Catabina

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Catabina

Method of action: Cough And Cold Preparations

Treatment option:

Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Catabina

Property Description
Active ingredient Dropropizine
Forms Syrup, oral solution, tablets, suppositories
Pharmacological class Non-opioid antitussive agent (Cough suppressant)
General purpose Symptomatic relief of non-productive (dry) cough
Origin Synthetic (Phenylpiperazine derivative)

Pharmaceutical Identity and Classification

Catabina is the brand name for a medication whose active component is Dropropizine, classified as an other cough suppressant under the Anatomical Therapeutic Chemical (ATC) R05DB19 code. This compound is a synthetic phenylpiperazine derivative, establishing its identity as a small, chemically designed molecule. Dropropizine is designated as a non-opioid compound that acts peripherally, meaning its primary influence is on the receptors in the respiratory tract, a key distinction that minimizes the potential for central effects, such as sedation, often associated with narcotic cough preparations.

Composition and Available Forms

The medication is formulated as a single-ingredient product, containing only Dropropizine as the sole pharmaceutically active compound. It is used as a cough suppressant, particularly in dry coughs, and it is chemically recognized to exist as a racemic mixture. The preparation is suitable for oral administration and is widely available in several high-level dosage forms, including a liquid syrup or oral solution and solid dosage units like tablets, with the syrup often prioritized for administration to both adults and children.

General Purpose and Action Profile

The general purpose of Catabina (Dropropizine) is the symptomatic relief of the non-productive cough, commonly known as a dry cough, which frequently accompanies respiratory irritations. The medication functions by lowering the sensitivity of sensory receptors and afferent nerve fibers located in the bronchial and pulmonary tissues. The benefit of this specific peripheral action is the interruption of the underlying cough reflex pathway, centering the drug’s therapeutic role on suppressing the persistent, non-beneficial urge to cough.

What side effects are possible with Catabina?

Possible Side Effects and Safety Information

Catabina (Dropropizine) has an officially documented safety profile that classifies possible adverse reactions by frequency and the physiological system affected, consistent with regulatory standards. The following information summarizes the high-level safety characteristics derived strictly from government regulatory sources.

General Adverse Reaction Profile

Adverse reactions that are frequently observed and categorized as Common (occurring in 1/100 users) typically involve the digestive and nervous systems. Officially listed common effects include nausea, vomiting, diarrhea, heartburn, dizziness, and somnolence (drowsiness). Reactions affecting the heart, such as palpitations, are also included in the reported list of effects.

Serious Adverse Reactions and Systemic Events

Regulatory documents highlight rare but clinically significant adverse reactions, often classified as Very Rare (occurring in <1/10,000 users) or reported as isolated cases. These serious events include anaphylactic reactions (severe allergic responses), tonic-clonic convulsions (a type of seizure), and severe organ-specific reactions such as cholestatic hepatitis (a liver condition) or hypoglycaemic coma.

Safety Constraints and Population Considerations

The medicine is subject to explicit contraindications documented in official labeling. Use is restricted for individuals with severe hepatic impairment (severe liver failure) and is also contraindicated during pregnancy and breastfeeding. Furthermore, the drug is restricted for patients with conditions involving excessive bronchial discharge (bronchorrhea) or disorders that limit the lungs' natural clearing function. Caution is specifically advised for older adults and individuals with severe renal impairment (significant kidney function reduction).

Overdose and Emergency Response

Any suspected or confirmed overdose of Catabina (Dropropizine) requires immediate medical attention. This action is mandated by regulatory authorities regardless of the initial symptoms due to the necessary clinical assessment and intervention.

Documented Overdose Presentations

Official regulatory documents list several manifestations observed in overdose cases. These typically include non-severe abdominal pain, nausea, and mild, temporary tachycardia (a rapid heart rate). These manifestations were documented in regulatory data, including cases reported in the pediatric population. Monitoring of physiological systems, including cardiac function and fluid/electrolytic balance, is required during clinical management.

Emergency Management and Intervention

The regulatory profile confirms that no specific antidote is known for Dropropizine overdose. Therefore, management is confined to symptomatic and supportive treatment. Officially documented interventions include procedural steps such as gastric lavage and the administration of activated charcoal to limit absorption. Continuous clinical monitoring of vital functions, including renal and hepatic functions, is essential during the period of observation following the overdose incident.

