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Medically reviewed by Militian Inessa Mesropovna, PharmD. Last updated on 20.03.2022
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Top 20 medicines with the same components:
Canoa
Choline Alfoscerate
acute period of TBI with predominantly stem-level lesions (impaired consciousness, comatose state, focal hemispheric symptoms, symptoms of brain stem damage),
ischemic (acute and recovery period) and hemorrhagic stroke (recovery period),
degenerative and involutional psycho-organic syndromes and consequences of cerebrovascular insufficiency, such as primary and secondary disorders of mnestic functions, characterized by memory disorders, confusion, disorientation, decreased motivation, initiative, ability to concentrate attention,
changes in the emotional and behavioral sphere: emotional lability, increased irritability, decreased interest, senile pseudomelancholia,
multi-infarction dementia.
Injections: in/m or v/v (drip).
Capsules: inside, before the meal.
Adults, in acute conditions: i / m-at a dose of 1000 mg/day (1 amp.) or I / v-1000-3000 mg/day. With intravenous administration, the contents of 1 amp. (4 ml) are diluted in 50 ml of saline solution, the infusion rate is 60-80 drops per minute. The duration of treatment is usually 10 days, but if necessary, treatment can be continued until positive dynamics appear and it is possible to switch to taking capsules inside.
For chronic cerebrovascular insufficiency, changes in the emotional and behavioral sphere, and multi-infarction dementia: inside-400 mg (1 capsule) 3 times a day.
The duration of therapy is 3-6 months.
Hypersensitivity to the components of the drug.
Nausea (as a result of dopaminergic activation), in this case, you should reduce the dose of the drug. Allergic reactions are possible.
As a rule, the drug is well tolerated even with prolonged use.
Symptoms: nausea.
If this symptom occurs, it is recommended to reduce the dose of the drug.
Improves the transmission of nerve impulses in cholinergic neurons, has a positive effect on the plasticity of neuronal membranes and on the function of receptors. Improves cerebral blood flow, enhances metabolic processes in the brain, activates the structures of the reticular formation of the brain and restores consciousness in traumatic brain damage.
It has a preventive and corrective effect on such pathogenetic factors of involutional psycho-organic syndrome as changes in the phospholipid composition of neuronal membranes and a decrease in cholinergic activity.
Experimental studies have shown that Canoa stimulates the dose-dependent release of acetylcholine under physiological neurotransmission conditions.
When ingested, it is broken down by the action of enzymes to choline and glycerophosphate.
Canoa, on the one hand, being a choline donor, increases the synthesis of acetylcholine and has a positive effect on neurotransmission, on the other — glycerophosphate participates in the synthesis of phosphatidylcholine (membrane phospholipid), as a result, both have a positive effect on membrane elasticity and on the function of receptors, which improves synaptic transmission.
Thus, pharmacodynamic studies have shown that Canoa acts on synaptic, including cholinergic neurotransmission, plasticity of the neural membrane, and receptor function.
Absorption when taken orally-88%, easily penetrates through the BBB, accumulates mainly in the brain (the concentration in the brain reaches 45% of the level in the blood), lungs and liver, 85% is excreted by the lungs in the form of carbon dioxide, the rest (15%) is excreted by the kidneys and through the intestines.
It does not affect the reproductive cycle, does not have teratogenic and mutagenic effects.
- Nootropic agent [Nootropics]