Cetoconazol+Dip Beta+Sul Neo Medley

Ketoconazole (Cetoconazol+Dip Beta+Sul Neo Medley) Tablets are indicated for the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.

Ketoconazole (Cetoconazol+Dip Beta+Sul Neo Medley) Tablets should not be used for fungal meningitis because it penetrates poorly into the cerebral-spinal fluid.

Ketoconazole (Cetoconazol+Dip Beta+Sul Neo Medley) Tablets are also indicated for the treatment of patients with severe recalcitrant cutaneous dermatophyte infections who have not responded to topical therapy or oral griseofulvin, or who are unable to take griseofulvin.

Topical treatment of tinea corporis, tinea cruris, tinea pedis, pityriasis versicolor & cutaneous candidiasis. Treatment & prevention of relapse of fungal skin infections eg dandruff, seborrhoeic dermatitis & pityriasis versicolor.

Not to be used in

* Acne vulgaris

* Allergy to this medicine or similar medicines

* Bacterial skin infections

* Children under 12 years of age

* Chronic inflammatory disorder of the facial skin (acne rosacea)

* Inflammatory rash around the mouth (perioral dermatitis)

* Nappy rash

* Viral skin infections such as chickenpox or herpes simplex

Ketoconazole (Cetoconazol+Dip Beta+Sul Neo Medley) is a potent inhibitor of the cytochrome P450 3A4 enzyme system. Coadministration of Ketoconazole (Cetoconazol+Dip Beta+Sul Neo Medley) Tablets and drugs primarily metabolized by the cytochrome P450 3A4 enzyme system may result in increased plasma concentrations of the drugs that could increase or prolong both therapeutic and adverse effects.

Ketoconazole (Cetoconazol+Dip Beta+Sul Neo Medley) Tablets inhibit the metabolism of terfenadine, resulting in an increased plasma concentration of terfenadine.

Ketoconazole (Cetoconazol+Dip Beta+Sul Neo Medley) inhibits the metabolism of astemizole. Ketoconazole (Cetoconazol+Dip Beta+Sul Neo Medley) potently inhibits the metabolism of cisapride resulting in a mean eight-fold increase in AUC of cisapride.

Ketoconazole (Cetoconazol+Dip Beta+Sul Neo Medley) Tablets may alter the metabolism of cyclosporine, tacrolimus, and methylprednisolone, resulting in elevated plasma concentrations of the latter drugs.

Coadministration of Ketoconazole (Cetoconazol+Dip Beta+Sul Neo Medley) Tablets with midazolam or triazolam has resulted in elevated plasma concentrations of the latter two drugs.

It is, therefore, advisable to monitor digoxin concentrations in patients receiving Ketoconazole (Cetoconazol+Dip Beta+Sul Neo Medley).

When taken orally, imidazole compounds like Ketoconazole (Cetoconazol+Dip Beta+Sul Neo Medley) may enhance the anticoagulant effect of coumarin-like drugs.

a potential interaction involving the latter agents when used concomitantly with Ketoconazole (Cetoconazol+Dip Beta+Sul Neo Medley) Tablets (an imidazole) can not be ruled out.

Concomitant administration of Ketoconazole (Cetoconazol+Dip Beta+Sul Neo Medley) Tablets with phenytoin may alter the metabolism of one or both of the drugs.

Concomitant administration of rifampin with Ketoconazole (Cetoconazol+Dip Beta+Sul Neo Medley) Tablets reduces the blood levels of the latter. INH (isoniazid) is also reported to affect Ketoconazole (Cetoconazol+Dip Beta+Sul Neo Medley) concentrations adversely.

In rare cases, anaphylaxis has been reported after the first dose. However, the most frequent adverse reactions were nausea and/or vomiting in approximately 3%, abdominal pain in 1.2%, pruritus in 1.5%, and the following in less than 1% of the patients: headache, dizziness, somnolence, fever and chills, photophobia, diarrhea, gynecomastia, impotence, thrombocytopenia, leukopenia, hemolytic anemia, and bulging fontanelles. In contrast, the rare occurrences of hepatic dysfunction require special attention. Skin irritation-burning sensation, pruritus, dermatitis Rarely, local burning sensation, itch, irritation, oily/dry hair & scalp, increased hair loss, abnormal hair texture, scalp pustules.