Cefasel

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Cefasel

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Cefasel

Quick Facts

Property Description
Active ingredient Sodium Selenite (INN)
Form Tablet (Oral solid dosage form)
Pharmacological class Mineral Supplement (Trace Element)
Common use Support for cellular defense and metabolic function
Origin Inorganic chemical compound

What Type of Preparation is Cefasel?

Cefasel is a branded pharmaceutical preparation and a Mineral Supplement, classified under the Selenium group (ATC Code A12CE02, for oral use). Manufactured by Cefak KG (Germany), the preparation is a single active ingredient product focused on mineral supplementation. It is provided as an oral tablet and is generally available over-the-counter (OTC) for adults seeking daily nutritional support. This classification establishes its role in metabolic maintenance rather than acute disease intervention.

Composition and Origin of the Active Ingredient

The sole active component of Cefasel is the inorganic chemical compound Sodium Selenite (INN). This substance is highly water-soluble and is utilized as a direct source of the essential trace element Selenium (Se). As an inorganic chemical compound, Sodium Selenite is a defined, non-yeast-based salt that the body can reduce and integrate into its protective systems.

General Purpose: Supporting Cellular Defense

The general purpose of Cefasel is to support the body’s intrinsic antioxidant defense mechanisms, which are important for maintaining tissue health. Selenium is required for the synthesis of key protective enzymes, such as glutathione peroxidase. These antioxidant enzymes play a role in preventing cell damage from oxidative stress. By ensuring an adequate supply of this essential nutrient, the preparation promotes cell protection and supports normal physiological processes, particularly the immune system and thyroid function.

Regulatory References

  1. MedlinePlus, NIH

What side effects are possible with Cefasel?

Possible Side Effects and Safety Information

The safety profile for sodium selenite preparations, such as Cefasel, is primarily defined by the risk of selenium toxicity, known as selenosis, which occurs from acute or chronic overdose rather than standard use for a proven deficiency. When administered to correct a deficiency, no adverse effects are typically expected.


Adverse Reactions from Toxicity

Adverse effects are categorized by the systems they affect, according to official regulatory documentation:

  • Skin and Subcutaneous Tissue disorders: Long-term excessive intake may lead to brittleness and loss of hair and nails.
  • Gastrointestinal disorders: Acute overdose can cause symptoms like nausea, diarrhoea, and abdominal pain.
  • Nervous System disorders: Chronic toxicity is associated with peripheral polyneuropathy.
  • General disorders: A common sign of excess selenium is a distinctive garlicky odor on the breath.

Safety Constraints and Special Populations

Regulatory documents include high-level safety constraints for the use of this trace element product:

  • Contraindications: Cefasel is officially contraindicated in individuals with a confirmed diagnosis of selenosis (selenium poisoning) or documented hypersensitivity to selenium-containing products.
  • Safety Margin: Selenium is recognized as having a narrow margin of safety between the essential dose required for metabolic function and toxic dose levels.
  • Pregnancy and Lactation: No adverse effects on the unborn child or infant are anticipated when the product is administered to treat a proven selenium deficiency.

Overdose and Emergency Response

Overdose and when to seek help

The official regulatory description of overdose for the active ingredient, Sodium Selenite, outlines both acute and chronic manifestations of selenium overexposure (Selenosis). Given the potential for severe health consequences, the guidance requires that an individual seek immediate medical attention upon suspicion of an overdose.

Documented Overdose Manifestations

Classification Signs and Symptoms (as listed in official sources)
Acute Toxicity Garlic odor on the breath, abdominal pain, nausea, vomiting, diarrhea, and extreme tiredness. Life-threatening complications, including circulatory collapse, acute respiratory distress, and renal failure, are documented in cases of severe acute intoxication.
Chronic Toxicity (Selenosis) Reversible hair loss (alopecia), brittle or deformed nails, and peripheral neuropathy.

Emergency Regulatory Actions

The profile for sodium selenite overdose is explicitly categorized as potentially life-threatening in cases of acute, high-level ingestion. Emergency management is described as symptomatic and supportive treatment, focusing on maintaining vital functions. Regulatory information confirms that no specific antidote is known for selenium toxicity. Procedures such as gastric lavage or the use of activated charcoal may be considered by medical professionals for acute ingestions. Monitoring of blood selenium levels and essential organ function is required during hospital observation.

The information above reflects the standardized, label-based overdose and emergency guidance provided by government health authorities (e.g., EMA/HPRA, NIH, FDA).

Therapeutic Uses of Cefasel

What Cefasel Treats: Main Uses and Benefits

Cefasel is a preparation containing the essential trace element selenium, typically used to help address a confirmed selenium deficiency. This element is utilized to help with systemic imbalance resulting from such a deficiency.

