Cilacar

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Cilacar

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Cilacar

Quick Facts

Property Description
Active Ingredients Cilnidipine, Chlorthalidone, Olmesartan Medoxomil
Form Oral tablet (Film-Coated)
Pharmacological Class Triple-Combination Antihypertensive
Common Use Management of essential hypertension
Origin Synthetic

The Identity of Cilacar: A Triple-Combination Antihypertensive

Cilacar, in its triple formulation, is a specialized, synthetic Fixed-Dose Combination (FDC) medicine, formally classified as an antihypertensive intended for systemic administration as an oral tablet. This formulation is typically utilized for adult patients whose hypertension remains inadequately controlled, necessitating a multi-faceted pharmacological strategy to meet treatment goals. Unlike single-drug or dual-combination therapies, the FDC integrates agents from three separate pharmacological classes to achieve a more profound and sustained effect in achieving target blood pressure goals.


Composition: Three Active Mechanisms in One Tablet

The medicine is composed of three active ingredients, each representing a distinct antihypertensive class: Cilnidipine, Chlorthalidone, and Olmesartan Medoxomil. Cilnidipine is a dihydropyridine Calcium Channel Blocker (CCB), Olmesartan Medoxomil is an Angiotensin II Receptor Blocker (ARB), and Chlorthalidone functions as a thiazide-like Diuretic. This combination provides complimentary actions simultaneously addressing vessel tension, fluid volume, and hormonal signaling. The combination is prepared as a solid, film-coated tablet, ensuring the precise delivery of all three components with a single administration.


General Purpose: Targeting Uncontrolled Blood Pressure

The general therapeutic purpose of this formulation is to achieve more powerful and consistent blood pressure reduction than typically possible with fewer agents. This medicine is utilized when a patient’s essential hypertension remains elevated despite standard therapy, providing a comprehensive approach to mitigate long-term cardiovascular risk. The inherent benefit of utilizing an FDC is the simplification of the treatment plan, which is recognized as a factor for enhancing treatment adherence in chronic disease management.

What side effects are possible with Cilacar?

Possible Side Effects and Safety Information

The official safety profile of this triple-combination medicine is organized around specific adverse reactions and safety constraints documented in regulatory labeling. Reactions are classified by frequency and the physiological systems affected, based on official regulatory standards.


Adverse Reactions and Frequencies

Adverse reactions are formally categorized to reflect their likelihood, with Common reactions (e.g., incidence 1%) appearing most often in regulatory summaries. Common side effects documented for the components include dizziness, headache, and generalized edema (swelling). Less frequent adverse effects are also reported, such as thrombocytopenia (low platelet count), classified as Uncommon.

Reactions are grouped by System-Organ Class (SOC), including Vascular Disorders (e.g., hypotension, flushing), Nervous System Disorders (e.g., insomnia), Gastrointestinal Disorders, and Metabolism and Nutrition Disorders, which encompass the potential for electrolyte imbalances (e.g., hypokalemia) due to the diuretic component.


Serious Safety Considerations

The medicine is subject to critical safety warnings concerning Serious Adverse Reactions.

  • Fetal Toxicity: Use during the second and third trimesters of pregnancy is strictly contraindicated due to the confirmed risk of injury and death to the developing fetus.
  • Sprue-like Enteropathy: Severe, chronic diarrhea with significant weight loss has been reported, sometimes occurring months to years after the Olmesartan component is initiated.

Population-Specific Constraints include a formal contraindication for individuals with severe hepatic impairment or severe renal impairment. Furthermore, Symptomatic Hypotension is a time-related safety pattern that may be anticipated after the initiation of treatment, particularly in patients who are volume-depleted.

Overdose and Emergency Response

Overdose and when to seek help

Overdose with the triple combination of Cilnidipine, Olmesartan Medoxomil, and Chlorthalidone may result in a combined pattern of symptoms, primarily affecting the cardiovascular and metabolic systems, as documented in regulatory information.

Documented Overdose Presentations

Classification Manifestations and Effects
Cardiovascular/Systemic Severe Hypotension (low blood pressure), leading to potential Circulatory Shock. Documented heart rate changes include Bradycardia or reflex Tachycardia.
Metabolic/Renal Critical Electrolyte Imbalances (e.g., severe Hypokalemia or Hyponatremia), Acute Renal Failure, Nausea, Vomiting, and sometimes Seizures or Decreased Consciousness.

