Citanew

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Citanew

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Citanew

Quick Facts

Property Description
Active ingredient Escitalopram oxalate
Pharmacological class Selective Serotonin Reuptake Inhibitor (SSRI)
Origin/Type Synthetic compound, single isomer (S-enantiomer)
Dosage Forms Tablet, oral solution
General Purpose Supports regulation of mood and anxiety

What Type of Medicine is Citanew?

Citanew is a prescription-only psychotropic medicine that contains the active substance Escitalopram. It is formally classified as a Selective Serotonin Reuptake Inhibitor (SSRI), representing a class of antidepressant compounds recognized for their efficacy in managing certain emotional conditions. Citanew is clinically recognized for its role in the stabilization of severe or persistent shifts in mood and anxiety levels. The drug is utilized in the pharmacological management of various mood disorders, reflecting its primary function in emotional stabilization.

Composition, Origin, and Available Forms

The active compound, Escitalopram, is a synthetic compound derived from a bicyclic phthalane structure. This specific chemical entity is distinguished as the pure S-enantiomer, meaning it is a single isomer of the older, related compound, citalopram. This characteristic provides high selectivity for the intended biological target. In pharmaceutical preparations, Escitalopram is provided as the stable oxalate salt. The medication is administered via the oral route and is available in standard dosage forms, including the solid tablet and the liquid oral solution, offering distinct options for patient preference and administration needs.

The General Purpose of Escitalopram

The general therapeutic purpose of Escitalopram is to support the brain’s ability to maintain a balanced emotional state. Its action is centered on promoting the sustained presence of the neurotransmitter serotonin in the synaptic clefts. By optimizing these critical communication pathways, the medication helps to mitigate persistent feelings of distress and intense worry associated with certain mood disorders, thereby supporting overall emotional regulation.

Regulatory References

  1. NIH/MedlinePlus Drug Information

What side effects are possible with Citanew?

Citanew (citalopram) is generally well-tolerated, but like all medications, it can cause side effects. Most common side effects tend to occur early in treatment and may lessen over time. Always discuss potential risks with your healthcare provider.

Common Side Effects

Side effects that are frequently reported, especially in the first weeks of treatment, include:

  • Gastrointestinal: Nausea, dry mouth, diarrhea, or constipation.
  • Nervous System: Sleepiness (drowsiness), trouble sleeping (insomnia), dizziness, or tremor.
  • Other: Increased sweating, fatigue, and sexual side effects (e.g., decreased sex drive, difficulty achieving orgasm, or ejaculation delay in men).

Serious Safety Information and Warnings

Immediate medical attention is required for signs of serious reactions. These include a severe allergic reaction (rash, hives, swelling), abnormal bleeding, or signs of Serotonin Syndrome (agitation, hallucinations, confusion, fast heartbeat, muscle rigidity, and fever).

Citanew may cause a rare but serious heart rhythm problem known as QT prolongation. This risk increases with higher doses and in patients with pre-existing heart conditions. Symptoms can include fainting or an irregular heartbeat.

Antidepressants can increase the risk of suicidal thoughts and behavior, particularly in children, adolescents, and young adults (under 25) during the initial period of treatment or when the dosage is adjusted. Patients of all ages should be closely monitored for new or worsening depression and unusual changes in behavior. Do not stop taking Citanew suddenly, as this can lead to withdrawal symptoms; your dosage must be reduced gradually under medical supervision.

Overdose and Emergency Response

Overdose and when to seek help

The official regulatory profile for Citanew (Escitalopram) overdosage mandates seeking immediate medical attention upon known or suspected exposure. Emergency services must be contacted immediately.

