Cinfatos

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Cinfatos

Treatment option: Cough

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Cinfatos

This foundational overview establishes the identity, class, and general purpose of Cinfatos, rigorously excluding details related to dosage, administration, or safety.

Property Description
Active Ingredient Dextromethorphan Hydrobromide
Form Oral Solution (Liquid/Syrup)
Pharmacological Class Antitussive (Cough Suppressant)
Common Purpose Relief from Non-productive, Dry Cough
Origin Synthetic (Levorphanol Derivative)

What is Cinfatos and Its Primary Classification?

Cinfatos 2 mg/ml Oral Solution is defined as a synthetic, single-ingredient medication that functions as an antitussive, or cough suppressant, intended for oral administration. The active ingredient is Dextromethorphan Hydrobromide, which belongs to the morphinan class of medications. This specific Oral Solution formulation is often positioned for the management of symptoms in adults and certain children’s groups above specified age thresholds. The medication’s general purpose is strictly the management of irritation and distress caused by persistent dry cough that serves no physiological function. The effectiveness of this substance has been established in clinical settings, supporting its role as a recognized antitussive agent.

Composition, Form, and Origin of the Medicine

The preparation is provided as an Oral Solution—a liquid or syrup—with the Dextromethorphan Hydrobromide dissolved in an aqueous liquid vehicle. This liquid format is a distinguishing feature, offering an alternative to solid forms for patients who prefer or require a liquid preparation. Chemically, the active substance is structured as a levorphanol derivative and is a structural analog of codeine. However, it is explicitly classified as a non-opioid cough suppressant because its primary effects are central, specifically modulating the neural pathways in the brain’s cough centre, without engaging in the addictive activity associated with traditional narcotic pain relievers. This pharmacological distinction is crucial for understanding its core function as a simple cough reflex modulator, an action clinically recognized for its role in easing the discomfort of an unproductive, irritative cough.

Regulatory References

  1. Dextromethorphan - StatPearls - NCBI Bookshelf

What side effects are possible with Cinfatos?

Possible side effects and safety information

The safety profile of Cinfatos 2 mg/ml Oral Solution, containing Dextromethorphan Hydrobromide, is characterized by adverse effects primarily affecting the central nervous system and the gastrointestinal tract, as documented in official regulatory labeling.


Documented Adverse Reactions and Frequency

The most frequently reported undesirable effects are typically classified as common in official documents, and include dizziness, slight drowsiness, and gastrointestinal disturbances such as nausea and stomach upset. Effects categorized as uncommon or of unknown frequency include vomiting, diarrhea, confusion, and various forms of rash or allergic reactions.

System-Organ Class Common Effects (Examples) Less Common Effects (Examples)
Nervous System Disorders Dizziness, Drowsiness Confusion, Nervousness
Gastrointestinal Disorders Nausea, Stomach Upset Vomiting, Diarrhea, Constipation

Serious Safety Considerations

The most serious documented risk involves the potential for Serotonin Syndrome, which is a life-threatening reaction listed as a strict contraindication when this medicine is used with Monoamine Oxidase Inhibitors (MAOIs). Additionally, the official labeling notes the potential for drug dependence associated with the prolonged use of the active substance, a risk acknowledged in individuals with a history of substance misuse. Rare but documented adverse effects include severe allergic responses, such as Angioedema (swelling of the face or throat).

Population-Specific Constraints

Official prescribing information advises caution for patients with hepatic impairment (liver problems) due to the drug's extensive metabolism. Specific age-based contraindications for use in younger pediatric groups are also defined in regulatory documents. Use during pregnancy or lactation is generally reserved only if the potential benefit outweighs the possible risk, as documented in authoritative sources.

Overdose and Emergency Response

Overdose with Dextromethorphan Hydrobromide is officially documented to present with a range of symptoms primarily affecting the central nervous system (CNS). These documented manifestations include agitation, confusion, somnolence, stupor, ataxia (unsteady walking), dizziness, muscle twitches, and altered vision such as dilated pupils and involuntary eye movements. Cardiovascular effects may include tachycardia (fast heartbeat) and fluctuations in blood pressure. Gastrointestinal symptoms like nausea and vomiting are also listed in regulatory profiles.

