Canac

Quick links to important sections

Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Canac

Quick Facts Overview

Property Description
Active ingredient Permethrin
Form Topical formulations (Cream, Lotion, Solution)
Pharmacological class Ectoparasiticide
Common purpose Elimination of parasitic skin infestations
Origin Synthetic pyrethroid

Defining Canac: A Topical Ectoparasiticide

Canac is a pharmaceutical preparation classified as an ectoparasiticide, which is a type of medicine specifically formulated to eliminate parasites found externally on the body. The single active ingredient it contains is Permethrin, a powerful synthetic compound. Permethrin is a synthetic pyrethroid, meaning it is chemically synthesized to offer a stable and effective alternative to natural pyrethrins, which are often less stable when exposed to light. Canac is designated as a single-ingredient product, focusing the medicine's entire action on the properties of the active compound.

Permethrin's Form and General Purpose

Canac is exclusively prepared as various topical formulations, including a cream, lotion, or liquid solution, designed for direct dermatological application. The medicine's fundamental purpose is the rapid clearance of parasitic infestations such as lice (pediculosis) and mites (scabies), providing a targeted solution for these common skin conditions. The medicine achieves this effect because Permethrin functions as a potent neurotoxin to the target organisms. This mechanism involves interfering with the nerve cells of the parasites, leading to continuous, uncontrolled nerve firing. It is used for the effective eradication of human scabies and lice infestations. The medicine's general benefit is achieving effective paralysis and subsequent death of the infesting organisms, providing relief by removing the source of the dermatological issue.

Regulatory References

  1. Antiparasitic Drugs - StatPearls - NIH
  2. Permethrin - StatPearls - NIH
  3. Permethrin Cream, 5% - DailyMed (FDA)
  4. Permethrin: Mechanism of Action - DrugBank Online

What side effects are possible with Canac?

Possible Side Effects and Safety Information

The safety profile of Canac, whose active ingredient is Permethrin, is defined primarily by topical and application-site reactions, according to official government regulatory documents. The side effects are classified by their frequency and the system-organ-class affected, reflecting the drug's use as a dermal ectoparasiticide.


Regulatory Classification of Adverse Reactions

The most frequently documented effects fall under Skin and Subcutaneous Tissue Disorders.

Frequency Category Common Adverse Reactions
Common Burning and stinging sensations, erythema (redness), and transient worsening of pruritus (itching)
Uncommon/Rare Contact dermatitis, headache, nausea, tingling, and numbness

These common local reactions are often time-related, meaning they are typically observed immediately after application or at the start of treatment and tend to resolve spontaneously, a pattern explicitly noted in regulatory safety texts.

Serious Reactions and Safety Constraints

Nervous System Disorders (headache, paresthesia) and Gastrointestinal Disorders (nausea) are documented, but less frequently than local skin effects. The official labeling recognizes the potential for rare, severe immune responses, such as anaphylaxis or other severe allergic reactions, as is standard for medicinal products.

Population-specific safety statements confirm the use of Permethrin is addressed for the Paediatric Population (often down to two months of age) and during Pregnancy/Lactation, where use is advised with standard precautionary principles.

The absolute safety restriction (contraindication) documented in all official prescribing information is known hypersensitivity to permethrin, other synthetic pyrethrins/pyrethroids, or any excipients in the formulation.

Overdose and Emergency Response

Overdose and When to Seek Help

The official overdose profile for Canac (Permethrin) is defined by the risks associated with accidental oral ingestion, which can lead to systemic toxicity.

Documented Clinical Manifestations

Overdose presentations, primarily following ingestion, involve gastrointestinal distress, including nausea, vomiting, and abdominal pain. Neurological effects officially noted include dizziness, headache, and in severe cases, tremors or convulsions. Severe systemic toxicity can progress to central nervous system depression. A life-threatening complication specifically associated with vomiting after ingestion is the risk of aspiration pneumonia.