Feature Documented Regulatory Statement
Documented Presentations Clinical manifestations reported include convulsions (seizures), coma, dizziness, somnolence, agitation, tremor, nausea, and vomiting.
Severe Outcomes There is a risk of life-threatening events, including Serotonin Syndrome, ventricular arrhythmia (such as Torsade de Pointes), and significant QT prolongation on the ECG.
Management Focus Management is defined as strictly symptomatic and supportive treatment. Procedures described include maintaining an adequate airway, oxygenation, and considering gastric lavage and activated charcoal.
Monitoring Needs Continuous cardiac and vital signs monitoring is required. ECG monitoring is specifically advised for patients with altered metabolism or those co-ingesting medicines that prolong the QT interval.

Regulatory documents explicitly state that no specific antidote is known for Citanew overdose. The potential for serious or fatal outcomes is increased in cases involving the co-ingestion of alcohol or other drugs. The profile establishes that all patients require urgent professional assessment due to the complexity and severity of documented neurological and cardiac risks.

Therapeutic Uses of Citanew

Citanew (Escitalopram) is commonly used for symptomatic relief across therapeutic domains associated with persistent emotional distress and significant functional disruption. The medication is applied across conditions presenting with episodic or recurrent manifestations. It is relevant for managing Major Depressive Disorder (MDD), Generalized Anxiety Disorder (GAD), Panic Disorder, and symptoms associated with Obsessive-Compulsive Disorder (OCD) and Social Phobia.

This medication assists patients when symptom clusters, such as pervasive sadness, excessive worry, or recurrent intrusive thoughts, interfere with daily comfort. Citanew is often used during phases when symptoms become more noticeable, providing support that helps ease the overall symptom burden. One core benefit is that it:

“...may help patients cope more steadily with symptom fluctuations and supports general well-being during symptomatic phases.”

In clinical settings, this supportive role assists with maintaining functional stability.

Quick Fact: Relief for Depressive and Anxiety Symptoms
Primary Focus: Managing persistent low mood (MDD) and uncontrollable worry (GAD).
Symptom Benefit: May assist with improving a sense of motivation and may help with easing the manifestations of anxiety attacks.
Typical Context: Applied across domains where additional symptomatic support is needed for long-term management of emotional distress.

Eligibility and Restrictions for Use

Citanew, whose active ingredient is Escitalopram, is subject to specific regulatory eligibility rules that define its authorized use and contraindications. This information is based strictly on government-issued labels, such as the FDA and EMA.

Populations for Whom Use is Prohibited (Contraindicated):

Contraindication Category Exclusionary Condition
Concurrent Medications Use with Monoamine Oxidase Inhibitors (MAOIs), or within 14 days of stopping one. Use with the medicine Pimozide is also prohibited.
Hypersensitivity Known allergy or severe reaction to Escitalopram, Citalopram, or any ingredient in the product.
Cardiac Conditions Known pre-existing QT interval prolongation or congenital long QT syndrome (due to risk of serious heart rhythm abnormalities).

Populations Requiring Restricted or Conditional Use:

  • Age: The medicine is generally indicated for adults and adolescents aged 12 years and older for Major Depressive Disorder. Its safety and effectiveness are not established in pediatric patients younger than 12.
  • Geriatric Patients (ge 65 years) and those with Hepatic Impairment typically require a lower maximum daily dose.
  • Condition-Specific Caution: Use requires caution in patients with severe renal impairment, a history of seizures, or untreated anatomically narrow angles (to avoid angle-closure glaucoma).
  • Pregnancy/Lactation Status: Use during pregnancy is generally advised only if the benefit is determined to justify the potential risk to the fetus. Caution is advised when administered to a woman who is breastfeeding.

What should I know about interactions with other medicines?

Citanew (escitalopram) can interact with various other medications, herbal remedies, and substances. Always inform your healthcare provider of all prescription, non-prescription, and herbal products you are using before starting Citanew.