In clinical settings, Cefasel is applied in addressing conditions where functional stability becomes affected due to this deficiency, such as those related to malabsorption or nutritional deficit. It is relevant in contexts involving heightened systemic burden and is often used during phases when symptoms become more noticeable. It is commonly used when symptom clusters related to organ-specific functional stress, heightened physiological activity, or physical discomfort arise. This approach supports the patient during difficult episodes by easing distress and may help patients cope more steadily with symptom fluctuations.

“It is relevant for managing symptoms that interfere with daily comfort.”

Quick Fact: Support for Symptom Clusters (Applied when multiple symptoms occur together and require supportive relief.)

Eligibility and Restrictions for Use

The eligibility for using Cefasel, an oral sodium selenite preparation, is strictly defined by regulatory authorities based on a patient's clinical status, rather than general use.

Populations Who Must Not Use Cefasel

The medicine is contraindicated and must not be used by:

  • Patients with Selenosis (selenium poisoning).
  • Individuals with a known hypersensitivity or allergy to the active substance, sodium selenite pentahydrate, or any other components of the preparation.

Conditional Eligibility for Use

For all other populations, eligibility is strictly conditional upon medical confirmation of a proven selenium deficiency. Use is permitted only to correct this deficiency and not for general supplementation.

Population Category Eligibility Status (Regulatory Basis)
Pregnancy & Breastfeeding Use is permitted when correcting a proven deficiency, with no adverse effects expected on the fetus or infant.
Age Groups All age groups, including children, adolescents, and older adults, are eligible if a deficiency is confirmed.
Organ Impairment Patients with renal (kidney) or hepatic (liver) impairment are eligible for use without requiring a dose adjustment.

What should I know about interactions with other medicines?

Cefasel contains the active ingredient selenium in the form of sodium selenite. Interactions between selenium and other medicines or nutritional supplements have been documented in scientific literature and clinical databases.

Interacting Medicinal Product Categories

Category Interaction Description
Chemotherapy (e.g., Cisplatin) Some chemotherapy drugs may lower selenium levels in the body, although the clinical significance of this effect is not always fully established.
Other Trace Elements (e.g., Zinc) Selenium metabolism and function can be complexly interrelated with other essential trace elements, potentially affecting the body’s use of each.
Antioxidants (e.g., Vitamin C, Vitamin E) High-dose selenium, especially when combined with other antioxidant supplements, may have effects on overall antioxidant status, though specific high-level clinical interactions are not uniformly reported in regulatory documentation.

Clinical and Procedural Notes

  • Malabsorption Syndromes: In conditions that impair the absorption of nutrients from the gastrointestinal tract, the absorption of orally administered selenium may be decreased, potentially necessitating a dosage adjustment. This is a condition-specific constraint on the interaction and efficacy profile.
  • Renal Dysfunction: Since selenium and other trace elements are partially excreted by the kidneys, individuals with impaired kidney function may require a careful adjustment or omission of supplemental doses. Monitoring of selenium levels may be advised in this population.

Key Precaution

Patients should inform their healthcare provider about all prescription and non-prescription medicines, as well as any other dietary supplements or herbal products they are taking, to allow for a proper assessment of the potential for interactions.

Mechanism of Action

Core Mechanism: Cellular Cofactor Integration

The mechanism of Cefasel is centered on the provision of the essential trace element Selenium via Sodium Selenite, which acts as a fundamental cofactor for the body’s endogenous enzyme systems. Its primary action focuses on the synthesis and activation of the Glutathione Peroxidase (GPx) family and Thioredoxin Reductase (TrxR) enzymes. Selenium is precisely incorporated as selenocysteine into the catalytic site of these selenoproteins, enabling their functional capacity.

Pathway Modulation and Systemic Influence

By restoring the synthesis of functional enzymes, this mechanism facilitates the cell's capacity to catalyze the reduction of harmful Reactive Oxygen Species (ROS), such as hydrogen peroxide. This action directly contributes to the maintenance of cellular redox homeostasis. Furthermore, Selenium is required for the proper function of Deiodinases, which are enzymes critical for the peripheral conversion of thyroxine (T4) into the active thyroid hormone, triiodothyronine (T3). This fundamental cofactor role influences enzyme activity required for metabolic and immune signaling pathways.

Mechanistic Constraint

This cofactor mechanism is saturable. Once adequate selenium is present to synthesize the necessary selenoproteins, increasing the dose does not produce a continuous, linear increase in enzyme activity due to the limited synthesis capacity of the cell.

Dosage and Administration Information

How Cefasel is Used in Clinical Practice

Cefasel, a preparation containing the trace element Sodium Selenite, is administered according to standardized regimens. The method and frequency of use are defined by the patient's clinical status and the specific dosage form being utilized. The primary routes of administration include oral intake (via tablet or solution) for general use and parenteral routes, such as Intravenous (IV) or Intramuscular (IM) injection, for specialized clinical needs.