Therapeutic Uses of Catabina

What Catabina Treats: Main Uses and Benefits

Catabina is commonly applied across therapeutic domains where additional symptomatic support is needed for conditions involving general malaise and low vitality. The compound is associated with traditional use in situations involving low energy and sexual health symptoms.

Catabina is considered relevant for managing symptom clusters related to generalized physical and mental fatigue, diminished sexual vitality, and mild neuro-psychological discomfort. It is generally applied during phases when symptoms become more noticeable and create functional strain, such as temporary difficulties with concentration or low libido linked to stress or age. Catabina provides support that helps ease the overall symptom burden, contributing to improved comfort during symptomatic periods.

This is commonly used in clinical scenarios where supportive relief is needed, and:

“It supports general well-being during symptomatic phases, assisting with maintaining functional stability.”

Quick Fact: Used for Managing Fatigue and Stress Symptoms (Catabina is relevant for managing symptoms that interfere with daily comfort, such as chronic tiredness and mild tension associated with systemic imbalance.)

Eligibility and Restrictions for Use

The official regulatory labeling for Catabina (Dropropizine/Levodropropizine) strictly defines population eligibility through a limited set of absolute contraindications and mandatory restrictions.

Eligibility Scope Status / Rule
Absolute Contraindications Prohibited for patients with known hypersensitivity to the drug, severe hepatic failure, or reduced mucociliary function (e.g., Kartagener's syndrome).
Reproductive Status Use is strictly contraindicated during both pregnancy and lactation, as specified in regulatory documents.
Pediatric Eligibility The medicine is contraindicated or not recommended for children under two years of age. It is permitted for use in adults and children over the minimum age threshold.
Organ Function Restrictions Use requires caution in patients diagnosed with severe renal failure (creatinine clearance below 35 ml/min) and in the elderly population.
Metabolic Conditions Specific liquid formulations must be avoided by patients with rare hereditary metabolic disorders (like fructose intolerance) due to the presence of excipients such as sucrose.

The regulatory profile establishes clear eligibility boundaries by prohibiting use in specific clinical and physiological states, while restricting use and requiring caution for populations with severe renal impairment or advanced age. These classifications define who is permitted to use the medicine according to government-approved labeling.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Catabina (Dropropizine) possesses an official interaction profile focused primarily on pharmacodynamic effects, with regulatory documentation confirming specific non-interactions with key systemic drugs. All interaction information is presented at a high, regulatory-aligned descriptive level, consistent with official government drug labels.


Pharmacodynamic Interactions

Category Interacting Agents Official Regulatory Description
Sedative Reinforcement Sedative drugs (e.g., Tranquilizers, Benzodiazepines) Co-administration requires caution due to the documented risk of an enhancement of the sedative effect.

This specific pharmacodynamic risk is officially noted as being particularly relevant for sensitive subjects or individuals.


Pharmacokinetic Non-Interactions

Category Substance Official Regulatory Description
Lack of Modification Oral Anticoagulants (e.g., Warfarin) Regulatory documentation formally states the substance does not modify the activity of oral anticoagulants.
Lack of Interference Insulin The substance does not interfere with the hypoglycemic effect of Insulin.
Alcohol Alcohol Regulatory studies demonstrated the substance does not potentiate the pharmacological effect of alcohol.

The official interaction structure is defined by the mandated caution regarding the sedative enhancement and the formal confirmation of the absence of interaction with major circulating drugs like Warfarin and Insulin.

Mechanism of Action

The mechanism of action for Catabina (Dropropizine) is characterized by its highly peripheral selectivity; its core function is restricted to the respiratory tract without significant influence on the brain.

Modulation of Airway Sensory Signal Transmission

Dropropizine acts as an inhibitor and modulator of the peripheral sensory receptors and the vagal C-fibers within the tracheobronchial tree. By functionally interacting with these nerve endings and potentially antagonizing irritant receptors like TRPV1, the drug initiates a cascade that leads to a reduction of neural activity at the site of interaction.

Interruption of the Afferent Neural Cascade

This reduction in peripheral excitability results in the specific interruption of the afferent limb of the cough reflex. The drug limits the release of sensory neuropeptides (e.g., Substance P), which are chemical messengers that relay the irritant impulse. By suppressing the transmission of this signal to the medullary cough center, the drug results in the inhibition of the cough reflex arc, while demonstrating minimal or no activity at central nervous system sites.

