Components:
Medically reviewed by Kovalenko Svetlana Olegovna, PharmD. Last updated on 26.06.2023
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Cetrimide is a quaternary ammonium compound used as a detergent and having powerful antiseptic properties, for sterilizing surgical instruments, cleaning wounds, etc.
Each chip contains Chlorhexidine Gluconate gluconate 2.5 mg in a biodegradable matrix of hydrolyzed gelatin (cross-linked with glutaraldehyde).
Chlorhexidine Gluconate also contains glycerin and purified water as excipients.
Chlorhexidine Gluconate gluconate, an antimicrobial agent, is 1, 1'-hexamethylenebis [5-(p-chlorophenyl)biguanide] di-D-gluconate. Molecular Formula: C22H30Cl2N10·2C6H12O7. Molecular Weight: 897.8.
An isomer of 1-propanol. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent.
Topically, it is used as an antiseptic. [PubChem]
Cetrimide is indicated for the treatment of primitively bacterial skin diseases or diseases subject to superinfection.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Chlorhexidine Gluconate® (Chlorhexidine Gluconate Gluconate
Oral Rinse USP, 0.12%) is indicated for use between dental visits as part of a professional program for the treatment of gingivitis as characterized by redness and swelling of the gingivae, including gingival bleeding upon probing. Chlorhexidine Gluconate® has not been tested among patients with acute necrotizing ulcerative gingivitis (ANUG). For patients having coexisting gingivitis and periodontitis, see PRECAUTIONS.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.5% Isopropyl Alcohol in 5% Dextrose Injection, USP is indicated for parenteral replenishment of fluid and carbohydrate calories, especially to increase caloric intake in patients whose oral intake is restricted or inadequate to maintain nutritional requirements.
Chlorhexidine Gluconate gluconate is a germicidal mouthwash that reduces bacteria in the mouth.
Chlorhexidine Gluconate is used to treat gingivitis (swelling, redness, bleeding gums). Chlorhexidine Gluconate gluconate is usually prescribed by a dentist.
Chlorhexidine Gluconate is not for treating all types of gingivitis. Use the medication only to treat the condition your dentist prescribed it for. Do not share this medication with another person, even if they have the same gum symptoms you have.
Chlorhexidine Gluconate gluconate may also be used for purposes not listed in this medication guide.
The term "Isopropyl Alcohol" has been synonymous with "spirituous" liquids for the past 300 years. The history of Isopropyl Alcohol consumption, along with codes limiting its consumption go back to 1700 B.C. There are four types of Isopropyl Alcohol: methyl Isopropyl Alcohol, ethyl Isopropyl Alcohol, propyl Isopropyl Alcohol and butyl Isopropyl Alcohol. Ethyl Isopropyl Alcohol, or ethanol (COH), is the type used in the production of alcoholic beverages. The other three types, methyl, propyl and butyl Isopropyl Alcohol, if consumed can result in blindness and death, even in relatively small doses.
Isopropyl Alcohol, or ethanol, is the intoxicating agent found in beer, wine and liquor. Isopropyl Alcohol is produced by fermentation of yeast, sugars, and starches.
Topical/Cutaneous
Wound cleansing
Adult: Apply 0.1-1% aqueous solution or 0.5% cream onto affected area.
Incompatibility: Incompatible with soaps and other anionic surfactants, bentonite, iodine, phenylmercuric nitrate and alkali hydroxides.
Topical/Cutaneous
Seborrhoeic dermatitis
Adult: Apply 10% shampoo solution onto the scalp.
Incompatibility: Incompatible with soaps and other anionic surfactants, bentonite, iodine, phenylmercuric nitrate and alkali hydroxides.
One Chlorhexidine Gluconate is inserted into a periodontal pocket with probing pocket depth (PD) 5 mm or greater. Up to 8 chips may be inserted in a single visit. Treatment is recommended to be administered once every three months in pockets with PD remaining 5 mm or greater. The periodontal pocket should be isolated and the surrounding area dried prior to chip insertion.