The official regulatory profile notes that overdose can lead to severe and potentially life-threatening outcomes, including seizures, coma, and respiratory depression (slow or no breathing). A critical, documented risk is Serotonin Syndrome, which is explicitly noted when the substance is co-administered with other serotonergic agents.

In case of a suspected overdose, regulatory guidance mandates that users immediately call emergency services or the national Poison Help hotline. Urgent medical attention is required for the onset of any severe or life-threatening symptom. Management, as described in official prescribing information, is symptomatic and supportive. Procedures may involve the administration of activated charcoal and the use of Naloxone to address associated respiratory or CNS depression. Continuous monitoring of vital signs and cardiac activity via ECG is also documented as a required measure in a hospital setting.

Therapeutic Uses of Cinfatos

What Cinfatos Treats: Main Uses and Benefits

Relief for Irritative, Non-Productive Cough

Cinfatos Oral Solution is commonly used to help with symptoms related to physical discomfort from dry, hacking coughs which are non-productive. This medication is applied in addressing symptom clusters related to inflammatory or irritative states in the throat and bronchial airways, which commonly appear during conditions associated with acute or disruptive episodes. This generally provides support that contributes to easing the symptom load during phases of increased distress or discomfort.

Symptomatic Support in Acute Respiratory Illnesses

It is commonly used across conditions presenting with acute episodes, relevant when groups of symptoms appear suddenly or fluctuate, and when symptoms create noticeable physiological strain. Cinfatos offers symptomatic relief that helps patients cope more steadily when groups of symptoms appear suddenly or fluctuate, providing supportive relief when symptoms interfere with routine activities. This supports general well-being during symptomatic phases by easing discomfort.

Easing Cough-Related Sleep Disruption

Cinfatos is relevant for managing symptoms that interfere with daily comfort, particularly when the cough disrupts nocturnal rest. This action may assist with short-term symptomatic assistance, contributing to improved comfort during periods of heightened symptoms.

“The focus is on easing the persistent cough, assisting with the patient's rest and comfort when symptoms intensify.”


Quick Fact: Relief for Non-Productive Cough The medication is used for managing coughs that are dry and persistent, often used during phases when symptoms become more noticeable and short-term symptomatic assistance is needed.

Regulatory References

  1. NIH MedlinePlus overview

Eligibility and Restrictions for Use

Cinfatos (Dextromethorphan pm Guaifenesin) is subject to strict eligibility rules based on regulatory labeling, primarily defining absolute contraindications and restrictions for vulnerable populations.

Absolute Contraindications

The medicine must not be used by individuals with:

  • A known hypersensitivity or allergy to Dextromethorphan, Guaifenesin, or any excipients.
  • Current or recent use (within the last 14 days) of a Monoamine Oxidase Inhibitor (MAOI), such as Phenelzine or Selegiline.
  • Pre-existing conditions like severe hepatic or kidney disease.

Population-Specific Restrictions

Population Category Regulatory Status
Age Use is contraindicated in children under 4 years; many formulations are not for use in children under 6 or 12 years due to lack of established safety and efficacy.
Pregnancy Generally not recommended. Some labels specify contraindication during the first trimester due to insufficient data.
Lactation Not recommended as it is unknown if the components pass into breast milk, requiring caution.
Comorbidities Caution and/or dose reduction is required for patients with hepatic or renal impairment. Patients with specific metabolic issues like Phenylketonuria (PKU) may be excluded from products containing aspartame.

Eligibility is strictly defined by these criteria; use is restricted to individuals who do not fall into these prohibited categories.

What should I know about interactions with other medicines?

Cinfatos Interactions with other medicines and products

The official interaction profile of Cinfatos (Dextromethorphan Hydrobromide) is structured around its primary metabolic pathway and central nervous system activity. Regulatory documents strictly classify co-administration with Monoamine Oxidase Inhibitors (MAOIs) as a contraindication due to the serious risk of a potentially fatal reaction known as Serotonin Syndrome. This prohibition requires a mandatory 14-day separation period between stopping an MAOI and starting Cinfatos.