When to Seek Immediate Help

Official regulatory guidance mandates that immediate medical attention must be sought for any suspected overdose. In cases of accidental oral ingestion or if severe symptoms—such as persistent vomiting, tremors, or loss of consciousness—are present, emergency services must be contacted immediately. For managing excessive topical application, the instruction is to wash the affected skin thoroughly with soap and water.

Management Protocol

Management for systemic toxicity is strictly symptomatic and supportive. Regulatory information confirms that no specific antidote is known for permethrin intoxication. Close clinical observation and hospital monitoring are required for patients demonstrating signs of significant systemic toxicity.

Therapeutic Uses of Canac

What Canac Treats: Main Uses and Benefits

Canac is a specialized topical medicine commonly used to treat two primary, contagious skin conditions: scabies, which is caused by mite infestation, and pediculosis (lice infestation). The medication is applied across domains where the core problem is the presence of living parasitic organisms, including the mites, lice, and their eggs (nits). The primary therapeutic focus is to assist in the management and removal of these parasitic organisms.

The medicine is applied in addressing symptom clusters that may become intense or disruptive, particularly severe pruritus (itching), which is commonly exacerbated at night, and associated inflammatory skin lesions. Because it targets the active organisms, Canac supports the patient in easing the overall symptom burden, contributes to easing the skin irritation, and supports the patient in returning to general comfort and stability.

The common indications for Canac include managing both mite infestations and lice outbreaks, covering all susceptible patient groups from children and adolescents to adults. This medication also plays a role in managing the cycle of transmission:

“It is considered relevant for managing outbreaks within households or closed communities.”


QuickFact Block

Property Description
Quick Fact: Relief for Intense Pruritus (itching) and Skin Irritation
Conditions Managed Scabies, Pediculosis (Lice)
Therapeutic Focus Supports the management and removal of parasitic organisms
Context of Use Contagion Management for household contacts

Regulatory References

  1. NIH MedlinePlus Drug Information

Eligibility and Restrictions for Use

Official Eligibility and Contraindications

Canac (Permethrin topical) is approved for use in adults, adolescents, and children aged 2 months and older. This includes the elderly, for whom no special systemic precautions are required, although the application area is specified to include the scalp and face.

Absolute Non-Eligibility

The medicine is contraindicated and must not be used by individuals with a known hypersensitivity or allergy to the active ingredient, Permethrin, to any component of the formulation, or to any other synthetic pyrethroid or pyrethrin.

Age and Condition Restrictions

Population Group Regulatory Eligibility Status
Infants under 2 months Safety and effectiveness not established. Not an eligible population.
Children 2 to 23 months Use is permitted, but treatment must be given only under close medical supervision (EMA/SmPC).
Pregnancy Classified as Category B (FDA). Use is restricted to situations only if clearly needed.
Lactation Official labeling advises caution, though minimal systemic absorption is documented.
Application Site Must not be applied to broken skin, open wounds, or mucous membranes (eyes, mouth, nose, genitals).

What should I know about interactions with other medicines?

Interactions with other medicines and products for Canac are limited, reflecting the medicine’s topical application and minimal systemic absorption into the bloodstream. Official regulatory documentation does not classify any systemic pharmacokinetic interactions with other medicinal products, such as those involving CYP enzymes or drug transporters, which are generally not known to be relevant for this formulation.

The interaction profile is officially structured around two non-systemic constraints: administration timing and excipient compatibility.

Pharmacodynamic Risk and Timing Requirements

An administration-based constraint is documented regarding the use of corticosteroids. Treatment for any eczematous-like reactions with topical or systemic corticosteroids should be withheld prior to the application of Canac. This timing requirement is in place because corticosteroid use may reduce the body's immune response to the parasite, creating a pharmacodynamic interaction that risks the exacerbation of the underlying infestation.

Excipient-Mediated Substance Incompatibility

A specific interaction is documented regarding the inactive ingredients in the cream formulation. The excipients, including liquid paraffin and white soft paraffin, can reduce the functioning and mechanical reliability of latex barrier contraceptives, such as condoms and diaphragms. This physical incompatibility is a documented restriction that must be noted during concurrent use of the cream formulation and latex products.