When to Seek Immediate Medical Help

An overdose is a medical emergency. Seek immediate medical attention by contacting emergency services or proceeding to the nearest hospital emergency room if an overdose is suspected, especially if symptoms include Fainting, Seizures, profound Dizziness, or collapse.

Official Emergency Requirements

  • Supportive Care: Management consists primarily of Symptomatic and supportive treatment, which includes administering Intravenous Fluids to manage hypotension and observing the patient under close medical supervision.
  • Monitoring: Continuous monitoring of Vital Signs, ECG, Electrolytes, and Renal Function is typically required.
  • Pregnancy Note: Due to the risk of Fetal and Neonatal Morbidity and Death from the Olmesartan component, the medicine must be Discontinued immediately if pregnancy is detected during treatment.

Regulatory documents confirm that no specific antidote is designated for this combined overdose.

Therapeutic Uses of Cilacar

Cilacar: Main Uses and Benefits

Cilacar (cilnidipine) is a medication utilized in the management of hypertension, commonly referred to as high blood pressure. Treatment with this agent is provided to support the reduction of elevated blood pressure levels in adults.

The primary therapeutic domain of Cilacar involves providing a means to achieve and maintain blood pressure within a target range determined by a healthcare provider. This management strategy is intended to assist in lowering the overall strain on the cardiovascular system. By contributing to better blood pressure control, the medication serves an important function in a comprehensive health plan.

Clinical use also indicates that Cilacar may be part of the regimen for reducing the risk of complications associated with long-term hypertension, such as issues affecting the heart and blood vessels. Cilnidipine is also studied for its potential to provide specific support in patients who have hypertension with co-occurring conditions, including those that involve the kidneys.


Quick Facts: Therapeutic Use

  • Treats: High blood pressure (hypertension).
  • Intended Action: Supports the reduction of elevated blood pressure.
  • Key Benefit: Helps to maintain blood pressure within a desired range.
  • Secondary Role: May assist in reducing the risk of complications related to uncontrolled blood pressure.

Eligibility and Restrictions for Use

Who Can and Cannot Use Cilacar?

Eligibility for Cilacar (Cilnidipine, Chlorthalidone, Olmesartan Medoxomil) is strictly defined by regulatory documents, combining the restrictions of its three components. The medicine is indicated for use in adults for the management of essential hypertension.

Contraindications and Restrictions

Population Group Eligibility Status Regulatory Basis
Pregnancy (2nd and 3rd Trimesters) Contraindicated Risk of fetal harm (Olmesartan ARB component).
Children and Adolescents (under 18) Not Recommended Safety and efficacy have not been established.
Severe Organ Impairment Contraindicated Includes anuria, severe hepatic impairment, cholestasis, or biliary obstruction.
Hypersensitivity Contraindicated To any active ingredient, sulfonamide-derived substances, or excipients.
Electrolyte Imbalances Contraindicated Refractory hypokalaemia, hyponatraemia, or hypercalcaemia (Chlorthalidone component).

Use is not recommended during the first trimester of pregnancy and during lactation. Use requires caution and monitoring in patients with mild to moderate renal or hepatic impairment.

What should I know about interactions with other medicines?

Interactions with other medicines and products


Drug-Drug Interactions

The official regulatory documents identify multiple patterns of interaction based on the components of this triple-combination medicine. Co-administration of the Olmesartan component with Aliskiren is formally prohibited in patients with diabetes mellitus due to an officially documented increased risk of renal impairment, hyperkalemia, and low blood pressure. Combining the medicine with Nonsteroidal Anti-inflammatory Drugs (NSAIDs) may result in a loss of blood pressure control and an increased risk of renal function decline. Furthermore, agents such as Lithium and Digoxin may experience reduced renal clearance when co-administered with the diuretic component, leading to increased plasma concentrations of these substances.

