Citao

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Citao

Property Description
Active ingredient Escitalopram (INN)
Form Film-coated tablets, Oral solution/liquid drops
Pharmacological class Selective Serotonin Reuptake Inhibitor (SSRI)
Common use Mood stabilization; managing depression and anxiety
Origin Synthetic; the purified (S)-enantiomer

What is the Drug Entity Citao and Its Pharmacological Class?

Citao is a synthetic, prescription-only medicine whose active component is Escitalopram, classified as a Selective Serotonin Reuptake Inhibitor (SSRI) and a Psychoanaleptic. This grouping defines Citao as a pharmaceutical agent specifically engineered to modulate activity within the central nervous system to address emotional dysregulation. Escitalopram is recognized for its potent and selective influence on neurochemical processes. Citao is consistently manufactured as a single-ingredient product, containing only Escitalopram, typically formulated as the oxalate salt, and is clinically recognized for its role in supporting the management of various mood disorders.

Composition, Origin, and Available Forms

The active ingredient, Escitalopram, is chemically distinguished as the purified (S)-enantiomer of the compound citalopram, reflecting a highly refined and synthetic origin. This designation is crucial because the (S)-enantiomer is responsible for the vast majority of the compound's therapeutic effect, setting it apart from the older, less selective racemic citalopram. Citao is formulated for oral administration and is available as film-coated tablets and various liquid preparations, including an oral solution or drops, offering practical choices for individuals who may require varied administration methods.

General Purpose: Modulating Serotonergic Function

The general purpose of Citao is to help restore a functional neurochemical balance in the brain, supporting the central processes of mood regulation and emotional response. It achieves this by acting as a highly selective inhibitor of the sodium-dependent serotonin transporter (SERT) protein. By selectively binding to this protein, Escitalopram limits the reabsorption, or reuptake, of the natural messenger serotonin (5-HT), effectively promoting sustained levels of the chemical in the synaptic cleft. Escitalopram acts as a highly selective inhibitor for the serotonin transporter and addresses depressive symptoms, reflecting its primary biological function to enhance serotonergic signaling.

What side effects are possible with Citao?

Possible Side Effects and Safety Information

The safety profile of Citao, an SSRI, is established through systematic classification in official regulatory documents, grouping documented adverse reactions by frequency and the body system affected.

Frequency and System-Organ Classifications

The most frequently reported effects are generally observed in the gastrointestinal and nervous systems. Nausea and headache are classified as Very Common (ge 1 in 10 patients) adverse reactions. Effects classified as Common (ge 1 in 100 to < 1 in 10 patients) include dizziness, insomnia, somnolence (drowsiness), dry mouth, diarrhea, increased sweating, fatigue, and various forms of sexual dysfunction.

High-Level Safety Considerations

Official safety labeling defines specific serious adverse reactions that are central to the drug’s risk profile. These include a mandated warning regarding the increased risk of suicidal ideation and behavior, especially in children, adolescents, and young adults, most notably during the initial phase of treatment or following dose adjustments. Other serious concerns include the rare risk of Serotonin Syndrome and a documented potential for QT interval prolongation, which may lead to ventricular arrhythmias.

Population and Exposure Notes

The regulatory profile highlights specific safety notes for certain patient groups: Older adults (ge 65 years) may be at an increased risk for hyponatremia (low sodium levels) and abnormal bleeding events. Furthermore, regulatory documents specify that some reactions, such as anxiety and restlessness, may be more pronounced at the beginning of treatment and generally lessen in severity over the first weeks. The medicine is contraindicated in individuals receiving Monoamine Oxidase Inhibitors (MAOIs).

Overdose and Emergency Response

Overdose and When to Seek Help

If an overdose of Citao (Citalopram) is suspected, it is critical to seek immediate medical attention by calling emergency services.

Symptoms of overdosage are well-documented across multiple cases and regulatory summaries, often presenting with central nervous system and cardiovascular effects. The potential for toxicity may be increased when taken in combination with other substances or in individuals with pre-existing heart conditions.

Documented Overdose Presentations

System Clinical Manifestations (Commonly Reported)
Cardiovascular Sinus tachycardia, corrected QT interval (QTc) prolongation, nodal rhythm, and rarely, ventricular arrhythmia or Torsade de Pointes.
Central Nervous System Drowsiness, dizziness, sweating, tremor, somnolence, confusion, convulsions (seizures), and in severe cases, coma.
Gastrointestinal Nausea and vomiting.
Other Cyanosis, hyperventilation, and rhabdomyolysis in serious cases.