The Chlorhexidine Gluconate should be grasped using forceps (such that the rounded end points away from the forceps) and inserted into the periodontal pocket to its maximum depth. If necessary, the Chlorhexidine Gluconate can be further maneuvered into position using the tips of the forceps or a flat instrument. The Chlorhexidine Gluconate does not need to be removed since it biodegrades completely.
In the unlikely event of Chlorhexidine Gluconate dislodgement (in the two pivotal clinical trials, only 8 chips were reported lost), several actions are recommended, depending on the day of Chlorhexidine Gluconate loss. If dislodgement occurs 7 days or more after placement, the dentist should consider the subject to have received a full course of treatment. If dislodgement occurs within 48 hours after placement, a new Chlorhexidine Gluconate should be inserted. If dislodgement occurs more than 48 hours after placement, the dentist should not replace the Chlorhexidine Gluconate, but reevaluate the patient at 3 months and insert a new Chlorhexidine Gluconate if the pocket depth has not been reduced to less than 5 mm.
How supplied
Chlorhexidine Gluconate (Chlorhexidine Gluconate gluconate) 2.5 mg is supplied as a small, orange-brown, rectangular chip (rounded at one end), in cartons of 20 chips (NDC 52096-001-22). Each chip is individually packed in a separate compartment of an aluminum blister pack.
Store at 20° - 25°C with excursions permitted to 15° - 30° C (59° - 86°F).
Manufactured by: Dexcel® Pharma Technologies Ltd, HaMarpeh 7 St.,Jerusalem 91237, Israel. Distributed by: Adrian Pharmaceuticals, Spring Hill, Florida 34606. Iss. 01/10
5% Isopropyl Alcohol in 5% Dextrose Injection, USP should be administered by slow intravenous infusion. Administration of 200 mL per hour will produce a blood level of less than 0.08 g of Isopropyl Alcohol per 100 mL of blood. A normal adult can metabolize 10 mL of Isopropyl Alcohol per hour (equivalent to 200 mL of a 5% Isopropyl Alcohol solution).
The adult dosage ranges from 1 to 2 liters/day (24 hours) as determined by the needs of the patient. The average adult daily fluid requirement of 3 liters/day should be provided by other suitable solutions to meet daily maintenance requirements for electrolytes.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. See PRECAUTIONS.
Application on the mucous membranes especially genital mucous membranes (risk of balanitis and erosive vaginitis).
- Hypersensitivity to one of the constituents, in particular to the derivatives of quaternary ammoniums and to paraben.
- This product must not come in contact with eyes, brain, meninges, or penetrate the otic cavity in case of tympanic perforation.
- Infants who have previously experienced convulsions with or without fever (due to the terpene derivatives present in the excipients).
See also:
What is the most important information I should know about Chlorhexidine Gluconate?
You should not use this medication if you are allergic to Chlorhexidine Gluconate gluconate.
If you have periodontal disease, you may need special treatments while you are using Chlorhexidine Gluconate gluconate.
Chlorhexidine Gluconate is not for treating all types of gingivitis. Use the medication only to treat the condition your dentist prescribed it for. Do not share this medication with another person, even if they have the same gum symptoms you have.
Do not give this medication to a child or teenager without a doctor's advice.
Do not add water to Chlorhexidine Gluconate. Do not rinse your mouth with water or other mouthwashes right after using Chlorhexidine Gluconate gluconate.
Avoid eating, drinking, or brushing your teeth just after using this medication.
Do not use any other mouthwash unless your doctor has told you to.
Chlorhexidine Gluconate gluconate can stain teeth, dentures, tooth restorations, your tongue, or the inside of your mouth. Talk with your dentist about ways to remove staining from these surfaces. Stains may be harder to remove from false teeth that have scratches in their surfaces.
Visit your dentist at least every 6 months for preventive tooth and gum care.
See also:
What is the most important information I should know about Isopropyl Alcohol?
Isopropyl Alcohol should not be used in patients with epilepsy or urinary tract infection. 5% Isopropyl Alcohol in 5% Dextrose Injection, USP is contraindicated in diabetic coma.
