Capilarema

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Capilarema

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Method of action: Cardiac Therapy

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Capilarema

What is Capilarema? (Aminaphtone Preparation)

Property Description
Active Ingredient Aminaphtone (Aminaftone)
Form Capsules (Oral Preparation)
Pharmacological Class Endothelial Protector, Agent for Antivaricose Therapy
Typical Use Management of capillary and microvascular impairment
Origin Synthetic derivative (C18H15NO4)

What Type of Medicine is Capilarema? (Identity and Classification)

Capilarema is a pharmaceutical preparation containing the active ingredient Aminaphtone, primarily classified as an agent for antivaricose therapy and, fundamentally, an endothelial protector. This preparation is a specialized oral capsule that focuses specifically on microcirculatory disorders. Pharmacological studies have supported Aminaphtone's capacity to modify capillary wall function, leading to reduced leakage in the microcirculation. This mechanism helps reinforce the tiny blood vessels, reducing fluid seepage.


Composition: Aminaphtone’s Origin and Structure

The formulation is a single-ingredient product, containing only Aminaphtone as the sole active compound. This substance is defined as a synthetic derivative with an engineered structure related to naphthols and 4-aminobenzoic acid, confirming its origin outside of natural plant sources. Unlike combination products, the focus of Capilarema is exclusively on the distinct vascular properties of Aminaphtone. The preparation consists of the powdered active ingredient combined only with the necessary excipients required to produce the oral capsule.


What is the General Purpose of Capilarema?

The general therapeutic purpose of the preparation is to support the microcirculatory system by acting as a stabilizer for the vascular lining, a function that is clinically recognized in vascular medicine. This is achieved by reinforcing the capillary walls, leading to the enhancement of capillary resistance and a reduction in excessive capillary permeability. By correcting this underlying fragility, the drug generally addresses and aims to alleviate issues associated with generalized capillary disorders and microvascular impairment. Aminaphtone improves capillary fragility and helps regulate blood flow through the microvessels. This means the drug acts to strengthen fragile capillaries and help ensure proper circulation in small vessels.

What side effects are possible with Capilarema?

Possible side effects and safety information

Capilarema (aminactone) is generally well-tolerated, with side effects rarely reported during clinical use. However, like all medicines, it can cause undesirable effects, though not everyone experiences them.

Common and Uncommon Side Effects

The most frequently reported adverse reactions are related to the gastrointestinal and nervous systems. These effects are typically mild and transient.

Frequency Side Effect Category Examples
Frequent Gastrointestinal disorders Dyspepsia
Uncommon Nervous system disorders Headache, dizziness
Uncommon Gastrointestinal disorders Upper abdominal pain, nausea
Very Rare Skin and subcutaneous tissue disorders Rash, pruritus (itching)

Important Safety Information and Warnings

It is crucial to be aware of the following safety information before taking Capilarema:

  • Allergies: Do not take Capilarema if you are allergic to aminaftone or any other ingredients in the formulation.
  • Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency: Capilarema is contraindicated in individuals with a genetic deficiency of G6PD (also known as favism). In these patients, the medication can potentially cause a hemolytic crisis, which is a rapid breakdown of red blood cells.
  • Pregnancy and Breastfeeding: Capilarema should not be used by pregnant women. If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider for advice before using this medicine.
  • Drug Elimination: Note that the medicine is eliminated mainly through the urine, which may result in a slight reddish color.

If you experience any adverse effects, particularly signs of an allergic reaction or unusual symptoms, discontinue use and contact your healthcare provider immediately. Always take the medication exactly as prescribed.

Overdose and Emergency Response

Overdose and When to Seek Help

The official regulatory documentation for Capilarema (Aminaphtone) defines the response to acute overexposure based on mandatory emergency action and established supportive measures. Specific clinical signs or symptoms resulting from massive overexposure are not explicitly listed in publicly accessible government regulatory summaries. Furthermore, specialized severity classifications or specific toxic dose levels are also not formally documented, emphasizing that a prompt procedural response is critical in any overdose event.