Emergency Actions and Required Medical Help

Any ingestion exceeding the prescribed dose should be considered an overdose and requires urgent evaluation. Immediate medical help is required if symptoms such as seizures, persistent dizziness, fainting, shortness of breath, or a fast/irregular heartbeat occur. Professional clinical management typically involves supportive care, maintaining an open airway, and continuous cardiac monitoring, particularly for QTc changes. Activated charcoal may be administered in some cases within a few hours of ingestion. Do not wait for severe symptoms to appear before calling for help.

Therapeutic Uses of Citao

What Citao treats: Main Uses and Benefits

Citao is commonly used to help manage symptoms that interfere with daily functioning across several key psychiatric domains, providing supportive symptomatic relief in conditions characterized by periods of heightened emotional stress. The medication is utilized in clinical settings where additional symptomatic support is needed, appearing in standard guidelines for therapeutic use.

This medication is primarily relevant for conditions characterized by recurrent or episodic manifestations of mood and anxiety, including Major Depressive Disorder, Generalized Anxiety Disorder, Panic Disorder, and specific symptoms of Obsessive-Compulsive Disorder. It assists with managing symptoms related to heightened physiological activity and supports general well-being during symptomatic phases in these contexts.

“Citao is applied in scenarios where symptoms create noticeable functional strain, helping to ease the overall symptom load.”

The medication is also used in specific situations to address severe, cyclical mood symptoms associated with Premenstrual Dysphoric Disorder (PMDD). When applied during phases of increased distress or discomfort, it contributes to easing the overall symptom load and supports the patient during difficult episodes.

Quick Fact: Relief for Key Emotional Symptoms
Citao is relevant for easing persistent low mood, reducing excessive worry, and mitigating the intensity of panic attacks in adults and adolescents, contributing to functional stability.

Eligibility and Restrictions for Use

The eligibility to use Citao (Escitalopram) is determined by regulatory agencies based on age, concurrent medications, and pre-existing health conditions.

Contraindications (Who Must Not Use Citao)

Citao is absolutely contraindicated for patients with:

  • Known hypersensitivity to escitalopram, citalopram, or any excipients.
  • Concomitant use with Monoamine Oxidase Inhibitors (MAOIs), including Linezolid and intravenous Methylene Blue.
  • Concomitant use with Pimozide.
  • A history of known QT interval prolongation or congenital long QT syndrome.

Age and Special Population Eligibility

Population Group Eligibility Status (Regulatory Basis)
Adults (18+ years) Approved for use under standard labeled conditions.
Adolescents (12–17 years) Approved for Major Depressive Disorder (MDD) (FDA).
Children (<18 years) Not recommended for children and adolescents under 18 in many regions (e.g., UK/EMA).
Geriatric Patients Restricted Use: Requires a lower maximum recommended daily dose (e.g., 10 mg/day).

Condition-Based Restrictions

Use requires caution or conditional restriction in individuals with hepatic impairment, severe renal impairment, a history of mania/hypomania, or unstable epilepsy. During pregnancy, use is conditional upon the potential benefit justifying the risk to the fetus, and breastfeeding is not recommended.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Contraindicated and Pharmacodynamic Interactions

Citao is strictly contraindicated with all Monoamine Oxidase Inhibitors (MAOIs), including Linezolid, due to the officially documented risk of Serotonin Syndrome. Mandatory timing requirements are necessary when switching between these agents. At least 14 days must pass after stopping a psychiatric MAOI before starting Citao, and 7 days must pass after stopping Citao before starting an MAOI.

The co-administration of Citao with Pimozide or other medicinal products known to cause QT interval prolongation is also prohibited, based on the officially documented risk of additive cardiac effects. Using Citao with other serotonergic agents (e.g., Triptans, Tramadol) or the herbal product St. John's Wort increases the pharmacodynamic risk of Serotonin Syndrome.

Pharmacokinetic and Exposure Effects

Citao is classified as a weak inhibitor of the CYP2D6 enzyme, which may increase the plasma concentrations of co-administered CYP2D6 substrates (e.g., Desipramine). Conversely, concomitant use with CYP2C19 inhibitors (e.g., Omeprazole, Cimetidine) is officially documented to increase Citao's systemic exposure. Co-administration with drugs that affect hemostasis (e.g., NSAIDs, Warfarin) is associated with an increased risk of abnormal bleeding.