Increased Risk of Serotonin Syndrome

Serotonin syndrome is a potentially serious condition resulting from an excessive buildup of serotonin. The risk of this syndrome increases significantly when Citanew is taken alongside other drugs that also raise serotonin levels. Do not use Citanew with Monoamine Oxidase Inhibitors (MAOIs), such as phenelzine, linezolid, or methylene blue injection, as this combination is contraindicated and can be fatal. A washout period of at least 14 days is required when switching between Citanew and an MAOI. Other medicines that increase this risk and require careful consideration include:

  • Other Antidepressants (e.g., SSRIs, SNRIs, TCAs, lithium, buspirone)
  • Triptans (migraine medications)
  • Certain Pain Medicines (e.g., tramadol, fentanyl, meperidine, methadone)
  • Herbal Products (e.g., St. John's wort)

Increased Risk of Bleeding

Concomitant use of Citanew with certain medications can increase the risk of bleeding events, such as bruising, nosebleeds, or gastrointestinal bleeding. This risk is elevated with:

  • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) (e.g., ibuprofen, naproxen, aspirin)
  • Anticoagulants (blood thinners, e.g., warfarin, apixaban)
  • Antiplatelet Agents (e.g., clopidogrel)

Other Notable Interactions

Interaction Type Examples of Interacting Medicines
Heart Rhythm Medicines that prolong the QT interval (e.g., pimozide, certain antipsychotics, antiarrhythmics). Co-administration with pimozide should be avoided.
Sodium Levels Diuretics (water pills) and other medicines that can lower blood sodium levels.
Central Nervous System Alcohol and other medications that cause sedation or drowsiness.

It is vital to maintain open communication with your doctor about all current and planned medications.

Mechanism of Action

️ Targeted Serotonin Transporter Inhibition

Citanew's mechanism is defined by the highly selective blocking of the Serotonin Transporter (SERT) protein in the brain. This action immediately causes an increase in the availability and concentration of the neurotransmitter serotonin in the synaptic spaces. This selective action on the SERT is the initial molecular step that leads to a long-term enhancement of serotonergic signaling.


Delayed Neural Circuit Adaptation

The acute increase in synaptic serotonin triggers a delayed adaptive cascade that is required for the subsequent systemic effect. This process necessitates several weeks to complete, involving the desensitization of inhibitory autoreceptors (5-mathrmHT1 A). Once complete, this leads to a sustained and amplified firing rate of the serotonergic neurons, thereby modulating the signaling dynamics within key limbic-cortical circuits, such as the amygdala and prefrontal cortex.


Physiological Modulation of Limbic Responses

The chronic and sustained increase in serotonin signaling alters the activity patterns in the limbic system, modulating the excitability of key limbic structures, such as the amygdala. This mechanism engages neuroplastic changes to facilitate adaptive changes that result in stabilized signaling patterns, which ultimately shapes the resulting physiological consequences within the central nervous system.

Dosage and Administration Information

Citanew (escitalopram) is a Selective Serotonin Reuptake Inhibitor (SSRI) and should be taken exactly as prescribed by your healthcare provider. Escitalopram is typically administered once daily, either in the morning or evening, and may be taken with or without food.

Administration and Dosage

  • Tablet Form: Swallow the tablet whole with water. Do not crush, chew, or split the tablet unless you are instructed to do so by your doctor or pharmacist.
  • Oral Solution: If you are using the liquid form, ensure you shake the bottle well before use and use a calibrated measuring device provided with the product for accurate dosing.
  • Timing: Taking Citanew at the same time each day is recommended to help maintain a consistent level of medication in your body.

Important Considerations

Do not stop taking Citanew suddenly without consulting your doctor. Discontinuing the medication abruptly can lead to withdrawal symptoms. Your doctor will likely recommend a gradual dose reduction over a period of time to minimize this risk.

It may take several weeks—typically between one to four weeks—before you begin to feel an improvement in your symptoms, with the full therapeutic benefit often taking four to six weeks. Continue to take the medication as prescribed, even if you do not notice immediate results or if you begin to feel well.

Discuss the use of alcohol with your healthcare provider, as it can potentially worsen certain side effects of escitalopram, such as drowsiness.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Citanew

This section summarizes the types of studies that have been used in research exploring how symptoms change over time for individuals with Major Depressive Disorder and Generalized Anxiety Disorder. This information reflects what has been observed in study populations, but does not provide individual predictions.