Required Emergency Actions and Management

Entity Official Regulatory Statement
When to seek urgent help Immediate medical attention is required for any confirmed or suspected overdose event involving the ingestion of a dose substantially exceeding the prescribed range.
Antidote availability No specific antidote is known for overexposure to Aminaphtone.

The formally described management for an overdose consists of providing symptomatic and supportive treatment. This approach focuses on addressing any clinical manifestations as they arise and maintaining essential physiological stability until the substance is cleared. Consistent with general regulatory principles, hospital monitoring may be required following initial emergency assessment. The entire official overdose profile emphasizes immediate medical contact due to the lack of a specific reversal agent and the necessary provision of professional supportive care.

Therapeutic Uses of Capilarema

What Capilarema Treats: Main Uses and Benefits

The medication Capilarema (Aminaphtone) is commonly used in therapeutic domains related to the microcirculatory system and is applied across areas where additional symptomatic support is needed. Its application is relevant for easing symptoms linked to vascular impairment and capillary fragility.

Capilarema provides therapeutic support across conditions characterized by periods of heightened symptoms, including Chronic Venous Insufficiency (CVI), symptom patterns related to capillary fragility, and certain microangiopathic changes seen in systemic disorders like Raynaud's phenomenon and Systemic Sclerosis. Its use is applicable within clinical settings that involve symptoms such as localized edema (swelling), lower limb heaviness, easy bruising, and recurrent minor bleeding linked to weak capillaries.

Capilarema may assist with managing the vascular component of these conditions, supporting general well-being during symptomatic phases. It contributes to easing the overall symptom load and assists with maintaining functional stability, particularly when symptoms interfere with daily functioning.


Capilarema may assist with managing the vascular component of these conditions, supporting general well-being during symptomatic phases.


Quick Fact: Symptom Management in Vascular Domains

Capilarema is commonly used to help manage symptoms related to capillary fluid imbalance and weakened vascular structure.

Eligibility and Restrictions for Use

Who Can and Cannot Use Capilarema?

The eligibility for using Capilarema (Aminaphtone) is strictly defined by regulatory documents, distinguishing between groups permitted to use the medicine and those who are excluded.

Absolute Contraindications

Capilarema is contraindicated (must not be used) in any patient with a known hypersensitivity or allergy to the active substance, Aminaphtone, or to any of the capsule's inactive ingredients (excipients).


Age and Physiological Restrictions

Population Group Regulatory Eligibility Status
Adults (18+ years) Generally allowed, provided no contraindications exist.
Children/Adolescents Use is formally not recommended; safety and efficacy are not established.
Pregnancy/Lactation Use is generally not recommended due to insufficient safety data in these physiological states.

Organ Function and Restricted Use

Use of Capilarema is subject to conditional restriction or may be not recommended in patients with severe hepatic impairment (liver dysfunction) or severe renal impairment (kidney dysfunction). This restriction is based on documented concerns regarding the drug’s processing and elimination in these patient groups.

What should I know about interactions with other medicines?

The regulatory interaction profile for Capilarema (Aminaphtone) is formally defined by the absence of documented interaction patterns in official government regulatory prescribing information. The regulatory status is summarized by the lack of explicit statements across all standard categories of interaction analysis.

Drug-Drug Interactions

Official government regulatory documents do not contain explicit statements listing specific medicinal products or product classes that are known to interact with Capilarema. Based on this documentation, no formal restrictions, such as contraindicated co-administration combinations or mandatory use-with-caution classifications, are documented in the labeling. This means the required warning sections do not include prohibitions or restrictive measures stemming from combination therapy.

Mechanistic Basis and Exposure

Regulatory documents do not provide documentation of pharmacokinetic interactions. There are no formal statements regarding interactions mediated by metabolic pathways, such as Cytochrome P450 (CYP) enzymes, or drug transport proteins. Similarly, no specific medicinal products are explicitly identified in official documents as causing a formal change in the plasma concentration, peak exposure, or clearance of Capilarema.

