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Calmidol Compuesto

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Calmidol Compuesto

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Treatment option:

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

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Overview of Calmidol Compuesto

Quick Facts

Property Description
Active Ingredient Ibuprofen and Caffeine
Form Tablet (Oral)
Pharmacological Class Combination Analgesic (NSAID + CNS Stimulant)
Common Use Enhanced Symptomatic Pain Relief
Origin Synthetic

What Type of Medicine is Calmidol Compuesto?

Calmidol Compuesto is defined as a specialized fixed-dose combination product intended for comprehensive symptomatic relief. It is formally classified as a Combination Analgesic, a category that unites two or more distinct therapeutic agents for a cohesive therapeutic effect. The product's core identity is based on the co-formulation of a Nonsteroidal Anti-Inflammatory Drug (NSAID) with a Central Nervous System (CNS) Stimulant. This combination approach is clinically recognized for its efficiency in addressing pain, with efficacy supported by pharmacological studies. The typical presentation is an oral tablet, positioning it for widespread use in adult populations seeking pain relief.

Active Ingredients: Ibuprofen, Caffeine, and Synergism

The formulation relies on the combined action of its two active ingredients: Ibuprofen and Caffeine. Ibuprofen is chemically a Propanoic acid derivative that acts as the primary pain-relieving and anti-inflammatory agent, while Caffeine is a Methylxanthine that functions as an adjuvant. Both components are typically of synthetic origin for pharmaceutical use. The rationale for this dual component composition is to achieve a synergistic effect, a principle where the combined therapeutic efficacy is recognized to exceed the effect of the compounds administered separately. This composition is designed to maximize the pain-relieving potential of its active components.

General Purpose of the Analgesic Combination

The general purpose of this specific analgesic combination is to provide enhanced and multifaceted symptomatic treatment for general discomfort and pain, such as that experienced with common muscular aches or headaches. By combining a component that mitigates the physical processes of inflammation (Ibuprofen) with one that potentiates the overall pain-blocking response (Caffeine), the product offers a robust, dual-pathway approach to relief. This structure defines the preparation’s role in delivering comprehensive and efficacious pain relief, positioning it as a potent option for general symptomatic needs.

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What side effects are possible with Calmidol Compuesto?

Calmidol Compuesto is a combination product typically containing acetaminophen (paracetamol) and ibuprofen. The safety profile is defined by the known risks associated with each active component, with warnings generally mandated by regulatory authorities for both drug classes.

General Safety Profile

Adverse reactions associated with this type of combination product most commonly involve the gastrointestinal system and the central nervous system. Frequent side effects may include nausea, vomiting, dyspepsia (indigestion), headache, and dizziness.

Serious and Clinically Significant Risks

Serious adverse events are primarily linked to the distinct mechanisms of action of the two main components:

  • Hepatotoxicity (Liver Damage): Products containing acetaminophen carry a significant risk of acute liver failure, sometimes requiring transplant or resulting in death, particularly when maximum daily doses are exceeded or when taken with alcohol.
  • Cardiovascular and Gastrointestinal Risk: The ibuprofen component, a nonsteroidal anti-inflammatory drug (NSAID), is associated with a potentially increased risk of serious cardiovascular thrombotic events, including myocardial infarction (heart attack) and stroke, which can be fatal. NSAIDs also pose a risk of serious gastrointestinal events, such as bleeding, ulceration, and perforation of the stomach or intestines.

Key Safety Warnings and Restrictions

Serious Skin Reactions: Both acetaminophen and NSAIDs have been associated with rare but serious skin reactions, including Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). Use should be discontinued at the first appearance of a rash or other signs of hypersensitivity.

Pre-existing Conditions: Caution is required in patients with a history of heart failure, stomach ulcers, kidney disease, or severe liver impairment. NSAID use is contraindicated immediately before or after coronary artery bypass graft (CABG) surgery.

Population Considerations: The use of NSAIDs after 20 weeks of pregnancy can harm the unborn baby. Older adults may be at greater risk for serious gastrointestinal adverse events. Safe use in children must adhere strictly to age- and weight-appropriate dosing guidelines. Monitoring for signs of stomach bleeding (e.g., bloody or tarry stools) or liver problems is necessary during use.