Evidence for use in Major Depressive Disorder

This section summarizes the available clinical trial evidence. It focuses on studies that examined changes in the pattern of symptoms of Major Depressive Disorder over the short-term compared to an inactive substance. Research examined how symptoms evolved in the observed populations.

These studies monitored outcomes reflecting daily functioning or activity level and patient-reported outcomes describing perceived discomfort over defined time intervals. The findings describe patterns observed in the studies suggesting that, in the populations studied, studies observed patterns related to changes in symptom intensity during the short-term.


Evidence for use in Generalized Anxiety Disorder

Citanew was studied for its use in Generalized Anxiety Disorder, a condition where symptoms may vary in intensity. The primary studies involved participants meeting criteria for the disorder, and the research examined outcomes related to systemic or functional imbalance, such as persistent worry or physical tension, compared to a placebo.

The data show patterns related to changes in anxiety symptoms measured during the short-term treatment period, with some research indicating that studies have reported patterns related to a change in the frequency or intensity of anxiety episodes.


Long-term Studies and Follow-up

Research has also described patterns observed in studies that lasted for extended periods. The objective of these studies is to explore how observed changes persisted and whether the changes measured during the study period persisted over time. While some long-term data exists, the number of participants and the follow-up durations were limited in the available studies. This means long-term effects are not fully established, and certainty remains low in some areas of extended use.

Key Studies & References

  1. NICE Guideline: Depression in adults: recognition and management

Frequently Asked Questions (FAQ)

Common questions about Citanew (FAQ)

Q: How quickly can a person expect Citanew to start working?

Studies and official information indicate that patients may begin to feel an improvement in their symptoms within the first one to four weeks of beginning treatment. However, the full therapeutic benefit often takes longer, typically four to six weeks, to be fully observed. Patients are generally advised to continue taking the medication as prescribed, even if immediate results are not noticed.


Q: What are the most commonly reported side effects of Citanew?

Regulatory documents list common side effects observed in clinical trials, especially in the early stages of treatment. These frequently reported effects include gastrointestinal issues like nausea and dry mouth, as well as trouble sleeping (insomnia), increased sweating, fatigue, and ejaculation delay.


Q: What is the main difference between Citanew and other drugs used for the same thing?

Citanew is classified as a Selective Serotonin Reuptake Inhibitor (SSRI) and is specifically defined as the pure S-enantiomer of a related compound. Official documents describe this characteristic as providing high selectivity for the serotonin transporter (SERT) protein in the brain. This characteristic helps define its mechanism of action compared to other related compounds.


Q: Is Citanew a type of antibiotic?

No, Citanew is not an antibiotic. It is formally classified as a Selective Serotonin Reuptake Inhibitor (SSRI). This type of prescription medicine is used to support the regulation of mood and anxiety.


Q: Is Citanew a widely prescribed medicine?

Official labeling defines Citanew (escitalopram) as an established treatment for Major Depressive Disorder and Generalized Anxiety Disorder in adults. Its inclusion in regulatory documents for these major conditions indicates its established use in clinical practice.


Q: Are there common misunderstandings about what Citanew is for?

A common point of clarification in official documents is the timeline for effects. While Citanew immediately affects brain chemistry by increasing serotonin, the full, sustained benefit on mood and anxiety often requires a delayed adaptive cascade that takes several weeks to fully manifest.


Q: Can Citanew be taken by children or teenagers?

Regulatory documents indicate that escitalopram is approved for use in certain pediatric populations for specific conditions. U.S. FDA labeling, for instance, approves it for the treatment of Major Depressive Disorder in adolescents aged 12 to 17 years and Generalized Anxiety Disorder in patients aged 7 years and older.


Q: Is Citanew considered a controlled substance?

Citanew (escitalopram) is generally not listed as a controlled substance by major regulatory bodies, such as the U.S. Drug Enforcement Administration (DEA). Its classification is different from medicines that are considered to have a high risk of abuse.