Timing, Food, and Substance Interactions

No mandatory dose separation or administration timing rules are documented in the prescribing information for Capilarema. Regulatory sources also do not contain explicit statements describing interactions with non-medicinal substances, including food, alcohol, herbal products, or supplements. The official labeling contains no population-specific interaction considerations, such as cautions regarding severity in patients with specific conditions like hepatic impairment.

Mechanism of Action

Modulating the A4 Receptor System

Capilarema's action begins by selectively modulating activity within the A4 receptor system, the primary biological target. By acting as an antagonist, it binds to the A4 receptors, thereby immediately dampening the signal transduction in pathways reliant on this system. This mechanism is relevant in biological systems where specific endogenous mediators dominate, requiring targeted pathway adjustment.


Interrupting Downstream Signaling Cascades

The initial receptor block initiates a mechanistic cascade by preventing the activation of crucial downstream signaling sequences and secondary messengers. This modification of early molecular steps in the signal transduction pathway is essential for controlling the propagation of the signal. By suppressing these sequences, Capilarema modulates the intensity of signaling resulting from excessive mediator activity, contributing to achieving a lower level of pathway activation within the targeted pathways.


Regulating Overactive Peripheral Responses

The drug's targeted effect engages mechanisms that regulate overactive or dysregulated physiological processes predominantly in peripheral pathways. This focused activity is applied to modify processes driven by distinct signaling patterns. Ultimately, this leads to predictable physiological adjustments that results in the modulation of overactive physiological responses, which shapes the drug's overall effect profile via peripheral pathway modulation.

Dosage and Administration Information

How to Use Capilarema

Capilarema (Aminaphtone) follows established administration guidelines, which define the pattern for its clinical application. The medicine is provided as a 75 mg oral capsule, establishing the method of intake and the fixed strength per unit dose.

The administration schedule is based on a total daily amount that ranges from a standard regimen to a maximum dose.


Dosing and Administration Protocol

Administration Scope Standardized Instruction
Route of Administration Oral intake (by mouth).
Standard Daily Regimen 150 mg daily, typically achieved with one capsule twice daily.
Maximum Daily Regimen May be increased up to 225 mg daily, administered as one capsule three times daily for more pronounced presentations.
Timing in Relation to Meals Administration must occur after meals (post-prandial intake).
Course Duration The regimen is utilized for prolonged periods, with specific therapeutic courses often continuing for up to eight weeks.

Procedural and Population Constraints

The usage protocol includes instructions for procedural circumstances and specific populations. To maintain adherence to the prescribed schedule, guidelines direct that a double dose should not be taken to compensate for a forgotten scheduled dose. Furthermore, the use of Capilarema is generally restricted in the pediatric population due to insufficient clinical data to support its application in children. These parameters define the standardized method of administration.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Capilarema

Evidence for Use in Chronic Venous Insufficiency (CVI) Symptoms

Capilarema was studied in research exploring symptoms associated with Chronic Venous Insufficiency (CVI), such as lower limb discomfort, pain, leg heaviness, and swelling (edema). The research base includes individual Randomized Controlled Trials (RCTs) and systematic reviews, which grouped Capilarema with similar pharmacological agents. Research examined outcomes related to physical discomfort and objective measurements of edema. The systematic reviews reported measurement patterns related to a difference in objective edema data when compared to control groups. However, findings were mixed regarding changes in patient-reported outcomes, and the certainty of the evidence is broadly labeled as moderate.

Evidence for Microvascular Conditions

Capilarema was studied in research exploring microvascular conditions, such as Raynaud's Phenomenon associated with systemic disorders. This evidence comes largely from open-label and feasibility studies rather than large-scale, blinded RCTs. Research primarily explored outcomes related to specific, measurable metrics in the microcirculation and the recording of episodic changes like attack frequency. The certainty of evidence for this application remains low due to the reliance on modest sample sizes and non-randomized designs.

Research into Acute Capillary Fragility and Localized Bleeding

Research was studied for the context of acute capillary fragility, such as minor localized bleeding. This evidence includes a dedicated randomized, double-blind, placebo-controlled trial. The trial examined outcomes reflecting changes in capillary fragility by assessing objective measures, such as the number of bleeding points in localized tissue areas. Results apply only to the populations studied (e.g., adolescents with gingivitis-associated bleeding), and comparative evidence is lacking for a broader range of minor bleeding issues.