Mechanism of Action

How Canac Works

Targeting Arthropod Voltage-Gated Sodium Channels

The core of Permethrin's mechanism is a specifically targeted modulation of the Voltage-Gated Sodium Channels (VGSCs) in the parasite's nerve cell membranes. Permethrin binds directly to these ion channels, slowing their normal inactivation and forcing them to remain open. This molecular interference leads to a massive, prolonged influx of sodium ions ( Na^+) into the neuron, rapidly inducing sustained membrane depolarization.

Cascading Neurotoxicity and Systemic Paralysis

The sustained depolarization triggered by the channels' failure causes neuronal hyperexcitability—the nerve cells begin firing continuous, uncoordinated signals. This relentless, widespread nervous system overstimulation rapidly consumes the parasite's energy and results in systemic neurotoxicity. The final physiological consequence is neuromuscular failure, manifesting as irreversible paralysis and eventual death of the organism.

️ Mechanism Limitations and Differential Action

The mechanism exhibits a differential effect on ectoparasites because their VGSCs possess a higher sensitivity to Permethrin than human VGSCs. However, the mechanism's functional output is limited when the target organism develops resistance, often due to genetic mutations (e.g., kdr mutation) that alter the channel binding site or through the enhanced metabolic breakdown of the drug by parasitic detoxifying enzymes.

Dosage and Administration Information

How to Use Canac — Official Administration Guidelines

Canac (Permethrin topical) is used according to strict, labeled instructions, establishing the specific administration route, contact time, and re-treatment schedule.


Administration Scope

Parameter Instruction
Route of administration Topical (Dermatological/Cutaneous application)
Dosing schedule Scabies (5% Cream): A single application from the neck to the soles of the feet. Maximum dose for an average adult is 60 grams.
Pediculosis (1% Rinse): Apply sufficient amount to saturate hair and scalp.
Age-group administration rules Approved for children 2 months of age and older. For infants and older adults, application must include the face, ears, scalp, hairline, temples, and forehead.
Special procedural conditions The 5% cream must remain on the skin for 8 to 14 hours. The 1% rinse must remain on the hair for 10 minutes.

Resulting Procedural Structure

The official guidelines mandate a specific sequence based on the formulation being used:

  • Application Condition: The 1% rinse is applied after hair has been shampooed and towel-dried; conditioner must not be used prior to application. The 5% cream is applied to clean, dry, and cool skin.
  • Removal: After the mandated contact time has elapsed, the medicine must be thoroughly removed by washing or bathing.
  • Conditional Re-treatment: The treatment is structured as a single-course application. A second application is administered only if live mites (14 days after the first dose) or live lice/nits (7 days after the first dose) are observed.

This protocol defines a precise, time-bound application and removal process, ensuring standardized use.


Recent Clinical Evidence

Research Evidence / Overview of Studies for Canac (Permethrin)

Evidence for the Treatment of Scabies (Mite Infestation)

The clinical evaluation of the active ingredient in Canac, Permethrin, for treating scabies (mite infestation) was explored in randomized controlled trials and systematic reviews spanning several decades. Research examined the outcomes of Microscopic Clearance, where research monitored the absence of live mites or eggs, and Clinical Clearance Status, defined by the resolution of the skin lesions that characterize the condition. Studies were conducted during periods of increased symptom activity and focused on outcomes related to physical discomfort. Comparative trials were studied for symptom evolution in the observed populations against other anti-scabietic treatments.

Evidence for the Management of Pediculosis (Lice Infestation)

The research base for using the active ingredient in Canac to treat pediculosis (lice infestation) was evaluated in Randomized Controlled Trials (RCTs). Research examined the medicine's role against both live lice and their eggs (nits). Trials monitored two primary outcomes: Lice Clearance, which is the absence of live adult lice, and Ovicidal Assessment, which measures the viability of eggs over the short-term study intervals. Systematic reviews exploring this research have documented that measured outcomes related to lice clearance show patterns related to variability across different study regions and timeframes, often associated with the documented presence of resistant lice strains in certain areas.


