Ccq-25

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Ccq-25

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Ccq-25

Property Description
Active Ingredients Clomifene Citrate, Ubidecarenone (Coenzyme Q10)
Form Tablet
Pharmacological Class Ovulation Stimulant (SERM), Antioxidant
Common Use Female infertility due to ovulatory dysfunction
Origin Synthetic and Vitamin-like Substance

What Type of Medicine is Ccq-25?

Ccq-25 is a specific fixed-dose combination medication classified primarily as an oral ovulation stimulant and a complementary cellular protectant, used to address female infertility caused by ovulatory dysfunction. It is a preparation available as a solid tablet intended for oral administration.

This preparation is fundamentally defined by its dual pharmacological class: the Clomifene Citrate component acts as a Selective Estrogen Receptor Modulator (SERM), while the Ubidecarenone component functions as a powerful antioxidant. The use of Clomifene Citrate is clinically recognized for triggering the pituitary-ovarian axis, a mechanism essential for promoting egg release. This combination design is distinct, merging the established hormonal action with supplementary metabolic support.

The Composition: Clomifene Citrate and Coenzyme Q10

The active ingredients in Ccq-25 are Clomifene Citrate and Ubidecarenone, the latter of which is widely known as Coenzyme Q10 or CoQ10. Clomifene Citrate is a synthetic nonsteroidal compound responsible for hormonal modulation, while Ubidecarenone is a naturally occurring, vitamin-like substance that falls under the classification of a nutraceutical.

The inclusion of Ubidecarenone is a key differentiating feature, as this fixed-dose combination aims to move beyond just hormonal induction. Coenzyme Q10 is essential for energy generation and functions as a lipid-soluble antioxidant. This combination is specifically beneficial for adult patients diagnosed with conditions like Oligo-ovulation, where both hormonal correction and enhanced cellular health are primary therapeutic goals.

What is the General Therapeutic Purpose?

The general therapeutic purpose of Ccq-25 is to help re-establish a regular ovulatory cycle and optimize the metabolic environment required for conception in women experiencing infertility. The core benefit stems from the product's ability to promote the release of eggs while simultaneously protecting the cellular integrity of the ovarian tissue. The combined action ensures the medicine addresses both the hormonal trigger and the underlying cellular resilience required for reproductive function, particularly in cases of anovulation or ovulatory dysfunction.

Regulatory References

  1. WHO Model List of Essential Medicines (Clomifene)

What side effects are possible with Ccq-25?

Ccq-25 (a combination medicine containing Clomiphene) has an officially documented safety profile detailing adverse reactions and specific usage restrictions based on government regulatory guidance.

Adverse Reactions by Frequency

Common adverse reactions documented in regulatory sources include hot flashes, ovarian enlargement, nausea, vomiting, abnormal uterine bleeding, pelvic discomfort, and blurred vision.

Rare but serious adverse reactions include Ovarian Hyperstimulation Syndrome (OHSS), which may be life-threatening; thromboembolic events (e.g., stroke); significant visual disturbances that may be permanent; liver impairment; and psychosis.

Safety Restrictions and Contraindications

Ccq-25 is not recommended for use in the following patient populations or conditions as documented in official labeling:

  • Pregnancy: The medicine is strictly contraindicated during pregnancy.
  • Liver Disease: Contraindicated in patients with liver disease or a history of impaired liver function.
  • Undiagnosed Bleeding: Contraindicated in the presence of abnormal vaginal bleeding of unknown cause.
  • Hormone-Dependent Tumors: Contraindicated in patients with hormone-dependent tumors or certain cancers, such as endometrial cancer.
  • Ovarian Cysts: Contraindicated in patients with ovarian cysts not related to Polycystic Ovary Syndrome (PCOS).
  • Age: Not recommended for use in children and adolescents below 18 years of age due to lack of established safety and efficacy data.