Metabolic and Exposure Effects

The Cilnidipine component is primarily metabolized by the Cytochrome P450 3A4 (CYP3A4) enzyme. Co-administration with known inhibitors of CYP3A4 (such as certain Azole antifungal agents) may increase the plasma concentration of Cilnidipine. Conversely, taking the medicine with CYP inducers like Rifampicin may increase the clearance of Cilnidipine, potentially reducing its action. An explicit timing requirement specifies that the Olmesartan component must be administered at least four hours before Colesevelam hydrochloride. Interactions resulting in changes to renal status, such as those with NSAIDs, are noted to be more clinically significant in patients with impaired kidney function.

Interactions with Food and Substances

The consumption of Grapefruit Juice is officially confirmed to increase the blood concentration of Cilnidipine.

Mechanism of Action

How Cilacar Works: Mechanism of Action

Cilacar’s active ingredient, Cilnidipine, is a calcium channel blocker that exerts its action by antagonizing two distinct voltage-gated calcium channels: L-type ( Ca v1.2) and N-type ( Ca v2.2).

Dual Inhibition and Physiological Effect

Inhibition of the L-type channels, located primarily in vascular smooth muscle cells, prevents the influx of extracellular calcium ions ( Ca^2+). This blockade interrupts the excitation-contraction coupling cascade, promoting arteriolar vasodilation and a resultant reduction in Total Peripheral Resistance.

Simultaneously, antagonism of N-type channels on presynaptic sympathetic nerve terminals limits the calcium-dependent release of the vasoconstrictor neurotransmitter norepinephrine. This action modulates sympathetic outflow, contributing to a lower overall level of mediator activity. The combined mechanism of direct vasodilation and reduced sympathetic activation produces a sustained modulation of blood pressure and reduces the reflex sympathetic activation (reflex tachycardia) that may follow a decrease in peripheral resistance.

Dosage and Administration Information

How to Use Cilacar: Official Administration Guidelines

The usage of the Cilacar fixed-dose combination, which contains Olmesartan Medoxomil, Cilnidipine, and Chlorthalidone, is defined by the route, frequency, and conditions for administration.


Official Administration Scope

Instruction Detail
Route of Administration The medication is intended solely for the oral route, administered as a film-coated tablet.
Dosing Schedule The standard frequency is once daily, with the full fixed-dose combination taken at once.
Timing and Intake The tablet may be taken with or without food and should be ingested whole using a glass of water to ensure proper delivery of all components.
Procedural Restriction The tablet must not be crushed, chewed, or dissolved. Maintaining a consistent daily schedule by taking the dose at the same time is a key procedural instruction.

Constraints and Long-Term Use

The FDC is intended for long-term management of chronic essential hypertension. Full blood pressure reduction following any dose adjustment is typically observed after two weeks.

Clinical guidelines specify limitations for certain patient populations. For example, the FDC is not recommended for patients under 18 years due to a lack of supporting data. Furthermore, the use of the combination is contraindicated in severe hepatic impairment, cholestasis, or biliary obstruction, and requires dose modification consideration in mild-to-moderate renal impairment.

These constraints establish a standardized protocol for how the triple therapy is administered, defining the conditions under which use is either allowed or prohibited.


Recent Clinical Evidence

Research Evidence / Overview of Studies for Cilacar

The body of research has been derived primarily from randomized controlled trials (RCTs) and scientific reviews that evaluate blood pressure metrics over defined time intervals. The medicine is a fixed-dose combination (FDC) therapy, meaning research explores the use of three active components—Cilnidipine, Olmesartan Medoxomil, and Chlorthalidone—given in a single tablet.


Evidence for Use in Essential Hypertension

Research examined the use of this triple combination in adults diagnosed with essential hypertension (high blood pressure) across various short-term clinical trials. These studies were structured to compare the FDC against regimens using only two active components. The main things researchers monitored were the change in systolic and diastolic blood pressure measures and the proportion of participants who reached a target blood pressure range.

Findings described patterns observed in the studies where trials reported the proportion of participants reaching specific blood pressure goals. Furthermore, research explored whether using a single FDC affected treatment adherence outcomes compared to taking the equivalent components as separate pills.


Evidence for Uncontrolled Hypertension (Treatment Intensification)

Research has also examined the FDC's role in a specific patient group: adults whose hypertension was not adequately addressed despite already being on a dual-drug regimen. The studies explored what happens when treatment is intensified by switching to the triple FDC.