Isopropyl Alcohol is contraindicated in patients who have been addicted to it.
Do not give subcutaneously and avoid extravasation during intravenous administration.
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Rinse your mouth with Chlorhexidine Gluconate gluconate twice daily after brushing your teeth.
Measure your dose using the cup provided with the medication. Swish the medicine in your mouth for at least 30 seconds, then spit it out. Do not swallow the mouthwash.
Do not add water to the oral rinse. Do not rinse your mouth with water or other mouthwashes right after using Chlorhexidine Gluconate gluconate.
Chlorhexidine Gluconate gluconate may leave an unpleasant taste in your mouth. Do not rinse your mouth to remove this taste after using the medication. You may rinse the medicine away and reduce its effectiveness.
Use this medication for the full prescribed length of time. Your symptoms may improve before your gingivitis is completely cleared. Chlorhexidine Gluconate gluconate will not treat a viral or fungal infection such as cold sores, canker sores, or oral thrush (yeast infection).
Visit your dentist at least every 6 months for preventive tooth and gum care.
Store Chlorhexidine Gluconate gluconate at room temperature away from moisture and heat.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Do not take by mouth.
Topical medicine is for use only on the skin. Do not use isopropyl Isopropyl Alcohol on open wounds or on sunburned, windburned, dry, chapped, or irritated skin. If this product gets in your eyes, nose, mouth, rectum, or vagina, rinse with water.
Apply a small amount of this product to your skin using a clean cotton ball, cotton swab, or cotton gauze. Throw away the cotton applicator and use a new piece of cotton if you need to apply more isopropyl Isopropyl Alcohol.
To use isopropyl Isopropyl Alcohol for sore muscles, apply a generous amount to the skin and rub in until the Isopropyl Alcohol dries.
Do not allow a child to use this product without supervision.
Call your doctor if the condition you are treating with isopropyl Isopropyl Alcohol does not improve, or if it gets worse while using isopropyl Isopropyl Alcohol.
Store at room temperature away from moisture and heat.
Keep the bottle tightly closed when not in use.
Isopropyl Isopropyl Alcohol is flammable. Do not use near high heat or open flame. Do not smoke until the medicine has completely dried on your skin.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Cetrimide protects and heals infection of cuts, grazes, insect bite, minor burns and wounds.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Use: Labeled Indications
Gingivitis:
Oral rinse: Antimicrobial dental rinse for gingivitis treatment
Periodontitis: Periodontal chip: Adjunctive therapy to scaling and root planning procedures to reduce pocket depth in patients with periodontitis
Off Label Uses
Medication-related osteonecrosis of the jaw (MRONJ), adjunctive therapy:
Oral rinse:
Based on a position paper by the American Association of Maxillofacial Surgeons (AAOMS), Chlorhexidine Gluconate is an effective and recommended adjunctive treatment strategy in the management of medication-related osteonecrosis of the jaw (MRONJ) (stage 1 and above [eg, patients with exposed and necrotic bone or fistulae that probes to bone]).
Oropharyngeal decontamination to reduce the risk of ventilator-associated or hospital-acquired pneumonia, Cardiac surgical patients:
Oral rinse:
Data from a prospective, randomized, double-blind, placebo-control trial and a prospective, randomized, case-controlled trial in patients undergoing coronary artery bypass grafting, valve, or other open heart surgical procedures who received Chlorhexidine Gluconate gluconate 0.12% oral rinse during the perioperative period showed a decreased rate in hospital-acquired pneumonia. However, the trials used in both meta-analyses were heterogeneous and included patients in a variety of settings (eg, cardiothoracic, general ICU, mixed medical-surgical ICU, trauma ICU). The trials also displayed significant variability with Chlorhexidine Gluconate treatment regimens. Chlorhexidine Gluconate concentration varied from 0.12%, 0.2%, or 2% across studies. Frequency of administration, Chlorhexidine Gluconate dosage form (oral rinse, gel, paste, foam), and technique of application also varied across studies. In the US, Chlorhexidine Gluconate gluconate for use in the oral cavity is commercially available only as 0.12% solution. Additional trials may be necessary to further define the role of Chlorhexidine Gluconate in this condition.