Safety Limitations

Patients are advised that the medicine may cause visual disturbances, such as blurred vision or seeing spots. Due to this potential effect, official documents note a safety restriction against activities requiring clear vision, such as driving or operating heavy machinery. Furthermore, regulatory guidelines typically limit the use of the Clomiphene component to a specific number of treatment cycles (e.g., generally not more than four to six cycles).

Overdose and Emergency Response

Overdose and When to Seek Help

The regulatory guidance for Ccq-25 overdose is focused on identifying specific clinical manifestations and mandating immediate emergency response, as described in official prescribing information.


Documented Overdose Manifestations

Overdose with the active component, Clomifene Citrate, may be characterized by visual disturbances, including blurred vision and scotomata (spots or flashes of light), in addition to symptoms such as nausea, vomiting, abdominal pain, and vasomotor flushes (hot flashes). Overdose exposure carries a risk of ovarian enlargement.

Severe Outcomes and Emergency Action

The primary severe risk documented is the potential for Ovarian Hyperstimulation Syndrome (OHSS), a condition classified as potentially life-threatening that requires urgent medical attention. There is also a documented risk of irreversible visual impairment.

Regulatory guidance mandates that patients seek immediate medical attention following any known or suspected overdose. Furthermore, treatment must be stopped immediately if any unusual visual symptoms occur.

Official Management Strategy

The management of overdose is restricted to appropriate supportive measures and symptomatic treatment. Regulatory documentation explicitly states that no specific antidote is known for this overdose. A complete ophthalmological examination is required if visual disturbances are reported and persist.

Therapeutic Uses of Ccq-25

Main Uses of Ccq-25

Ccq-25 is a medication primarily utilized in the management of specific endocrine and reproductive health conditions. Its function is centered on the modulation of hormonal pathways to address underlying physiological imbalances.

Ovulatory Dysfunction and Infertility

The primary application of Ccq-25 is the induction of ovulation in individuals who do not ovulate naturally or who experience irregular ovulatory cycles. By interacting with estrogen receptors, the medication encourages the pituitary gland to increase the release of hormones necessary for the development and maturation of ovarian follicles.

Polycystic Ovary Syndrome (PCOS)

Ccq-25 is frequently used as a first-line therapeutic option for managing infertility associated with Polycystic Ovary Syndrome. In these cases, the medication helps to overcome the hormonal barriers that prevent regular egg release, thereby improving the likelihood of conception.

Benefits and Clinical Goals

The therapeutic objectives of Ccq-25 treatment extend beyond the immediate induction of ovulation, focusing on restoring a more predictable reproductive cycle.

  • Restoration of Regular Cycles: By stimulating the hormonal trigger for ovulation, Ccq-25 can help establish a more consistent menstrual pattern in individuals with chronic anovulation.
  • Follicular Development: The medication supports the growth of healthy follicles within the ovaries, which is a critical step in the reproductive process.
  • Targeted Hormonal Response: Ccq-25 works by temporarily altering the body's perception of estrogen levels, which prompts a natural physiological increase in follicle-stimulating hormone (FSH) and luteinizing hormone (LH).

Regulatory References

  1. NIH MedlinePlus guidance

Eligibility and Restrictions for Use

Who can and cannot use Ccq-25? — Official Regulatory Information

The use of Ccq-25 is restricted to women who are experiencing infertility due to the absence of or irregular ovulation, such as those with Polycystic Ovary Syndrome (PCOS). The medicine is specifically indicated only for this population, and its use is not recommended for men, children, or adolescents under 18 years of age.


Ccq-25 must not be used (Contraindications) in the following groups:

  • Women who are pregnant. Pregnancy must be ruled out before starting treatment.
  • Individuals with a known allergy or hypersensitivity to any component of the medicine.
  • Patients with active liver disease or a documented history of liver dysfunction.
  • Women experiencing abnormal uterine or vaginal bleeding of an undetermined cause.
  • Patients with an ovarian cyst or enlarged ovary that is not due to PCOS.
  • Individuals with a pituitary tumor or a hormone-dependent cancer.

Use is also not recommended in:

  • Breastfeeding women, as it may inhibit milk production.
  • Patients with active or uncontrolled thyroid or adrenal gland disorders.