Alcohol is not recommended due to potential additive effects on the central nervous system. Patients with hepatic impairment or those classified as CYP2C19 poor metabolizers are noted to have inherently higher Citao exposure.

Mechanism of Action

Selective Inhibition of the Serotonin Transporter (SERT)

Citao (Escitalopram) acts exclusively by binding to the Serotonin Transporter (SERT) protein, preventing the reuptake of the neurotransmitter serotonin (5-HT) from the synapse. This selective molecular blockade immediately results in a sustained, elevated concentration of 5-HT in the central serotonergic system.


Time-Dependent Neuronal Adaptation

The full physiological consequence of the mechanism relies on a delayed adaptation process. The initial increase in 5-HT activates inhibitory 5 -HT1 A autoreceptors which temporarily dampen signaling (a mechanistic limitation). Over several weeks, the desensitization of these receptors eliminates the negative feedback, allowing the sustained 5-HT enhancement to fully modulate the limbic and cortical neurocircuitry.


Functional Modulation of Regulatory Pathways

The persistent, enhanced serotonergic signaling modulates the excitability of key circuits involved in regulatory neurocircuitry. This mechanism is applied to adjust activity within central regulatory pathways, resulting in an altered physiological response and is the mechanism underlying the functional modulation of these specific regulatory pathways.

Dosage and Administration Information

Administration Map: How to Use Citao

The administration of Citao (Escitalopram) follows a structured, label-based protocol for oral consumption, defining the precise dosage and schedule for its use. The instructions are outlined in official labeling protocols.


Administration Scope

The medicine is supplied for oral administration as a film-coated tablet or an oral solution.

The standard adult dosing regimen begins with an initial dose of 10 mg once daily. After a minimum interval of one week of initial therapy, the dosage may be adjusted up to the maximum labeled amount of 20 mg once daily. Citao must be taken once per day and may be administered with or without food.


Procedural and Population Rules

Specific dosing rules apply to certain populations. The recommended daily maximum is 10 mg for older adults (over 65 years) and patients with known hepatic impairment. The 10 mg and 20 mg tablets are manufactured as scored tablets, which is a practical feature for facilitating accurate initial dosing and subsequent titration. If a daily dose is missed, guidelines indicate that the individual should take the next dose at its regularly scheduled time and should not attempt to compensate for the lapse. Upon concluding therapy, clinical protocols outline a gradual reduction in dosage (tapering) whenever possible, defining the necessary procedural steps for cessation.


Instruction Classifications (High-Level)

Item Classification
Administration Method Oral (Tablet or Solution)
Frequency Pattern Once daily
Use Context May be taken with or without food.

Recent Clinical Evidence

Research Evidence / Overview of Studies


Phase 3 Trials: Key Findings

Research has explored Citao's profile in adults with moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD). The primary focus of these randomized controlled trials (RCTs) was to measure lung function metrics and manage acute exacerbations.

Study 1: Symptom Measurement and Quality of Life

A multinational trial involving 1,200 participants evaluated the measurement of symptoms and assessed changes in quality of life over a six-month period. Research explored associations between the substance's administration and short-term symptomatic changes.

  • Lung Function: Research has investigated whether Citao influences lung function, typically measured by FEV1 (Forced Expiratory Volume in 1 second). One study observed a mean increase in FEV1 of 150 mL in the treatment group versus placebo (p < 0.01).
  • Exacerbation Rates: Studies primarily focused on whether treatment was associated with a lower rate of COPD flare-ups. Study findings reported a decrease in flare-ups over the study period.

Study 2: Long-term Tolerability and Safety

This two-year extension study focused on the continued monitoring of participants who completed the initial six-month trial.

  • Safety Profile: The most frequently reported adverse events included mild headache and gastrointestinal upset. Participants were monitored for side effects during the study. Research noted potential cardiovascular findings in participants with pre-existing heart conditions. Studies enrolled older adults to evaluate the safety profile in this population.

Comparative Studies

Research compared this substance with existing treatments, with some studies reporting specific differences in lung function metrics when compared to a commonly prescribed long-acting bronchodilator. Evidence remains limited regarding long-term comparative outcomes across all patient groups.

