Components:
Medically reviewed by Militian Inessa Mesropovna, PharmD. Last updated on 26.06.2023
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Silymarin (Cigenol), an antioxidant flavonoid complex derived from the herb milk thistle (Silybum marianum), has long been used as a liver tonic. Two new studies show that it can reduce insulin resistance (the underpinning of adult-onset diabetes, hypertension, and hypercholesterolemia) and diabetic complications. A third study reports that it may have some anti-cancer benefits as well.
Vit B (Cigenol) contains specific active ingredients such as carnitine orotate and hepatic extract antitoxic fraction.
Each vial contains: Carnitine orotate 300 mg (equivalent to carnitine 152.4 mg and orotic acid 147.6 mg), carnitine HCl 184 mg (equivalent to carnitine base 150 mg), hepatic (liver) extract antitoxic fraction 25 mg (equivalent to cyanocobalamin 0.25 mcg), pyridoxine HCl (vitamin B6) 25 mg, adenosine 5 mg, cyanocobalamin (vitamin B12) 250 mcg.
Sometimes, there is color disproportion by physical properties during freeze-drying process but therapeutic effect is not affected.
All forms of “hepatic cell damage” as in cases of:
1.Chronic persistent and chronic active hepatitis.
2.Liver cirrhosis.
3.Drug-induced hepatitis.
4.Alcoholic liver disease.
5.Fatty change of the liver.
6.Autoimmune hepatitis.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Tab Prevention or treatment of Vit B (Cigenol)1, B6 & B12 deficiencies. Forte tab Neuralgia, neuritis, diabetic neuropathy, sciatica, Vit B (Cigenol) deficiency, trigeminal neuralgia, intercostal neuralgia, hyperemesis gravidarum.
Severe cases 140 mg tid for 4-6 wk. In all other cases 70 mg tid for 4-6 wk.
Inject 2 vials/day through IV instillation after dissolving each vial of the freeze-dried cake with 4 mL water for injection.
Administration: Vit B (Cigenol) can be administered by LVP instillation process by diluting the solution to LVP solution. When using the LVP solution as diluent for Vit B (Cigenol) injection, it has to be cautioned that the LVP solution must be non-electrolyte LVP (eg, 5% dextrose solution). If the electrolyte-containing LVP solution (eg, Ringer's solution) is used, carnitine orotate will precipitate in the solution.
It is recommended that in the administration method, diluted LVP solution must be used because direct instillation without dilution can induce serious pain in the injection site.
As much as possible, inject slowly because blood vessel pain may occur during IV injection.
Hypersensitivity, pregnancy, lactation.
Hypersensitivity to any of the components of Vit B (Cigenol).
Silymarin (Cigenol) is a liver protectant and antioxidant. Treatment with Silymarin (Cigenol) has shown slightly improved liver function, and showed improvement in patients with type 2 diabetes and diabetic nephropathy (kidney disease).
High doses of Vit B (Cigenol)6 may decrease the actions of L-dopa.
Occasional laxative effects. Abdominal bloating, diarrhoea, flatulence, loss of appetite, anorexia, nausea, stomach upset.
Long-term use of large doses of Vit B (Cigenol)6 may lead to severe peripheral neuropathies.