What should I know about interactions with other medicines?

This section describes the officially documented interaction patterns between Ccq-25 and other medicinal products, supplements, or food, as detailed in regulatory prescribing information. The overall interaction profile is defined by the properties of its two active components.

Drug-Drug Interactions

Ccq-25 has documented interaction patterns involving both pharmacokinetic (PK) and pharmacodynamic (PD) mechanisms. The pharmacodynamic interaction concerns Vitamin K Antagonists (such as Warfarin). Regulatory documentation indicates that the Ubidecarenone component may antagonize the anticoagulant effect of these medicines. This PD interaction requires close procedural monitoring of the International Normalized Ratio (INR) to assess coagulation status.

The pharmacokinetic interaction relates to the primary metabolism of Clomifene Citrate via the CYP2D6 enzyme. Co-administration with medicinal products classified as CYP2D6 inhibitors may result in increased systemic exposure (higher plasma concentration) of Clomifene Citrate. Conversely, Clomifene Citrate itself may inhibit CYP2D6, potentially altering the exposure of other co-administered CYP2D6 substrate drugs.

Drug-Food and Supplement Interactions

A significant drug-food interaction is documented concerning the absorption of the Ubidecarenone component. Administration of Ccq-25 with a fat-containing meal is shown to enhance the absorption and bioavailability of Ubidecarenone. Furthermore, Vitamin K-containing supplements or foods may reinforce the antagonistic effect of Ubidecarenone on Vitamin K Antagonists, contributing to a greater reduction in the anticoagulant effect. No specific timing separation rules or formally contraindicated combinations are listed in official regulatory labeling for Ccq-25.

Mechanism of Action

How Ccq-25 Works

Ccq-25 is a molecular modulator that engages specific biological mechanisms to influence defined signaling pathways. Its action influences cellular activity by altering existing signaling patterns rather than initiating new ones.

Targeting Specific Receptors and Enzymes

Ccq-25 exerts its primary action by selectively binding to high-affinity receptors and/or altering the activity of key regulatory enzymes within relevant biological systems. This molecular interaction engages the initial mechanistic step, influencing the immediate cellular response and contributing to the downstream effects on communication.

Modifying Signal Transduction Cascades

Following target engagement, Ccq-25 rapidly modifies the downstream signal transduction cascades that rely on specific neurotransmitters or mediators. This process operates within systems characterized by specific signaling dynamics, where its action initiates or suppresses molecular sequences that contribute to systemic physiological effects.

Influencing Physiological Signaling Patterns

The resulting effect of receptor targeting and cascade modulation influences the activity state of the affected pathways, altering the extent of mediator signaling. This action influences the signaling patterns of physiological responses, resulting in altered mechanistic feedback that shapes the overall biological activity.

Dosage and Administration Information

How to Use Ccq-25

The administration of Ccq-25 is strictly governed by a cyclic protocol, defining the dose, frequency, and duration of therapy as detailed in prescribing information. This preparation is a fixed-dose combination oral medicine containing Clomifene Citrate 50 mg and Ubidecarenone 100 mg and is always administered by mouth.


Official Usage Protocol

Treatment is initiated in courses, each lasting five consecutive days. The standard practice is to begin the first course around the fifth day of the menstrual cycle, or at any time in an anovulatory patient after specialist consultation. The medicine is taken once daily with water and may be administered independent of meals.

The usual starting regimen is one tablet daily (50 mg Clomifene Citrate equivalent). If the initial response is not achieved, the dose may be increased in subsequent, supervised courses to a maximum of two tablets (100 mg Clomifene Citrate equivalent) once daily. The five-day course must be strictly adhered to and should not be extended.


Duration and Special Conditions

Therapy is restricted to a maximum of six total treatment courses to align with established procedural limits for this class of medicine. Ccq-25 must only be used under the ongoing guidance and monitoring of a specialist. Dose interruption or discontinuation is specified for patients exhibiting evidence of severe hepatic impairment, underscoring the necessity of clinical oversight during the cyclic administration.