The main pharmacokinetic interaction involves the Cytochrome P450 2D6 (CYP2D6) enzyme. Since Cinfatos is a substrate for this enzyme, co-use with potent CYP2D6 inhibitors (such as Quinidine, Fluoxetine, or Paroxetine) causes a significant reduction in its clearance. This inhibition of metabolism leads to a substantial increase in Cinfatos's systemic exposure and plasma concentrations, raising the risk of dose-related toxic effects.

Pharmacodynamic interactions are defined by additive effects. Concomitant use with other serotonergic agents (including SSRIs and TCAs) increases the risk of Serotonin Syndrome. Caution is also required with alcohol and other CNS depressants, as these combinations may result in additive CNS depression. Due to the extensive breakdown in the liver, official documents note that Hepatic Impairment may affect Cinfatos clearance and should be considered.

Mechanism of Action

Cinfatos exerts its targeted pharmacodynamic action primarily within the central nervous system (CNS) through receptor modulation. The mechanism involves dual interaction with key regulatory systems.

Targeting Glutamatergic and Sigma Receptor Systems

The compound functions as a non-competitive antagonist at the N-methyl-D-aspartate (NMDA) receptor, which mediates fast excitatory signaling via glutamate. Simultaneously, it acts as an agonist at the Sigma-1 receptor. This dual modulation modifies activity within specific CNS pathways by altering neuronal excitability thresholds and regulating neurotransmitter release.

Modulating Hyperexcitable Neural Pathways

Interference at the receptor level initiates an intracellular cascade that mediates the dampening of excessive nerve activity. This molecular action interrupts the downstream propagation of hyperexcitable signals, resulting in the modulation of rapid signal transmission through central reflex circuits.

Influencing Central Regulatory Feedback

The short-term, targeted modification of receptor activity engages regulatory feedback mechanisms within these neural pathways. This process subsequently modulates activity levels in targeted systems, influencing the drug’s overall physiological effect profile.

Dosage and Administration Information

Cinfatos is an Oral Solution intended exclusively for oral administration and is regulated for short-term symptomatic use. The administration protocol requires accurate measurement using a calibrated dose-measuring device to ensure precision, rather than a standard household spoon. The solution can generally be taken with or without food.

The medication's usage schedule is defined by a maximum allowable daily intake. For adults and children 12 years and older, the dose typically ranges from 10 mg to 30 mg, administered on an as-needed basis every 4 to 8 hours, and must not exceed 120 mg in any 24-hour period. Guidelines are clear that the product should not be used in children under 6 years of age. For pediatric patients aged 6 to 11 years, a reduced maximum daily dose is stipulated, emphasizing the importance of label-based age constraints.

The duration of use is constrained by the short-term intent; official instructions dictate that the medication should be discontinued if the cough persists for more than seven days. If a dose is missed, the protocol is to take the next scheduled dose at the usual time without attempting to double the amount. Furthermore, patients are restricted from co-administering Cinfatos with other medicines that contain dextromethorphan to prevent exceeding the regulatory maximum dose. This procedural structure strictly governs the use according to official labeling.

Recent Clinical Evidence

Research Evidence: Overview of Studies for Cinfatos

The Research Base for Acute Non-Productive Cough

Cinfatos was evaluated in research exploring acute, non-productive cough, which often occurs during conditions associated with acute or disruptive episodes, such as the common cold. The research in this area relies heavily on short-term Randomized Controlled Trials (RCTs). These studies were applied in research contexts involving fluctuating or unstable symptoms, and they were designed to assess short-term or episodic symptom patterns.

Researchers examined two main categories of outcomes: objective and subjective. Objective outcomes examined measurements such as 24-hour cough counts, measured using specialized instruments, and tests that explored how the body's cough reflex sensitivity responds to certain agents. Simultaneously, studies monitored subjective, patient-reported outcomes describing perceived discomfort, such as how often a person coughed and how severe they felt the cough was.