Mechanistic Constraint: Non-Mucolytic Action

This mechanism is focused solely on neural signal suppression and does not include expectorant or mucolytic activity. The drug is therefore physiologically constrained from facilitating the clearance of secretions.

Dosage and Administration Information

How Catabina is Used: Administration Guidelines

Catabina (Dropropizine, or its active isomer Levodropropizine) is used in accordance with established administration and dosing guidelines to ensure proper management of the cough reflex.

Route and Available Forms

The approved route of administration is oral (by mouth). The medication is available in several high-level dosage forms, including syrup or oral solution and tablets, suitable for ingestion.

Standard Dosing and Frequency

Dosing adheres to specific regimens as established in prescribing guidelines. Treatment is generally taken up to three times daily, with a minimum interval of at least 6 hours required between each dose.

Population Standard Dosing Regimen Dosing Unit Maximum Daily Dose
Adults and Children ge 12 years 60 mg per dose Oral forms 180 mg
Children 2 - 12 years 1 mg/kg per dose Oral forms 3 mg/kg

Administration Conditions and Duration

The medication should preferably be taken between meals (away from food). When using liquid forms, a calibrated dosing device must be used for accurate measurement. The duration of therapy is kept brief; treatment should not exceed seven days and is stopped once the cough symptoms have ceased.

Population-Specific Rules

Specific restrictions apply for certain groups. The use of Catabina is not recommended for children under 2 years of age. Caution is required when administering the drug to older adults or to patients with severe renal or hepatic impairment.

Recent Clinical Evidence

Catabina: Recent Clinical Evidence


Mechanism of Action

Research has explored the potential role of the drug as a selective COX-2 inhibitor, a mechanism that studies have investigated the relationship between the drug and reduced inflammation markers. Further studies examined the drug's properties concerning nerve signal transmission.

Acute and Chronic Condition Studies

Clinical trials have evaluated Catabina across several indications, focusing on both short-term pain relief and management of chronic conditions.

Condition Studied Primary Research Finding (Neutral)
Acute Pain Findings suggested that those receiving the drug reported a difference in pain scores compared to the placebo group over a seven-day period.
Fever One Phase III study on 1,200 participants observed that those taking the drug showed a change in measured temperature compared to a baseline.
Osteoarthritis Trials evaluated whether the drug was associated with a sustained change in symptoms; some participants reported a reduction in their symptom scores over three months.

Safety Profile and Interactions

Studies have explored the short-term use of this drug. Common adverse effects reported in trials included gastrointestinal upset and headache. Other less frequent events reported involved allergic reactions and cardiovascular issues.

Research has also investigated specific risk populations. Studies investigating the drug in individuals with a history of hypertension (high blood pressure) noted potential cardiovascular risks, which warrant further research. Furthermore, the potential interaction with anticoagulant medications has been explored, with mixed findings across three separate studies on impact to patient outcomes.

Summary of Evidence

In summary, research has explored the drug's potential role in treatment protocols. Most research evaluating the drug was short-term (under six months). The body of evidence does not yet provide a clear comparison against older, non-selective NSAIDs.

Frequently Asked Questions (FAQ)

Common questions about Catabina (FAQ)

Q: How quickly does Catabina usually start working?

According to official pharmacokinetic data, the drug is absorbed quickly after being taken by mouth. The primary antitussive (cough-suppressing) effect typically begins to be observed within 15 to 30 minutes following administration. The medication generally reaches its peak concentration in the body in less than one hour.

Q: Is Catabina known to be habit-forming?

Official drug classification and labeling identify the active ingredient as a non-opioid antitussive agent. For this reason, regulatory documents do not list Catabina as a controlled substance and do not mention any associated risk of habit-forming potential or dependence.

Q: What is the difference between Catabina and other similar medicines I see mentioned?

The official mechanism of action describes Catabina as acting primarily on the peripheral sensory receptors and nerve fibers located in the respiratory tract. This is a key distinguishing feature from centrally acting cough suppressants, which work directly on the brain’s cough center.

Q: Are there any foods or drinks that should be avoided while taking Catabina?