Standard Dosing and Frequency

Administration is typically given once daily. For adults with confirmed deficiency, the standard daily dose ranges from 100 µg to 200 µg selenium. For short-term correction, the dose may be increased up to 500 µg selenium daily, under monitoring. The duration of treatment is not based on a fixed timeline but continues until selenium levels in whole blood or serum are confirmed to be normalized through testing.


Contextual and Population-Specific Instructions

  • Oral Timing Constraint: Instructions require a time-separation rule: oral administration must be separated from intake of reducing substances, such as Vitamin C, by at least 4 hours.
  • Parenteral Preparation: Solutions intended for IV use are concentrated and must be diluted or prepared as an admixture in compatible infusion solutions prior to administration.
  • Pediatric Dosing: Dosage for children is calculated based on body weight, starting at 2 µg/kg/day and adjusted to a 1 µg/kg maintenance dose. No routine dosage adjustment is required for patients with renal or hepatic impairment.

Recent Clinical Evidence

Research evidence / Overview of studies for Cefasel

This overview summarizes the research evidence and study landscape for Sodium Selenite (Cefasel), focusing only on the findings reported in scientific and regulatory literature. This information is intended to describe the available research, not to provide medical advice or instructions for use.


Evidence for Deficiency and Thyroid Conditions

Research has explored the administration of sodium selenite in adult populations with confirmed selenium deficiency. Studies monitored immediate and short-term outcomes, such as changes in serum selenium levels and the activity of key antioxidant enzymes. Findings indicate that supplementation was associated with changes in these measured biological markers. This evidence contributes to the body of research related to this essential nutrient.

Research has also been conducted for conditions where research has explored selenium's role, such as autoimmune thyroiditis. Studies monitored immune biomarkers, specifically Thyroid Peroxidase Antibodies (TPOAb) levels. While studies reported a measurable change in TPOAb levels, corresponding changes in patient-reported outcomes or thyroid hormone replacement needed were mixed or inconsistent across various systematic reviews.


Study Limitations and Research Uncertainty

Research into the use of sodium selenite during severe, acute episodes like sepsis involved short-term Randomized Controlled Trials (RCTs). The findings were mixed concerning major clinical endpoints, including mortality rates, with some larger trials describing no clear patterns related to changes in patient outcomes. This variability across studies is often due to differences in patient selection and dosing protocols.

Follow-up durations were limited in many studies, meaning that long-term effects are not fully established, and evidence describing the durability of any observed response is often insufficient. Data for certain groups remain insufficient, including children, older adults without documented deficiency, and pregnant populations. The research landscape highlights that a consistent link between observed biomarker shifts and major clinical outcomes is not fully established.

Key Studies & References

  1. Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Frequently Asked Questions (FAQ)

Common questions about Cefasel (FAQ)


Q: How does Cefasel work to support the immune system?

A: Cefasel provides the essential trace element selenium, which acts as a key component, or cofactor, for the body's protective enzymes. By supporting the synthesis of these enzymes, Cefasel helps maintain cellular defense mechanisms. According to regulatory documents, this action supports normal physiological processes, including the proper function of the immune system.


Q: How is the selenium in Cefasel, which is sodium selenite, absorbed by the body?

A: Cefasel contains selenium in the form of sodium selenite, a highly water-soluble inorganic compound. Once ingested, this form is readily available for the body to use. It is metabolized into selenide, which the body then uses to synthesize vital selenoproteins for cellular protection.


Q: What is the connection between Cefasel and spermatogenesis?

A: Selenium, the element in Cefasel, is recognized in research as an essential trace element involved in the processes of sperm production (spermatogenesis). It is integrated into key selenoproteins that are vital for maintaining the structure and function of male reproductive cells.


Q: Is it normal to experience a laxative effect when taking Cefasel?

A: Regulatory information lists symptoms like nausea, diarrhoea, and abdominal pain as adverse effects associated with acute overdose or toxicity (selenosis). While these effects involve the digestive system, a mild laxative effect is not typically listed as a known or expected side effect when taking the standard therapeutic dose. Persistent symptoms may be a sign of excessive intake or toxicity.


Q: Are there any food or drinks that should be avoided while taking Cefasel?

A: Official instructions specify that oral administration of Cefasel must be separated from intake of reducing substances, such as Vitamin C, by at least four hours. This separation is required because concurrent intake of reducing substances can interfere with the availability of selenium. No specific warnings are generally given for other common foods or drinks.


Q: Does Cefasel interfere with any common medications like blood thinners or diabetes drugs?

A: Official product information specifically notes potential interactions with chemotherapy agents and other antioxidants. Individuals taking long-term medications, such as blood thinners or diabetes drugs, should ensure their healthcare provider is aware of all supplements to allow for a proper assessment of potential interactions.


Q: Can Cefasel be taken on an empty stomach?

