Chrome

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Chrome

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Chrome

Chromium (specifically, trivalent chromium, Cr^3+) is an essential trace mineral that the human body requires in small quantities. It is widely available over-the-counter (OTC) as a dietary supplement, often in the form of chromium picolinate, which is thought to be a more efficiently absorbed version of the mineral.

Role and Typical Use

Chromium is generally recognized for its role in enhancing the action of the hormone insulin, which is critical for regulating blood sugar (glucose) levels and for the metabolism of carbohydrates, fats, and proteins. In individuals with a confirmed chromium deficiency—a rare occurrence—supplementation may be necessary to correct related metabolic issues.

Due to this suspected role in glucose control, chromium supplements are a popular choice for people looking to support healthy blood sugar metabolism, such as those with type 2 diabetes or prediabetes. However, while some research suggests benefits in certain populations, particularly those with poor glucose control, the American Diabetes Association does not currently recommend chromium supplements for blood glucose management in people without an underlying nutritional deficiency.

Differentiating Factors

The vast majority of individuals obtain sufficient chromium through a varied diet, including foods like whole grains, broccoli, and brewer's yeast. Supplements like chromium picolinate are typically offered in doses (often 200 to 1,000 micrograms daily) that significantly exceed the established Adequate Intake (AI) levels set by major health bodies. It is important to note that while chromium in the trivalent form is considered safe, high-dose or long-term supplementation has been associated with reports of serious adverse effects, including potential kidney or liver damage. For this reason, consultation with a healthcare provider is recommended before initiating any high-dose mineral supplement regimen.

Regulatory References

  1. Chromium - Health Professional Fact Sheet

What side effects are possible with Chrome?

Possible Side Effects and Safety Information

The safety profile for trivalent chromium (Cr^3+), commonly available as chromium picolinate, is evaluated based on toxicological reviews and documented case reports, as formal frequency classifications (e.g., Common, Uncommon) typically found in prescription drug labels are generally not applied to this over-the-counter mineral supplement.


Documented Adverse Reactions

Side effects reported at typical supplemental doses are generally mild and may include:

  • Gastrointestinal Disturbances: Stomach upset or irritation.
  • Nervous System Effects: Headache and difficulty sleeping (insomnia).
  • Psychiatric Effects: Mood changes or irritability.

Serious Safety Considerations

The most serious adverse reactions, which are officially documented primarily in cases of chronic ingestion at high doses (significantly exceeding recommended levels), are linked to potential systemic toxicity:

  • Organ Damage: Reports of renal failure (kidney damage) and liver dysfunction.
  • Blood Disorders: Severe hematological issues, including anemia and hemolysis (destruction of red blood cells).

Population-Specific Constraints

The risk of toxicity dictates specific safety cautions for certain groups:

  • Pre-existing Conditions: Individuals with a history of kidney or liver disease are advised against high-dose chromium supplementation due to the documented risk of further organ damage.
  • Safety Identity: All official safety data applies strictly to the trivalent ( Cr^3+) form. The hexavalent ( Cr^6+) form of chromium is classified by regulatory authorities as a severe environmental toxin and a carcinogen, and is not used in supplements.

This information structures the official understanding that while low levels of chromium are essential, the critical safety concern is defined by a dose- and duration-dependent toxicity that manifests as serious internal organ damage only when intake is chronic and excessive.

Overdose and Emergency Response

Overdose and when to seek help

High-dose exposure to trivalent chromium (Cr^3+) is associated with severe systemic toxicity that constitutes an overdose risk. Documented overdose manifestations include severe gastrointestinal irritation, such as vomiting and diarrhea, irregular heart rhythms, and signs of internal hemorrhage ( blood in stools or coughing up blood). High-dose ingestion has also been linked to motor and cognitive dysfunction, including confusion and severe headache.

The most critical life-threatening outcomes involve acute kidney injury ( renal failure) and chemical-induced liver injury ( hepatic dysfunction). These effects can progress to multisystem organ failure and circulatory collapse. Hematological system effects, such as hemolysis and anemia, are also documented.

Official regulatory documents mandate that anyone suspecting an overdose must seek emergency medical attention immediately and contact a Poison Help line or emergency services. Management for documented toxicity relies solely on symptomatic and supportive care, as no specific antidote is known for chromium toxicity. Severe cases require hospital monitoring of renal and hepatic function and may necessitate specialized procedures like hemodialysis or blood product transfusions.

Therapeutic Uses of Chrome

What Chromium Treats: Main Uses and Benefits

Chromium supplementation is generally recognized for its utility in supporting specific metabolic and nutritional needs, primarily used in supportive contexts for blood sugar management and addressing nutritional deficits. The supplement is considered relevant for patients dealing with conditions marked by disruptions in metabolism.

Chromium is commonly sought as an adjunctive aid for conditions involving Impaired Glucose Regulation, such as Type 2 diabetes and prediabetes. Its use provides a key therapeutic benefit: support for healthy blood sugar metabolism and contributes to supporting long-term glycemic stability.

“Chromium plays a role in managing symptoms that interfere with daily comfort by supporting functional stability.”

In the rare, critical context of a confirmed Chromium Deficiency, supplementation plays a role in providing supportive relief to address the metabolic issues. This assists in supporting functional stability when symptoms are more noticeable. This benefit is also relevant for addressing the associated symptom pattern of Disturbed Lipid/Fat Metabolism.


Therapeutic Focus: Support for Blood Sugar Chromium is commonly used to help with managing symptoms related to systemic imbalance, particularly when Impaired Glucose Regulation creates noticeable physiological strain. Its use supports patients during episodes of heightened discomfort by easing the overall symptom load.

Eligibility and Restrictions for Use

Who Can and Cannot Use Chromium Picolinate?

The population eligibility profile for Chromium Picolinate is based on warnings from government health authorities, primarily restricting use in individuals with certain pre-existing conditions and limiting intake for developmental populations.

Contraindicated and Restricted Populations

Population Group Regulatory Status and Restriction
Patients with Kidney Disease Contraindicated: Use is strongly advised against due to the risk of exacerbating or causing kidney damage.
Patients with Liver Disease Contraindicated: Use is advised against due to the risk of liver damage.
Age Groups (0–18 years) Not Recommended above established Adequate Intake (AI) levels.
Pregnancy and Lactation Restricted Use: Taking amounts above the AI is not recommended without specific medical advice.
Psychiatric Conditions Conditional Use: Caution is required as the supplement might worsen conditions like anxiety or depression.

General Eligibility

Use is generally allowed for healthy Adults when taken at or below nutritional Adequate Intake (AI) levels. Individuals with confirmed Chromium Deficiency may require supplementation. All use in patients with Diabetes Mellitus or those taking Levothyroxine requires professional oversight and careful monitoring.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The official interaction profile for chromium is defined by documented changes in systemic exposure and additive pharmacological effects, established in authoritative government regulatory sources.

Contraindications and Restrictions

Co-administration with the antiviral Baloxavir Marboxil is formally restricted and classified as an Avoid Combination. This is due to a pharmacokinetic interaction involving cation binding in the gastrointestinal tract, which significantly reduces the systemic exposure of the antiviral agent.

Exposure Alterations and Timing Rules

The systemic exposure of chromium is affected by several substances. Antacids and other gastrointestinal absorption inhibitors are documented to reduce chromium levels and must be administered at least two hours apart. Conversely, Corticosteroids are documented to decrease plasma chromium levels by increasing its renal clearance. Chromium may also decrease the absorption of Levothyroxine, requiring administration to be strictly separated by 30 minutes before or 3–4 hours after.

Pharmacodynamic and Nutrient Interactions

A pharmacodynamic synergism is documented when chromium is combined with Antidiabetes Medications (e.g., Insulin, Sulfonylureas), potentially increasing the glucose-lowering effect. In nutrient contexts, Vitamin C may enhance chromium absorption, while Iron exhibits competitive binding for key transport proteins.

Population Note

For individuals with Renal Dysfunction, supplemental doses are subject to mandatory adjustment or omission due to the risk of impaired urinary excretion and resulting accumulation.

Mechanism of Action

How Chrome Works: Mechanism of Action


Potentiating the Insulin Signal

The core mechanism of trivalent chromium (Cr^3+) is its action as an essential cofactor for the endogenous peptide apo-LMWCr, facilitating the formation of the active holo-LMWCr complex. This complex specifically binds to the beta-subunit of the activated Insulin Receptor (IR) and functions as a positive allosteric modulator. This binding amplifies and sustains the receptor's intrinsic tyrosine kinase activity, which results in the amplification of the insulin signal inside the cell.


Modulating Cellular Glucose Transporters

The resulting amplified signal cascade quickly leads to the enhanced translocation of GLUT4 (Glucose Transporter 4) storage vesicles to the membrane surface of peripheral tissues like muscle and fat. This increased presence of GLUT4 transporters directly raises the cell's capacity to transport glucose from the surrounding circulation into the cell. This resulting physiological effect modulates the systemic movement of glucose. The mechanism is strictly reliant on the presence of endogenous insulin to initially activate the receptor; its functional relevance is observed primarily in systems where the natural insulin response is active.

Dosage and Administration Information

Chromium, specifically the trivalent form (Cr^3+), is used through two distinct routes: oral administration for general supplementation and intravenous (IV) administration for nutritional support. The choice of route and dose depends on the intended use.

Administration and Dosing Standards

For oral use, chromium is typically taken as a capsule or tablet (e.g., chromium picolinate). The baseline for daily consumption is the Adequate Intake (AI), which is 35 10% per day for adult men and 25 10% per day for adult women. Some prescriptive patterns used in supportive contexts involve higher daily doses, often ranging from 200 10% to 1000 10%, and are typically administered once daily or in a divided regimen.

For intravenous use, chromium is prescribed as Chromic Chloride Injection, strictly as a trace element additive for patients receiving Total Parenteral Nutrition (TPN). The adult dose is generally 10 10% to 15 10% per day of the element, which is administered continuously in the TPN solution.

Preparation and Contextual Constraints

The IV solution requires mandatory dilution by a pharmacist into a large volume of intravenous fluid, such as the TPN admixture, before it can be infused; the solution should never be administered undiluted. For oral supplements, some forms are instructed to be taken in relation to mealtimes. The IV dose must be lowered or omitted in patients with severe kidney impairment because the element is eliminated primarily through the kidneys.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Chromium

Evidence for Use in Impaired Glucose Regulation (Type 2 Diabetes and Prediabetes)

Research exploring how certain biomarkers are measured in conditions characterized by systemic or functional imbalance has been primarily conducted using short-term Randomized Controlled Trials (RCTs) and subsequent meta-analyses that combine trial data. These studies were evaluated in adult populations with confirmed diagnoses of Type 2 Diabetes, prediabetes, or established insulin resistance. Researchers monitored several outcomes related to systemic or functional imbalance, such as the long-term marker Glycated Hemoglobin (HbA1c) and the short-term measure of fasting blood sugar (FBS). They also examined how insulin function was measured using tools like the HOMA-IR index.

Findings were mixed and varied across studies when the combined data was assessed. Some trials reported measurements of lower FBS and HOMA-IR readings in the observed populations during the study period. However, the evidence relating to the more stable, long-term marker HbA1c is less consistent, and certainty remains low for this outcome. Follow-up durations were limited in most of this research, meaning long-term effects are not fully established.

Research on Related Metabolic Conditions

Studies exploring chromium in related metabolic conditions often included outcomes reflecting systemic or functional imbalance. This research frequently takes the form of RCTs where outcomes related to systemic or functional imbalance, specifically blood lipid biomarkers, were monitored. Research highlights changes measured in certain blood lipid markers like Triglycerides and HDL-C during the study period. However, patterns related to other key markers like LDL-C were observed in some studies but not consistently across the broader research landscape. Overall, the data available for lipid parameters are often from secondary outcomes of trials focused on glucose, meaning the evidence base for effects on lipids alone is limited.

Evidence for Addressing Confirmed Nutritional Deficiency

The evidence that contributed to understanding chromium as an essential nutrient stems from case reports and small observational cohorts. Research was evaluated in a very rare population: critically ill patients receiving specialized intravenous feeding (Total Parenteral Nutrition or TPN) that was completely lacking in chromium. Following the administration of chromium, the reports subsequently documented how the patients' symptoms evolved, with glucose tolerance measured as returning to normal patterns. However, the results apply only to the populations studied—individuals with documented, severe deficiency—and do not provide insight into the use of the supplement for common metabolic conditions like Type 2 diabetes in the general public.

Key Limitations and Areas of Research Uncertainty

Review of the overall evidence landscape highlights several key limitations in the available data. Across the many studies that were evaluated in populations with impaired glucose regulation, findings were mixed and evidence quality varies across studies. Furthermore, the typical sample sizes were modest, and follow-up durations were limited, contributing to the low certainty for many long-term outcomes. Comparative evidence is lacking to determine whether different forms of chromium may be associated with different patterns of change. Research provides context but not individual predictions, and continued research is needed to resolve these open questions and provide clearer, consistent findings.

Key Studies & References

  1. Effects of chromium supplementation on glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials
  2. Chromium Fact Sheet for Consumers - NIH Office of Dietary Supplements

Frequently Asked Questions (FAQ)

Common questions about Chrome (FAQ)

Q: Can people with kidney or liver problems use Chrome?

Official regulatory documents indicate that patients with severe kidney impairment may need the dose of the intravenous (IV) form to be lowered or omitted entirely. This is because the kidneys are the primary route for the body to eliminate the element.

Regulatory documents primarily focus on renal processing; specific dose adjustments for liver impairment are not usually detailed in the official prescribing information.

Q: Is Chrome taken with food or on an empty stomach?

Instructions for taking the oral forms of Chrome vary depending on the specific product. Official labels for some oral products describe taking the element with meals or with food.

The product label contains the most accurate instructions for use.

Q: Does Chrome come in different strengths, and why?

Yes, the element comes in different concentrations and forms. Official information indicates that the concentration and dose required are dependent upon the intended use.

For example, the dosage needed to meet the daily Adequate Intake (AI) is typically much lower than the dose prescribed for intensive nutritional support, such as during Total Parenteral Nutrition (TPN).

Q: Why is the official guidance so strict about who can and cannot use Chrome?

Official regulatory guidance defines who can and cannot use Chrome because the body processes and eliminates the element through specific organs, like the kidneys. Therefore, precautions exist, such as the required dose reduction for people with severe kidney impairment.

These official restrictions define the conditions required for appropriate product use.

Q: What is the main reason Chrome is prescribed by doctors?

The intravenous (IV) product is indicated for use in nutritional support, where it is prescribed as a trace element additive for patients receiving Total Parenteral Nutrition (TPN). This helps prevent deficiency symptoms.

Oral forms are generally used for nutritional supplementation.

Q: Is Chrome a new medicine, or has it been around for a while?

The active element in Chrome, chromium, is widely recognized as an essential trace element.

Official documents confirm that various forms of the element, including the trivalent form, have been regulated and available for a long time in both supplement and pharmaceutical-grade forms.

Q: What kind of conditions is Chrome meant to help with?

In regulated settings, the IV product is used for general nutritional support as part of Total Parenteral Nutrition (TPN). The overall purpose, according to official information, is aligned with addressing or preventing a chromium deficiency.

Q: What is the typical timeframe for how long Chrome stays in your system?

Official product information confirms that the element is primarily eliminated from the body through the kidneys.

Individual factors may influence the rate of elimination, and specific timeframes are not detailed in general patient-facing documents.

Q: Does Chrome have any ingredients that are similar to other common drugs?

Chrome is the element trivalent chromium ( Cr^3+), which is an essential nutrient.

Due to its elemental classification, it is not chemically related to the active ingredients found in most common prescription drug classes, such such as antibiotics.

Q: Is Chrome an opioid, a stimulant, or something else entirely?

Official regulatory classification identifies Chrome as an essential trace element. It is not classified as a controlled substance, such as an opioid or a stimulant.

Q: Can Chrome cause changes in mood or energy levels?

Regulatory safety documents include general central nervous system (CNS) effects in their list of adverse reactions. This may include symptoms such as dizziness or headache.

Official adverse reaction reports may list symptoms like dizziness or headache. Effects on mood or energy are reported as part of these general CNS effects in safety documents.

Q: Are there any common foods or drinks that should be avoided while taking Chrome?

Regulatory documents sometimes advise on specific dietary exclusions for the oral forms of the product, such as the consumption of alcohol and grapefruit juice.

Official patient information should be reviewed for details on any necessary dietary exclusions.

Q: Do over-the-counter pain relievers interact with Chrome?

The official drug interaction sections list all known, clinically relevant interactions. Because Chrome is an element excreted by the kidneys, there is potential for interaction with medicines that affect kidney excretion.

Patients are encouraged to review the official list of known drug interactions for their specific product.

Q: Does taking Chrome mean I can't have certain medical tests?

Official product labels may offer information regarding the management of blood sampling or laboratory testing while the product is in use. The label for the IV product, for example, advises that if specialized testing is necessary, samples can be sent to a reference laboratory for assay.

Q: Why do some people say Chrome made them feel tired?

Official safety documents for the product include general symptoms like fatigue and weakness among the reported adverse reactions. This indicates that feeling tired is a reported outcome in clinical data.

Q: Is getting a headache a normal side effect when starting Chrome?

Official safety information for some forms of Chrome includes headache in the list of adverse reactions reported in clinical data. This indicates it is a recognized possible effect of the product.

Q: How common are the more serious side effects listed for Chrome?

Official documents group adverse reactions by their reported frequency (such as common, uncommon, or rare). These rates are compiled from clinical trial data and are detailed in the Adverse Reactions section of the official documents.

Q: What is the difference between an 'adverse event' and a 'side effect' for Chrome?

Official definitions explain that an adverse event is any undesirable experience that happens while using the product. A side effect is a term often used to describe a known, secondary effect of the product, while an adverse event refers to any undesirable experience occurring during product use.

Q: Is Chrome generally considered a long-term or short-term treatment?

Official indications support the use of the product for ongoing nutritional support. For instance, the IV form is administered over extended periods when patients require Total Parenteral Nutrition (TPN).

Q: Are there any special warnings for older adults using Chrome?

Official labels contain a specific section on Geriatric Use. This guidance advises caution in dose selection for older adults, often due to the potential for decreased kidney function.

This caution is noted because the element is primarily eliminated via the kidneys.

Q: What happens if I forget to take a dose of Chrome?

Instructions for managing a missed dose of the oral product are explicitly stated on the official product label. These instructions typically provide guidance for managing a missed dose.

Q: Can Chrome affect my ability to drive or operate machinery?

The official label section addressing driving ability often advises caution if specific side effects, such as dizziness or lightheadedness, are experienced.

Patients experiencing such effects are advised to exercise caution before engaging in activities like driving or operating machinery.

Q: Is there a possibility of developing dependence on Chrome?

Official regulatory documents confirm that because Chrome is an essential trace element, there is no known potential for abuse or physical dependence associated with its approved use.

Q: What does the research say about Chrome's long-term safety?

Official regulatory documents compile data from pre-clinical studies and post-marketing surveillance to assess the element's potential long-term safety. This information supports the regulatory assessment of safety limits and potential risks associated with extended exposure.

Q: Where can I find the official regulatory information about Chrome?

Official information can be found on government websites, such as the National Institutes of Health (NIH) Fact Sheet or the FDA DailyMed database, which provide regulatory details and labeling for specific products.

Q: Are there different versions or brands of Chrome available?

Yes, the element is available in several different chemical forms, such as picolinate and chloride. These different forms are sold under a large number of different commercial brands.

Q: What is the role of the inactive ingredients in the Chrome tablet/capsule?

Inactive ingredients, also known as excipients, are listed on the official product label. Their function is to provide the pill with necessary features like stability, size, and appearance.

Their purpose is solely to support the formulation and physical characteristics of the product, not to contribute to the element's primary intended effect.

Q: Can Chrome cause changes to my appetite or weight?

Official safety information for some forms of Chrome has reported changes in appetite (such as decreased appetite) and weight changes as adverse reactions in clinical trial data.

Q: Is it common to feel a little dizzy when standing up after taking Chrome?

The adverse reaction list for some official products includes dizziness or vertigo. This is a recognized possible effect of the product based on clinical trial data.

Q: What age group is Chrome usually studied on in clinical trials?

Official product labels provide summaries of the clinical studies conducted. These summaries detail the age groups that were included in the trials that supported the product's regulatory filing.

Q: Does Chrome interact with birth control pills?

The official interaction section of the product's label explicitly lists all known, clinically relevant drug-drug interactions. This list includes whether the element has a known interaction with hormonal contraceptives.

Q: Why is Chrome sometimes restricted in terms of who can get it?

Official guidance includes restrictions and precautions to ensure the product is used appropriately. These restrictions exist because regulatory documents define specific contraindications and conditions where the product’s use is cautioned, such as severe kidney impairment.

Q: Does Chrome show up on standard drug screening tests?

The element is classified as an essential mineral, not an illicit drug. Therefore, official information indicates that Chrome does not typically trigger a positive result on standard drug screening panels for common drugs of abuse.

Q: What are the main research findings that led to Chrome's approval?

The Clinical Studies section of the regulatory label summarizes the efficacy and safety studies that provided the evidence base for the product's approval. These findings demonstrated the product's ability to provide nutritional support in the approved use setting.

Q: Can I drink alcohol in moderation while on Chrome?

Official regulatory labels for some forms often include explicit warnings or guidance regarding alcohol consumption. The specific product information indicates whether alcohol use should be avoided or limited during use.

Q: Do existing health conditions make a person ineligible for Chrome?

The official Contraindications section of the regulatory documents explicitly lists the pre-existing health conditions or clinical states that would generally make a person ineligible for the product. One example is a known allergy to the active substance or any of its components.

Q: Is Chrome safe to use while pregnant or breastfeeding?

Official regulatory information on pregnancy and breastfeeding advises that the decision regarding use is made by a healthcare provider after considering risks and benefits. For instance, it is often unknown if the product is excreted in human milk.

Q: Does Chrome affect sleep patterns?

Official safety data includes adverse reactions related to the central nervous system. These can include changes to sleep patterns, such as insomnia or general sleepiness.

Q: Why is it important to tell my doctor about all the medicines I take before starting Chrome?

It is important to discuss all other products you take because Chrome has the potential for drug-drug interactions. These interactions could potentially change how Chrome or your other medicines work in the body.

Q: Does Chrome interact with grapefruit or grapefruit juice?

Official regulatory labels sometimes include explicit warnings regarding potential interactions with food substances like grapefruit or grapefruit juice in the official interaction sections. The relevance depends on the specific product formulation.

Q: How are the side effects of Chrome monitored during clinical trials?

The methods used to collect and assess safety data, including all adverse events and side effects, are clearly described in the official clinical study documentation. This process involves standardized reporting to monitor the product's safety profile.

Q: Is it possible to be allergic to Chrome?

Yes, the primary contraindication listed in official documents for any product is a known hypersensitivity or allergy. This means that if a person has a known allergy to the active substance or any of the inactive ingredients, they are advised not to use the product.

Q: Are there any long-term follow-up studies available on Chrome users?

Regulatory documentation summarizes whether specific long-term studies or post-market safety surveillance programs have been completed or are ongoing. This information is used to continually monitor the safety of the product over time.

Q: What class of drug does Chrome belong to?

According to official regulatory classification from government health agencies, Chrome, in its trivalent form ( Cr^3+), is categorized as an essential trace element.

Q: Does Chrome affect blood pressure or heart rate?

Official safety information includes adverse reactions related to the cardiovascular system. These reactions may include changes in blood pressure (such as hypotension or hypertension) or changes in heart rate (tachycardia).

How should Chrome be stored and disposed of?

How to Store and Dispose of Chromium Picolinate Supplements

Storage of chromium picolinate supplements must adhere to labeled regulatory requirements to maintain product stability and ensure safety. The product must be stored at controlled room temperature, typically 20 C to 25 C, and requires protection from both excessive heat and moisture.

Storage and Handling

Condition Regulatory Requirement
Temperature Store at controlled room temperature, protected from heat.
Container Keep in the original container with the cap tightly closed.
Safety Must be stored out of the sight and reach of children.

Disposal Instructions

Unused or expired product should be disposed of via a drug take-back program. If this is unavailable, the official method involves mixing the product with an undesirable substance, such as used coffee grounds or dirt, sealing the mixture in a container, and discarding it in the household trash. The supplement must not be flushed down the toilet.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

Equivalent of Chrome found in:

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