Study Findings in Specific Patient Groups and Uncertainties

For Children 2 Months of Age and Older, studies specifically evaluated the use of the topical formulation, and the findings describe patterns observed in these specific populations for outcomes related to parasitic clearance. However, data for certain groups remain insufficient. Research conducted for regulatory review does not typically include data for populations such as those who are pregnant or breastfeeding.

Most key clinical trials evaluated outcomes over short-to-intermediate-term follow-up durations. This means that while research provides insight into short-term changes, there is limited information for long-term outcomes beyond these time points. The continued presence of significant itching (pruritus) for weeks after the time point when clearance was observed was observed in some studies, highlighting an area where research provides limited insight into complete symptomatic relief.

Key Studies & References

  1. MedlinePlus Drug Information: Permethrin Topical (General Drug Overview)
  2. NIH MedlinePlus Drug Information: Permethrin Topical (Indications and Use)

Frequently Asked Questions (FAQ)

Common questions about Canac (FAQ)


Q: Why is Canac prescribed for [Condition A] but not [Condition B]?

According to official regulatory documents, the active ingredient in Canac is described as being exclusively indicated for treating infestations with Sarcoptes scabiei (scabies) and for the treatment of pediculosis (lice). The medicine is not authorized or described in official documents for use against other medical conditions.


Q: Does Canac start working immediately or does it take time?

The mechanism of action for Canac is described in official documents as immediately disrupting the nerve cell membranes of the target organisms upon contact. This neurotoxic action is described as rapidly leading to the sustained paralysis and subsequent elimination of the parasite.


Q: Can Canac be taken by someone with a history of heart problems?

Official regulatory safety information does not list heart problems or cardiovascular disease as a specific contraindication or special precaution for the topical use of Canac. The minimal systemic absorption of the medicine is noted in regulatory information.


Q: Are there any specific foods or drinks to avoid while using Canac?

Regulatory documents indicate that interactions are not expected with other orally taken drugs, foods, or drinks because Canac is only applied to the skin and has minimal systemic absorption. No specific dietary restrictions are noted in the official prescribing information.


Q: Can Canac affect the results of blood tests or other lab work?

It is recognized that metabolites of the active ingredient in Canac can be detected in blood or urine following use. However, the detection of these metabolites in testing does not, on its own, serve as an indication of an adverse health effect.


Q: Are there different forms of Canac (e.g., tablet, liquid, extended-release)?

The active ingredient in Canac is officially formulated and approved only as topical preparations, such as a cream, lotion, or liquid solution. It is not available in oral forms like tablets or extended-release capsules.


Q: How long do doctors typically recommend staying on Canac?

Official administration instructions define Canac as a single-course application designed for short-term use for parasite clearance. A second application is noted in regulatory documents as being conditionally administered only if live organisms are observed after the initial follow-up period.


Q: What is the typical time frame for noticing the full benefits of Canac?

Clinical trial information notes that symptoms like itching may continue for up to two to four weeks following treatment. The persistence of symptoms is noted to not necessarily mean the organism has not been cleared.


Q: What is the risk of dependence or addiction with Canac?

Regulatory documents classify the medicine as a topical ectoparasiticide. Official safety information does not include warnings or precautions related to dependence, addiction, or abuse potential for this formulation.


Q: Are there any age limits for using Canac?

Official documents state that Canac is suitable for use in patients aged two months and older, including the elderly population. Safety and effectiveness are not established for infants younger than two months of age.


Q: Does Canac affect sleep patterns?

Official regulatory labeling does not list insomnia or changes to sleep patterns as a common or frequently reported adverse reaction for the topical formulation of Canac.


Q: Are there any common misuses of Canac that regulatory bodies warn against?

Regulatory warnings emphasize that the product is strictly for cutaneous (skin) use only. Misuse warnings specifically state that the product should not be applied to broken skin, open wounds, the eyes, or any mucous membranes.


Q: If I think I'm having a reaction to Canac, what should I do?