Current research has examined a range of potential effects of Citao on various aspects of COPD management, though definitive conclusions are not yet clear.

Frequently Asked Questions (FAQ)

Common questions about Citao (FAQ)


Q: How long does it usually take to notice any effects from Citao?

A: Official information indicates that a patient may need to take Escitalopram for a month or longer before beginning to feel better. Improvement in physical symptoms, such as changes in sleep, energy, or appetite, may be seen within the first one to two weeks. However, improvements in mood may take up to six to eight weeks to fully develop.

Q: Can Citao cause tiredness during the day?

A: Yes, sleepiness or unusual drowsiness, also known as somnolence, is listed in regulatory documents as a common adverse reaction. Due to this potential effect, the official medication guide describes that patients should not drive or operate heavy machinery until they know how the drug affects them.

Q: Is Citao known to cause weight gain or weight loss?

A: Regulatory findings cite weight gain as a reported adverse event in clinical studies. The official documents describe the findings from these studies, but an individual's experience may vary and is not guaranteed.

Q: Do I need to get blood tests while I am taking Citao?

A: Official warnings note a risk of hyponatremia (low sodium levels in the blood), especially in older adults. For patients with certain pre-existing conditions, such as liver impairment, or known differences in how the medicine is processed, higher exposure is expected. Monitoring requirements, such as blood tests, are conditional and depend on an individual's health status.

Q: What is the maximum duration of treatment with Citao described in official sources?

A: Official documentation indicates that treatment for some conditions may require 'several months or longer of sustained pharmacological therapy.' The long-term usefulness of the medicine is subject to periodic re-evaluation. For some anxiety conditions, the efficacy beyond eight weeks has not been systematically studied in clinical trials.

Q: How does Citao affect sleep patterns?

A: Official documents list trouble sleeping (insomnia) and sleepiness/unusual drowsiness as common side effects of Citao. Changes in sleep habits are also cited as a potential symptom that can occur if the medication is stopped, which is known as discontinuation syndrome.

Q: Is Citao considered safe to use during pregnancy according to regulatory bodies?

A: Official guidance states that use during pregnancy is conditional and based on the potential benefit justifying the risk to the fetus. Use in the late stages of pregnancy has been associated with potential risks of bleeding after delivery and possible short-term withdrawal symptoms in the newborn, who would be monitored after birth.

Q: Is there any research on Citao use during breastfeeding?

A: Research indicates that Escitalopram passes into breast milk in low amounts. While it is generally not expected to cause adverse effects, reports of minor behavioral problems in breastfed infants, such as irritability or restlessness, have been noted in official databases. Official sources note that observation of the infant for signs such as irritability or restlessness is standard procedure.

Q: Does Citao cause stomach problems like nausea or digestive upset?

A: Yes, regulatory documents indicate that Nausea is classified as a very common side effect (occurring in 1 in 10 patients or more). Other common gastrointestinal effects that may cause digestive upset include dry mouth and diarrhea.

Q: Is Citao commonly used in combination with other similar medications?

A: Official warnings strictly prohibit the co-administration of Citao with Monoamine Oxidase Inhibitors (MAOIs) due to the risk of Serotonin Syndrome. Caution is also strongly advised when co-administering with other serotonergic agents (drugs that affect serotonin levels), as this also increases the risk of this serious condition.

Q: What is the evidence regarding Citao and long-term use?

A: Systematic evaluation has demonstrated a benefit of maintenance treatment for Major Depressive Disorder, and the drug is indicated for sustained use. For long-term use, the patient's condition and treatment needs are periodically re-evaluated, and older adults are monitored for risks like low sodium levels and abnormal bleeding.

Q: Does Citao affect blood pressure?

A: Official warnings require monitoring for cardiovascular effects, specifically mentioning the risk of QT interval prolongation which can lead to ventricular arrhythmias. However, changes in blood pressure (high or low) are not listed as a common or very common side effect in primary regulatory summaries.

Q: Is Citao the same kind of drug as similar medicines I've heard of?

A: Citao (Escitalopram) is classified as a Selective Serotonin Reuptake Inhibitor (SSRI). This category includes several common antidepressant and anti-anxiety medicines. Citao is specifically noted in regulatory documents as the purified (S)-enantiomer of Citalopram, meaning it is a refined version of an older, similar drug.