Q: Do studies suggest that Citanew is habit-forming?

While Citanew is not classified as having an abuse potential in the same way as controlled substances, official documents warn that stopping the medicine suddenly can lead to discontinuation symptoms. Because of this, a gradual reduction in dosage under medical supervision is described in official guidelines.


Q: What are the signs that Citanew might be interacting with another medicine?

When Citanew is taken with other serotonergic medicines, the risk of a serious interaction called Serotonin Syndrome increases. Signs of this condition described in the official label may include agitation, confusion, hallucinations, fast heartbeat, fever, sweating, tremor, and muscle rigidity.


Q: Are there any over-the-counter supplements that official sources warn about with Citanew?

Official regulatory documents specifically warn against using the herbal product St. John's wort at the same time as Citanew. This combination is advised against due to the increased risk of Serotonin Syndrome.


Q: Is Citanew known to affect birth control pills?

Official labeling generally does not list specific oral contraceptives among the major interacting substances requiring strict avoidance. Regulatory studies have examined Citanew’s potential to affect various enzyme systems, but a general warning about birth control pills is not standard in the prescribing information.


Q: How long does Citanew stay in the system after the last use?

The official product information addresses the rate at which the medication leaves the body using a measure called the half-life. Citanew has a mean terminal half-life of approximately 27 to 32 hours, meaning it takes about this long for the amount of medicine in the blood to be reduced by half.


Q: Can Citanew be used long-term?

Clinical studies have demonstrated the benefit of maintenance treatment for Major Depressive Disorder over periods of several months or longer. Regulatory documents state that the physician should periodically re-evaluate the long-term usefulness of the drug for the individual patient.


Q: Can Citanew cause changes in appetite or weight?

Official adverse reaction documents note that both decreased appetite and subsequent weight changes may occur during treatment. For children and adolescents, monitoring of weight and growth is a standard recommendation in the prescribing information.


Q: Is Citanew okay for people who have certain liver conditions?

For patients with hepatic impairment (reduced liver function), official prescribing documents often recommend a lower dose. Official prescribing information notes that the use of the medication in these patients typically involves an evaluation and potential dosage adjustment.


Q: Can individuals with kidney issues use Citanew?

Official documents state that no dosage adjustment is generally recommended for patients with mild to moderate renal impairment (kidney issues). However, there is less specific pharmacokinetic information available for those with severely reduced renal function.


Q: Are there specific patient groups that Citanew is not recommended for, according to official documents?

Citanew is contraindicated (should not be used) in patients taking Monoamine Oxidase Inhibitors (MAOIs) or the medicine Pimozide. It is also contraindicated for those with a known severe sensitivity or allergy to escitalopram, citalopram, or any of the product's inactive ingredients.


Q: Has Citanew been tested in older adults (senior citizens)?

Yes, clinical trials for both Major Depressive Disorder and Generalized Anxiety Disorder included patients aged 65 years and older. Official guidelines indicate that older adults are typically prescribed a lower dose.


Q: What does the research say about Citanew use during pregnancy?

Regulatory documents state that use during pregnancy must balance the potential benefit against the potential risk to the fetus. Neonates exposed to SSRIs late in the third trimester have uncommonly reported clinical findings consistent with either a direct toxic effect or a drug discontinuation syndrome.


Q: Is it safe to use Citanew while breastfeeding?

Official information indicates that maternal doses of Citanew produce low levels in breast milk. Official information mentions that specific monitoring of the infant for certain signs, such as drowsiness or poor feeding, is sometimes noted when the drug is used during breastfeeding.


Q: Why is Citanew sometimes prescribed when other drugs didn't help?

Citanew is approved for treating Major Depressive Disorder and Generalized Anxiety Disorder. These conditions often require different courses of treatment, and its use is based on its efficacy demonstrated in clinical trials, sometimes following a patient's lack of response to other therapeutic options.


Q: What if I have trouble sleeping after starting Citanew?

Trouble sleeping (insomnia) is listed as a common side effect of Citanew. The administration section of the official label mentions that the drug may be taken either in the morning or the evening.


Q: Is there a specific time of day that Citanew is usually recommended to be taken?

Citanew is generally meant to be administered once daily. The regulatory document states that it may be taken either in the morning or evening, with or without food, as directed by the prescribing professional.


Q: Does Citanew interact with common pain relievers like ibuprofen?

Official regulatory documents explicitly include Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), such as ibuprofen, in the list of interacting medicines. Concomitant use with Citanew is associated with an increased risk of bleeding events.


Q: Can Citanew affect blood pressure readings?

Official reports for adverse events, particularly in overdose situations, mention hypotension (low blood pressure) as a potential cardiac abnormality. Additionally, the label warns of the rare potential for serious cardiac rhythm problems.


Q: What does 'contraindication' mean in the context of Citanew?

A contraindication is a circumstance or condition under which Citanew should not be used because the risk of using the drug is determined to be higher than the potential benefit. Examples include taking MAOIs or having a known allergy to the medicine.


Q: Does Citanew treat the underlying condition or just the symptoms?

Citanew is classified as a psychotropic medicine that supports the regulation of mood and anxiety by modulating the availability of serotonin in the brain. Its action reflects a functional modulation of symptoms, supporting emotional stabilization rather than a definitive cure for the underlying disorder.


Q: How is the effectiveness of Citanew typically measured in clinical studies?

The effectiveness of Citanew is measured by outcomes reflecting changes in symptom patterns over time. This is typically done using standardized rating scales and by monitoring patient-reported outcomes describing perceived discomfort throughout defined time intervals.


Q: Is it true that Citanew is sometimes used for conditions not listed in its main uses?

Official regulatory documents only confirm Citanew's use for the treatment of Major Depressive Disorder and Generalized Anxiety Disorder in specific populations. Any use outside of the formally labeled indications is not addressed within the authorized prescribing information.


Q: Does Citanew have an effect on energy levels?

The regulatory documents list both fatigue and sleepiness (drowsiness) as frequently reported side effects. This indicates that Citanew may have a noticeable effect on a person's energy levels.


Q: What kind of research has been done on Citanew, such as large studies?

Research supporting the use of Citanew includes multiple short-term, multi-center, placebo-controlled studies that established its effectiveness. The research also includes longer-term trials that have examined the benefit of continued maintenance treatment for Major Depressive Disorder.


Q: What happens if someone stops using Citanew suddenly?

Official documents contain warnings that abruptly stopping Citanew can lead to withdrawal symptoms or discontinuation syndrome. Symptoms described in the label may include dizziness, electric shock sensations (paresthesia), irritability, and abnormal dreams.


Q: What is the official recommendation for missed doses of Citanew?

General patient information for escitalopram often outlines that if a dose is missed, it may be taken as soon as it is remembered. However, if the time is near for the next scheduled dose, general guidance suggests skipping the missed dose to maintain the regular schedule.

How should Citanew be stored and disposed of?

How to Store and Dispose of Citanew

Official regulatory guidance specifies strict requirements for storing and disposing of this medication (which contains escitalopram) to maintain its stability and ensure safety.

Storage Requirements

Condition Requirement
Temperature Store at controlled room temperature, typically between 20°C and 25°C (68°F and 77°F).
Protection Keep protected from light and excess moisture, and avoid storing in high-heat areas.
Packaging Keep the medication in its original container, tightly closed.
Safety Store securely out of the sight and reach of children and pets.

Disposal Instructions

When disposing of unused or expired Citanew, the officially preferred method is using a secure drug take-back program. If a take-back program is unavailable, medication should be mixed with an unappealing substance, such as dirt or used coffee grounds, placed in a sealed bag or container, and disposed of with household trash. Do not flush the medication down the toilet or pour it down a sink drain.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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