A: Official product instructions provide a constraint on timing related to Vitamin C intake but do not specify whether the supplement must be taken with or without food. Guidance on optimal administration timing can be found by consulting the specific product packaging or a healthcare professional.


Q: Are there studies on Cefasel's role in oxidative stress protection?

A: Yes. Selenium is essential for enzymes like Glutathione Peroxidase, which help neutralize harmful Reactive Oxygen Species (ROS). The core mechanism involves selenium's role in the body's defense against damage from ROS, and research has explored selenium's impact on various biological markers related to oxidative stress.


Q: Can Cefasel be taken alongside a multivitamin that also contains selenium?

A: It is important to be aware of the total daily intake of selenium from all sources, including multivitamins and other supplements. This is necessary to avoid the risk of selenosis, or selenium toxicity. Your overall dosage is typically determined based on correcting a confirmed deficiency.


Q: Is it true that Cefasel can help with general hormonal balance?

A: Selenium's role is well-established in the body's hormonal system. Official information states that selenium is required for enzymes (Deiodinases) that convert inactive thyroid hormone (T4) into the active thyroid hormone (T3). This is its most recognized influence on hormonal function.


Q: What are the research-backed benefits for Cefasel beyond the immune system?

A: Studies have investigated the use of sodium selenite in adult populations with confirmed selenium deficiency, autoimmune thyroiditis (monitoring TPOAb levels), and in the context of severe, acute episodes like sepsis. This research informs the understanding of this essential nutrient.


Q: Can Cefasel cause a garlic-like odor in the breath or sweat?

A: According to official regulatory documents, a distinctive garlic-like odor on the breath or sweat is listed as a common sign of excessive selenium intake or chronic toxicity, known as selenosis. This sign is associated with excessive selenium intake or chronic toxicity.


Q: How does Cefasel compare to selenium yeast supplements?

A: Cefasel contains the inorganic form of selenium, known as Sodium Selenite, which is a highly water-soluble, non-yeast based salt. This differs from organic forms like selenomethionine, which is the predominant form typically found in selenium-enriched yeast supplements.


Q: Is Cefasel considered a drug or a dietary supplement?

A: Cefasel is classified as a branded pharmaceutical preparation and a Mineral Supplement by the World Health Organization (WHO). While it is often marketed over-the-counter for nutritional support, the high-dose forms used to correct severe deficiencies in hospital settings may be classified as prescription-only drugs, depending on the country.


Q: Are there different strengths or concentrations of Cefasel available?

A: Official product information for sodium selenite preparations indicates that different strengths and dosage forms may be available, which are used to address a confirmed deficiency. These are intended to provide the necessary amount of selenium.


Q: Does Cefasel contain common allergens like lactose or gluten?

A: Regulatory documents list all inactive ingredients, or excipients, in the product. The full list of inactive ingredients (excipients) is available in the official package leaflet or Summary of Product Characteristics, which can be consulted for information on specific allergens like lactose or gluten.


Q: Is Cefasel something you take for a short time, or is it meant for long-term use?

A: The duration of treatment is not based on a fixed timeline. According to official product information, supplementation is continued until selenium levels in whole blood or serum are confirmed to be normalized through testing. There is no set time limit for appropriate supplementary doses.


Q: Why do some sources list Cefasel as prescription-only and others as a supplement?

A: The specific regulatory status of selenium preparations can vary between countries and jurisdictions. While Cefasel is marketed as an over-the-counter mineral supplement in some regions, the high-dose forms used to correct severe deficiencies in clinical settings may be classified as prescription-only drugs.


Q: Does Cefasel need to be stored in a specific way, like away from light or heat?

A: Official storage instructions require that the product be kept in the original package, tightly closed to protect it from moisture, and stored in a cool place, typically not above 25 , C. This is to maintain the stability of the product.


Q: Can taking Cefasel affect the results of a thyroid lab test?

A: Selenium is a required element for the enzymes that help convert the inactive thyroid hormone (T4) into the active form (T3). While research indicates it may influence the activity of selenium-dependent enzymes, studies have not established a consistent direct effect on standard blood levels of thyroid hormones.

How should Cefasel be stored and disposed of?

Official Storage and Disposal Instructions

Cefasel (Sodium Selenite) must be stored strictly according to the conditions listed in the official regulatory documents.

Requirement Area Regulatory Statement
Storage Temperature Store in a cool and well-ventilated place, typically not above 25°C (room temperature).
Protection & Packaging The container must be kept tightly closed in the original package to protect from moisture.
Child Safety The medicine must be kept out of the sight and reach of children.
Disposal Unused or expired Cefasel must be disposed of in accordance with local requirements to an approved waste plant.

Disposal must not involve throwing the medicine into household waste or flushing it down a toilet or drain, as the active substance is classified as very toxic to aquatic life.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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