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Overdose and Emergency Response

Overdose and When to Seek Help

Overdose of Calmidol Compuesto, which contains Ibuprofen, occurs when an individual intentionally or accidentally consumes more than the recommended quantity of the medication.

Documented Overdose Profile

The most critical manifestations of Ibuprofen overdose can include effects on the central nervous system, such as confusion, drowsiness, and in severe cases, convulsions. The cardiovascular and gastrointestinal systems may also be affected, potentially leading to low blood pressure or gastrointestinal bleeding. Overdose may also pose a risk to the kidneys and liver.

Required Emergency Action

Immediate medical attention is required in all suspected cases of overdose. If an overdose is suspected, immediately call the local emergency number or contact a poison control center. Do not wait for symptoms to worsen.

Clinical Response

Healthcare providers may initiate measures such as the administration of activated charcoal to limit absorption, and provide general supportive care. Monitoring of vital signs, including blood pressure and respiratory rate, is standard. In rare, severe instances of very large overdose, specialized interventions like kidney dialysis may be necessary. Recovery is generally probable with prompt medical treatment; however, very large exposures can potentially lead to chronic injury to the liver or kidneys.

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Therapeutic Uses of Calmidol Compuesto

The medication is generally used to provide supportive symptom management, leveraging the combined therapeutic effect of its components to provide supportive relief when short-term symptomatic assistance is needed. The addition of caffeine to ibuprofen contributes to supportive symptomatic management in acute settings.

It is commonly used across conditions characterized by periods of heightened symptoms such as muscular aches, acute dental pain, and the discomfort stemming from menstrual cramps (dysmenorrhea), and is applicable within clinical settings for managing headache pain and symptoms related to the intensity of migraines. The preparation is relevant for managing symptoms related to inflammatory or irritative states. The therapeutic support helps ease the overall symptom burden and supports patients during episodes of heightened discomfort.

Quick Fact: Relevant for Moderate to Severe Symptom Intensity

“This dual-component support is relevant in contexts marked by increased discomfort or tension, and is considered relevant for managing pain intensity classified as moderate to severe.”

This approach assists with maintaining functional stability when symptoms are more noticeable, providing support that helps ease the overall symptom load and may help patients cope more steadily with symptom fluctuations.

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Eligibility and Restrictions for Use

Eligibility Map: Who can and cannot use Calmidol Compuesto

The official regulatory profile for Calmidol Compuesto (Ibuprofen and Caffeine) defines specific population groups that must not use the medicine. Use is strictly contraindicated for patients with a known hypersensitivity to Ibuprofen, Caffeine, or other NSAIDs, and for those with an active or history of recurrent gastrointestinal bleeding or peptic ulcers. Contraindication also applies to patients with severe hepatic impairment, severe heart failure, or those treated for peri-operative pain after Coronary Artery Bypass Graft (CABG) surgery.

Eligibility Rule Regulatory Status
Pregnancy Contraindicated at or after 20 weeks gestation.
Lactation Not Recommended (Active ingredients transfer to breast milk).
Pediatric Use Not recommended for children under 12 years of age.
Organ Function Contraindicated in severe hepatic, renal, or cardiac impairment.
Geriatric Use Use requires special care and the lowest effective dose.

Use is not recommended during the first and second trimesters of pregnancy. The regulatory profile is built on the established constraints for NSAIDs, ensuring that individuals with significant comorbidities or specific physiological states are formally excluded from use to maintain regulatory safety boundaries.

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What should I know about interactions with other medicines?

Interactions with other medicines and products

This section outlines the officially documented interaction patterns for Calmidol Compuesto (Ibuprofen and Caffeine), based on governmental regulatory information.


Contraindicated and High-Risk Combinations

Co-administration with other Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) is strictly restricted due to the substantially increased, documented risk of serious gastrointestinal (GI) bleeding and ulceration. The use of the Ibuprofen component is formally contraindicated in the setting of peri-operative pain for Coronary Artery Bypass Graft (CABG) surgery.

Combining this medicine with Anticoagulants (e.g., Warfarin) or Corticosteroids is associated with a high, officially documented risk of GI bleeding due to additive pharmacodynamic effects.

Pharmacokinetic and Pharmacodynamic Interactions

Interacting Substance Formal Interaction Outcome
Lithium or Methotrexate Reduced renal clearance leading to increased plasma concentrations and potential toxicity.
Diuretics/ACE Inhibitors/ARBs Diminished antihypertensive effect and increased risk of NSAID-mediated renal toxicity.
Stimulant Drugs Additive CNS effects, resulting in officially documented nervousness or rapid heart rate.

Timing and Substance Restrictions

A mandatory timing rule requires Ibuprofen to be separated from non-enteric coated Aspirin by at least 8 hours before or 30 minutes after Aspirin dosing to prevent interference with its antiplatelet action. Consumption of Alcohol is restricted due to the documented increase in GI bleeding risk. Intake of excessive Caffeine-Containing Products (foods, beverages) must also be limited to prevent stimulant potentiation.

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Mechanism of Action

How Calmidol Compuesto Works


Modulation of Cyclooxygenase Pathways

This domain involves the action of the analgesic components (likely Paracetamol and Ibuprofen) on the cyclooxygenase (COX) enzymes, primarily COX-1 and COX-2. The mechanism reduces the synthesis of prostaglandins—lipid mediators that intensify physiological responses—resulting in the adjustment of activity within targeted pathways. The resulting biochemical alteration affects peripheral signaling.


Central Nervous System Activation

The presence of a central nervous system (CNS) stimulant (likely Caffeine) engages mechanisms that influence receptor-mediated signaling in the brain. This pathway modulation, which may involve adenosine antagonism, leads to increased neuronal activity and affects systems where specific transmitters dominate, influencing specific neural activity and modifying sensory signal transmission.


Influence on Peripheral Mediator Activity

The combined components modify early molecular steps in inflammatory and nociceptive cascades. By limiting the production of peripheral mediators, this action helps to limit the impact of excessive mediator activity, leading to measurable modifications in localized physiological parameters, and modifying the biochemical environment surrounding the receptor sites.

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Dosage and Administration Information

How to Use Calmidol Compuesto: Official Administration Guidelines

This section outlines the standardized administration protocols for the Ibuprofen 400 mg / Caffeine 100 mg fixed-dose combination, based strictly on official regulatory guidance and clinical usage models.


Administration Scope

Instruction Detail
Route of Administration The only approved route is oral (by mouth).
Dosing Schedule The single dose is one tablet or capsule. The daily maximum is restricted to three doses in any 24-hour period, equaling 1200 mg Ibuprofen and 300 mg Caffeine.
Dosing Interval A minimum of six to eight hours must pass between administrations.
Timing in Relation to Meals Doses are advised to be taken with or after food to help mitigate potential gastrointestinal discomfort.
Age-Group Rules Use is generally restricted to adults and adolescents over 12 years of age.

Use Protocol and Duration

Instruction Detail
Duration of Use The medication is officially designated for short-term use only.
Administration Method The unit must be swallowed whole with sufficient water, without chewing or crushing.
Caffeine Consumption Intake of other caffeine-containing products must be limited to control total caffeine exposure.
Adjustment Principle Use of the lowest effective dose for the shortest duration is the guiding principle for this NSAID combination, particularly relevant for older adults.

The official instructions establish a standardized oral regimen that defines the maximum daily frequency and minimum interval between doses, thereby preventing overexposure. The protocol strictly confines the administration duration to acute, short-term symptomatic support.

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Recent Clinical Evidence

Research Evidence / Overview of Studies for Calmidol Compuesto

Evidence for Use in Acute Postoperative Pain

The research exploring this combination for outcomes related to physical discomfort following procedures, such as surgical tooth removal, primarily involves randomized controlled trials (RCTs) and comprehensive systematic reviews. Studies included adult populations where pain intensity was classified as moderate to severe at the start of the research. Research examined key outcomes related to pain intensity difference and total pain scores measured over specific post-dose intervals (e.g., 6 to 8 hours), and monitored the need for rescue medication.

Studies reported that measurements related to total pain scores measured showed patterns that were associated with the combination compared to Ibuprofen monotherapy. However, because the evidence is mainly derived from single-dose studies, the research does not provide extensive context regarding symptom patterns or daily functioning over multiple days of use.


Evidence for Use in Acute Headache Pain

The combination was studied for research exploring short-term changes in acute headache symptoms, including both episodic tension-type headache and migraine. Studies monitored patient-reported outcomes describing perceived discomfort, focusing on metrics such as the time it took to report a change in symptom severity measured. Research has also explored the proportion of people who report resolution of headache scores at specific time points after administration.

Trials described measured patterns related to the time to perceived change in symptom severity that was observed in some studies to be shorter with the combination compared to Ibuprofen monotherapy. Data show patterns related to resolution of headache scores sometimes varied across studies.


The Role of the Combination as an Analgesic Adjuvant

Studies have explored the combination as an adjuvant effect of caffeine when it is combined with Ibuprofen. This evidence is derived from systematic reviews that pool data across multiple acute pain models. Studies focus on patient-reported outcomes describing perceived discomfort, specifically examining how the addition of caffeine affects the proportion of participants who report achieving a predefined threshold of pain relief (e.g., at least 50% of the maximum possible).

Research highlights that combining caffeine with an analgesic was associated with a measured, statistically discernible increase in the proportion of individuals who reported achieving a predefined relief threshold in the observed populations. This measured increase was observed in some studies to be a small but pattern observed in the studies.

Key Studies & References

  1. A Study Comparing the Combination of Ibuprofen and Caffeine to Ibuprofen Alone in Patients With Pain Following Surgery for Impacted Teeth (NCT00977259)
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Frequently Asked Questions (FAQ)

Common questions about Calmidol Compuesto (FAQ)


Q: How long does it usually take for Calmidol Compuesto to start working?

Official regulatory documents rely on pharmacokinetic studies to define how the drug is absorbed, including the time it takes for the components to reach their maximum concentration in the body. However, these documents generally do not provide a specific, patient-reported time for when the pain relief effect will begin.


Q: Can Calmidol Compuesto be taken every day?

According to the official product information, this drug is designated for short-term use only to manage acute symptoms. Official product information emphasizes minimizing the duration of use to the shortest possible time that provides relief.


Q: Do any common foods or drinks interact with Calmidol Compuesto?

Official documents specifically advise caution regarding the co-consumption of alcohol due to documented potential risks. Furthermore, the intake of other caffeine-containing products is restricted to mitigate the risk of excessive stimulant effects from the combination of ingredients.


Q: What is the difference between Calmidol Compuesto and Ibuprofen for pain?

Calmidol Compuesto is defined as a fixed-dose combination product. Regulatory documents describe that the caffeine component acts as an analgesic adjuvant, meaning it is observed to enhance the pain-relieving effects of the primary analgesic ingredient (Ibuprofen).


Q: Is Calmidol Compuesto approved by the FDA or other major health agencies?

The ingredients and use conditions for this drug are defined in official documents published by major health agencies, such as the FDA Drug Facts Label or the European Medicines Agency (EMA) SmPC. These documents reflect the regulatory authorization for the product.


Q: How long do the effects of Calmidol Compuesto typically last?

The official administration protocol requires a minimum time interval between doses to manage the medication in your system. This required interval is typically six to eight hours, which guides the recommended maximum usage frequency over a 24-hour period.


Q: Is there a maximum number of days Calmidol Compuesto should be used continuously?

Administration guidelines consistently specify that the drug should be used for short-term symptomatic relief only. The official documents emphasize minimizing the duration of use to the necessary period, but they may not define a specific maximum number of days.


Q: Does Calmidol Compuesto cause drowsiness or affect driving?

Official documents note that side effects such as dizziness or headache may occur with use. It is stated that these effects could potentially affect the ability to safely drive vehicles or operate heavy machinery.


Q: Is Calmidol Compuesto safe for people with high blood pressure?

Regulatory documents state that caution must be exercised when the product is used by patients with a history of hypertension (high blood pressure). The risks associated with the NSAID component, such as diminished antihypertensive effects, are outlined in the official warnings.


Q: Is the research evidence for Calmidol Compuesto considered strong?

Official regulatory summaries describe the evidence supporting this combination as being derived from randomized, controlled clinical trials (RCTs). These studies examine specific pain outcomes, such as changes in pain intensity over time, to establish the product's defined use.


Q: Can Calmidol Compuesto make me feel tired?

The official safety information lists fatigue as an undesirable effect sometimes associated with the use of this drug.


Q: What should I do if the medicine causes stomach pain?