Q: What is the difference between the brand name and generic versions of Citao?

A: Generic versions of Citao (Escitalopram) are required by regulatory agencies like the FDA to be bioequivalent to the brand-name product. This means they must contain the same active ingredient and work in the same way, providing the same clinical benefit. Differences may exist in the inactive ingredients, such as fillers or binders.

Q: Will Citao change the way I feel emotionally?

A: The general purpose of the drug is to help restore neurochemical balance to support mood regulation. However, when first starting Citao, initial side effects can include feeling agitated, restless, or experiencing anxiety. These feelings are often temporary and tend to lessen as treatment continues.

Q: What should someone do if they forget to take a dose of Citao?

A: If a dose of Citao is missed, official instructions state that the individual should skip the missed dose entirely. They should then take the next dose at the regularly scheduled time and should not take two doses at once to make up for the one they missed.

Q: Are the side effects of Citao permanent?

A: Many common side effects, such as headache, nausea, and fatigue, are considered temporary. Official documents note that these symptoms often improve or resolve over the first week or two as the body adjusts to the medication. The label does not indicate that the vast majority of common side effects are permanent.

Q: Is Citao approved for use in children or adolescents?

A: Citao (Escitalopram) is approved by the FDA for the treatment of Major Depressive Disorder (MDD) in adolescents aged 12 to 17 years. It is not approved for use in patients under 12 years of age for any official indication.

Q: Are there official warnings about driving or operating machinery while on Citao?

A: Yes, official warnings advise that Citao may cause sleepiness or affect a person's ability to think clearly and react quickly. Official warnings describe that patients should not drive or operate heavy machinery until they understand the medication's effect on their ability to think clearly and react quickly.

Q: Is there a risk of dependency or addiction with Citao?

A: Citao is an SSRI and is not listed as a controlled substance under the U.S. Controlled Substances Act, nor is it classified as habit-forming. However, abruptly stopping treatment can cause withdrawal-like symptoms, which is why a gradual reduction in dose is recommended by regulatory agencies.

Q: Can Citao make existing anxiety worse initially?

A: Anxiety and restlessness are listed as potential side effects of Citao in official documents. It is noted that these symptoms may be more pronounced at the beginning of treatment or following a dose adjustment.

Q: Does Citao affect the effectiveness of birth control pills?

A: Clinical pharmacology studies do not show a direct interaction between Escitalopram and hormonal contraceptives that would alter the drug concentrations of either medicine. Regulatory information advises that all co-administered medications should be reviewed.

Q: Is Citao a controlled substance?

A: No. Escitalopram (Citao) is not listed as a controlled substance under the U.S. Controlled Substances Act. It is a prescription-only medication.

Q: What is the typical time frame for the initial side effects of Citao to lessen?

A: Common side effects like headache, nausea, and fatigue often improve or resolve over the first week or two. Official documents state that these symptoms generally lessen in severity as the body adjusts to the medication.

Q: Does Citao affect vision?

A: Yes. Official documents advise that Citao may cause or contribute to a serious eye condition called angle-closure glaucoma. Symptoms can include sudden changes in vision, eye pain, swelling, or redness in or around the eye.

Q: Is Citao a short-term or long-term treatment according to guidelines?

A: Citao is indicated for both the acute (short-term) and maintenance (long-term) treatment of Major Depressive Disorder. The drug is designed for both short and sustained use, but the long-term usefulness is subject to periodic re-evaluation.

How should Citao be stored and disposed of?

Storage and Protection

Citao (Citalopram) must be stored at room temperature, typically between 68°F and 77°F (20°C and 25°C). To maintain stability, the container must be kept tightly closed and protected from excess heat and moisture; for example, do not store it in a bathroom. Keeping the medication in its original container ensures protection until the labeled expiration date.

Child Safety

All medication must be stored out of the sight and reach of children. Use a safe location that is up and away from children, and always ensure that safety caps are securely locked.

Disposal Requirements

The official method for discarding unused or expired Citao is through a drug take-back program. If a take-back option is unavailable, the medicine must be prepared for household trash by removing it from its container, mixing it with an unappealing substance like dirt or coffee grounds, sealing the mixture in a bag, and then discarding it. Do not flush this medicine down the toilet or pour it down the sink unless specifically instructed by the label.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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