In the event of a suspected severe allergic reaction, such as difficulty breathing or swelling of the face, tongue, or throat, or if skin irritation persists significantly beyond the expected period of four weeks, official patient information describes the need for the patient to contact a healthcare professional.


Q: Is it normal to feel [mild, common symptom] after starting Canac?

Official labeling describes it as common for mild, temporary sensations like burning, stinging, or a transient increase in itching to occur. These feelings are often observed immediately after application or at the start of treatment.


Q: What is the main difference between Canac and a standard over-the-counter remedy?

Canac contains Permethrin, which is a synthetic pyrethroid ectoparasiticide. This active ingredient is defined by its specific mechanism of action, which involves acting as a neurotoxin to target the parasites.


Q: How long does the effect of a single dose of Canac typically last?

Regulatory guidance suggests that a single, standardized application is usually curative and sufficient to eliminate the infestation. Some formulations are stated to help prevent recurrence or re-infestation for up to 14 days after the treatment.


Q: Is Canac considered a long-term or short-term treatment?

Official administration instructions define Canac as a single-course treatment for parasite clearance. It is intended for short-term use and is not designed or authorized for chronic or daily long-term administration.


Q: Does Canac interact with commonly used vitamins or supplements?

Because the medicine is applied topically and is only minimally absorbed into the bloodstream, a systemic interaction between Canac and orally taken vitamins or supplements is not considered likely according to regulatory data.


Q: Can I drink alcohol while taking Canac?

Regulatory documents do not mention a systemic interaction between Canac and alcohol. The risk of such an interaction is minimized because the topical formulation is associated with minimal absorption into the bloodstream.


Q: Can Canac be used by older adults (e.g., people over 65)?

Canac is officially approved for use in the elderly population (over 65) without specific systemic precautions. For this age group, instructions require the application to include the entire scalp and hairline as part of the treatment area.


Q: If I miss a dose of Canac, what do official instructions say I should do?

Official instructions and patient information state that the concept of 'missing a dose' does not apply to Canac. This is because the treatment protocol is defined as a single-use, single-course topical application.


Q: Does Canac cause drowsiness or affect the ability to drive?

Drowsiness (somnolence) is not listed as a common or frequently reported adverse reaction in the official labeling for the topical product. Central Nervous System effects reported are limited to headache or dizziness.


Q: What are the official recommendations for stopping the use of Canac?

Official instructions specify that after the required contact time (which is between 8 and 14 hours for the cream), the medicine is to be thoroughly removed by washing or bathing.


Q: Why might a patient switch from a different drug to Canac?

Research evidence indicates that variations in effectiveness against local parasite strains may influence treatment choice. These variations can be linked to the documented presence of resistant lice strains in certain areas, which can prompt a change in medication.


Q: How to Store and Dispose of Canac?

Official labeling requires storing the product at controlled room temperature, typically between 20 C and 25 C, and advises against freezing or exposure to excessive heat. For disposal, regulatory documents state the product should not be poured down drains or into wastewater due to its documented toxicity to aquatic life.

How should Canac be stored and disposed of?

How to Store and Dispose of Canac?

The storage and disposal rules for Canac (Permethrin topical) are defined strictly by regulatory labeling to maintain product stability and ensure public safety.


Official Storage Requirements

Condition Regulatory Mandate
Temperature Store at 20 C to 25 C (68 F to 77 F) (Controlled Room Temperature).
Prohibited Do not freeze; keep away from excess heat and moisture.
Protection Keep the container tightly closed and away from direct light.
Child Safety Must be kept out of the sight and reach of children.

Handling and Disposal Rules

Disposal must be conducted according to local regulatory requirements for unused or expired medicine. A critical environmental restriction requires that Canac must not be poured down drains or into wastewater due to the substance's toxicity to aquatic life. Additionally, fabrics that have come into contact with the product may be easily ignited by a naked flame, necessitating that the product and contaminated materials be kept away from fire.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

Available in countries:

Equivalent of Canac found in:

A-Z Index: