Components:
Medically reviewed by Militian Inessa Mesropovna, PharmD. Last updated on 26.06.2023
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Cetrimide is a quaternary ammonium compound used as a detergent and having powerful antiseptic properties, for sterilizing surgical instruments, cleaning wounds, etc.
Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. It is a waxy, crystalline substance, clear or white in color, which is solid at room temperature and melts slightly above. The main form of menthol occurring in nature is (-)-menthol, which is assigned the (1R,2S,5R) configuration. Menthol has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation.
Shampoo: Permethrin contains 1% w/w permethrin (10 mg/g).
Lotion: Permethrin contains 5% w/w permethrin (50 mg/g).
Cetrimide is indicated for the treatment of primitively bacterial skin diseases or diseases subject to superinfection.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
Oral
Nasal congestion; Throat irritation
Adult: As a loz (usually in combination with eucalyptus oil or cetylpyridinium chloride): 1 loz every 3 hr, to be sucked slowly.
Child: >6 yr: As a lozenge (usually in combination with eucalyptus oil or cetylpyridinium chloride): 1 lozenge every 3 hr, to be sucked slowly.
Topical/Cutaneous
Muscular aches and pains
Adult: As an ointment/cream (usually in combination with camphor, clove oil or methyl salicylate): Apply and rub gently onto the affected skin areas 2-3 times daily.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Permethrin (permethrin) Cream 5% is indicated for the treatment of infestation with Sarcoptes scabiei (scabies).
Relieving minor pain caused by conditions such as arthritis, backache, bruising, bursitis, cramping, muscle strains or sprains, and tendonitis. It may also be used for other conditions as determined by your doctor.
Menthol is a topical analgesic. It works by temporarily relieving minor pain.
Permethrin is an anti-parasite medication.
Permethrin topical (for the skin) is used to treat head lice and scabies.
Permethrin topical may also be used for other purposes not listed in this medication guide.
Topical/Cutaneous
Wound cleansing
Adult: Apply 0.1-1% aqueous solution or 0.5% cream onto affected area.
Incompatibility: Incompatible with soaps and other anionic surfactants, bentonite, iodine, phenylmercuric nitrate and alkali hydroxides.
Topical/Cutaneous
Seborrhoeic dermatitis
Adult: Apply 10% shampoo solution onto the scalp.
Incompatibility: Incompatible with soaps and other anionic surfactants, bentonite, iodine, phenylmercuric nitrate and alkali hydroxides.
Oral
Nasal congestion; Throat irritation
Adult: As a loz (usually in combination with eucalyptus oil or cetylpyridinium chloride): 1 loz every 3 hr, to be sucked slowly.
Child: >6 yr: As a lozenge (usually in combination with eucalyptus oil or cetylpyridinium chloride): 1 lozenge every 3 hr, to be sucked slowly.
Topical/Cutaneous
Muscular aches and pains
Adult: As an ointment/cream (usually in combination with camphor, clove oil or methyl salicylate): Apply and rub gently onto the affected skin areas 2-3 times daily.
Usual Adult Dose for Scabies
Permethrin topical 5% cream:
Thoroughly massage into the skin from the neck to the soles of the feet. The cream should be removed by washing (shower or bath) after 8 to 14 hours.
Usual Adult Dose for Lice
Permethrin topical 1% kit:
Apply lotion/creme rinse to shampooed and towel-dried hair until hair and scalp are saturated (especially behind the ears and on the nape of the neck). Leave on hair for 10 minutes and rinse with water. Use comb and/or gloves provided to remove remaining nits.
Permethrin topical 1% solution:
Apply to shampooed and towel-dried hair until hair and scalp are saturated (especially behind the ears and on the nape of the neck). Leave on hair for 10 minutes and rinse with water.
Usual Pediatric Dose for Scabies
Permethrin topical 5% cream
Infants: Thoroughly massage along the hairline, neck, temple, and forehead. The cream should be removed by washing after 8 to 14 hours.
Usual Pediatric Dose for Lice
Permethrin topical 1% kit:
2 months or older: Apply lotion/creme rinse to shampooed and towel-dried hair until hair and scalp are saturated (especially behind the ears and on the nape of the neck). Leave on hair for 10 minutes and rinse with water. Use comb and/or gloves provided to remove remaining nits.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
For external use only. Avoid contact with the eyes and mucous membranes. If contact occurs, wash the area thoroughly with water.
Usually 30 grams of Permethrin is sufficient for an average adult.
Scabies rarely infest the scalp of adults, although the hairline, neck, temple, and forehead may be infested in geriatric patients and infants.
One application is generally curative. A second treatment of Permethrin may be given for patients that present with live lice 7 days after the initial treatment.
Patients may experience persistent pruritus after treatment for scabies. Demonstrable living mites after 14 days indicate retreatment is necessary.
Safety and efficacy in children under the age of 2 months have not been established.
Dialysis
Data not available
Other Comments
Concomitant treatment of individuals in the household is recommended to avoid reinfestation. Thorough cleaning of all clothing and bedding is required once treatment has begun.
For proper head lice management, nits should be removed with a nit comb.
Application on the mucous membranes especially genital mucous membranes (risk of balanitis and erosive vaginitis).
- Hypersensitivity to one of the constituents, in particular to the derivatives of quaternary ammoniums and to paraben.
- This product must not come in contact with eyes, brain, meninges, or penetrate the otic cavity in case of tympanic perforation.
- Infants who have previously experienced convulsions with or without fever (due to the terpene derivatives present in the excipients).