Comparing Objective and Subjective Findings in Studies

Studies reported measurements describing patterns often showing differences between objective and subjective results. Studies using objective measurement tools research described patterns related to the cough reflex response. However, research evaluating patient-reported outcomes describing perceived discomfort showed patterns that were mixed and described variability across different trials and systematic reviews. These research findings indicate that a pronounced difference frequently occurs between the objective measurements taken and how patients reported their experience during the study.

Evidence in Specific Age Groups (Special Populations)

The primary body of evidence examined adults who experienced temporary physiological imbalance due to an uncomplicated viral cough. Studies were also conducted on specific pediatric age groups.

Studies monitored short-term symptom changes in children aged 6 to 11 years with acute cough. Using objective cough-counting devices, studies reported measurements related to daytime cough frequency for this group. However, the same studies described limited information regarding nocturnal cough, and no parallel patterns were consistently reported for outcomes linked to the impact of cough on sleep. Data for certain groups, particularly very young children, remain insufficient in high-quality research, meaning results apply only to the populations studied.

Study Duration and Long-Term Observations

Clinical research examining Cinfatos was relevant in trials assessing short-term symptom patterns. Study designs primarily focused on observing responses over defined time intervals that covered the acute phase of illness. Follow-up durations were limited, with primary outcomes often assessed within the first 24 hours of starting the medicine. The studies help show what has been observed so far regarding episodic or acute changes. However, there is limited information for long-term outcomes, and research describing potential effects or changes in symptoms over an extended period is not fully established.

Research Gaps and Areas of Uncertainty

The evidence contributes to understanding symptom patterns, but the certainty remains low regarding the research. A key limitation noted in the scientific literature is the heterogeneity of the evidence, meaning that evidence quality varies across studies, and consistent findings are not always available. Findings were mixed when researchers compared Cinfatos to an inactive placebo pill, a common pattern in the study of cough symptoms. Furthermore, comparative evidence is lacking, and the research provides limited insight into whether the observed objective changes were associated with a meaningful change in patient-reported outcomes describing perceived discomfort. The available data are still emerging regarding the magnitude of the measured effect, and certainty remains low regarding the consistency of results across all populations. Study results reflect the specific conditions under which they were conducted, and findings describe group patterns, not personal outcomes.

Key Studies & References

  1. Dextromethorphan - StatPearls - NCBI Bookshelf
  2. Objective and self-reported evidence of dextromethorphan antitussive efficacy in children, aged 6-11 years, with acute cough due to the common cold
  3. Cough (acute): antimicrobial prescribing - Summary of the evidence (NICE Guidance NG120)

Frequently Asked Questions (FAQ)

Common questions about Cinfatos (FAQ)

Q: How long does it typically take for Cinfatos to start having an effect?

According to pharmacokinetic data, Cinfatos is absorbed quickly into the body after oral administration. The antitussive (cough-suppressing) effect typically begins within 15 to 30 minutes after the oral solution is taken.

Q: Does Cinfatos stay in the body for a long period after the last use?

The active ingredient is formulated to provide symptom relief for a defined time period. The effect generally lasts between 3 to 8 hours. The time it takes for half of the medicine to be cleared from the body, known as the half-life, is typically 2 to 4 hours for most individuals.

Q: What is meant by the 'half-life' of Cinfatos?

The half-life is a scientific measurement indicating the time required for the amount of medicine in the body to be reduced by half. For most individuals, the half-life of the active component is around 2 to 4 hours. However, this clearance rate can vary significantly, potentially taking up to 24 hours for certain individuals known as 'poor metabolizers.'

Q: How is Cinfatos generally eliminated or processed by the body?

The active ingredient in Cinfatos is processed in the liver by enzymes, primarily CYP2D6 and CYP3A4. It is rapidly broken down into metabolites, which are then largely eliminated from the body through the urine. This process of elimination is why co-administration with other medicines that inhibit the CYP2D6 enzyme can increase the drug's concentration in the bloodstream.

Q: What is the general guidance on stopping the use of Cinfatos?

The medication is intended for acute symptom relief and is typically used for short periods only. Official guidance states that use should be discontinued if the cough persists for more than seven days. Furthermore, regulatory documents advise that use should be discontinued if the cough is accompanied by a fever, a rash, or a persistent headache.