The research describes that when patients transitioned to this triple-combination therapy, trials reported the mean changes in blood pressure measurements after the switch. These short-term findings indicate a pattern where trials reported the proportion of participants who reached the target blood pressure range after receiving the intensified regimen. The evidence contributes to understanding symptom patterns for this population where symptoms may vary in intensity.


What Research Gaps and Uncertainties Remains

A significant limitation is that long-term effects are not fully established regarding major clinical events. While blood pressure outcomes are known from short-term trials, the full long-term evidence relies on extrapolation from the established evidence base of its components. Additionally, the comparative evidence is lacking for a head-to-head evaluation of this specific triple FDC against every other major three-drug regimen used in clinical practice. Research provides context but not individual predictions, and certainty remains low regarding these distant outcomes.

Key Studies & References

  1. Medication adherence with fixed-dose versus free-equivalent combination therapies: Systematic review and meta-analysis
  2. Fixed-dose combination antihypertensive medications, adherence, and clinical outcomes: A population-based retrospective cohort study

Frequently Asked Questions (FAQ)

Common questions about Cilacar (FAQ)

Q: Are there any long-term side effects associated with Cilacar use?

A: Official regulatory documents indicate that the Olmesartan component of this medicine has been associated with a specific, chronic diarrhea called sprue-like enteropathy. This condition can occur months or even years after initiating the medicine and is characterized by significant weight loss. This condition is noted as a serious safety concern in the official labeling related to long-term use.

Q: Are there any food or drink restrictions when taking Cilacar?

A: The tablet itself can be taken with or without food. However, official product information confirms that consuming Grapefruit Juice should be avoided. Grapefruit juice is confirmed to increase the blood concentration of the Cilnidipine component.

Q: Does Cilacar interact with commonly used over-the-counter pain relievers?

A: Yes, official labeling notes an interaction with Nonsteroidal Anti-inflammatory Drugs (NSAIDs), which includes many common over-the-counter pain relievers. Combining these medications may lead to a reduction in the blood pressure-lowering effect of Cilacar and may increase the risk of developing kidney problems.

Q: What interactions should I be aware of between Cilacar and other heart medicines?

A: Regulatory information documents specific interactions with certain heart-related medications. For instance, co-administration with Aliskiren is prohibited in patients with diabetes, and co-administration with Digoxin can result in reduced renal clearance of Digoxin. It is important that healthcare providers are aware of all current medications to check for potential interactions.

Q: Does Cilacar interact with commonly used anti-diabetic medicines?

A: Yes, the official prescribing information includes a specific contraindication. Co-administration of the Olmesartan component with the drug Aliskiren is formally prohibited in patients with diabetes mellitus due to an officially documented increased risk of severe adverse events.

Q: What scientific evidence supports the use of Cilacar for hypertension?

A: Studies and official information indicate that the medicine's effectiveness is established through randomized controlled trials (RCTs). These short-term clinical trials reported greater reductions in systolic and diastolic blood pressure compared to dual-drug regimens.

Q: Does Cilacar have a specific effect on peripheral blood vessels?

A: Yes, official mechanism of action data shows the Cilnidipine component works primarily on peripheral blood vessels. It acts by promoting arteriolar vasodilation, which means widening the small arteries, and thereby reduces the Total Peripheral Resistance (the resistance the heart must work against to push blood through the body).

Q: Is there any research on the safety of Cilacar during pregnancy?

A: Official information confirms that use during the second and third trimesters of pregnancy is strictly contraindicated. This restriction is based on research and clinical evidence showing a confirmed risk of injury and death to the developing fetus, mainly due to the Olmesartan component.

Q: What are the signs of an allergic reaction to Cilacar?

A: Regulatory documents list that serious adverse reactions, which may indicate a hypersensitivity or allergy, can include swelling of the face, lips, tongue, or throat (angioedema), or the appearance of hives (urticaria). Official guidance indicates that signs of a severe reaction should be reviewed immediately by a healthcare professional.

Q: What's the best time of day to take Cilacar?

A: While the regulatory information does not specify an exact time of day (morning or evening), it mandates that the medication be taken once daily. To help ensure the medicine works consistently, the most important instruction is maintaining a consistent daily schedule by taking the dose at the same time each day.