See also:
What is the most important information I should know about Menthol?
Not to be used in
No known conditions.
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
See also:
What is the most important information I should know about Permethrin?
Permethrin Lotion is contraindicated for premature neonates because their skin may be more permeable than full term infants and their liver enzymes may not be sufficiently developed. It is also contraindicated for patients with Norwegian (crusted) scabies due to possible increased absorption. It is also contraindicated for patients with known seizure disorders and for individuals with a known sensitivity to the product or any of its components.
Use Menthol as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Wash your hands before and right after using Menthol.
- Spray Menthol directly onto the affected area. Do not rub or massage the medicine into the skin.
- Do not wrap, bandage, or use a heating pad on the treated area.
- Do not apply Menthol more than 4 times daily.
- If you miss a dose of Menthol, use it as soon as you remember. Continue to use it as directed by your doctor or on the package label.
Ask your health care provider any questions you may have about how to use Menthol.
Use Permethrin as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Before using, wash hair with regular shampoo and towel dry.
- Permethrin is for external use only. Do not get Permethrin in the eyes. Keep eyes closed until Permethrin is rinsed out of the hair. If using Permethrin on a child, cover the eyes with a washcloth or towel.
- Apply enough of Permethrin to saturate hair and scalp, especially behind the ears and on the nape of the neck. Leave on hair for 10 minutes, but no longer. Rinse with water.
- If live lice are observed after 7 days or more after the first application, treat hair and scalp a second time.
- Head lice live on the scalp and lay small white eggs (nits) on the hair close to the scalp. For proper head lice management, remove eggs with the comb provided.
- All personal headgear, scarves, coats, and bed linen should be disinfected by machine washing in hot water and drying. Use the hot cycle of a dryer for at least 20 minutes.
- Personal articles of clothing or bedding that cannot be washed or dried by machine may be dry cleaned, sealed in a plastic bag for a period of about 2 weeks, or sprayed with a product specifically designed for this purpose.
- Personal combs and brushes may be disinfected by soaking in hot water above 130 degrees F (54 degrees C) for 5 to 10 minutes.
- Thoroughly vacuum rooms, including furniture, of individuals infected with lice.
- If you miss a dose of Permethrin, use it as soon as you remember. Continue to use it as directed by your doctor.
Ask your health care provider any questions you may have about how to use Permethrin.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Cetrimide protects and heals infection of cuts, grazes, insect bite, minor burns and wounds.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Pharmaceutical Aid
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.This medication is used to treat scabies, a condition caused by tiny insects called mites that infest and irritate your skin. Permethrin belongs to a class of drugs known as pyrethrins. Permethrin works by paralyzing and killing the mites and their eggs.
How to use Permethrin topical
This medication is for use on the skin only. Apply this medication as soon as possible after it is prescribed. Apply the medicine from your head to the soles of your feet, including under your nails and in skin folds such as between the toes, as directed. Massage the cream into the skin. Do not use more medication than prescribed. Wash off the cream after 8-14 hours by showering or taking a bath.
Avoid getting the cream into your eyes, nose, mouth, or vagina. If the medication gets in your eyes, flush the eyes with plenty of water. Consult your doctor if irritation persists.
Symptoms of scabies include an intense itching that is usually worse at bedtime. You may also see small, fine, wavy lines on the skin with a tiny insect at the end (a burrow). Burrows are usually found on finger/toe webs, wrists, elbows, armpits, belt line, lower buttocks, female nipples, or male genitals. Even if permethrin kills all the scabies, the dead mites can still make you itch for up to 4 weeks after treatment. Ask your doctor about other medications that may be used to soothe the itching. Inform your doctor if your condition persists or worsens 2 weeks after treatment. Your doctor may need to look for living mites and recommend more treatment.
The quaternary ammoniums are incompatible with soaps and anionic compounds.
-The quaternary ammoniums are inactive in the presence of cellulose and cotton fibers.
Tell your doctor of any over-the-counter or prescription medication you may take including: blood thinners.
Do not start or stop any medicine without doctor or pharmacist approval.
See also:
What other drugs will affect Permethrin?
Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.
Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
Chlorhexidine and Cetrimide Irrigation Solution helps most people when used for washing and cleansing the skin or wounds, but it may have some unwanted side-effects in a few people.
All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.
Tell your doctor if you experience a skin rash or reaction. If you get a skin rash it may be because you have had an allergic reaction to the irrigation. If this is the case, you should no longer use this irrigation.
Tell your doctor, nurse or pharmacist as soon as possible if you feel anything unusual during or after Chlorhexidine and Cetrimide Irrigation Solution has been used.
See also:
What are the possible side effects of Menthol?
May cause hypersensitivity reactions such as cutaneous dermatitis. Ingestion of large amount of menthol may cause GI effects such as severe abdominal pain, nausea, vomiting, vertigo, ataxia, drowsiness and coma.
See also:
What are the possible side effects of Permethrin?
In clinical trials, generally mild and transient burning and stinging followed application with Permethrin, 5% in 10% of patients and was associated with the severity of infestation. Pruritus was reported in 7% of patients at various times post-application. Erythema, numbness, tingling, and rash were reported in 1 to 2% or less of patients. Other adverse events reported since marketing Permethrin, 5% include: headache, fever, dizziness, abdominal pain, diarrhea and nausea and/or vomiting. Although extremely uncommon and not expected when used as directed, rare occurrences of seizure have been reported. None have been medically confirmed as associated with Permethrin, 5% treatment.