Official warnings state that if signs of serious adverse events—such as gastrointestinal bleeding or ulceration—are observed, the product’s use is to be discontinued. The official label specifies the necessity of obtaining immediate medical assistance in these situations.


Q: Does Calmidol Compuesto affect the birth control pill?

The regulatory document lists interactions with various types of medications. While a specific interaction with oral contraceptives may not be explicitly listed, official warnings require the assessment of potential risks when the product is used with all concurrent medications.


Q: Is Calmidol Compuesto available without a prescription in some places?

The availability of the drug without a prescription depends entirely on the regulatory status defined by the governing authority in each region. This status determines whether the product is classified as Prescription-Only or Non-Prescription (OTC).


Q: What should I do if I forget to use Calmidol Compuesto?

Official administration guidelines contain specific protocols for handling a missed dose. This guidance generally directs users to skip the missed dose and adhere to the regular schedule thereafter, thereby avoiding excessive dosing.


Q: Can Calmidol Compuesto be used for nerve pain?

The official indications define the use of the product for the treatment of acute, mild to moderate pain conditions. The product information specifies whether a certain type of pain, such as nerve pain, is included within the approved indications.


Q: Does Calmidol Compuesto contain any habit-forming ingredients?

The components of this product are classified by regulatory agencies. Neither Ibuprofen nor Caffeine is scheduled as a controlled substance for dependence, meaning official documents do not identify them as habit-forming ingredients.


Q: What is the list of inactive ingredients in Calmidol Compuesto?

Official regulatory documents, such as the EMA SmPC, are required to provide the complete list of all components. This list includes both the active ingredients and the inactive ingredients, which are sometimes called excipients.


Q: What kind of medical professional usually prescribes Calmidol Compuesto?

The professional required to administer the drug depends on its regulatory status in your region. If the national authority classifies it as Over-the-Counter (OTC), a prescription from a medical professional is not required.


Q: Can Calmidol Compuesto be used during a menstrual period?

Official regulatory indications often include the use of the product for the treatment of pain associated with menstruation, often referred to as primary dysmenorrhea. This is an approved use for the product's analgesic components.


Q: What are the signs of taking too much Calmidol Compuesto?

Official documents detail the clinical presentation and management of acute overdose for the active components. Symptoms of taking too much of the drug are described in the official documents under the Overdose section.


Q: What is the difference between a side effect and an allergic reaction to Calmidol Compuesto?

Regulatory documents define hypersensitivity (an allergic reaction) as a specific warning or contraindication for use. This is distinct from a common undesirable effect (side effect), which is listed as a generally known possible consequence of using the medicine.


Q: Can Calmidol Compuesto be used for muscle cramps?

Official regulatory documents define the product's purpose for conditions that include musculoskeletal pain and muscle aches. These categories encompass a variety of related discomforts, including the types of pain associated with muscle cramps.


Q: What if I'm taking herbal supplements—do they interact with Calmidol Compuesto?

The official regulatory label requires disclosure of all concurrent product use, which includes herbal products and supplements. This is necessary to assess the potential for interactions, as the combination with certain substances may increase risks.


Q: Is it possible to develop a tolerance to Calmidol Compuesto?

The regulatory documents define the product's use for acute, short-term pain management. For acute use as indicated, there is no standard concern regarding the development of tolerance mentioned in the official documents.


Q: What conditions is Calmidol Compuesto NOT intended to treat?

The regulatory label defines the specific conditions for which the product is indicated. Furthermore, the section on Contraindications defines a list of medical conditions where the drug must not be used.

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How should Calmidol Compuesto be stored and disposed of?

How to Store and Dispose of Calmidol Compuesto?

Official regulatory guidelines mandate specific conditions for storing and disposing of Calmidol Compuesto to maintain its stability and ensure environmental safety.


Storage Conditions

Requirement Instruction
Temperature Store at a temperature inferior to 30°C.
Prohibitions Do NOT refrigerate and Do NOT freeze the product.
Protection Keep in the original container to protect it from light and moisture.
Child Safety Must be kept out of the sight and reach of children.

Disposal Instructions

Expired or unused Calmidol Compuesto must NOT be disposed of via wastewater or household waste. The product must be returned to a designated pharmacy or collection point for medicinal waste, following local pharmaceutical waste regulations.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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