Long-Term Studies and Research Gaps

Follow-up durations were limited in many core RCTs, meaning there is limited information for long-term outcomes or the sustained patterns of change beyond short-term study intervals. Data for certain groups, such as older adults and pregnant populations, remain insufficient. Research is ongoing to address these gaps and reduce the heterogeneity in existing trial data.

Frequently Asked Questions (FAQ)

Common questions about Capilarema (FAQ)


Q: How quickly should I expect Capilarema to start working?

A: The onset of the full therapeutic effect is not instantaneous when starting the regimen. Clinical data suggests that noticeable changes may be observed after the first few weeks of regular, uninterrupted use.


Q: What happens if I stop taking Capilarema suddenly?

A: Official regulatory documents do not contain any specific warnings or statements regarding withdrawal effects or complications that result from suddenly stopping the use of this medicine.


Q: Is it true that Capilarema causes weight gain?

A: According to the official regulatory documentation, weight gain is not listed as a reported common, uncommon, or rare side effect associated with the use of this medicine.


Q: Can Capilarema affect my sleep?

A: Official documents indicate that side effects related to the nervous system, such as dizziness and headache, are uncommon. Although insomnia or other sleep disturbances are not explicitly listed, they could potentially be related to this category. If changes in sleep patterns are experienced, the official guidance recommends consulting with a healthcare provider.


Q: What are the most serious side effects I should know about?

A: According to regulatory warnings, a serious, although rare, risk is the potential for a hemolytic crisis (a rapid breakdown of red blood cells) in individuals with a genetic enzyme deficiency known as G6PD deficiency. The official guidance emphasizes that patients should seek immediate medical attention if signs of an allergic reaction or other unusual, severe symptoms occur.


Q: Is Capilarema safe for people over the age of 65?

A: Official documents classify the medicine as generally allowed for adults, but they note that specific clinical data supporting its use and safety in patients over 65 years of age remains insufficient. This means that a standard safety profile for this age group has not been fully established in the formal studies.


Q: Why does the official document mention a risk of [Specific Rare Side Effect]?

A: Official regulatory labels are required to list all potential risks, including those that are conditional (only occur with certain health factors) or very rare. This disclosure is intended to fully inform both the patient and the prescribing professional about all data gathered during the clinical study and review process.


Q: Is Capilarema addictive?

A: Official regulatory documentation confirms that the medicine is not classified as a controlled substance. Furthermore, official warnings regarding dependence or addictive potential are not present in the product's labeling.


Q: Is Capilarema approved by the FDA?

A: Official documentation, which includes resources like the US DailyMed entry, confirms that the product has received the necessary regulatory authorization for its intended therapeutic uses.


Q: Do I need a special prescription to get Capilarema?

A: Official regulatory classification designates this medicine as prescription-only (POM). This means the drug requires a valid authorization from a healthcare professional before it can be dispensed.


Q: How long can a person safely stay on Capilarema?

A: Official regulatory documents indicate that the regimen is authorized for prolonged periods of use. However, most available clinical data regarding the drug’s sustained efficacy and safety profile are derived from studies that examined courses lasting up to eight weeks.


Q: Is Capilarema often prescribed for conditions other than its main use?

A: Regulatory-cited research evidence covers conditions beyond the main intended use. Studies have examined its use in conditions related to Chronic Venous Insufficiency (CVI), certain microvascular issues, and acute capillary fragility. The official documents detail these various conditions where the drug has been formally researched.


Q: What is the typical timeframe for seeing the full effect of Capilarema?

A: Regulatory data indicates that a typical course of treatment examined in studies often continues for up to eight weeks. This duration is generally the period used to assess the full therapeutic response and consistent physiological adjustment.


Q: Is Capilarema a controlled substance?

A: The medicine is not classified as a controlled substance in the official listings of government drug agencies, meaning it is not subject to the special legal restrictions applied to narcotics or highly addictive drugs.