Usage Constraint Official Guideline
Administration Route Oral (tablet)
Dosing Frequency Once daily, for five consecutive days
Maximum Total Use Six total treatment courses

Recent Clinical Evidence

Research evidence / Overview of studies for Ccq-25

Evidence for Use in Ovulatory Dysfunction

The evidence primarily comes from short-term Randomized Controlled Trials (RCTs) and systematic reviews that synthesized the findings of these trials. These studies were applied in research contexts involving fluctuating or unstable conditions related to female infertility. Specifically, trials examined the combination as an approach to managing situations where patients experience difficulty with egg release, which is known as ovulatory dysfunction.

The primary outcomes monitored in these trials was studied for achieving ovulation, and researchers also measured the resulting clinical pregnancy rate during the study period. Findings described patterns observed in the studies where the combination was compared to treatment with Clomifene Citrate alone. The evidence contributes to understanding the patterns observed for reproductive outcomes, but the data primarily reflect measurements taken during short-term cycles.


Focus on Specific Study Populations

The research focused most closely on a specific group of adult women who met the definition of Clomifene Citrate-resistant (failure to achieve ovulation in previous treatment cycles with Clomifene Citrate alone). Studies monitored the outcomes observed in this specific subpopulation receiving the fixed-dose combination.

Reported outcomes were short-term and based on these narrower populations. The results apply only to the populations studied. The research examined the combination for patients diagnosed with Polycystic Ovary Syndrome (PCOS) who met the criteria for inclusion in the trials. However, data for certain groups of women with ovulatory issues remain insufficient, and findings have focused primarily on the CC-resistant group.


What is Still Uncertain About Ccq-25 Research

The research landscape for Ccq-25 contains several gaps and limitations. Evidence quality varies across studies, and some trials utilized relatively modest sample sizes, which may limit the generalizability of the findings. Research has focused primarily on women categorized as Clomifene Citrate-resistant, meaning data for the broader population of women experiencing ovulatory dysfunction remain insufficient.

Furthermore, because the research largely focused on short treatment periods (typically three to four consecutive cycles), certainty remains low regarding outcomes that develop over an extended duration, such as sustained conception or live birth rates. While research provides context, it does not offer individual predictions, and the evidence highlights what is known and what is still uncertain.

Key Studies & References

  1. Effect of Administrating Coenzyme Q10 with Clomiphene Citrate on Ovulation Induction in Polycystic Ovary Syndrome Cases with Resistance to Clomiphene Citrate: A Randomized Controlled Trial
  2. Clomifene - WHO Electronic Essential Medicines List (eEML) for Female Infertility

Frequently Asked Questions (FAQ)

Common questions about Ccq-25 (FAQ)


Q: How does Ccq-25 generally differ from similar treatments like Ccr-50?

Regulatory documents describe Ccq-25 as a fixed-dose combination medication. It contains not only the hormonal component, Clomifene Citrate, but also the antioxidant Ubidecarenone, which is also known as Coenzyme Q10. This dual composition is its distinguishing feature compared to treatments that may use only the hormonal component.

Q: Are there official warnings about the drug's potential to affect mental focus?

Official product labeling indicates that the medicine may cause visual disturbances, such as seeing spots or having blurred vision. Because of this, activities requiring clear sight, like driving or operating machinery, are restricted. Additionally, reports have included effects such as nervous tension and restlessness, which may indirectly affect concentration.

Q: Are there any foods or drinks officially recommended to avoid while using Ccq-25?

Regulatory information does not list a specific food or drink to completely avoid, but it does describe important interactions. Administration with a fat-containing meal is noted to increase the absorption of the Ubidecarenone component. Also, consuming foods or supplements high in Vitamin K may reinforce an antagonistic effect on certain blood-thinning medicines, which is a factor that requires procedural monitoring.

Q: How long does the active ingredient of Ccq-25 typically remain in the body?

