.


Q: Does taking Citragel cause any noticeable changes in energy or alertness?

The official adverse reaction profile for this preparation does not include fatigue, drowsiness, or stimulating effects as common or rare side effects. Symptoms such as sluggishness or lethargy are occasionally noted as part of a severe, uncommon side effect called hypercalcaemia (excessively high blood calcium).


Q: What kind of research has been done on Citragel?

The evidence for the active ingredients comes primarily from Randomized Controlled Trials (RCTs), systematic reviews, and bioavailability studies. This research explores two main areas: the combination's effect on maintaining Bone Mineral Density (BMD) and its role in correcting documented Calcium and Vitamin D Deficiency States.


Q: Is Citragel safe to take while pregnant or breastfeeding, based on official information?

Use during pregnancy is officially described as conditional and is generally limited to correcting a documented deficiency, with regulatory guidance emphasizing the avoidance of overdose. Use while lactating (breastfeeding) requires specific caution because the preparation's metabolites can pass into breast milk, but is generally considered acceptable in recommended amounts.


Q: Why do some people say they felt sick when they first started Citragel?

The official safety profile for the preparation classifies several Gastrointestinal Disorders as common adverse reactions. This includes nausea and vomiting, which are frequently reported in regulatory documentation, particularly when individuals first begin taking the preparation.


Q: Is there a maximum age limit for who can use Citragel?

The established populations for use are Adults and the Elderly. Official constraints focus on pre-existing conditions and mineral status, such as severe renal impairment or hypercalcaemia, rather than a specific maximum chronological age limit for otherwise healthy elderly individuals.


Q: Can I take Citragel at the same time as my antacid medication?

Official information advises that timing separation is required. Taking Citragel at the same time as aluminum-containing antacids may increase the systemic absorption of aluminum. For this reason, regulatory information describes that the two preparations should not be taken simultaneously.


Q: Is the active ingredient in Citragel naturally occurring, or is it synthetic?

The preparation contains two active components. Colecalciferol (Vitamin D3) is chemically defined as the naturally occurring form of Vitamin D. Calcium Citrate Malate (CCM), however, is a derived combination salt used for its high bioavailability.


Q: Is the effect of Citragel cumulative, meaning it builds up over time?

Yes, regulatory documents note that the preparation is intended to affect and maintain mineral balance. The official safety profile states that long-term treatment can lead to an increased possibility of excessive mineral levels (hypercalcaemia), which indicates a cumulative effect on the body's mineral stores.


Q: Does Citragel make you more sensitive to the sun?

The official safety profile lists generalized skin reactions such as rash and hives (urticaria) as rare adverse events. However, official regulatory documentation does not list photosensitivity (increased sun sensitivity) as a documented side effect of the preparation.


Q: Are there any long-term effects described for continuous use of Citragel?

Long-term use at high dosages is officially associated with an increased possibility of developing hypercalciuria (high urinary calcium) and hypercalcaemia (high blood calcium). The development of these conditions is officially associated with the potential formation of kidney stones.


Q: Is it important to take Citragel at the same time every day?

Official instructions specify that the dose must be administered with or immediately after a meal. Taking the dose at a consistent time in relation to meals is noted in regulatory sources as a way to optimize the utilization of the ingredients.


Q: Are there any known interactions with birth control pills and Citragel?

Authoritative sources confirm that the active ingredient Colecalciferol (Vitamin D3) is not known to stop or interfere with the efficacy of any type of contraception, including hormonal birth control pills. It is not listed as an interacting medication in regulatory tables.


Q: What should I do if I notice a common side effect while taking Citragel?

For common, generally mild effects like nausea, official guidance suggests trying to take the preparation with food or avoiding particularly rich or spicy food. If any side effect persists, becomes bothersome, or causes concern, official instructions suggest that consultation with a doctor or pharmacist may be appropriate.

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How should Citragel be stored and disposed of?

How to Store and Dispose of Citragel

The official storage conditions for Citragel oral gel are set to maintain the stability of the Calcium Citrate Malate and Colecalciferol components. The medicine must be stored at controlled room temperature, typically 20 C to 25 C, and kept tightly closed in its original container. The product must be protected from freezing, moisture, and excessive heat, and should be kept away from direct light.

Child-Safety and Disposal

It is a mandatory requirement to keep Citragel out of the reach and sight of children. For unused or expired product, the official procedure is to utilize a community drug take-back program. If one is unavailable, dispose of the medicine in the household trash after mixing it with an undesirable substance, such as dirt or used coffee grounds, and placing the mixture in a sealed container.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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