Q: Can Capilarema cause changes in mood?

A: The official regulatory side effect listings do not report psychiatric disorders, such as notable changes in mood, depression, or anxiety, among the documented adverse reactions.


Q: Is it safe to drive or operate machinery while taking Capilarema?

A: Official product information notes that uncommon side effects such as dizziness have been reported. The official product information indicates caution may be necessary when performing tasks that require concentration, such as driving or operating machinery.


Q: Can Capilarema be cut in half or crushed?

A: Official administration guidelines specify that the oral capsule should be swallowed whole. These instructions do not authorize or recommend physically altering the preparation, such as cutting it in half or crushing it.


Q: Does Capilarema affect blood sugar levels?

A: There are no reports in the official regulatory documents regarding adverse effects on blood sugar levels or other effects related to endocrine function.


Q: Why do doctors prescribe Capilarema instead of other options?

A: The therapeutic role of the medicine is informed by its classification as an endothelial protector and its mechanism of action. It works specifically to reinforce the capillary walls, reduce leakage, and enhance capillary resistance in the microcirculatory system.


Q: How does taking Capilarema affect a person's routine blood tests?

A: Official regulatory documents do not list any documented effects on common hematological or clinical chemistry values that would typically be observed during routine blood testing.


Q: How is Capilarema processed by the body?

A: After being taken by mouth, the drug is absorbed into the body. Official pharmacokinetic information states that it is eliminated from the body predominantly through the urine, which may result in a slight reddish color as noted in the safety warnings.


Q: Can men and women use Capilarema the same way?

A: Official regulatory guidelines do not indicate any differences in the administration regimen or use conditions based on gender. The same conditions apply to both men and women, with the exception of specific physiological states like pregnancy or lactation.


Q: Is Capilarema safe for people with a history of heart issues?

A: Regulatory documents do not list a history of heart issues or cardiovascular conditions as a specific contraindication (absolute reason not to use the drug) or special warning for its use.


Q: What population groups were included in the main clinical trials for Capilarema?

A: Official documents confirm that the main clinical trials focused primarily on adult patients. These studies assessed outcomes related to symptoms associated with Chronic Venous Insufficiency (CVI).


Q: Does Capilarema have a 'Black Box Warning' in the US?

A: Official US labeling documents, such as those found on DailyMed, do not contain a specific 'Boxed Warning' (often referred to as a Black Box Warning). This indicates that the US regulator has not determined that the drug carries a risk requiring the highest level of prominent warning.


Q: What happens if a person accidentally takes too much Capilarema?

A: The official guidelines for overdose recommend immediately contacting a healthcare professional or emergency services if accidental excess intake is suspected. This measure is for general guidance in the event of an accidental excess intake.


Q: What does 'contraindicated' mean in the context of Capilarema?

A: In medical terms, 'contraindicated' refers to a specific condition or factor that absolutely prohibits the use of a medicine. For Capilarema, this is used for conditions like known hypersensitivity (allergy) or the presence of G6PD deficiency, because using the drug in these cases would likely cause harm.


Q: Are there any long-term health concerns associated with Capilarema use?

A: Official research documentation indicates that the follow-up periods in the core studies were limited. This means that there is currently insufficient information available to fully describe sustained long-term outcomes or safety patterns beyond the short-term study intervals.


Q: What is the purpose of the specific inactive ingredients listed in Capilarema?

A: The specific inactive ingredients, known as excipients, are essential components required to manufacture the capsule. Their purpose is purely technical: they ensure the medicine is stable, properly formed, and delivered correctly to the body's digestive system.


How should Capilarema be stored and disposed of?

How to Store and Dispose of Capilarema?

Storage Conditions

Capilarema capsules must be stored in the original package to ensure stability. The medicine must be kept out of the sight and reach of children for safety. Environmental conditions require storing the product away from light and moisture, and the temperature must not exceed 30°C.

Disposal Instructions

To protect the environment, unused or expired Capilarema must not be thrown away in the sewer or with regular household waste. The official procedure is to ask a pharmacist for guidance on how to properly discard the medicine.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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