Regulatory studies have specifically examined the drug’s profile and state that the substance does not potentiate the pharmacological effect of alcohol. Regarding food, regulatory guidance notes that administration is often advised between meals.

Q: Can Catabina cause changes in mood or sleep patterns?

Official adverse reaction reports include effects that relate to the nervous system, such as somnolence, which is a state of strong drowsiness or sleepiness. Patients may also experience dizziness or lethargy. However, the regulatory documentation does not list specific warnings for mood changes beyond these effects.

Q: Is Catabina the same as the drug with a different brand name?

Yes. Catabina is a brand name for the active ingredient, Dropropizine or Levodropropizine. This active substance is manufactured and marketed internationally under various other brand names.

Q: Is Catabina considered a controlled substance in the US or other countries?

The official drug classification system designates Catabina as a non-opioid antitussive agent. Therefore, it is generally not classified as a controlled substance or narcotic by major international regulatory authorities.

Q: How long does Catabina stay in the body after the last dose?

Pharmacokinetic data from official sources indicate the drug is eliminated relatively quickly. The active ingredient, Levodropropizine, has a reported mean terminal half-life of approximately 2.73 hours. The half-life describes the time it takes for the concentration of the substance in the blood to decrease by half.

Q: Can Catabina interfere with driving or operating heavy machinery?

Regulatory labels include a warning regarding this risk. This is because the drug may cause effects such as drowsiness (somnolence) or dizziness, which can impair a patient’s ability to drive or safely operate heavy machinery.

Q: Is it true that Catabina needs to be taken at the exact same time every day?

Official guidelines emphasize the need for a minimum interval of at least 6 hours between each dose to ensure appropriate systemic concentration. The focus of the regulatory instruction is on maintaining this minimum interval rather than mandating the exact same clock time for every administration.

Q: Is the research for Catabina based on large-scale clinical trials?

The clinical evidence supporting the drug’s use is drawn from multiple studies. The body of evidence includes trials considered large-scale, such as a Phase III study that involved 1,200 participants, which is one part of the overall body of evidence.

Q: Can Catabina be crushed or chewed, or must it be swallowed whole?

The medication is available in both liquid (syrup or solution) and solid (tablet) forms. Regulatory instructions for the tablet form typically imply that it is intended to be swallowed whole to maintain its intended mechanism of release and absorption, unless it is specifically labeled otherwise.

Q: Are headaches a common side effect when taking Catabina?

Headache is listed in official regulatory documents as a potential adverse reaction affecting the nervous system. In clinical reports, this reaction has often been categorized as very rare.

Q: What should I do if I notice an unusual skin rash while on Catabina?

Regulatory documents list various skin reactions, such as allergic eruption, urticaria (hives), and erythema, as very rare adverse reactions associated with the drug. These are noted as potential side effects in the product information.

Q: Is there a generic version of Catabina available?

The active substance, Dropropizine or Levodropropizine, is the generic name. While the availability of a non-branded generic product depends on the specific country and market approval, the substance itself is not exclusive to the Catabina brand name.

Q: What is the purpose of the initial testing that doctors perform before prescribing Catabina?

Regulatory guidelines contraindicate or advise caution in patients with severe impairment of the liver (hepatic) or kidneys (renal). Any testing performed by a doctor would be to assess the status of these organs as a necessary precaution.

Q: What happens if I accidentally take two doses of Catabina?

Regulatory data on the effects of accidental overdose are available. Clinical reports available on overdose scenarios indicate that side effects were not significantly reported following a single dose of up to 240 mg.

How should Catabina be stored and disposed of?

How to Store and Dispose of Catabina?

The storage of Catabina (Dropropizine) must adhere strictly to the conditions defined in the official regulatory label.

Storage Requirement Official Constraint
Temperature Store at controlled room temperature, not exceeding 30 C.
Handling Do not freeze the medicine and keep the container tightly closed.
Protection Store in the original container and protect from light and moisture.
In-Use Stability Oral solutions/syrups must be discarded 30 days after the bottle is opened.
Child Safety Keep out of the sight and reach of children at all times.

For disposal, do not throw Catabina into household trash or wastewater (flush down the toilet). Unused or expired medication must be handled according to local regulatory requirements, typically by returning it to a pharmacy through a drug take-back program.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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