Studies on the pharmacokinetics (how the body processes the drug) of the primary component indicate it has a long clearance time. One of its isomers, called zuclomiphene, has a particularly long half-life, meaning detectable levels can persist in the body for up to 14 to 20 days or even longer after the last dose.

Q: What is the classification of Ccq-25 in terms of drug safety categories?

The medicine is strictly contraindicated and is not recommended for use during pregnancy. It is designated this way due to its potential to harm a developing fetus. Historically, this type of contraindication often corresponded to a Pregnancy Category X classification, signifying a high-risk factor.

Q: What is the difference between the 25mg dose and other possible strengths of Ccq?

The Ccq-25 nomenclature refers to the formulation, while the standard dosing regimen is described in terms of the Clomifene Citrate component. The initial cycle typically uses a 50 mg equivalent of Clomifene Citrate, and the protocol allows for doses up to 100 mg in subsequent cycles.

Q: Are changes in weight or appetite listed as a possible effect of Ccq-25?

Yes, changes related to appetite and weight are mentioned in official safety materials. Reports from postmarketing surveillance include both increases in appetite and changes in body weight, which can manifest as either weight gain or weight loss.

Q: Can you take Ccq-25 with alcohol according to official guidance?

Official regulatory documents do not contain an explicit contraindication against consuming alcohol while taking this medicine. The decision to consume alcohol is not specifically addressed with a contraindication, but it is a factor that is processed by the liver, similar to the drug.

Q: Does Ccq-25 interact with non-prescription pain relievers like ibuprofen or acetaminophen?

The official labeling notes that the Clomifene Citrate component is metabolized (broken down) by an enzyme known as CYP2D6. Caution is advised when taking other medicines—including some over-the-counter pain relievers—that may affect the activity of this specific enzyme pathway.

Q: Is there a known interaction between Ccq-25 and common blood pressure medications?

Regulatory warnings note two types of potential interactions. The medicine has been associated with interactions involving Vitamin K Antagonists (a class of blood thinners). Additionally, interactions are noted with any substance that affects the CYP2D6 enzyme, which may include certain blood pressure medicines.

Q: How long after starting treatment is Ccq-25 is expected to begin showing its effect?

Official patient information indicates that the therapeutic effect, which is the release of the egg, is generally expected to occur within a specific window. Ovulation is commonly observed 5 to 12 days after the completion of the 5-day course of treatment.

Q: What is the official procedure to follow if a dose of Ccq-25 is missed?

Official guidance describes a protocol where a missed dose is to be taken as soon as the patient remembers. If it is nearly time for the next scheduled dose, the missed dose is to be skipped. Regulatory warnings state that compensating with a double dose is not part of the procedure.

Q: Is Ccq-25 classified as a controlled substance in official drug schedules?

According to federal regulatory lists, the active component of the medicine, Clomifene Citrate, is not classified as a controlled substance. This means it is not assigned to Schedules I, II, III, IV, or V used to regulate drugs with abuse potential.

Q: Is it necessary to have certain tests before starting treatment with Ccq-25?

Yes, regulatory documents recommend that certain tests be performed before starting treatment to ensure patient safety. These typically include verifying a negative pregnancy test, excluding the presence of ovarian cysts, and assessing baseline hepatic function (liver function).

How should Ccq-25 be stored and disposed of?

CCQ-25 tablets must be stored and disposed of according to strict requirements defined in official regulatory documents to ensure the product's quality and safety.

Storage Conditions and Protection

The medication must be stored at room temperature, typically defined as a non-cold chain temperature range of 10 C to 25 C or below 30 C.

Storage Requirement Rule Constraint
Temperature Room temperature Keep from freezing
Environment Cool and dry place Protect from moisture and light
Container Closed container Store in original pack

Crucially, the tablets must be kept out of the sight and reach of children to prevent accidental ingestion.

Disposal Instructions

Unused or expired CCQ-25 must be disposed of in accordance with local regulations for pharmaceutical waste. The official labeling specifies that the medicine should not be discarded via household wastewater, sewage systems, or into the environment, to avoid potential contamination.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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