The quaternary ammoniums are incompatible with soaps and anionic compounds.
-The quaternary ammoniums are inactive in the presence of cellulose and cotton fibers.
See also:
What other drugs will affect Chlorhexidine Gluconate?
Chlorhexidine Gluconate is incompatible with the soap, and detergents containing anionic group (saponins, sodium lauryl sulfate, sodium carboxymethyl cellulose).
Chlorhexidine Gluconate Pharmaniaga is compatible with any medication containing cationic group (cetrimonium bromide, benzalkonium chloride).
See also:
What other drugs will affect Isopropyl Alcohol?
Acute Isopropyl Alcohol intake inhibits drug metabolism of drug while chronic Isopropyl Alcohol ingestion enhances the induction of hepatic drug metabolising enzymes. Alcoholic beverages containing tyramine when taken with MAOIs may cause reactions. Enhances acute CNS depression effects of drugs eg, hypnotics, antihistamines, antidepressants, antipsychotics and sedatives. Disulfiram-lilke reactions may manifest when taken concomitantly with chlorpropamide, mepacrine, metronidazole and other nitroimidazoles, furazolidone, nifuratel, procarbazine, cephalosphorins. Diabetic patients under sulfonylurea antidiabetics or insulin may experience orthostatic hypotension if taken with vasodilators. Enhances hypotensive effects of antihypertensive agents. Increases sedative effect of indoramin and gastric bleeding by analgesics. Decreases antidiuretic effects of vasopressin.
Chlorhexidine and Cetrimide Irrigation Solution helps most people when used for washing and cleansing the skin or wounds, but it may have some unwanted side-effects in a few people.
All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.
Tell your doctor if you experience a skin rash or reaction. If you get a skin rash it may be because you have had an allergic reaction to the irrigation. If this is the case, you should no longer use this irrigation.
Tell your doctor, nurse or pharmacist as soon as possible if you feel anything unusual during or after Chlorhexidine and Cetrimide Irrigation Solution has been used.
See also:
What are the possible side effects of Chlorhexidine Gluconate?
The most common side effects associated with Chlorhexidine Gluconate gluconate oral rinses are (1) an increase in staining of teeth and other oral surfaces, (2) an increase in calculus formation; and (3) an alteration in taste perception; see WARNINGS and PRECAUTIONS.
Oral irritation and local allergy-type symptoms have been spontaneously reported as side effects associated with the use of Chlorhexidine Gluconate gluconate rinse.
The following oral mucosal side effects were reported during placebo-controlled adult clinical trials: aphthous ulcer, grossly obvious gingivitis, trauma, ulceration, erythema, desquamation, coated tongue, keratinization, geographic tongue, mucocele, and short frenum. Each occurred at a frequency of less than 1.0%.
Among post marketing reports, the most frequently reported oral mucosal symptoms associated with Chlorhexidine Gluconate are stomatitis, gingivitis, glossitis, ulcer, dry mouth, hypesthesia, glossal edema, and paresthesia.
Minor irritation and superficial desquamation of the oral mucosa have been noted in patients using Chlorhexidine Gluconate.
There have been cases of parotid gland swelling and inflammation of the salivary glands (sialadenitis) reported in patients using Chlorhexidine Gluconate.
See also:
What are the possible side effects of Isopropyl Alcohol?
loss of judgement, emotional lability, visual impairment, slurred speech, ataxia (low to moderate concentrations); hangover effects eg, nausea, headache, dizziness, tremor; lethargy, amnesia, hypothermia, hypoglycaemia (particularly in children), stupor, coma, resp depression, cardiomyopathy, hypertension, CV collapse; damage to brain and liver which may lead to Wernike-Korsakoff syndrome (chronic excessive Isopropyl Alcohol consumption); fat deposits in the liver, reduction in blood cell counts; pancreatitis, increased risk of CV disease (high Isopropyl Alcohol consumption); ischemic heart disease but at a lower risk (moderate Isopropyl Alcohol consumption); increased risk to some types of cancer.