Q: Does Cilacar affect cholesterol levels?

A: The official safety profile indicates that the diuretic component, Chlorthalidone, is associated with the potential for hyperlipidemia. This is an adverse event related to metabolism, which can involve changes to blood lipid or cholesterol levels.

Q: How does Cilacar affect the heart?

A: The medicine primarily affects the cardiovascular system by promoting vasodilation (widening of blood vessels) and reducing sympathetic nervous system activity to lower blood pressure. Less common reported side effects related to the heart include tachycardia (a fast heart rate) and angina pectoris (chest pain).

Q: Is it normal to feel a mild headache after starting Cilacar?

A: Yes, headache is listed as a common side effect in the official safety profile. It is often experienced during the initial phase of treatment.

Q: How long does Cilacar stay in your system after taking a dose?

A: Pharmacokinetic data suggests that the Olmesartan component has a terminal elimination half-life of approximately 13 hours. This means it takes about half a day for the amount of medicine in your body to be reduced by half. Consistent daily dosing helps the body achieve steady-state levels within three to five days.

Q: What happens if I accidentally take two doses of Cilacar?

A: Overdose may result in exaggerated blood pressure lowering (hypotension). Official guidance advises against doubling up on doses to make up for a missed dose. If a double dose is taken, medical review is recommended.

Q: Are there any known withdrawal symptoms if Cilacar is stopped suddenly?

A: Product information for the Cilnidipine component advises caution regarding sudden cessation. Abrupt discontinuation of the calcium channel blocker part of the medicine has been reported in studies to potentially exacerbate angina (worsen or bring on chest pain).

Q: Is it normal to have warm skin or flushing after taking Cilacar?

A: Yes, flushing (a feeling of warmth or redness of the skin) is listed as an adverse reaction in the vascular disorders category. This effect is commonly associated with the vasodilating action of the Cilnidipine component, as blood vessels widen.

Q: Can Cilacar affect my mood or cause sleeplessness?

A: The official safety profile lists insomnia (sleeplessness) as a potential adverse reaction under Nervous System Disorders. This indicates that some patients may experience difficulty sleeping while taking this medication.

Q: What happens if I forget to take my dose of Cilacar?

A: Official patient information suggests that if you forget a dose, you should skip the missed dose if it is close to the next scheduled time. You should not take a double dose to make up for the forgotten one, but rather continue with your normal schedule.

Q: Can I stop taking Cilacar once my blood pressure is under control?

A: Official regulatory documents state that this medicine is intended for the long-term management of chronic essential hypertension. Blood pressure control typically requires continuous, ongoing therapy to maintain stable levels and manage cardiovascular risk.

Q: Is it safe to drink alcohol while taking Cilacar?

A: Alcohol is known to interact with blood pressure medications. Official information suggests that consuming alcohol can potentiate the blood pressure-lowering effects of the medicine, which may increase the risk of dizziness or fainting.

Q: Is a persistent cough a known side effect of Cilacar?

A: Yes, the official safety profile includes cough as an adverse reaction, though it is typically listed as a less common effect. This side effect is mainly associated with the Angiotensin II Receptor Blocker (ARB) component, Olmesartan.

Q: Does Cilacar cause dry mouth?

A: Yes, dry mouth is listed as a potential side effect in the official safety profile. This effect is specifically associated with the diuretic component of the medicine, Chlorthalidone.

How should Cilacar be stored and disposed of?

Storage & Disposal Map: How to Store and Dispose of Cilacar

Item Official Regulatory Requirement
Labeled storage temperature requirements Store below 30 C
Light/moisture protection requirements Must be protected from light; keep in a cool and dry place
Child-protection storage requirements Keep out of the sight and reach of children and pets
Disposal instructions Dispose of unused or expired product according to local requirements

The official labeling mandates that Cilacar tablets must be stored at a temperature not exceeding 30 C and actively protected from light and moisture. To prevent accidental ingestion, the medicine must be secured out of the sight and reach of children. Regarding disposal, the product should not be discarded via household waste or wastewater, and all unused or expired medicine must be handled following specific local requirements for pharmaceutical waste.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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