Cedan

Cedan Cedan is an anti-histaminic drug which is mainly used for the control of vomiting due to motion sickness. Cedan Cedan was first synthesized by Janssen Pharmaceutica in 1955t acts by interfering with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus. The disparity of signal processing between inner ear motion receptors and the visual senses is abolished, so that the confusion of brain whether the individual is moving or standing is reduced. Vomiting in motion sickness is actually a physiological compensatory mechanism of the brain to keep the individual from moving so that it can adjust to the signal perceptioninnarizine Cedan could be also viewed as a nootropic drug because of its vasorelaxating abilities (due to calcium channel blockage), which happen mostly in brain. It is also effectively combined with other nootropics, primarily piracetam; in such combination each drug potentiate the other in boosting brain oxygen supply.

paracetamol is a pain reliever and fever reducer.

Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of paracetamol, chlorpheniramine, and phenylephrine is used to treat runny or stuffy nose, sinus congestion, sneezing, and pain or fever caused by allergies or the common cold.

paracetamol, chlorpheniramine, and phenylephrine may also be used for other purposes not listed in this medication guide.

There are many brands and forms of guaifenesin and phenylephrine available and not all brands are listed on this leaflet.

Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Guaifenesin and phenylephrine is a combination medicine used to treat stuffy nose and sinus congestion, and to reduce chest congestion caused by the common cold or flu.

Guaifenesin and phenylephrine may also be used for purposes not listed in this medication guide.

Adults and Children >12 years: Peripheral Circulatory Disorders: Two to three 25-mg tab 3 times daily.

Disorders of Balance: One 25-mg tab 3 times daily.

The maximum recommended dosage should not exceed 225 mg (9 tabs) daily, if necessary the dosage may be divided over 2 or 3 intakes/day. As the effect of Cedan on vertigo is dose dependent, the dosage should be increased progressively.

Motion Sickness: Adults: 25 mg may be taken 2 hrs before the start of the journey and 12.5-25 mg may be repeated every 8 hrs during the journey when necessary.

Children 8-12 years: 12.5 mg 3 times daily when necessary; 5-7 years: 6.25 mg 3 times daily when necessary.

As with other antihistamines, Cedan may cause epigastric distress; taking it after meals may diminish gastric irritation.

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What is the most important information I should know about Cedan?

In patients with known hypersensitivity to Cedan.

The safety of Cedan tablets in pregnant and lactating women has not been established.

Parkinson’s disease.

This combination medication is used to temporarily treat cough and runny/stuffy nose (nasal congestion) caused by infections (such as the common cold), allergies (such as hay fever), and other breathing illnesses. This product is usually not used for ongoing cough from smoking or long-term breathing problems (such as chronic bronchitis, emphysema) unless directed by your doctor. Guaifenesin is an expectorant. It works by thinning and loosening mucus in the airways, clearing congestion, and making breathing easier. Phenylephrine is a decongestant (sympathomimetic). It reduces nasal congestion by narrowing the blood vessels in the nose.

If you are self-treating with this medication, it is important to read the package instructions carefully before you start using this product to be sure it is right for you.

Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products (such as long-acting tablets/capsules) are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely.

These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not give other cough-and-cold medication that might contain the same or similar ingredients. Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).

How to use Cedan

Take this medication by mouth with or without food, as directed by your doctor. If you are self-treating, follow all directions on the product package. To prevent trouble sleeping, do not take this medication close to bedtime. If you are uncertain about any of the information, ask your doctor or pharmacist.

Dosage is based on your age, medical condition, and response to treatment. Do not increase your dose or take this drug more often than directed.

Guaifenesin may have a bitter taste. Swallow capsules and tablets whole. Scored tablets may be split for lower doses. Chewable tablets may be swallowed whole or chewed.

Drink plenty of fluids while taking this medication. Fluids will help to break up mucus and clear congestion.

If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. If your liquid form is a suspension, shake the bottle well before each dose.

Tell your doctor if your condition is accompanied by fever, severe sore throat, rash, persistent headache, or if it persists, returns, or worsens after 7 days. These may be signs of a serious medical problem. Seek immediate medical attention if you think you may have a serious medical problem.

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What other drugs will affect Cedan?

Alcohol, CNS Depressants and Tricyclic Antidepressants: Concurrent use may potentiate the sedative effects of either of these medications or of Cedan.

Diagnostic Interference: Because of its antihistamine effect, Cedan may prevent otherwise positive reactions to dermal reactivity indicators if used up to 4 days prior to skin testing.

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What are the possible side effects of Cedan?

The most common antihistaminic side-effect of Cedan is sedation which can vary from slight drowsiness to deep sleep, and including inability to concentrate, lassitude, dizziness, and inco-ordination. Sedative effects, when they occur, may diminish after a few days.

Other side-effects include gastro-intestinal disturbances such as nausea, vomiting, diarrhoea or constipation, anorexia or increased appetite and epigastric pain.

Somnolence and gastro-intestinal disturbances are usually transient and may often be prevented by achieving the optimum dosage gradually.

Cedan may also produce antimuscarinic effects such as blurred vision, difficulty in micturition, dysuria, dryness of mouth and tightness of chest.

Central effects may include muscular weakness, headache and euphoria.

Weight gain, perspiration or allergic reactions may be observed. Cases of lichen planus and lupus-like symptoms and an isolated case of cholestatic jaundice have been reported.

In elderly people cases of aggravation or an appearance of extrapyramidal symptoms sometimes associated with depressive feelings have been described during prolonged therapy. The treatment should be discontinued in such cases.

Interactions:

Cedan may enhance the sedative effect of central nervous system depressants including alcohol, barbiturates, hypnotics, narcotic analgesics, tricyclic antidepressants, sedatives and tranquillisers.

The side-effects of anticholinergic substances such as atropine and tricyclic antidepressants may be enhanced by the concomitan administration of antihistamines.

Monoamine-oxidase inhibitors may enhance the antimuscarinic effects of antihistamines.