Q: Is Cinfatos known to cause any long-term effects on the body?

According to regulatory documents, Cinfatos is primarily intended for short-term symptomatic use. Official instructions state that the medication should be discontinued if the cough persists for more than seven days. This focus on acute use means there is limited information from research on potential long-term effects beyond the risk of dependence associated with prolonged, non-indicated use.

Q: Are there any specific foods or drinks that should be avoided while taking Cinfatos?

Official product information states the oral solution can generally be taken with or without food. Although no specific food restrictions are typically listed, the drug label does caution against the use of alcohol due to the potential for additive central nervous system (CNS) depressant effects.

Q: Are there any known interactions between Cinfatos and common dietary supplements?

Official drug interaction databases highlight that the herbal supplement St. John’s wort may interact with Cinfatos. This combination carries an increased risk of a serious reaction called Serotonin Syndrome.

Q: Can Cinfatos be taken with over-the-counter pain relievers or fever reducers?

Regulatory information indicates that Cinfatos is generally compatible with common single-ingredient pain relievers like ibuprofen or acetaminophen. However, the label strongly restricts co-administration with any other cold or cough medicine that contains dextromethorphan to avoid exceeding the regulatory maximum daily dose.

Q: Can Cinfatos be used by elderly patients (aged 65 and over)?

Regulatory guidelines indicate that the standard adult dosage applies to elderly patients. Nevertheless, official product information often advises caution, noting that a healthcare professional may consider the lower end of the recommended dosage range due to the potential for increased sensitivity to side effects like drowsiness in this population.

Q: Does Cinfatos affect blood pressure levels?

The active ingredient itself does not commonly list blood pressure changes as a standard side effect. However, high blood pressure and rapid heart rate are documented as serious symptoms of Serotonin Syndrome, which is a known risk when Cinfatos is combined with other serotonergic agents.

Q: Is Cinfatos appropriate for patients with pre-existing heart rhythm issues?

Rapid heartbeat is listed as a potential serious adverse effect associated with Cinfatos use or overdose. Due to this potential effect, official labeling advises caution for patients who have pre-existing heart rhythm issues.

Q: Is Cinfatos known to cause dry mouth or changes in taste?

Yes, dry mouth is frequently reported as a common side effect of the active ingredient, Dextromethorphan Hydrobromide, according to official adverse reaction data. Changes in taste, however, are not typically listed among the common effects.

Q: Is it normal to feel a mild headache when starting Cinfatos?

Headache is not usually listed as a common side effect in the official safety documents for Cinfatos. However, official guidance advises that use be discontinued if the cough is accompanied by a persistent headache, particularly if also present with a fever or rash.

Q: Is Cinfatos considered a high-alert or specialty medication?

Drug safety organizations classify the liquid formulation of this medicine as a 'High-Alert Medication.' This designation is based on the potential risk of significant harm from dosing errors, particularly in children, which underscores the importance of using a calibrated measuring device.

Q: What is the purpose of the 'black box' or 'important safety information' sometimes associated with Cinfatos?

While the single-ingredient cough suppressant generally does not carry a 'Boxed Warning,' the official label includes critical safety information. The most serious warning is the strict contraindication against concurrent use with Monoamine Oxidase Inhibitors (MAOIs) due to the serious risk of Serotonin Syndrome.

How should Cinfatos be stored and disposed of?

How to Store and Dispose of Cinfatos Oral Solution

Cinfatos Oral Solution must be stored at controlled room temperature, typically between 20°C and 25°C. To maintain its stability, the medicine must be protected from freezing, refrigeration, and excessive heat. Keep the product in its original, tightly closed container and store it away from moisture and direct light.


Child Safety and Disposal

It is a mandatory regulatory requirement to keep Cinfatos Oral Solution strictly out of the sight and reach of children.

Disposal of unused or expired medicine should follow official guidelines. The preferred method is to utilize a drug take-back program. If this is unavailable, the product should be mixed with an undesirable substance, sealed in a container, and discarded in the household trash, in accordance with local regulations. The medicine should not be poured down a sink or flushed down the toilet.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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